Details for: KNTC1

Gene ID: 9735

Symbol: KNTC1

Ensembl ID: ENSG00000184445

Description: kinetochore associated 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.04
    Marker Score: 3,572
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169,222
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.32
    Marker Score: 739
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.01
    Marker Score: 15,772
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,792
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,017
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.96
    Marker Score: 1,386
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 492
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 446
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,728
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5,096
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.87
    Marker Score: 1,765
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.85
    Marker Score: 513
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.8
    Marker Score: 967
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,253
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.76
    Marker Score: 515
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.74
    Marker Score: 1,147
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 563
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 381
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.73
    Marker Score: 237
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.71
    Marker Score: 285
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.7
    Marker Score: 4,229
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 630
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.68
    Marker Score: 6,995
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.67
    Marker Score: 1,831
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.67
    Marker Score: 192
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.67
    Marker Score: 40,942
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.66
    Marker Score: 822
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.65
    Marker Score: 203
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.64
    Marker Score: 1,510
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.64
    Marker Score: 1,082
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.63
    Marker Score: 2,659
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.63
    Marker Score: 716
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.63
    Marker Score: 5,959
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6
    Marker Score: 1,792
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.58
    Marker Score: 279
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.58
    Marker Score: 2,245
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.56
    Marker Score: 4,795
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.55
    Marker Score: 555
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.55
    Marker Score: 362
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.54
    Marker Score: 718
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.54
    Marker Score: 314
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.52
    Marker Score: 451
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.52
    Marker Score: 138
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.51
    Marker Score: 383
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.49
    Marker Score: 260
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.47
    Marker Score: 210
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.47
    Marker Score: 229
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.46
    Marker Score: 376
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.45
    Marker Score: 422
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.45
    Marker Score: 4,199
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.45
    Marker Score: 325
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.45
    Marker Score: 1,722
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.44
    Marker Score: 216
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.43
    Marker Score: 578
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.42
    Marker Score: 110
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.42
    Marker Score: 6,310
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.42
    Marker Score: 277
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.42
    Marker Score: 116
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.41
    Marker Score: 456
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.41
    Marker Score: 391
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.4
    Marker Score: 372
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.4
    Marker Score: 100
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.4
    Marker Score: 104
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.38
    Marker Score: 406
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.37
    Marker Score: 157
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.37
    Marker Score: 416
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.37
    Marker Score: 1,510
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.36
    Marker Score: 2,791
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.36
    Marker Score: 126
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.36
    Marker Score: 1,481
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.36
    Marker Score: 1,490
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.36
    Marker Score: 208
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.35
    Marker Score: 370
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.35
    Marker Score: 1,446
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.34
    Marker Score: 215
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.34
    Marker Score: 12,561
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.34
    Marker Score: 355
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.34
    Marker Score: 169
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.34
    Marker Score: 107
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.33
    Marker Score: 138
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.33
    Marker Score: 133
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.32
    Marker Score: 391
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.32
    Marker Score: 603
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.31
    Marker Score: 84
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.31
    Marker Score: 6,102
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.31
    Marker Score: 209
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.3
    Marker Score: 11,573
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.3
    Marker Score: 139
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.3
    Marker Score: 191
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.3
    Marker Score: 482
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.29
    Marker Score: 315
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.29
    Marker Score: 182
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.28
    Marker Score: 84

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Kinetochore-associated protein**: KNTC1 is a protein that specifically localizes to the kinetochore, a critical structure responsible for chromosome attachment to the mitotic spindle. 2. **Cell cycle regulation**: KNTC1 is involved in the regulation of cell cycle progression, particularly during mitosis, where it ensures accurate chromosome segregation. 3. **Spindle microtubule regulation**: KNTC1 regulates the attachment of spindle microtubules to the kinetochore, ensuring proper chromosome alignment and separation. 4. **Sister chromatid cohesion resolution**: KNTC1 is involved in the resolution of sister chromatid cohesion, a process essential for accurate chromosome segregation. **Pathways and Functions:** 1. **Amplification of signal from unattached kinetochores**: KNTC1 amplifies signals from unattached kinetochores via a Mad2 inhibitory signal, ensuring proper chromosome alignment and separation. 2. **Regulation of spindle microtubule attachment**: KNTC1 regulates the attachment of spindle microtubules to the kinetochore, ensuring proper chromosome alignment and separation. 3. **Resolution of sister chromatid cohesion**: KNTC1 is involved in the resolution of sister chromatid cohesion, a process essential for accurate chromosome segregation. 4. **Signaling by Rho GTPases**: KNTC1 interacts with Rho GTPases, which activate formins, leading to the regulation of actin cytoskeleton dynamics and cell cycle progression. **Clinical Significance:** Dysregulation of KNTC1 has been implicated in various diseases, including: 1. **Cancer**: Alterations in KNTC1 expression have been observed in several types of cancer, including breast, colon, and lung cancer. 2. **Genetic disorders**: Mutations in KNTC1 have been associated with genetic disorders, such as Down syndrome and Prader-Willi syndrome. 3. **Neurodevelopmental disorders**: Abnormalities in KNTC1 expression have been linked to neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. In conclusion, KNTC1 plays a critical role in maintaining genome stability and regulating cell cycle progression. Further research is necessary to elucidate the molecular mechanisms underlying KNTC1's functions and its clinical significance.

Genular Protein ID: 4028545703

Symbol: KNTC1_HUMAN

Name: Kinetochore-associated protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8724849

Title: Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 8724849

DOI: 10.1093/dnares/3.1.17

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11146660

Title: Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores.

PubMed ID: 11146660

DOI: 10.1038/35046598

PubMed ID: 11590237

Title: The ZW10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore.

PubMed ID: 11590237

DOI: 10.1242/jcs.114.17.3103

PubMed ID: 12686595

Title: Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions.

PubMed ID: 12686595

DOI: 10.1091/mbc.e02-09-0624

PubMed ID: 15824131

Title: ZW10 links mitotic checkpoint signaling to the structural kinetochore.

PubMed ID: 15824131

DOI: 10.1083/jcb.200411118

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20462495

Title: Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery.

PubMed ID: 20462495

DOI: 10.1016/j.str.2010.02.014

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 2209
  • Mass: 250749
  • Checksum: 514C948733CBFDAC
  • Sequence:
  • MWNDIELLTN DDTGSGYLSV GSRKEHGTAL YQVDLLVKIS SEKASLNPKI QACSLSDGFI 
    IVADQSVILL DSICRSLQLH LVFDTEVDVV GLCQEGKFLL VGERSGNLHL IHVTSKQTLL 
    TNAFVQKAND ENRRTYQNLV IEKDGSNEGT YYMLLLTYSG FFCITNLQLL KIQQAIENVD 
    FSTAKKLQGQ IKSSFISTEN YHTLGCLSLV AGDLASEVPV IIGGTGNCAF SKWEPDSSKK 
    GMTVKNLIDA EIIKGAKKFQ LIDNLLFVLD TDNVLSLWDI YTLTPVWNWP SLHVEEFLLT 
    TEADSPSSVT WQGITNLKLI ALTASANKKM KNLMVYSLPT MEILYSLEVS SVSSLVQTGI 
    STDTIYLLEG VCKNDPKLSE DSVSVLVLRC LTEALPENRL SRLLHKHRFA EAESFAIQFG 
    LDVELVYKVK SNHILEKLAL SSVDASEQTE WQQLVDDAKE NLHKIQDDEF VVNYCLKAQW 
    ITYETTQEML NYAKTRLLKK EDKTALIYSD GLKEVLRAHA KLTTFYGAFG PEKFSGSSWI 
    EFLNNEDDLK DIFLQLKEGN LVCAQYLWLR HRANFESRFD VKMLESLLNS MSASVSLQKL 
    CPWFKNDVIP FVRRTVPEGQ IILAKWLEQA ARNLELTDKA NWPENGLQLA EIFFTAEKTD 
    ELGLASSWHW ISLKDYQNTE EVCQLRTLVN NLRELITLHR KYNCKLALSD FEKENTTTIV 
    FRMFDKVLAP ELIPSILEKF IRVYMREHDL QEEELLLLYI EDLLNRCSSK STSLFETAWE 
    AKAMAVIACL SDTDLIFDAV LKIMYAAVVP WSAAVEQLVK QHLEMDHPKV KLLQESYKLM 
    EMKKLLRGYG IREVNLLNKE IMRVVRYILK QDVPSSLEDA LKVAQAFMLS DDEIYSLRII 
    DLIDREQGED CLLLLKSLPP AEAEKTAERV IIWARLALQE EPDHSKEGKA WRMSVAKTSV 
    DILKILCDIQ KDNLQKKDEC EEMLKLFKEV ASLQENFEVF LSFEDYSNSS LVADLREQHI 
    KAHEVAQAKH KPGSTPEPIA AEVRSPSMES KLHRQALALQ MSKQELEAEL TLRALKDGNI 
    KTALKKCSDL FKYHCNADTG KLLFLTCQKL CQMLADNVPV TVPVGLNLPS MIHDLASQAA 
    TICSPDFLLD ALELCKHTLM AVELSRQCQM DDCGILMKAS FGTHKDPYEE WSYSDFFSED 
    GIVLESQMVL PVIYELISSL VPLAESKRYP LESTSLPYCS LNEGDGLVLP VINSISALLQ 
    NLQESSQWEL ALRFVVGSFG TCLQHSVSNF MNATLSEKLF GETTLVKSRH VVMELKEKAV 
    IFIRENATTL LHKVFNCRLV DLDLALGYCT LLPQKDVFEN LWKLIDKAWQ NYDKILAISL 
    VGSELASLYQ EIEMGLKFRE LSTDAQWGIR LGKLGISFQP VFRQHFLTKK DLIKALVENI 
    DMDTSLILEY CSTFQLDCDA VLQLFIETLL HNTNAGQGQG DASMDSAKRR HPKLLAKALE 
    MVPLLTSTKD LVISLSGILH KLDPYDYEMI EVVLKVIERA DEKITNININ QALSILKHLK 
    SYRRISPPVD LEYQYMLEHV ITLPSAAQTR LPFHLIFFGT AQNFWKILST ELSEESFPTL 
    LLISKLMKFS LDTLYVSTAK HVFEKKLKPK LLKLTQAKSS TLINKEITKI TQTIESCLLS 
    IVNPEWAVAI AISLAQDIPE GSFKISALKF CLYLAERWLQ NIPSQDEKRE KAEALLKKLH 
    IQYRRSGTEA VLIAHKLNTE EYLRVIGKPA HLIVSLYEHP SINQRIQNSS GTDYPDIHAA 
    AKEIAEVNEI NLEKVWDMLL EKWLCPSTKP GEKPSELFEL QEDEALRRVQ YLLLSRPIDY 
    SSRMLFVFAT STTTTLGMHQ LTFAHRTRAL QCLFYLADKE TIESLFKKPI EEVKSYLRCI 
    TFLASFETLN IPITYELFCS SPKEGMIKGL WKNHSHESMA VRLVTELCLE YKIYDLQLWN 
    GLLQKLLGFN MIPYLRKVLK AISSIHSLWQ VPYFSKAWQR VIQIPLLSAS CPLSPDQLSD 
    CSESLIAVLE CPVSGDLDLI GVARQYIQLE LPAFALACLM LMPHSEKRHQ QIKNFLGSCD 
    PQVILKQLEE HMNTGQLAGF SHQIRSLILN NIINKKEFGI LAKTKYFQML KMHAMNTNNI 
    TELVNYLAND LSLDEASVLI TEYSKHCGKP VPPDTAPCEI LKMFLSGLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.