Genular: Defining Cellular Identity and Function

Details for: DOCK4

Gene ID: 9732

Symbol: DOCK4

Ensembl ID: ENSG00000128512

Description: dedicator of cytokinesis 4

Associated with

Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Hemostasis
(R-HSA-109582)
Rac1 gtpase cycle
(R-HSA-9013149)
Rac2 gtpase cycle
(R-HSA-9013404)
Rhog gtpase cycle
(R-HSA-9013408)
Rho gtpase cycle
(R-HSA-9012999)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Cell chemotaxis
(GO:0060326)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Golgi apparatus
(GO:0005794)
Gtpase activator activity
(GO:0005096)
Guanyl-nucleotide exchange factor activity
(GO:0005085)
Membrane
(GO:0016020)
Negative regulation of vascular associated smooth muscle contraction
(GO:1904694)
Nucleolus
(GO:0005730)
Pdz domain binding
(GO:0030165)
Plasma membrane
(GO:0005886)
Positive regulation of vascular associated smooth muscle cell migration
(GO:1904754)
Protein binding
(GO:0005515)
Receptor tyrosine kinase binding
(GO:0030971)
Sh3 domain binding
(GO:0017124)
Small gtpase-mediated signal transduction
(GO:0007264)
Small gtpase binding
(GO:0031267)
Stereocilium
(GO:0032420)
Stereocilium bundle
(GO:0032421)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: mature microglial cell (CL0002629)
Fold Change: 7.97
Marker Score: 2,882
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 6.72
Marker Score: 3,738
Cell Name: chromaffin cell (CL0000166)
Fold Change: 5.37
Marker Score: 7,552
Cell Name: mature astrocyte (CL0002627)
Fold Change: 5.2
Marker Score: 3,419
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 4.31
Marker Score: 22,589
Cell Name: macroglial cell (CL0000126)
Fold Change: 4.3
Marker Score: 9,873
Cell Name: Purkinje cell (CL0000121)
Fold Change: 4.21
Marker Score: 142,162
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 4.17
Marker Score: 9,973
Cell Name: granule cell (CL0000120)
Fold Change: 4.14
Marker Score: 31,227
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 3.9
Marker Score: 1,937
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 3.74
Marker Score: 2,171
Cell Name: stellate neuron (CL0000122)
Fold Change: 3.66
Marker Score: 19,645
Cell Name: neuronal brush cell (CL0000555)
Fold Change: 3.52
Marker Score: 11,815
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 3.25
Marker Score: 69,406
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 3.17
Marker Score: 4,610
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 3.02
Marker Score: 8,613
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 2.95
Marker Score: 4,954
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.74
Marker Score: 21,001
Cell Name: CNS interneuron (CL0000402)
Fold Change: 2.7
Marker Score: 1,297
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 2.67
Marker Score: 5,130
Cell Name: hepatoblast (CL0005026)
Fold Change: 2.61
Marker Score: 8,562
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 2.58
Marker Score: 818
Cell Name: astrocyte (CL0000127)
Fold Change: 2.47
Marker Score: 2,143
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 2.46
Marker Score: 1,470
Cell Name: lactocyte (CL0002325)
Fold Change: 2.37
Marker Score: 38,119
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 2.34
Marker Score: 2,510
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.33
Marker Score: 34,807
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 2.32
Marker Score: 893
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.3
Marker Score: 87,440
Cell Name: cardiac neuron (CL0010022)
Fold Change: 2.28
Marker Score: 2,840
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 2.22
Marker Score: 2,520
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 2.22
Marker Score: 81,768
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 2.19
Marker Score: 20,615
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 2.19
Marker Score: 1,154
Cell Name: microglial cell (CL0000129)
Fold Change: 2.18
Marker Score: 3,978
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 2.18
Marker Score: 2,077
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 2.15
Marker Score: 9,955
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 2.15
Marker Score: 1,206
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.13
Marker Score: 8,221
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.12
Marker Score: 42,119
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 2.11
Marker Score: 1,872
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 2.1
Marker Score: 1,455
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 2.04
Marker Score: 640
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 2.04
Marker Score: 8,503
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 2.03
Marker Score: 2,511
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.02
Marker Score: 124,163
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.98
Marker Score: 20,465
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.92
Marker Score: 42,981
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.92
Marker Score: 18,255
Cell Name: neuron (CL0000540)
Fold Change: 1.87
Marker Score: 7,626
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.87
Marker Score: 16,079
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.87
Marker Score: 3,802
Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.85
Marker Score: 1,602
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 1.83
Marker Score: 1,377
Cell Name: podocyte (CL0000653)
Fold Change: 1.79
Marker Score: 663
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.79
Marker Score: 7,412
Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.66
Marker Score: 536
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.64
Marker Score: 2,525
Cell Name: lung goblet cell (CL1000143)
Fold Change: 1.63
Marker Score: 469
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.61
Marker Score: 1,732
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 1.59
Marker Score: 578
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.58
Marker Score: 779
Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 1.57
Marker Score: 432
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.54
Marker Score: 3,635
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 1.51
Marker Score: 996
Cell Name: mesangial cell (CL0000650)
Fold Change: 1.51
Marker Score: 1,822
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.48
Marker Score: 9,497
Cell Name: mural cell (CL0008034)
Fold Change: 1.45
Marker Score: 166,763
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.45
Marker Score: 5,166
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.42
Marker Score: 7,609
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.41
Marker Score: 1,623
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.39
Marker Score: 524
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.37
Marker Score: 5,896
Cell Name: skin fibroblast (CL0002620)
Fold Change: 1.35
Marker Score: 350
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.34
Marker Score: 977
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.34
Marker Score: 1,340
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.33
Marker Score: 799
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.31
Marker Score: 20,513
Cell Name: endothelial cell (CL0000115)
Fold Change: 1.3
Marker Score: 1,163
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 1.26
Marker Score: 514
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.24
Marker Score: 5,173
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.15
Marker Score: 293
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.14
Marker Score: 2,508
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4,766
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 1.12
Marker Score: 270
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 1.11
Marker Score: 1,341
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.07
Marker Score: 448
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.07
Marker Score: 2,769
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.06
Marker Score: 18,881
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 1.06
Marker Score: 281
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 1.05
Marker Score: 331
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1.04
Marker Score: 1,107
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 1.04
Marker Score: 6,247
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251,711
Cell Name: retina horizontal cell (CL0000745)
Fold Change: 1.04
Marker Score: 994
Cell Name: ganglion interneuron (CL0000397)
Fold Change: 1.02
Marker Score: 311
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 1.02
Marker Score: 882
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.01
Marker Score: 2,014
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 1.01
Marker Score: 477
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1
Marker Score: 901

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

**Key Characteristics:** DOCK4 is a guanine nucleotide exchange factor (GEF) that activates small GTPases, including Rac1, Rac2, and Rho, by facilitating their GTP binding and hydrolysis. It is also involved in the regulation of actin cytoskeleton dynamics, cell migration, and cell growth. DOCK4 is primarily expressed in cells of the immune system, including microglia, macrophages, and astrocytes. Its expression is also detected in neurons, epithelial cells, and smooth muscle cells. **Pathways and Functions:** DOCK4 is involved in several signaling pathways, including: 1. **Rho GTPase signaling pathway:** DOCK4 regulates the activity of small GTPases, including Rac1, Rac2, and Rho, which are essential for cell migration, cytoskeleton organization, and cell growth. 2. **Cell migration:** DOCK4 is involved in the regulation of cell migration, including the migration of immune cells, such as macrophages and microglia. 3. **Cytoskeleton organization:** DOCK4 regulates the organization of the actin cytoskeleton, which is essential for cell migration, cell growth, and cell division. 4. **Immune response:** DOCK4 is involved in the regulation of immune responses, including the regulation of cytokine production and the activation of immune cells. 5. **Hemostasis:** DOCK4 is involved in the regulation of hemostasis, including the regulation of platelet activation and aggregation. **Clinical Significance:** DOCK4 has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases:** DOCK4 has been shown to play a role in the regulation of immune responses in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer:** DOCK4 has been implicated in the regulation of cell migration and invasion in cancer, including breast, lung, and colon cancer. 3. **Neurological disorders:** DOCK4 has been implicated in the regulation of immune responses in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Inflammatory disorders:** DOCK4 has been shown to play a role in the regulation of inflammatory responses in disorders, such as asthma and chronic obstructive pulmonary disease (COPD). In conclusion, DOCK4 is a multifunctional protein that plays a crucial role in various cellular processes, including cell migration, signaling, and immune response. Its dysregulation has been implicated in various immune-related disorders, highlighting the need for further research into the role of DOCK4 in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Dedicator of cytokinesis protein 4

Genular Protein ID: 1853811218

Symbol: DOCK4_HUMAN

Name: Dedicator of cytokinesis protein 4

UniProtKB Accession Codes:

Q8N1I0 O14584 O94824 Q8NB45

Database IDs:

Citations:

PubMed ID: 12628187

Title: DOCK4, a GTPase activator, is disrupted during tumorigenesis.

PubMed ID: 12628187

DOI: 10.1016/s0092-8674(03)00155-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 9872452

Title: Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9872452

DOI: 10.1093/dnares/5.5.277

PubMed ID: 12432077

Title: Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.

PubMed ID: 12432077

DOI: 10.1242/jcs.00219

PubMed ID: 16464467

Title: An isoform of GTPase regulator DOCK4 localizes to the stereocilia in the inner ear and binds to harmonin (USH1C).

PubMed ID: 16464467

DOI: 10.1016/j.jmb.2006.01.017

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19807924

Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

PubMed ID: 19807924

DOI: 10.1186/1471-2172-10-53

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20679435

Title: Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism.

PubMed ID: 20679435

DOI: 10.1083/jcb.201005141

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

Length: 1966
Mass: 225206
Checksum: 9CFB6299F7730AA9
Sequence:

MWIPTEHEKY GVVIASFRGT VPYGLSLEIG DTVQILEKCD GWYRGFALKN PNIKGIFPSS 
YVHLKNACVK NKGQFEMVIP TEDSVITEMT STLRDWGTMW KQLYVRNEGD LFHRLWHIMN 
EILDLRRQVL VGHLTHDRMK DVKRHITARL DWGNEQLGLD LVPRKEYAMV DPEDISITEL 
YRLMEHRHRK KDTPVQASSH HLFVQMKSLM CSNLGEELEV IFSLFDSKEN RPISERFFLR 
LNRNGLPKAP DKPERHCSLF VDLGSSELRK DIYITVHIIR IGRMGAGEKK NACSVQYRRP 
FGCAVLSIAD LLTGETKDDL ILKVYMCNTE SEWYQIHENI IKKLNARYNL TGSNAGLAVS 
LQLLHGDIEQ IRREYSSVFS HGVSITRKLG FSNIIMPGEM RNDLYITIER GEFEKGGKSV 
ARNVEVTMFI VDSSGQTLKD FISFGSGEPP ASEYHSFVLY HNNSPRWSEL LKLPIPVDKF 
RGAHIRFEFR HCSTKEKGEK KLFGFSFVPL MQEDGRTLPD GTHELIVHKC EENTNLQDTT 
RYLKLPFSKG IFLGNNNQAM KATKESFCIT SFLCSTKLTQ NGDMLDLLKW RTHPDKITGC 
LSKLKEIDGS EIVKFLQDTL DTLFGILDEN SQKYGSKVFD SLVHIINLLQ DSKFHHFKPV 
MDTYIESHFA GALAYRDLIK VLKWYVDRIT EAERQEHIQE VLKAQEYIFK YIVQSRRLFS 
LATGGQNEEE FRCCIQELLM SVRFFLSQES KGSGALSQSQ AVFLSSFPAV YSELLKLFDV 
REVANLVQDT LGSLPTILHV DDSLQAIKLQ CIGKTVESQL YTNPDSRYIL LPVVLHHLHI 
HLQEQKDLIM CARILSNVFC LIKKNSSEKS VLEEIDVIVA SLLDILLRTI LEITSRPQPS 
SSAMRFQFQD VTGEFVACLL SLLRQMTDRH YQQLLDSFNT KEELRDFLLQ IFTVFRILIR 
PEMFPKDWTV MRLVANNVII TTVLYLSDAL RKNFLNENFD YKIWDSYFYL AVIFINQLCL 
QLEMFTPSKK KKVLEKYGDM RVTMGCEIFS MWQNLGEHKL HFIPALIGPF LEVTLIPQPD 
LRNVMIPIFH DMMDWEQRRS GNFKQVEAKL IDKLDSLMSE GKGDETYREL FNSILLKKIE 
RETWRESGVS LIATVTRLME RLLDYRDCMK MGEVDGKKIG CTVSLLNFYK TELNKEEMYI 
RYIHKLYDLH LKAQNFTEAA YTLLLYDELL EWSDRPLREF LTYPMQTEWQ RKEHLHLTII 
QNFDRGKCWE NGIILCRKIA EQYESYYDYR NLSKMRMMEA SLYDKIMDQQ RLEPEFFRVG 
FYGKKFPFFL RNKEFVCRGH DYERLEAFQQ RMLNEFPHAI AMQHANQPDE TIFQAEAQYL 
QIYAVTPIPE SQEVLQREGV PDNIKSFYKV NHIWKFRYDR PFHKGTKDKE NEFKSLWVER 
TSLYLVQSLP GISRWFEVEK REVVEMSPLE NAIEVLENKN QQLKTLISQC QTRQMQNINP 
LTMCLNGVID AAVNGGVSRY QEAFFVKEYI LSHPEDGEKI ARLRELMLEQ AQILEFGLAV 
HEKFVPQDMR PLHKKLVDQF FVMKSSLGIQ EFSACMQASP VHFPNGSPRV CRNSAPASVS 
PDGTRVIPRR SPLSYPAVNR YSSSSLSSQA SAEVSNITGQ SESSDEVFNM QPSPSTSSLS 
STHSASPNVT SSAPSSARAS PLLSDKHKHS RENSCLSPRE RPCSAIYPTP VEPSQRMLFN 
HIGDGALPRS DPNLSAPEKA VNPTPSSWSL DSGKEAKNMS DSGKLISPPV PPRPTQTASP 
ARHTTSVSPS PAGRSPLKGS VQSFTPSPVE YHSPGLISNS PVLSGSYSSG ISSLSRCSTS 
ETSGFENQVN EQSAPLPVPV PVPVPSYGGE EPVRKESKTP PPYSVYERTL RRPVPLPHSL 
SIPVTSEPPA LPPKPLAARS SHLENGARRT DPGPRPRPLP RKVSQL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: DOCK4

Associated with

Cells (max top 100)

Other Information

DOCK4, a GTPase activator, is disrupted during tumorigenesis. PubMed ID: 12628187

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of human chromosome 7. PubMed ID: 12853948

Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 9872452

Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity. PubMed ID: 12432077

An isoform of GTPase regulator DOCK4 localizes to the stereocilia in the inner ear and binds to harmonin (USH1C). PubMed ID: 16464467

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. PubMed ID: 19807924

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism. PubMed ID: 20679435

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569