Details for: CD70

Gene ID: 970

Symbol: CD70

Ensembl ID: ENSG00000125726

Description: CD70 molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 26.3589
    Cell Significance Index: -4.1000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 16.2433
    Cell Significance Index: -4.1200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 11.4213
    Cell Significance Index: -4.6400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.3456
    Cell Significance Index: -4.1300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.9695
    Cell Significance Index: 87.2100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.3635
    Cell Significance Index: 75.7000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.1667
    Cell Significance Index: 132.8400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.0028
    Cell Significance Index: 43.3900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.4291
    Cell Significance Index: 22.1100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.2632
    Cell Significance Index: -3.8800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.1908
    Cell Significance Index: -3.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6720
    Cell Significance Index: 127.8900
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.4958
    Cell Significance Index: 8.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4450
    Cell Significance Index: 243.0200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4341
    Cell Significance Index: 9.2500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4010
    Cell Significance Index: 39.6700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3376
    Cell Significance Index: 304.8100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.2496
    Cell Significance Index: 6.0900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2469
    Cell Significance Index: 14.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2266
    Cell Significance Index: 36.8500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2235
    Cell Significance Index: 14.4200
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: 0.2130
    Cell Significance Index: 2.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1923
    Cell Significance Index: 9.7200
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.1804
    Cell Significance Index: 3.1000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1378
    Cell Significance Index: 9.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0959
    Cell Significance Index: 11.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0929
    Cell Significance Index: 10.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0365
    Cell Significance Index: 7.2500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0293
    Cell Significance Index: 0.3700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0239
    Cell Significance Index: 0.4100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0174
    Cell Significance Index: 0.3400
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.0077
    Cell Significance Index: 0.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0076
    Cell Significance Index: 2.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0006
    Cell Significance Index: 0.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0003
    Cell Significance Index: -0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0005
    Cell Significance Index: -0.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0007
    Cell Significance Index: -1.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0009
    Cell Significance Index: -0.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0010
    Cell Significance Index: -1.8200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0017
    Cell Significance Index: -2.6800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0023
    Cell Significance Index: -0.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0032
    Cell Significance Index: -4.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0050
    Cell Significance Index: -3.7600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0053
    Cell Significance Index: -3.9000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0056
    Cell Significance Index: -0.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0064
    Cell Significance Index: -3.6200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0065
    Cell Significance Index: -4.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0066
    Cell Significance Index: -4.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0069
    Cell Significance Index: -5.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0082
    Cell Significance Index: -1.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0098
    Cell Significance Index: -4.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0154
    Cell Significance Index: -2.7800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0176
    Cell Significance Index: -0.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0184
    Cell Significance Index: -1.8800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0191
    Cell Significance Index: -4.0200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0236
    Cell Significance Index: -0.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0238
    Cell Significance Index: -3.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0243
    Cell Significance Index: -3.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0285
    Cell Significance Index: -3.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0325
    Cell Significance Index: -4.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0334
    Cell Significance Index: -4.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0341
    Cell Significance Index: -4.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0399
    Cell Significance Index: -4.1500
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0463
    Cell Significance Index: -0.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0507
    Cell Significance Index: -3.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0547
    Cell Significance Index: -2.5700
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: -0.0571
    Cell Significance Index: -0.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0589
    Cell Significance Index: -4.5200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0638
    Cell Significance Index: -1.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0680
    Cell Significance Index: -5.0700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0722
    Cell Significance Index: -1.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0746
    Cell Significance Index: -2.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0789
    Cell Significance Index: -4.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0868
    Cell Significance Index: -4.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0894
    Cell Significance Index: -4.1700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0895
    Cell Significance Index: -4.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0911
    Cell Significance Index: -4.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0920
    Cell Significance Index: -4.7800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0976
    Cell Significance Index: -2.5100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0995
    Cell Significance Index: -1.5000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1040
    Cell Significance Index: -2.5200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1047
    Cell Significance Index: -3.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1063
    Cell Significance Index: -2.9700
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.1084
    Cell Significance Index: -0.7800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1090
    Cell Significance Index: -4.7400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1105
    Cell Significance Index: -3.8700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1124
    Cell Significance Index: -3.5800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1156
    Cell Significance Index: -3.7900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1200
    Cell Significance Index: -4.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1255
    Cell Significance Index: -3.3500
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1255
    Cell Significance Index: -1.2100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1258
    Cell Significance Index: -0.7600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1281
    Cell Significance Index: -0.8500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1293
    Cell Significance Index: -3.4000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1318
    Cell Significance Index: -3.7600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1416
    Cell Significance Index: -4.4800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1428
    Cell Significance Index: -2.0500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1455
    Cell Significance Index: -3.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1485
    Cell Significance Index: -5.1600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1507
    Cell Significance Index: -3.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** CD70 is widely expressed in various tissues, including the immune system, epithelial cells, and muscle cells. Notably, it is highly expressed in T cells, particularly in alpha-beta memory T cells. 2. **Receptor Binding:** CD70 interacts with its receptor, TNFRSF4 (DR3), to regulate T cell activity. This interaction has been shown to activate signaling pathways that promote T cell proliferation and survival. 3. **Signaling Pathways:** CD70 is involved in various signaling pathways, including the NF-κB pathway, the JAK/STAT pathway, and the MAPK pathway. These pathways regulate a range of cellular processes, including cell proliferation, differentiation, and survival. 4. **Cellular Specificity:** CD70 has been shown to regulate the activity of various cell types, including T cells, epithelial cells, and muscle cells. **Pathways and Functions:** 1. **T Cell Immunity:** CD70 plays a critical role in regulating T cell-mediated immunity. The CD70-DR3 interaction promotes T cell proliferation, differentiation, and survival, making it a key player in the immune response. 2. **Cell-Cell Signaling:** CD70 is involved in cell-cell signaling, regulating the interaction between cells and promoting the exchange of signals that influence cellular behavior. 3. **Cytokine Activity:** CD70 regulates cytokine activity, influencing the production and function of cytokines that are essential for immune response. 4. **Protease Binding:** CD70 interacts with proteases, regulating their activity and influencing cellular processes. 5. **Extracellular Exosome Signaling:** CD70 is involved in extracellular exosome signaling, regulating the exchange of signals between cells and influencing cellular behavior. **Clinical Significance:** 1. **Immunological Disorders:** CD70 has been implicated in various immunological disorders, including autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer:** CD70 has been shown to play a role in cancer development and progression, particularly in lymphomas and leukemias. 3. **Infectious Diseases:** CD70 has been implicated in the regulation of immune responses to infectious diseases, such as HIV and tuberculosis. 4. **Transplantation:** CD70 has been shown to play a role in the regulation of immune responses to transplanted organs, making it a potential target for immunosuppressive therapies. In conclusion, the CD70 gene plays a critical role in regulating T cell-mediated immunity and has been implicated in various other cellular processes, including cell-cell signaling, cytokine activity, and protease binding. Its dysregulation has been linked to various immunological disorders, including autoimmune diseases and cancer. Further research is needed to fully understand the role of CD70 in human health and disease.

Genular Protein ID: 3963984982

Symbol: CD70_HUMAN

Name: N/A

UniProtKB Accession Codes:

P32970 B4DPR8 Q53XX4 Q96J57

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 1 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8387892

Title: Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor.

PubMed ID: 8387892

DOI: 10.1016/0092-8674(93)90133-b

PubMed ID: 8120384

Title: The cloning of CD70 and its identification as the ligand for CD27.

PubMed ID: 8120384

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 11920585

Title: CD70/CD27 ligand, a member of the TNF family, is expressed in human brain tumors.

PubMed ID: 11920585

DOI: 10.1002/ijc.10207

PubMed ID: 34419446

Title: Structural delineation and phase-dependent activation of the costimulatory CD27:CD70 complex.

PubMed ID: 34419446

DOI: 10.1016/j.jbc.2021.101102

PubMed ID: 28011863

Title: Inherited CD70 deficiency in humans reveals a critical role for the CD70-CD27 pathway in immunity to Epstein-Barr virus infection.

PubMed ID: 28011863

DOI: 10.1084/jem.20160784

PubMed ID: 28011864

Title: Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency.

PubMed ID: 28011864

DOI: 10.1084/jem.20160849

Sequence Information:

  • Length: 193
  • Mass: 21118
  • Checksum: 9265856E33BE4D50
  • Sequence:
    • MPEEGSGCSV RRRPYGCVLR AALVPLVAGL VICLVVCIQR FAQAQQQLPL ESLGWDVAEL 
QLNHTGPQQD PRLYWQGGPA LGRSFLHGPE LDKGQLRIHR DGIYMVHIQV TLAICSSTTA 
SRHHPTTLAV GICSPASRSI SLLRLSFHQG CTIASQRLTP LARGDTLCTN LTGTLLPSRN 
TDETFFGVQW VRP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.