Details for: EMC2

Gene ID: 9694

Symbol: EMC2

Ensembl ID: ENSG00000104412

Description: ER membrane protein complex subunit 2

Associated with

Other Information

Genular Protein ID: 1331854663

Symbol: EMC2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q15006 Q8WUE1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 6 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 7 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7788527

Title: Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7788527

DOI: 10.1093/dnares/2.1.37

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22119785

Title: Defining human ERAD networks through an integrative mapping strategy.

PubMed ID: 22119785

DOI: 10.1038/ncb2383

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30415835

Title: EMC Is Required to Initiate Accurate Membrane Protein Topogenesis.

PubMed ID: 30415835

DOI: 10.1016/j.cell.2018.10.009

PubMed ID: 29809151

Title: The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins.

PubMed ID: 29809151

DOI: 10.7554/elife.37018

PubMed ID: 29242231

Title: The ER membrane protein complex is a transmembrane domain insertase.

PubMed ID: 29242231

DOI: 10.1126/science.aao3099

PubMed ID: 33964204

Title: WNK1 is an assembly factor for the human ER membrane protein complex.

PubMed ID: 33964204

DOI: 10.1016/j.molcel.2021.04.013

PubMed ID: 32459176

Title: The architecture of EMC reveals a path for membrane protein insertion.

PubMed ID: 32459176

DOI: 10.7554/elife.57887

PubMed ID: 32439656

Title: Structural basis for membrane insertion by the human ER membrane protein complex.

PubMed ID: 32439656

DOI: 10.1126/science.abb5008

Sequence Information:

  • Length: 297
  • Mass: 34834
  • Checksum: CA5903AEC3B3E36A
  • Sequence:
    • MAKVSELYDV TWEEMRDKMR KWREENSRNS EQIVEVGEEL INEYASKLGD DIWIIYEQVM 
IAALDYGRDD LALFCLQELR RQFPGSHRVK RLTGMRFEAM ERYDDAIQLY DRILQEDPTN 
TAARKRKIAI RKAQGKNVEA IRELNEYLEQ FVGDQEAWHE LAELYINEHD YAKAAFCLEE 
LMMTNPHNHL YCQQYAEVKY TQGGLENLEL SRKYFAQALK LNNRNMRALF GLYMSASHIA 
SNPKASAKTK KDNMKYASWA ASQINRAYQF AGRSKKETKY SLKAVEDMLE TLQITQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.