ULK2 | ENSG00000083290 | NCBI 9706

Details for: ULK2

Gene ID: 9706

Symbol: ULK2

Ensembl ID: ENSG00000083290

Description: unc-51 like autophagy activating kinase 2

Associated with

Atp binding
(GO:0005524)
Autophagosome
(GO:0005776)
Autophagosome assembly
(GO:0000045)
Autophagy
(GO:0006914)
Autophagy of mitochondrion
(GO:0000422)
Axon extension
(GO:0048675)
Collateral sprouting
(GO:0048668)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle membrane
(GO:0030659)
Cytosol
(GO:0005829)
Negative regulation of collateral sprouting
(GO:0048671)
Peptidyl-serine phosphorylation
(GO:0018105)
Phagophore assembly site
(GO:0000407)
Phagophore assembly site membrane
(GO:0034045)
Piecemeal microautophagy of the nucleus
(GO:0034727)
Positive regulation of autophagy
(GO:0010508)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Response to starvation
(GO:0042594)
Reticulophagy
(GO:0061709)
Signal transduction
(GO:0007165)

Other Information

Proteins

Serine/threonine-protein kinase ULK2

Genular Protein ID: 1645724910

Symbol: ULK2_HUMAN

Name: Serine/threonine-protein kinase ULK2

UniProtKB Accession Codes:

Q8IYT8 A8MY69 O75119

Database IDs:

Citations:

PubMed ID: 9734811

Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9734811

DOI: 10.1093/dnares/5.3.169

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18936157

Title: Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism.

PubMed ID: 18936157

DOI: 10.1128/mcb.01082-08

PubMed ID: 21460635

Title: The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy.

PubMed ID: 21460635

DOI: 10.4161/auto.7.7.15450

PubMed ID: 21460634

Title: Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop.

PubMed ID: 21460634

DOI: 10.4161/auto.7.7.15451

PubMed ID: 21795849

Title: ULK1 inhibits the kinase activity of mTORC1 and cell proliferation.

PubMed ID: 21795849

DOI: 10.4161/auto.7.10.16660

PubMed ID: 21690395

Title: Ammonia-induced autophagy is independent of ULK1/ULK2 kinases.

PubMed ID: 21690395

DOI: 10.1073/pnas.1107969108

PubMed ID: 21205641

Title: Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy.

PubMed ID: 21205641

DOI: 10.1126/science.1196371

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 1036
Mass: 112694
Checksum: D311F01FA058CBBC
Sequence:

MEVVGDFEYS KRDLVGHGAF AVVFRGRHRQ KTDWEVAIKS INKKNLSKSQ ILLGKEIKIL 
KELQHENIVA LYDVQELPNS VFLVMEYCNG GDLADYLQAK GTLSEDTIRV FLHQIAAAMR 
ILHSKGIIHR DLKPQNILLS YANRRKSSVS GIRIKIADFG FARYLHSNMM AATLCGSPMY 
MAPEVIMSQH YDAKADLWSI GTVIYQCLVG KPPFQANSPQ DLRMFYEKNR SLMPSIPRET 
SPYLANLLLG LLQRNQKDRM DFEAFFSHPF LEQGPVKKSC PVPVPMYSGS VSGSSCGSSP 
SCRFASPPSL PDMQHIQEEN LSSPPLGPPN YLQVSKDSAS TSSKNSSCDT DDFVLVPHNI 
SSDHSCDMPV GTAGRRASNE FLVCGGQCQP TVSPHSETAP IPVPTQIRNY QRIEQNLTST 
ASSGTNVHGS PRSAVVRRSN TSPMGFLRPG SCSPVPADTA QTVGRRLSTG SSRPYSPSPL 
VGTIPEQFSQ CCCGHPQGHD SRSRNSSGSP VPQAQSPQSL LSGARLQSAP TLTDIYQNKQ 
KLRKQHSDPV CPSHTGAGYS YSPQPSRPGS LGTSPTKHLG SSPRSSDWFF KTPLPTIIGS 
PTKTTAPFKI PKTQASSNLL ALVTRHGPAE EQSKDGNEPR ECAHCLLVQG SERQRAEQQS 
KAVFGRSVST GKLSDQQGKT PICRHQGSTD SLNTERPMDI APAGACGGVL APPAGTAASS 
KAVLFTVGSP PHSAAAPTCT HMFLRTRTTS VGPSNSGGSL CAMSGRVCVG SPPGPGFGSS 
PPGAEAAPSL RYVPYGASPP SLEGLITFEA PELPEETLME REHTDTLRHL NVMLMFTECV 
LDLTAMRGGN PELCTSAVSL YQIQESVVVD QISQLSKDWG RVEQLVLYMK AAQLLAASLH 
LAKAQIKSGK LSPSTAVKQV VKNLNERYKF CITMCKKLTE KLNRFFSDKQ RFIDEINSVT 
AEKLIYNCAV EMVQSAALDE MFQQTEDIVY RYHKAALLLE GLSRILQDPA DIENVHKYKC 
SIERRLSALC HSTATV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ULK2

Associated with

Other Information

Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. PubMed ID: 9734811

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. PubMed ID: 18936157

The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy. PubMed ID: 21460635

Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop. PubMed ID: 21460634

ULK1 inhibits the kinase activity of mTORC1 and cell proliferation. PubMed ID: 21795849

Ammonia-induced autophagy is independent of ULK1/ULK2 kinases. PubMed ID: 21690395

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. PubMed ID: 21205641

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846