Details for: DCAF1
Associated with
Other Information
Genular Protein ID: 3367577976
Symbol: DCAF1_HUMAN
Name: HIV-1 Vpr-binding protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9872452
Title: Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 9872452
PubMed ID: 12168954
Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
PubMed ID: 12168954
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11223251
Title: Cytoplasmic retention of HIV-1 regulatory protein Vpr by protein-protein interaction with a novel human cytoplasmic protein VprBP.
PubMed ID: 11223251
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 8195203
Title: Biochemical mechanism of HIV-I Vpr function. Specific interaction with a cellular protein.
PubMed ID: 8195203
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16949367
Title: A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.
PubMed ID: 16949367
PubMed ID: 16964240
Title: Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.
PubMed ID: 16964240
DOI: 10.1038/nature05175
PubMed ID: 17314515
Title: HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase.
PubMed ID: 17314515
DOI: 10.4161/cc.6.2.3732
PubMed ID: 17620334
Title: The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor.
PubMed ID: 17620334
PubMed ID: 17626091
Title: DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest.
PubMed ID: 17626091
DOI: 10.1128/jvi.01380-07
PubMed ID: 17630831
Title: HIV-1 Vpr-mediated G2 arrest involves the DDB1-CUL4A[VPRBP] E3 ubiquitin ligase.
PubMed ID: 17630831
PubMed ID: 17609381
Title: Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle.
PubMed ID: 17609381
PubMed ID: 17559673
Title: HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system.
PubMed ID: 17559673
PubMed ID: 18524771
Title: Assembly with the Cul4A-DDB1[DCAF1] ubiquitin ligase protects HIV-1 Vpr from proteasomal degradation.
PubMed ID: 18524771
PubMed ID: 18220336
Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
PubMed ID: 18220336
DOI: 10.1021/pr0705441
PubMed ID: 18606781
Title: Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development.
PubMed ID: 18606781
DOI: 10.1128/mcb.00232-08
PubMed ID: 18332868
Title: VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation.
PubMed ID: 18332868
DOI: 10.1038/onc.2008.44
PubMed ID: 18464893
Title: Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection.
PubMed ID: 18464893
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19264781
Title: The human immunodeficiency virus type 2 Vpx protein usurps the CUL4A-DDB1 DCAF1 ubiquitin ligase to overcome a postentry block in macrophage infection.
PubMed ID: 19264781
DOI: 10.1128/jvi.00187-09
PubMed ID: 19287380
Title: Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase.
PubMed ID: 19287380
DOI: 10.1038/ncb1848
PubMed ID: 19838296
Title: Characterization of the molecular determinants of primary HIV-1 Vpr proteins: impact of the Q65R and R77Q substitutions on Vpr functions.
PubMed ID: 19838296
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20178741
Title: Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus.
PubMed ID: 20178741
PubMed ID: 20644714
Title: Involvement of Lgl and Mahjong/VprBP in cell competition.
PubMed ID: 20644714
PubMed ID: 19923175
Title: Evidence for an activation domain at the amino terminus of simian immunodeficiency virus Vpx.
PubMed ID: 19923175
DOI: 10.1128/jvi.01437-09
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22072767
Title: Proteomic profiling of the human cytomegalovirus UL35 gene products reveals a role for UL35 in the DNA repair response.
PubMed ID: 22072767
DOI: 10.1128/jvi.05442-11
PubMed ID: 23362280
Title: Dyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradation.
PubMed ID: 23362280
PubMed ID: 23063525
Title: EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex.
PubMed ID: 23063525
PubMed ID: 22184063
Title: Vpr-binding protein antagonizes p53-mediated transcription via direct interaction with H3 tail.
PubMed ID: 22184063
DOI: 10.1128/mcb.06037-11
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24140421
Title: VprBP has intrinsic kinase activity targeting histone H2A and represses gene transcription.
PubMed ID: 24140421
PubMed ID: 24116224
Title: HIV-1 Vpr Induces the Degradation of ZIP and sZIP, Adaptors of the NuRD Chromatin Remodeling Complex, by Hijacking DCAF1/VprBP.
PubMed ID: 24116224
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24357321
Title: CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins.
PubMed ID: 24357321
PubMed ID: 25557551
Title: CRL4(VprBP) E3 ligase promotes monoubiquitylation and chromatin binding of TET dioxygenases.
PubMed ID: 25557551
PubMed ID: 28068668
Title: The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERalpha.
PubMed ID: 28068668
DOI: 10.1038/nature20829
PubMed ID: 24336198
Title: Structural basis of lentiviral subversion of a cellular protein degradation pathway.
PubMed ID: 24336198
DOI: 10.1038/nature12815
Sequence Information:
- Length: 1507
- Mass: 169007
- Checksum: 7E71AB2CAC4962C5
- Sequence:
MTTVVVHVDS KAELTTLLEQ WEKEHGSGQD MVPILTRMSQ LIEKETEEYR KGDPDPFDDR HPGRADPECM LGHLLRILFK NDDFMNALVN AYVMTSREPP LNTAACRLLL DIMPGLETAV VFQEKEGIVE NLFKWAREAD QPLRTYSTGL LGGAMENQDI AANYRDENSQ LVAIVLRRLR ELQLQEVALR QENKRPSPRK LSSEPLLPLD EEAVDMDYGD MAVDVVDGDQ EEASGDMEIS FHLDSGHKTS SRVNSTTKPE DGGLKKNKSA KQGDRENFRK AKQKLGFSSS DPDRMFVELS NSSWSEMSPW VIGTNYTLYP MTPAIEQRLI LQYLTPLGEY QELLPIFMQL GSRELMMFYI DLKQTNDVLL TFEALKHLAS LLLHNKFATE FVAHGGVQKL LEIPRPSMAA TGVSMCLYYL SYNQDAMERV CMHPHNVLSD VVNYTLWLME CSHASGCCHA TMFFSICFSF RAVLELFDRY DGLRRLVNLI STLEILNLED QGALLSDDEI FASRQTGKHT CMALRKYFEA HLAIKLEQVK QSLQRTEGGI LVHPQPPYKA CSYTHEQIVE MMEFLIEYGP AQLYWEPAEV FLKLSCVQLL LQLISIACNW KTYYARNDTV RFALDVLAIL TVVPKIQLQL AESVDVLDEA GSTVSTVGIS IILGVAEGEF FIHDAEIQKS ALQIIINCVC GPDNRISSIG KFISGTPRRK LPQNPKSSEH TLAKMWNVVQ SNNGIKVLLS LLSIKMPITD ADQIRALACK ALVGLSRSST VRQIISKLPL FSSCQIQQLM KEPVLQDKRS DHVKFCKYAA ELIERVSGKP LLIGTDVSLA RLQKADVVAQ SRISFPEKEL LLLIRNHLIS KGLGETATVL TKEADLPMTA ASHSSAFTPV TAAASPVSLP RTPRIANGIA TRLGSHAAVG ASAPSAPTAH PQPRPPQGPL ALPGPSYAGN SPLIGRISFI RERPSPCNGR KIRVLRQKSD HGAYSQSPAI KKQLDRHLPS PPTLDSIITE YLREQHARCK NPVATCPPFS LFTPHQCPEP KQRRQAPINF TSRLNRRASF PKYGGVDGGC FDRHLIFSRF RPISVFREAN EDESGFTCCA FSARERFLML GTCTGQLKLY NVFSGQEEAS YNCHNSAITH LEPSRDGSLL LTSATWSQPL SALWGMKSVF DMKHSFTEDH YVEFSKHSQD RVIGTKGDIA HIYDIQTGNK LLTLFNPDLA NNYKRNCATF NPTDDLVLND GVLWDVRSAQ AIHKFDKFNM NISGVFHPNG LEVIINTEIW DLRTFHLLHT VPALDQCRVV FNHTGTVMYG AMLQADDEDD LMEERMKSPF GSSFRTFNAT DYKPIATIDV KRNIFDLCTD TKDCYLAVIE NQGSMDALNM DTVCRLYEVG RQRLAEDEDE EEDQEEEEQE EEDDDEDDDD TDDLDELDTD QLLEAELEED DNNENAGEDG DNDFSPSDEE LANLLEEGED GEDEDSDADE EVELILGDTD SSDNSDLEDD IILSLNE
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.