CD79A | ENSG00000105369 | NCBI 973

Details for: CD79A

Gene ID: 973

Symbol: CD79A

Ensembl ID: ENSG00000105369

Description: CD79a molecule

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Disease
(R-HSA-1643685)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Potential therapeutics for sars
(R-HSA-9679191)
Sars-cov infections
(R-HSA-9679506)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
B cell activation
(GO:0042113)
B cell differentiation
(GO:0030183)
B cell proliferation
(GO:0042100)
B cell receptor complex
(GO:0019815)
B cell receptor signaling pathway
(GO:0050853)
External side of plasma membrane
(GO:0009897)
Identical protein binding
(GO:0042802)
Igm b cell receptor complex
(GO:0071755)
Membrane raft
(GO:0045121)
Multivesicular body
(GO:0005771)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Transmembrane signaling receptor activity
(GO:0004888)

Other Information

Proteins

B-cell antigen receptor complex-associated protein alpha chain

Genular Protein ID: 3250443677

Symbol: CD79A_HUMAN

Name: B-cell antigen receptor complex-associated protein alpha chain

UniProtKB Accession Codes:

P11912 A0N775 Q53FB8

Database IDs:

Citations:

PubMed ID: 1395095

Title: Structure and expression of the mb-1 transcript in human lymphoid cells.

PubMed ID: 1395095

DOI: 10.1111/j.1365-2249.1992.tb05846.x

PubMed ID: 1534761

Title: Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29.

PubMed ID: 1534761

DOI: 10.1002/eji.1830220641

PubMed ID: 1639443

Title: Molecular cloning of the Ig-alpha subunit of the human B-cell antigen receptor complex.

PubMed ID: 1639443

DOI: 10.1007/bf00215058

PubMed ID: 1729378

Title: Human mb-1 gene: complete cDNA sequence and its expression in B cells bearing membrane Ig of various isotypes.

PubMed ID: 1729378

PubMed ID: 1538135

Title: Molecular cloning and expression pattern of a human gene homologous to the murine mb-1 gene.

PubMed ID: 1538135

PubMed ID: 7916003

Title: Chromosomal localization, genomic structure, and allelic polymorphism of the human CD79 alpha (Ig-alpha/mb-1) gene.

PubMed ID: 7916003

DOI: 10.1007/bf00189974

PubMed ID: 8207205

Title: Structure, chromosomal localization, and methylation pattern of the human mb-1 gene.

PubMed ID: 8207205

PubMed ID: 7643857

Title: Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells.

PubMed ID: 7643857

DOI: 10.1016/0161-5890(95)00023-8

PubMed ID: 7514267

Title: Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex.

PubMed ID: 7514267

DOI: 10.1016/0161-5890(94)90061-2

PubMed ID: 2463161

Title: B lymphocyte lineage-restricted expression of mb-1, a gene with CD3-like structural properties.

PubMed ID: 2463161

DOI: 10.1002/j.1460-2075.1988.tb03220.x

PubMed ID: 8617796

Title: Cooperativity and segregation of function within the Ig-alpha/beta heterodimer of the B cell antigen receptor complex.

PubMed ID: 8617796

DOI: 10.1074/jbc.271.9.5158

PubMed ID: 9057631

Title: B-cell antigen receptor-induced apoptosis requires both Ig alpha and Ig beta.

PubMed ID: 9057631

PubMed ID: 10525050

Title: Mutations in Igalpha (CD79a) result in a complete block in B-cell development.

PubMed ID: 10525050

DOI: 10.1172/jci7696

PubMed ID: 10900006

Title: The serine and threonine residues in the Ig-alpha cytoplasmic tail negatively regulate immunoreceptor tyrosine-based activation motif-mediated signal transduction.

PubMed ID: 10900006

DOI: 10.1073/pnas.97.15.8451

PubMed ID: 11920841

Title: Novel Igalpha (CD79a) gene mutation in a Turkish patient with B cell-deficient agammaglobulinemia.

PubMed ID: 11920841

DOI: 10.1002/ajmg.10296

PubMed ID: 10748115

Title: Substrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptor.

PubMed ID: 10748115

DOI: 10.1074/jbc.m909044199

PubMed ID: 35981043

Title: Cryo-EM structure of the human IgM B cell receptor.

PubMed ID: 35981043

DOI: 10.1126/science.abo3923

Sequence Information:

Length: 226
Mass: 25038
Checksum: 6E5B837409969292
Sequence:

MPGGPGVLQA LPATIFLLFL LSAVYLGPGC QALWMHKVPA SLMVSLGEDA HFQCPHNSSN 
NANVTWWRVL HGNYTWPPEF LGPGEDPNGT LIIQNVNKSH GGIYVCRVQE GNESYQQSCG 
TYLRVRQPPP RPFLDMGEGT KNRIITAEGI ILLFCAVVPG TLLLFRKRWQ NEKLGLDAGD 
EYEDENLYEG LNLDDCSMYE DISRGLQGTY QDVGSLNIGD VQLEKP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CD79A

Associated with

Other Information

Structure and expression of the mb-1 transcript in human lymphoid cells. PubMed ID: 1395095

Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29. PubMed ID: 1534761

Molecular cloning of the Ig-alpha subunit of the human B-cell antigen receptor complex. PubMed ID: 1639443

Human mb-1 gene: complete cDNA sequence and its expression in B cells bearing membrane Ig of various isotypes. PubMed ID: 1729378

Molecular cloning and expression pattern of a human gene homologous to the murine mb-1 gene. PubMed ID: 1538135

Chromosomal localization, genomic structure, and allelic polymorphism of the human CD79 alpha (Ig-alpha/mb-1) gene. PubMed ID: 7916003

Structure, chromosomal localization, and methylation pattern of the human mb-1 gene. PubMed ID: 8207205

Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells. PubMed ID: 7643857

Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex. PubMed ID: 7514267

B lymphocyte lineage-restricted expression of mb-1, a gene with CD3-like structural properties. PubMed ID: 2463161

Cooperativity and segregation of function within the Ig-alpha/beta heterodimer of the B cell antigen receptor complex. PubMed ID: 8617796

B-cell antigen receptor-induced apoptosis requires both Ig alpha and Ig beta. PubMed ID: 9057631

Mutations in Igalpha (CD79a) result in a complete block in B-cell development. PubMed ID: 10525050

The serine and threonine residues in the Ig-alpha cytoplasmic tail negatively regulate immunoreceptor tyrosine-based activation motif-mediated signal transduction. PubMed ID: 10900006

Novel Igalpha (CD79a) gene mutation in a Turkish patient with B cell-deficient agammaglobulinemia. PubMed ID: 11920841

Substrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptor. PubMed ID: 10748115

Cryo-EM structure of the human IgM B cell receptor. PubMed ID: 35981043