Details for: ZNF646

Gene ID: 9726

Symbol: ZNF646

Ensembl ID: ENSG00000167395

Description: zinc finger protein 646

Associated with

  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Metal ion binding
    (GO:0046872)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,802
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,027
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 492
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,410
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 446
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,730
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5,159
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.89
    Marker Score: 1,811
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,275
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.82
    Marker Score: 1,548
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,243
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.75
    Marker Score: 11,756
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 382
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 661
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.7
    Marker Score: 538
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.69
    Marker Score: 276
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,858
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.62
    Marker Score: 1,450
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.58
    Marker Score: 183
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.58
    Marker Score: 188
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.57
    Marker Score: 1,004
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.56
    Marker Score: 339
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 435
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.41
    Marker Score: 194
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.39
    Marker Score: 192
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.36
    Marker Score: 241
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.33
    Marker Score: 330
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.31
    Marker Score: 175
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3
    Marker Score: 202
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.3
    Marker Score: 1,792
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.29
    Marker Score: 200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.29
    Marker Score: 276
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.28
    Marker Score: 125
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.28
    Marker Score: 278
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.28
    Marker Score: 396
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.28
    Marker Score: 115
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.27
    Marker Score: 79
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.27
    Marker Score: 70
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.26
    Marker Score: 407
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.26
    Marker Score: 83
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.25
    Marker Score: 167
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.24
    Marker Score: 301
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.23
    Marker Score: 244
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.23
    Marker Score: 1,420
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.23
    Marker Score: 61
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.23
    Marker Score: 1,976
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.23
    Marker Score: 93
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.23
    Marker Score: 138
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.23
    Marker Score: 145
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.22
    Marker Score: 179
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.22
    Marker Score: 77
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.22
    Marker Score: 540
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.21
    Marker Score: 13,171
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2
    Marker Score: 348
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.2
    Marker Score: 45
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2
    Marker Score: 47
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.2
    Marker Score: 371
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.2
    Marker Score: 44
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2
    Marker Score: 1,765
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.2
    Marker Score: 213
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.2
    Marker Score: 80
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2
    Marker Score: 67
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.2
    Marker Score: 45
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.2
    Marker Score: 176
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.19
    Marker Score: 44
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.19
    Marker Score: 39
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.19
    Marker Score: 75
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.19
    Marker Score: 80
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.19
    Marker Score: 48
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.19
    Marker Score: 308
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.19
    Marker Score: 42
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.19
    Marker Score: 46
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.19
    Marker Score: 48
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.19
    Marker Score: 47
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.19
    Marker Score: 170
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.19
    Marker Score: 4,857
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.19
    Marker Score: 126
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.19
    Marker Score: 43
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.19
    Marker Score: 1,777
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.19
    Marker Score: 393
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.18
    Marker Score: 185
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.18
    Marker Score: 169
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.18
    Marker Score: 101
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.18
    Marker Score: 48
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.18
    Marker Score: 45
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.18
    Marker Score: 47
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.18
    Marker Score: 10,053
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.18
    Marker Score: 112
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.18
    Marker Score: 1,798
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.18
    Marker Score: 134
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.18
    Marker Score: 46
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.18
    Marker Score: 52
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.18
    Marker Score: 86
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.18
    Marker Score: 1,305

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcription Factor**: ZNF646 is a transcription factor that regulates gene expression by binding to specific DNA sequences. 2. **Zinc Finger Domain**: The protein contains a zinc finger domain, which is a conserved structural motif that allows it to bind to DNA. 3. **Metal Ion Binding**: ZNF646 has been shown to bind to metal ions, which is essential for its DNA-binding activity. 4. **RNA Polymerase II-Specific**: The protein is specifically involved in the regulation of RNA polymerase II-specific transcription, which is a crucial process in the expression of protein-coding genes. **Pathways and Functions:** 1. **DNA-templated transcription**: ZNF646 regulates the transcription of specific genes by binding to DNA and recruiting RNA polymerase II. 2. **RNA polymerase II-specific transcription**: The protein is specifically involved in the regulation of RNA polymerase II-specific transcription, which is a crucial process in the expression of protein-coding genes. 3. **Metal ion binding**: ZNF646 binds to metal ions, which is essential for its DNA-binding activity. 4. **Regulation of transcription by RNA polymerase II**: The protein regulates the transcription of specific genes by binding to RNA polymerase II and modulating its activity. **Clinical Significance:** 1. **Neurological disorders**: ZNF646 has been implicated in the regulation of gene expression in cerebral cortex GABAergic interneurons, which are involved in neurological disorders such as schizophrenia and bipolar disorder. 2. **Intestinal disorders**: The protein has been detected in intestinal epithelial cells, where it regulates the expression of genes involved in intestinal homeostasis and immune function. Abnormal expression of ZNF646 has been linked to intestinal disorders such as inflammatory bowel disease. 3. **Cancer**: ZNF646 has been shown to be overexpressed in certain types of cancer, including colon cancer, where it regulates the expression of genes involved in cell proliferation and survival. 4. **Immune system disorders**: The protein has been implicated in the regulation of gene expression in immature innate lymphoid cells, which are involved in immune system disorders such as autoimmune diseases. In conclusion, ZNF646 is a transcription factor that plays a crucial role in regulating gene expression in various cell types. Its dysregulation has been implicated in a range of human diseases, including neurological disorders, intestinal disorders, cancer, and immune system disorders. Further research is needed to fully understand the role of ZNF646 in human health and disease.

Genular Protein ID: 957817138

Symbol: ZN646_HUMAN

Name: N/A

UniProtKB Accession Codes:

O15015 Q8IVD8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 4 SAM 1 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9205841

Title: Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9205841

DOI: 10.1093/dnares/4.2.141

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 1832
  • Mass: 200825
  • Checksum: A93549B71745C803
  • Sequence:
    • MEDTPPSLSC SDCQRHFPSL PELSRHRELL HPSPNQDSEE ADSIPRPYRC QQCGRGYRHP 
GSLVNHRRTH ETGLFPCTTC GKDFSNPMAL KSHMRTHAPE GRRRHRPPRP KEATPHLQGE 
TVSTDSWGQR LGSSEGWENQ TKHTEETPDC ESVPDPRAAS GTWEDLPTRQ REGLASHPGP 
EDGADGWGPS TNSARAPPLP IPASSLLSNL EQYLAESVVN FTGGQEPTQS PPAEEERRYK 
CSQCGKTYKH AGSLTNHRQS HTLGIYPCAI CFKEFSNLMA LKNHSRLHAQ YRPYHCPHCP 
RVFRLPRELL EHQQSHEGER QEPRWEEKGM PTTNGHTDES SQDQLPSAQM LNGSAELSTS 
GELEDSGLEE YRPFRCGDCG RTYRHAGSLI NHRKSHQTGV YPCSLCSKQL FNAAALKNHV 
RAHHRPRQGV GENGQPSVPP APLLLAETTH KEEEDPTTTL DHRPYKCSEC GRAYRHRGSL 
VNHRHSHRTG EYQCSLCPRK YPNLMALRNH VRVHCKAARR SADIGAEGAP SHLKVELPPD 
PVEAEAAPHT DQDHVCKHEE EATDITPAAD KTAAHICSIC GLLFEDAESL ERHGLTHGAG 
EKENSRTETT MSPPRAFACR DCGKSYRHSG SLINHRQTHQ TGDFSCGACA KHFHTMAAMK 
NHLRRHSRRR SRRHRKRAGG ASGGREAKLL AAESWTRELE DNEGLESPQD PSGESPHGAE 
GNLESDGDCL QAESEGDKCG LERDETHFQG DKESGGTGEG LERKDASLLD NLDIPGEEGG 
GTHFCDSLTG VDEDQKPATG QPNSSSHSAN AVTGWQAGAA HTCSDCGHSF PHATGLLSHR 
PCHPPGIYQC SLCPKEFDSL PALRSHFQNH RPGEATSAQP FLCCLCGMIF PGRAGYRLHR 
RQAHSSSGMT EGSEEEGEEE GVAEAAPARS PPLQLSEAEL LNQLQREVEA LDSAGYGHIC 
GCCGQTYDDL GSLERHHQSQ SSGTTADKAP SPLGVAGDAM EMVVDSVLED IVNSVSGEGG 
DAKSQEGAGT PLGDSLCIQG GESLLEAQPR PFRCNQCGKT YRHGGSLVNH RKIHQTGDFL 
CPVCSRCYPN LAAYRNHLRN HPRCKGSEPQ VGPIPEAAGS SELQVGPIPE GGSNKPQHMA 
EEGPGQAEVE KLQEELKVEP LEEVARVKEE VWEETTVKGE EIEPRLETAE KGCQTEASSE 
RPFSCEVCGR SYKHAGSLIN HRQSHQTGHF GCQACSKGFS NLMSLKNHRR IHADPRRFRC 
SECGKAFRLR KQLASHQRVH MERRGGGGTR KATREDRPFR CGQCGRTYRH AGSLLNHRRS 
HETGQYSCPT CPKTYSNRMA LKDHQRLHSE NRRRRAGRSR RTAVRCALCG RSFPGRGSLE 
RHLREHEETE REPANGQGGL DGTAASEANL TGSQGLETQL GGAEPVPHLE DGVPRPGERS 
QSPIRAASSE APEPLSWGAG KAGGWPVGGG LGNHSGGWVP QFLTRSEEPE DSVHRSPCHA 
GDCQLNGPTL SHMDSWDNRD NSSQLQPGSH SSCSQCGKTY CQSGSLLNHN TNKTDRHYCL 
LCSKEFLNPV ATKSHSHNHI DAQTFACPDC GKAFESHQEL ASHLQAHARG HSQVPAQMEE 
ARDPKAGTGE DQVVLPGQGK AQEAPSETPR GPGESVERAR GGQAVTSMAA EDKERPFRCT 
QCGRSYRHAG SLLNHQKAHT TGLYPCSLCP KLLPNLLSLK NHSRTHTDPK RHCCSICGKA 
FRTAARLEGH GRVHAPREGP FTCPHCPRHF RRRISFVQHQ QQHQEEWTVA GSGAPVAPVT 
GRGDLPLPPP PTPTTPLLDP SPQWPADLSF SL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.