Details for: ACYP1

Gene ID: 97

Symbol: ACYP1

Ensembl ID: ENSG00000119640

Description: acylphosphatase 1

Associated with

  • Acylphosphatase activity
    (GO:0003998)
  • Phosphate-containing compound metabolic process
    (GO:0006796)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.94
    Marker Score: 3945
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.83
    Marker Score: 15923
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 1.83
    Marker Score: 2248
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.75
    Marker Score: 1400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.68
    Marker Score: 2029.5
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.64
    Marker Score: 4466
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.56
    Marker Score: 1627
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.5
    Marker Score: 1416
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.45
    Marker Score: 2763
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.45
    Marker Score: 5382
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.31
    Marker Score: 1200
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.29
    Marker Score: 2247
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.26
    Marker Score: 1186
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.24
    Marker Score: 588
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.2
    Marker Score: 816
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.18
    Marker Score: 1191
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.07
    Marker Score: 1200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.07
    Marker Score: 2229
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.06
    Marker Score: 10971
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.03
    Marker Score: 1101
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.02
    Marker Score: 336
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.01
    Marker Score: 1072
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.01
    Marker Score: 985
  • Cell Name: neuron (CL0000540)
    Fold Change: 1
    Marker Score: 4061
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71683
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47907
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.99
    Marker Score: 622
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.99
    Marker Score: 231
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30390
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.98
    Marker Score: 735
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.98
    Marker Score: 36069
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.97
    Marker Score: 709
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.96
    Marker Score: 322
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.94
    Marker Score: 348
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2394
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.93
    Marker Score: 32363
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.93
    Marker Score: 1435
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 478
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.92
    Marker Score: 56701
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 434
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5192
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.91
    Marker Score: 607
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.91
    Marker Score: 3715
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2694
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.9
    Marker Score: 1525
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.9
    Marker Score: 3711
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.87
    Marker Score: 8227
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.87
    Marker Score: 2038
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5226
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.86
    Marker Score: 13408
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.86
    Marker Score: 11300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.85
    Marker Score: 1257
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.85
    Marker Score: 32407
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.85
    Marker Score: 2921
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.84
    Marker Score: 386
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.84
    Marker Score: 2005
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.84
    Marker Score: 462
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.84
    Marker Score: 364
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.82
    Marker Score: 397
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.81
    Marker Score: 159
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.81
    Marker Score: 760
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.8
    Marker Score: 2044
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8
    Marker Score: 2384
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.8
    Marker Score: 1876
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 318
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.79
    Marker Score: 1299
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.79
    Marker Score: 1982
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.78
    Marker Score: 7445
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.78
    Marker Score: 326
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 589
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.76
    Marker Score: 737
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.76
    Marker Score: 5837
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.76
    Marker Score: 295
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.76
    Marker Score: 378
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.76
    Marker Score: 358
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.76
    Marker Score: 785
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.74
    Marker Score: 15829
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.74
    Marker Score: 752
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.74
    Marker Score: 1226
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.74
    Marker Score: 4723
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.73
    Marker Score: 219
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.73
    Marker Score: 832
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.73
    Marker Score: 2875
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.73
    Marker Score: 389
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.72
    Marker Score: 227
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.72
    Marker Score: 300
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.72
    Marker Score: 249
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.72
    Marker Score: 2777
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.71
    Marker Score: 411
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 456
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.71
    Marker Score: 1097
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.71
    Marker Score: 7206
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.7
    Marker Score: 1881
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.7
    Marker Score: 261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 639
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.7
    Marker Score: 1989
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.7
    Marker Score: 1002

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Other Information

**Key characteristics:** * ACYP1 is a transmembrane protein that is expressed in a variety of cell types. * It is a member of the acylphosphatase family of enzymes. * ACYP1 is involved in the regulation of phosphate-containing compound metabolic process. **Pathways and functions:** * ACYP1 is involved in the regulation of phosphate metabolism. * It is responsible for the dephosphorylation of a variety of substrates, including ATP, GTP, and phospholipids. * These dephosphorylation events are involved in a variety of cellular processes, including cell cycle regulation, differentiation, and apoptosis. **Clinical significance:** * Mutations in the ACYP1 gene have been linked to a number of human diseases, including diabetes, cancer, and cardiovascular disease. * One common mutation in ACYP1 is a deletion of the entire gene. This mutation can lead to a decrease in the expression of ACYP1 protein, which can result in a decrease in phosphate metabolism and a number of cellular problems. **Additional information:** * ACYP1 is a highly conserved protein, with a similar protein found in mice. * It is a transmembrane protein that is expressed on the surface of cells. * It is a multi-pass protein, with a transmembrane domain and a cytoplasmic domain. * It is a member of the acylphosphatase family of enzymes, which are enzymes that catalyze the hydrolysis of phosphate groups from molecules.

Genular Protein ID: 3258514958

Symbol: ACYP1_HUMAN

Name: Acylphosphatase-1

UniProtKB Accession Codes:

P07311 A6NDV8 B2R590

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 7 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 2 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 7 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 Rhea 1 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3026468

Title: A new acylphosphatase isoenzyme from human erythrocytes: purification, characterization, and primary structure.

PubMed ID: 3026468

DOI: 10.1021/bi00372a044

PubMed ID: 7796909

Title: Cloning and expression of the cDNA coding for the erythrocyte isoenzyme of human acylphosphatase.

PubMed ID: 7796909

DOI: 10.1016/0014-5793(95)00553-l

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 16511269

Title: Crystallization and preliminary crystallographic analysis of human common-type acylphosphatase.

PubMed ID: 16511269

DOI: 10.1107/s174430910504145x

PubMed ID: 19196981

Title: Rational stabilization of enzymes by computational redesign of surface charge-charge interactions.

PubMed ID: 19196981

DOI: 10.1073/pnas.0808220106

Sequence Information:

  • Length: 99
  • Mass: 11261
  • Checksum: F9F787E490BC8296
  • Sequence:
    • MAEGNTLISV DYEIFGKVQG VFFRKHTQAE GKKLGLVGWV QNTDRGTVQG QLQGPISKVR 
HMQEWLETRG SPKSHIDKAN FNNEKVILKL DYSDFQIVK

Genular Protein ID: 912175996

Symbol: G3V2U7_HUMAN

Name: N/A

UniProtKB Accession Codes:

G3V2U7

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EC 1 EMBL 1 EPD 2 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 4 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 1 RuleBase 2 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 129
  • Mass: 14125
  • Checksum: 49D17A620B0A3200
  • Sequence:
    • MPASARLAGA GLLLAFLRAL GCAGRAPGLS MAEGNTLISV DYEIFGKVQG VFFRKHTQAE 
GKKLGLVGWV QNTDRGTVQG QLQGPISKVR HMQEWLETRG SPKSHIDKAN FNNEKVILKL 
DYSDFQIVK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.