Details for: HERPUD1

Gene ID: 9709

Symbol: HERPUD1

Ensembl ID: ENSG00000051108

Description: homocysteine inducible ER protein with ubiquitin like domain 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 4.74
    Marker Score: 4040
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.12
    Marker Score: 3077
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.07
    Marker Score: 7806
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.96
    Marker Score: 1801.5
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.84
    Marker Score: 7979.5
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.82
    Marker Score: 2211.5
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.82
    Marker Score: 5915
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.77
    Marker Score: 1671
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.76
    Marker Score: 3153
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.74
    Marker Score: 27113
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.71
    Marker Score: 4728.5
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.66
    Marker Score: 2286
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.66
    Marker Score: 1060
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.65
    Marker Score: 616
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.63
    Marker Score: 906
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.62
    Marker Score: 2203
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.6
    Marker Score: 1860
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.59
    Marker Score: 3132
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.59
    Marker Score: 6936
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.58
    Marker Score: 1054
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.56
    Marker Score: 907
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.55
    Marker Score: 1258.5
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.52
    Marker Score: 2522.5
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.51
    Marker Score: 2235.5
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.49
    Marker Score: 2349
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.47
    Marker Score: 3570.5
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.43
    Marker Score: 4440
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 2.43
    Marker Score: 1060
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.42
    Marker Score: 1411
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.41
    Marker Score: 7140.5
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.4
    Marker Score: 3981
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.39
    Marker Score: 1002
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.39
    Marker Score: 9223
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.39
    Marker Score: 5413
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 2.37
    Marker Score: 866
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.37
    Marker Score: 1263.5
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.37
    Marker Score: 565
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.36
    Marker Score: 1788
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.36
    Marker Score: 732
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.35
    Marker Score: 2105
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.32
    Marker Score: 5673
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.29
    Marker Score: 5930
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.28
    Marker Score: 2743
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.27
    Marker Score: 1033.5
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.26
    Marker Score: 11119
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.26
    Marker Score: 2167
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2.26
    Marker Score: 2017
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.26
    Marker Score: 4760
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.25
    Marker Score: 1165
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.25
    Marker Score: 5420
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.24
    Marker Score: 2700
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 2.23
    Marker Score: 1691
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.23
    Marker Score: 3660
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.23
    Marker Score: 6151.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.23
    Marker Score: 1328.5
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 2.22
    Marker Score: 1299
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.21
    Marker Score: 823
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.2
    Marker Score: 9495
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.2
    Marker Score: 25574
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.2
    Marker Score: 3035
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 2.2
    Marker Score: 765
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.19
    Marker Score: 4444
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 2.18
    Marker Score: 1520
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 2.18
    Marker Score: 1444
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.18
    Marker Score: 13894.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.18
    Marker Score: 74080
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.15
    Marker Score: 3454
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 2.14
    Marker Score: 1512
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.14
    Marker Score: 1232
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.13
    Marker Score: 614
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.11
    Marker Score: 4808
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 2.11
    Marker Score: 463
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.1
    Marker Score: 7757
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 2.09
    Marker Score: 496
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 2.08
    Marker Score: 420
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.07
    Marker Score: 3051.5
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.07
    Marker Score: 1939
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.06
    Marker Score: 858
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.05
    Marker Score: 2233
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.05
    Marker Score: 3737
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.05
    Marker Score: 5367
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.05
    Marker Score: 1747
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 2.05
    Marker Score: 506
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.04
    Marker Score: 4082
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.04
    Marker Score: 2195
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.04
    Marker Score: 1355
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.03
    Marker Score: 1275
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.02
    Marker Score: 13181
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.02
    Marker Score: 112869
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2
    Marker Score: 530
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2
    Marker Score: 6281
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 2
    Marker Score: 1147
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.99
    Marker Score: 631
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.99
    Marker Score: 26710
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.98
    Marker Score: 2307
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.97
    Marker Score: 3487
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.97
    Marker Score: 484
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 1.96
    Marker Score: 1728
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.95
    Marker Score: 986
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.95
    Marker Score: 548

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Other Information

**Key characteristics:** * HERPUD1 is a transmembrane protein that is localized to the ER. * It contains a ubiquitin-like domain 1 (ELK1) that is responsible for its interaction with the Erad pathway. * HERPUD1 is a key regulator of ER stress response. **Pathways and functions:** * HERPUD1 is activated by the endoplasmic reticulum (ER) stress sensor Erad. * Erad activates HERPUD1 through the phosphorylation of its ELK1 domain. * HERPUD1 then recruits the E2F1 transcription factor to the ER stress response element (ERS) on the PERK promoter. * PERK is a key regulator of ER stress response. * Activation of PERK by HERPUD1 leads to the expression of genes that are involved in ER stress response, such as those involved in protein translation, folding, and trafficking. **Clinical significance:** * Mutations in HERPUD1 have been linked to the development of several human diseases, including amyotrophic lateral sclerosis, Alzheimer's disease, and cancer. * Herpud1 is a potential therapeutic target for these diseases. **Other important points:** * HERPUD1 is a highly conserved protein that is found in organisms from yeast to humans. * It is a member of the ER chaperone family of proteins. * HERPUD1 is a key regulator of ER stress response, which is a major contributor to the development of many human diseases.

Genular Protein ID: 441289959

Symbol: HERP1_HUMAN

Name: Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

UniProtKB Accession Codes:

Q15011 E9PGD1 O60644 Q6IAN8 Q96D92

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10922362

Title: Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress.

PubMed ID: 10922362

DOI: 10.1074/jbc.m002063200

PubMed ID: 7584026

Title: Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.

PubMed ID: 7584026

DOI: 10.1093/dnares/1.1.27

PubMed ID: 11112790

Title: Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response.

PubMed ID: 11112790

DOI: 10.1074/jbc.m010486200

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11799129

Title: Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein.

PubMed ID: 11799129

DOI: 10.1074/jbc.m112372200

PubMed ID: 10708769

Title: The novel MMS-inducible gene Mif1/KIAA0025 is a target of the unfolded protein response pathway.

PubMed ID: 10708769

DOI: 10.1016/s0014-5793(00)01253-9

PubMed ID: 16289116

Title: The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway.

PubMed ID: 16289116

DOI: 10.1016/j.jmb.2005.10.020

PubMed ID: 16940180

Title: Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element.

PubMed ID: 16940180

DOI: 10.1128/mcb.01046-06

PubMed ID: 18307982

Title: Herp enhances ER-associated protein degradation by recruiting ubiquilins.

PubMed ID: 18307982

DOI: 10.1016/j.bbrc.2008.02.086

PubMed ID: 18656546

Title: Ubxd1 is a novel co-factor of the human p97 ATPase.

PubMed ID: 18656546

DOI: 10.1016/j.biocel.2008.06.008

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28827405

Title: Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD).

PubMed ID: 28827405

DOI: 10.1242/jcs.206847

Sequence Information:

  • Length: 391
  • Mass: 43720
  • Checksum: 3CA827DC7EF0ED22
  • Sequence:
    • MESETEPEPV TLLVKSPNQR HRDLELSGDR GWSVGHLKAH LSRVYPERPR PEDQRLIYSG 
KLLLDHQCLR DLLPKQEKRH VLHLVCNVKS PSKMPEINAK VAESTEEPAG SNRGQYPEDS 
SSDGLRQREV LRNLSSPGWE NISRPEAAQQ AFQGLGPGFS GYTPYGWLQL SWFQQIYARQ 
YYMQYLAATA ASGAFVPPPS AQEIPVVSAP APAPIHNQFP AENQPANQNA APQVVVNPGA 
NQNLRMNAQG GPIVEEDDEI NRDWLDWTYS AATFSVFLSI LYFYSSLSRF LMVMGATVVM 
YLHHVGWFPF RPRPVQNFPN DGPPPDVVNQ DPNNNLQEGT DPETEDPNHL PPDRDVLDGE 
QTSPSFMSTA WLVFKTFFAS LLPEGPPAIA N

Genular Protein ID: 1302453206

Symbol: Q53FP9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53FP9

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 Pfam 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 391
  • Mass: 43692
  • Checksum: 23A737C371E0ED22
  • Sequence:
    • MESETEPEPV TLLVKSPNQR HRDLELSGDR GWSVGHLKAH LSRVYPERPR PEDQRLIYSG 
KLLLDHQCLR DLLPKQEKRH VLHLVCNVKS PSKMPEINAK VAESTEEPAG SNRGQYPEDS 
SSDGLRQREV LRNLSSPGWE NISRPEAAQQ AFQGLGPGFS GYTPYGWLQL SWFQQIYARQ 
YYMQYLAATA ASGAFVPPPS AQEIPVVSAP APAPIHNQFP AENQPANQNA APQVVVNPGA 
NQNLRMNAQG GPIVEEDDEI NRDWLDWTYS AATFSVFLSI LYFYSSLSRF LMVMGATVVM 
YLHHVGWFPF RPRPVQNFPN DGPPPDAVNQ DPNNNLQEGT DPETEDPNHL PPDRDVLDGE 
QTSPSFMSTA WLVFKTFFAS LLPEGPPAIA N

Genular Protein ID: 3449574380

Symbol: A4UAE9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A4UAE9

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 1 GenomeRNAi 1 InterPro 3 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 17420289

Title: The ubiquitin E3 ligase POSH regulates calcium homeostasis through spatial control of Herp.

PubMed ID: 17420289

DOI: 10.1083/jcb.200611036

Sequence Information:

  • Length: 275
  • Mass: 30635
  • Checksum: 2C9917ED99406C9B
  • Sequence:
    • MESETEPEPV TLLVKSPNQR HRDLELSGDR GWSVGHLKAH LSRVYPERPR PEDQRLIYSG 
KLLLDHQCLR DLLPKQEKRH VLHLVCNVKS PSKMPEINAK VAESTEEPAG SNRGQYPEDS 
SSDGLRQREV LRNLSSPGWE NISRPEAAQQ AFQGLGPGFS GYTPYGWLQL SWFQQIYARQ 
YYMQYLAATA ASGAFVPPPS AQEIPVVSAP APAPIHNQFP AENQPANQNA APQVVVNPGA 
NQNLRMNAQG ITLGGFHLDR GRFRTSQMMV LLLTL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.