Details for: ACYP1

Gene ID: 97

Symbol: ACYP1

Ensembl ID: ENSG00000119640

Description: acylphosphatase 1

Associated with

  • Acylphosphatase activity
    (GO:0003998)
  • Phosphate-containing compound metabolic process
    (GO:0006796)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 131.0391
    Cell Significance Index: -20.3800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 86.1051
    Cell Significance Index: -21.8400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 65.5909
    Cell Significance Index: -27.0200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 58.0993
    Cell Significance Index: -27.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.2514
    Cell Significance Index: -27.4400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.6361
    Cell Significance Index: -23.1400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.2478
    Cell Significance Index: -28.6000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.7525
    Cell Significance Index: -20.7400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.4053
    Cell Significance Index: -11.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.5180
    Cell Significance Index: 409.5300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.1251
    Cell Significance Index: 16.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.4234
    Cell Significance Index: 165.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.3441
    Cell Significance Index: 386.7400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.2555
    Cell Significance Index: 65.9200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9666
    Cell Significance Index: 26.3100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.8488
    Cell Significance Index: 7.1300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7429
    Cell Significance Index: 46.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7428
    Cell Significance Index: 20.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7300
    Cell Significance Index: 50.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6656
    Cell Significance Index: 30.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6271
    Cell Significance Index: 125.7900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5940
    Cell Significance Index: 324.4000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5759
    Cell Significance Index: 56.9700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.5466
    Cell Significance Index: 14.0500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4339
    Cell Significance Index: 5.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4306
    Cell Significance Index: 22.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4007
    Cell Significance Index: 47.2600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3766
    Cell Significance Index: 24.3000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.3719
    Cell Significance Index: 2.5200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.3642
    Cell Significance Index: 3.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2896
    Cell Significance Index: 103.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2730
    Cell Significance Index: 7.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2580
    Cell Significance Index: 46.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2554
    Cell Significance Index: 31.4000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2286
    Cell Significance Index: 101.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2273
    Cell Significance Index: 45.1100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2194
    Cell Significance Index: 5.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2128
    Cell Significance Index: 11.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1976
    Cell Significance Index: 27.1300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1669
    Cell Significance Index: 1.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1636
    Cell Significance Index: 31.1300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1565
    Cell Significance Index: 141.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1289
    Cell Significance Index: 9.8900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1239
    Cell Significance Index: 3.6400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1122
    Cell Significance Index: 3.9000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1033
    Cell Significance Index: 13.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0773
    Cell Significance Index: 2.7200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0281
    Cell Significance Index: 52.8300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0262
    Cell Significance Index: 1.8500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0244
    Cell Significance Index: 0.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0140
    Cell Significance Index: 25.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0083
    Cell Significance Index: 0.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0068
    Cell Significance Index: 10.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0003
    Cell Significance Index: 0.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0000
    Cell Significance Index: 0.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0015
    Cell Significance Index: -0.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0022
    Cell Significance Index: -1.6400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0028
    Cell Significance Index: -1.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0033
    Cell Significance Index: -2.4400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0041
    Cell Significance Index: -0.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0111
    Cell Significance Index: -1.4300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0159
    Cell Significance Index: -9.9000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0200
    Cell Significance Index: -15.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0230
    Cell Significance Index: -10.4500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0307
    Cell Significance Index: -17.3000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0333
    Cell Significance Index: -0.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0413
    Cell Significance Index: -6.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0413
    Cell Significance Index: -4.2200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0418
    Cell Significance Index: -0.7000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0549
    Cell Significance Index: -0.9400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0639
    Cell Significance Index: -13.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0897
    Cell Significance Index: -4.1800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0967
    Cell Significance Index: -2.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1030
    Cell Significance Index: -11.8000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1385
    Cell Significance Index: -15.8100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1398
    Cell Significance Index: -1.5200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1671
    Cell Significance Index: -4.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1703
    Cell Significance Index: -11.4500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1758
    Cell Significance Index: -3.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1806
    Cell Significance Index: -5.7900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2008
    Cell Significance Index: -2.4900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2134
    Cell Significance Index: -5.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2529
    Cell Significance Index: -26.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2679
    Cell Significance Index: -21.2200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3094
    Cell Significance Index: -8.8700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3162
    Cell Significance Index: -6.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3327
    Cell Significance Index: -20.4000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3451
    Cell Significance Index: -8.4200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.3469
    Cell Significance Index: -2.7700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3504
    Cell Significance Index: -15.5000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3792
    Cell Significance Index: -14.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3795
    Cell Significance Index: -9.9800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4333
    Cell Significance Index: -26.6300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4473
    Cell Significance Index: -8.7300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4978
    Cell Significance Index: -7.3500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5045
    Cell Significance Index: -12.6100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5081
    Cell Significance Index: -3.0700
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.5449
    Cell Significance Index: -4.8000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5532
    Cell Significance Index: -16.3000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5551
    Cell Significance Index: -9.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ACYP1 is a gene that encodes for the acylphosphatase-1 enzyme, which is involved in the degradation of phosphoacids. The gene exhibits significant expression in various cell types, including GABAergic amacrine cells, ciliated columnar cells of the tracheobronchial tree, B-2 B cells, pulmonary interstitial fibroblasts, glycinergic neurons, and erythroid progenitor cells. This widespread expression pattern suggests that ACYP1 plays a crucial role in maintaining cellular homeostasis and regulating various physiological processes. **Pathways and Functions:** ACYP1 is implicated in several metabolic pathways, including acylphosphatase activity and phosphate-containing compound metabolic process. The enzyme catalyzes the hydrolysis of phosphoacids, which are essential intermediates in various biochemical reactions. The ACYP1 gene's involvement in these pathways highlights its potential role in regulating cellular metabolism, energy homeostasis, and the response to environmental stressors. Furthermore, ACYP1 has been shown to interact with other genes and proteins, influencing the function of various cell types. For instance, its interaction with the GABAergic system suggests a potential role in modulating neurotransmission and neuronal function. Similarly, its expression in B-2 B cells implies a possible involvement in immune system regulation. **Clinical Significance:** The ACYP1 gene's expression in various cell types and its involvement in metabolic pathways underscore its potential significance in human disease. Dysregulation of ACYP1 has been implicated in several conditions, including cancer, where it may contribute to tumor progression and metastasis. Additionally, its expression in immune cells suggests a potential role in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Furthermore, the ACYP1 gene's involvement in energy metabolism and cellular homeostasis makes it a potential target for therapeutic interventions in metabolic disorders, such as diabetes and obesity. Elucidating the ACYP1 gene's functions and mechanisms of action will be crucial in developing novel therapeutic strategies for these diseases. In conclusion, the ACYP1 gene is a complex and multifaceted gene that warrants further investigation. Its diverse expression patterns, involvement in metabolic pathways, and potential role in human disease make it an attractive candidate for research into the immunological and clinical significance of acylphosphatase-1.

Genular Protein ID: 3258514958

Symbol: ACYP1_HUMAN

Name: Acylphosphatase-1

UniProtKB Accession Codes:

P07311 A6NDV8 B2R590

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 7 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 2 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 Rhea 1 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3026468

Title: A new acylphosphatase isoenzyme from human erythrocytes: purification, characterization, and primary structure.

PubMed ID: 3026468

DOI: 10.1021/bi00372a044

PubMed ID: 7796909

Title: Cloning and expression of the cDNA coding for the erythrocyte isoenzyme of human acylphosphatase.

PubMed ID: 7796909

DOI: 10.1016/0014-5793(95)00553-l

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 16511269

Title: Crystallization and preliminary crystallographic analysis of human common-type acylphosphatase.

PubMed ID: 16511269

DOI: 10.1107/s174430910504145x

PubMed ID: 19196981

Title: Rational stabilization of enzymes by computational redesign of surface charge-charge interactions.

PubMed ID: 19196981

DOI: 10.1073/pnas.0808220106

Sequence Information:

  • Length: 99
  • Mass: 11261
  • Checksum: F9F787E490BC8296
  • Sequence:
    • MAEGNTLISV DYEIFGKVQG VFFRKHTQAE GKKLGLVGWV QNTDRGTVQG QLQGPISKVR 
HMQEWLETRG SPKSHIDKAN FNNEKVILKL DYSDFQIVK

Genular Protein ID: 912175996

Symbol: G3V2U7_HUMAN

Name: N/A

UniProtKB Accession Codes:

G3V2U7

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 1 RuleBase 2 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 129
  • Mass: 14125
  • Checksum: 49D17A620B0A3200
  • Sequence:
    • MPASARLAGA GLLLAFLRAL GCAGRAPGLS MAEGNTLISV DYEIFGKVQG VFFRKHTQAE 
GKKLGLVGWV QNTDRGTVQG QLQGPISKVR HMQEWLETRG SPKSHIDKAN FNNEKVILKL 
DYSDFQIVK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.