Details for: CD79A

Gene ID: 973

Symbol: CD79A

Ensembl ID: ENSG00000105369

Description: CD79a molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 53.4893
    Cell Significance Index: -8.3200
  • Cell Name: centroblast (CL0009112)
    Fold Change: 46.9297
    Cell Significance Index: 109.4900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 31.7779
    Cell Significance Index: -12.9100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 28.7017
    Cell Significance Index: -7.2800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 19.4441
    Cell Significance Index: -9.1800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.6372
    Cell Significance Index: -13.0200
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 13.1172
    Cell Significance Index: 58.6600
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 9.9830
    Cell Significance Index: 30.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 7.2094
    Cell Significance Index: 850.2100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.6345
    Cell Significance Index: -8.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 5.9411
    Cell Significance Index: 383.2900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.4743
    Cell Significance Index: -14.6700
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 5.0352
    Cell Significance Index: 30.4100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 3.8811
    Cell Significance Index: 99.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.3004
    Cell Significance Index: 82.5000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 3.0257
    Cell Significance Index: 65.5500
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 2.8427
    Cell Significance Index: 14.2200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.2453
    Cell Significance Index: -8.8600
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.5551
    Cell Significance Index: 7.8000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.8397
    Cell Significance Index: 10.6400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7900
    Cell Significance Index: 150.3500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.7814
    Cell Significance Index: -2.4000
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.5702
    Cell Significance Index: 5.0100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5184
    Cell Significance Index: 11.0400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3991
    Cell Significance Index: 23.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3261
    Cell Significance Index: 32.2600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3048
    Cell Significance Index: 33.1500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2753
    Cell Significance Index: 248.5500
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.2491
    Cell Significance Index: 1.5900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2137
    Cell Significance Index: 34.7500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1660
    Cell Significance Index: 11.4800
  • Cell Name: lymphocyte of B lineage (CL0000945)
    Fold Change: 0.0552
    Cell Significance Index: 0.4100
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.0282
    Cell Significance Index: 0.3000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0115
    Cell Significance Index: 0.1700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.0047
    Cell Significance Index: 0.0500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0045
    Cell Significance Index: 0.0700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0045
    Cell Significance Index: 0.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0005
    Cell Significance Index: -0.2300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0015
    Cell Significance Index: -0.1900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0017
    Cell Significance Index: -0.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0031
    Cell Significance Index: -0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0045
    Cell Significance Index: -8.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0072
    Cell Significance Index: -13.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0079
    Cell Significance Index: -0.3600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0084
    Cell Significance Index: -0.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0089
    Cell Significance Index: -13.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0100
    Cell Significance Index: -13.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0107
    Cell Significance Index: -5.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0114
    Cell Significance Index: -8.6600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0150
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0151
    Cell Significance Index: -11.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0162
    Cell Significance Index: -0.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0194
    Cell Significance Index: -10.9300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0222
    Cell Significance Index: -14.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0228
    Cell Significance Index: -8.1900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0246
    Cell Significance Index: -0.5100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0298
    Cell Significance Index: -13.5200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0339
    Cell Significance Index: -2.4000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0345
    Cell Significance Index: -0.5200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0347
    Cell Significance Index: -0.9700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0379
    Cell Significance Index: -0.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0390
    Cell Significance Index: -7.7400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0409
    Cell Significance Index: -8.2100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0430
    Cell Significance Index: -1.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0527
    Cell Significance Index: -15.1700
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0558
    Cell Significance Index: -0.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0563
    Cell Significance Index: -7.7300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0595
    Cell Significance Index: -10.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0606
    Cell Significance Index: -7.0600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0635
    Cell Significance Index: -0.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0636
    Cell Significance Index: -10.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0656
    Cell Significance Index: -13.8100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0780
    Cell Significance Index: -4.7900
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.0784
    Cell Significance Index: -0.5100
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: -0.0819
    Cell Significance Index: -0.4400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0835
    Cell Significance Index: -1.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0892
    Cell Significance Index: -10.9700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0915
    Cell Significance Index: -11.8200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0941
    Cell Significance Index: -1.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0965
    Cell Significance Index: -11.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0974
    Cell Significance Index: -14.1600
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.1025
    Cell Significance Index: -0.9700
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.1126
    Cell Significance Index: -0.7500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1189
    Cell Significance Index: -2.0200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1219
    Cell Significance Index: -1.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1260
    Cell Significance Index: -12.8700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1405
    Cell Significance Index: -9.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1591
    Cell Significance Index: -7.4200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1610
    Cell Significance Index: -2.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1662
    Cell Significance Index: -12.3900
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1736
    Cell Significance Index: -2.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1756
    Cell Significance Index: -11.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1826
    Cell Significance Index: -10.2500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1840
    Cell Significance Index: -2.0000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1854
    Cell Significance Index: -14.6800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1881
    Cell Significance Index: -9.7700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1948
    Cell Significance Index: -10.2300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.2014
    Cell Significance Index: -2.2500
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.2038
    Cell Significance Index: -1.4400
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.2134
    Cell Significance Index: -2.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** The CD79A protein is a transmembrane receptor tyrosine kinase that is part of the B cell receptor complex, which consists of the CD79A alpha chain and the immunoglobulin heavy chain beta chain. 2. **Function:** The CD79A gene encodes for a protein that is involved in the signaling pathway of the B cell receptor, leading to the activation of downstream signaling pathways and the initiation of B cell responses. 3. **Expression:** The CD79A gene is expressed in various types of B cells, including naive, memory, and germinal center B cells, as well as in plasma cells and B-1 B cells. 4. **Pathways:** The CD79A gene is involved in several signaling pathways, including the antigen-activated B cell receptor (Bcr) pathway, the Cd22-mediated Bcr regulation pathway, and the signaling pathway of the B cell receptor (Bcr) complex. **Pathways and Functions:** 1. **Adaptive Immune Response:** The CD79A gene plays a crucial role in the adaptive immune response by regulating the activation, proliferation, and differentiation of B cells in response to antigens. 2. **B Cell Receptor Signaling Pathway:** The CD79A gene is involved in the signaling pathway of the B cell receptor, which leads to the activation of downstream signaling pathways and the initiation of B cell responses. 3. **Cd22-Mediated Bcr Regulation:** The CD79A gene is also involved in the regulation of B cell receptor signaling by Cd22, a surface molecule that modulates B cell receptor signaling. 4. **Antigen-Activated B Cell Receptor (Bcr) Pathway:** The CD79A gene is involved in the antigen-activated B cell receptor pathway, which leads to the activation of downstream signaling pathways and the initiation of B cell responses. **Clinical Significance:** 1. **Immunodeficiency Diseases:** Mutations in the CD79A gene have been associated with immunodeficiency diseases, such as X-linked lymphoproliferative disease (XLP) and CD19 deficiency. 2. **Cancer:** The CD79A gene is also involved in the development of certain types of cancer, such as Burkitt lymphoma, which is characterized by the expression of aberrant CD19-CD79A junctions. 3. **Viral Infections:** The CD79A gene plays a crucial role in the immune response to viral infections, such as SARS-CoV, where it is involved in the recognition and elimination of infected cells. 4. **Therapeutic Applications:** The CD79A gene has been identified as a potential target for therapeutic interventions in the treatment of autoimmune diseases and cancer. In conclusion, the CD79A gene is a crucial component of the B cell receptor complex and plays a pivotal role in the activation, proliferation, and differentiation of B cells. Its dysregulation has been associated with various diseases, including immunodeficiency diseases, cancer, and viral infections. Further research is needed to fully understand the mechanisms of CD79A in the immune system and to explore its therapeutic potential.

Genular Protein ID: 3250443677

Symbol: CD79A_HUMAN

Name: B-cell antigen receptor complex-associated protein alpha chain

UniProtKB Accession Codes:

P11912 A0N775 Q53FB8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 ELM 1 EMBL 10 EMDB 4 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1395095

Title: Structure and expression of the mb-1 transcript in human lymphoid cells.

PubMed ID: 1395095

DOI: 10.1111/j.1365-2249.1992.tb05846.x

PubMed ID: 1534761

Title: Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29.

PubMed ID: 1534761

DOI: 10.1002/eji.1830220641

PubMed ID: 1639443

Title: Molecular cloning of the Ig-alpha subunit of the human B-cell antigen receptor complex.

PubMed ID: 1639443

DOI: 10.1007/bf00215058

PubMed ID: 1729378

Title: Human mb-1 gene: complete cDNA sequence and its expression in B cells bearing membrane Ig of various isotypes.

PubMed ID: 1729378

PubMed ID: 1538135

Title: Molecular cloning and expression pattern of a human gene homologous to the murine mb-1 gene.

PubMed ID: 1538135

PubMed ID: 7916003

Title: Chromosomal localization, genomic structure, and allelic polymorphism of the human CD79 alpha (Ig-alpha/mb-1) gene.

PubMed ID: 7916003

DOI: 10.1007/bf00189974

PubMed ID: 8207205

Title: Structure, chromosomal localization, and methylation pattern of the human mb-1 gene.

PubMed ID: 8207205

PubMed ID: 7643857

Title: Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells.

PubMed ID: 7643857

DOI: 10.1016/0161-5890(95)00023-8

PubMed ID: 7514267

Title: Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex.

PubMed ID: 7514267

DOI: 10.1016/0161-5890(94)90061-2

PubMed ID: 2463161

Title: B lymphocyte lineage-restricted expression of mb-1, a gene with CD3-like structural properties.

PubMed ID: 2463161

DOI: 10.1002/j.1460-2075.1988.tb03220.x

PubMed ID: 8617796

Title: Cooperativity and segregation of function within the Ig-alpha/beta heterodimer of the B cell antigen receptor complex.

PubMed ID: 8617796

DOI: 10.1074/jbc.271.9.5158

PubMed ID: 9057631

Title: B-cell antigen receptor-induced apoptosis requires both Ig alpha and Ig beta.

PubMed ID: 9057631

PubMed ID: 10525050

Title: Mutations in Igalpha (CD79a) result in a complete block in B-cell development.

PubMed ID: 10525050

DOI: 10.1172/jci7696

PubMed ID: 10900006

Title: The serine and threonine residues in the Ig-alpha cytoplasmic tail negatively regulate immunoreceptor tyrosine-based activation motif-mediated signal transduction.

PubMed ID: 10900006

DOI: 10.1073/pnas.97.15.8451

PubMed ID: 11920841

Title: Novel Igalpha (CD79a) gene mutation in a Turkish patient with B cell-deficient agammaglobulinemia.

PubMed ID: 11920841

DOI: 10.1002/ajmg.10296

PubMed ID: 10748115

Title: Substrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptor.

PubMed ID: 10748115

DOI: 10.1074/jbc.m909044199

PubMed ID: 35981043

Title: Cryo-EM structure of the human IgM B cell receptor.

PubMed ID: 35981043

DOI: 10.1126/science.abo3923

Sequence Information:

  • Length: 226
  • Mass: 25038
  • Checksum: 6E5B837409969292
  • Sequence:
    • MPGGPGVLQA LPATIFLLFL LSAVYLGPGC QALWMHKVPA SLMVSLGEDA HFQCPHNSSN 
NANVTWWRVL HGNYTWPPEF LGPGEDPNGT LIIQNVNKSH GGIYVCRVQE GNESYQQSCG 
TYLRVRQPPP RPFLDMGEGT KNRIITAEGI ILLFCAVVPG TLLLFRKRWQ NEKLGLDAGD 
EYEDENLYEG LNLDDCSMYE DISRGLQGTY QDVGSLNIGD VQLEKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.