CCP110 | ENSG00000103540 | NCBI 9738

Details for: CCP110

Gene ID: 9738

Symbol: CCP110

Ensembl ID: ENSG00000103540

Description: centriolar coiled-coil protein 110

Associated with

Anchoring of the basal body to the plasma membrane
(R-HSA-5620912)
Aurka activation by tpx2
(R-HSA-8854518)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Centrosome maturation
(R-HSA-380287)
Cilium assembly
(R-HSA-5617833)
Deubiquitination
(R-HSA-5688426)
G2/m transition
(R-HSA-69275)
Loss of nlp from mitotic centrosomes
(R-HSA-380259)
Loss of proteins required for interphase microtubule organization from the centrosome
(R-HSA-380284)
Metabolism of proteins
(R-HSA-392499)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic prometaphase
(R-HSA-68877)
M phase
(R-HSA-68886)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Post-translational protein modification
(R-HSA-597592)
Recruitment of mitotic centrosome proteins and complexes
(R-HSA-380270)
Recruitment of numa to mitotic centrosomes
(R-HSA-380320)
Regulation of plk1 activity at g2/m transition
(R-HSA-2565942)
Rho gtpase cycle
(R-HSA-9012999)
Rhov gtpase cycle
(R-HSA-9013424)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Ub-specific processing proteases
(R-HSA-5689880)
Centriole
(GO:0005814)
Centriole replication
(GO:0007099)
Centrosome
(GO:0005813)
Centrosome duplication
(GO:0051298)
Ciliary basal body organization
(GO:0032053)
Cilium
(GO:0005929)
Cytosol
(GO:0005829)
Negative regulation of centriole elongation
(GO:1903723)
Negative regulation of cilium assembly
(GO:1902018)
Positive regulation of cilium assembly
(GO:0045724)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Regulation of cytokinesis
(GO:0032465)

Other Information

Proteins

Centriolar coiled-coil protein of 110 kDa

Genular Protein ID: 719893828

Symbol: CP110_HUMAN

Name: Centriolar coiled-coil protein of 110 kDa

UniProtKB Accession Codes:

O43303 B7WP23 O43335 Q68DV9 Q8NE13

Database IDs:

Citations:

PubMed ID: 9455477

Title: Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9455477

DOI: 10.1093/dnares/4.5.307

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 10493829

Title: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.

PubMed ID: 10493829

DOI: 10.1006/geno.1999.5927

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12361598

Title: CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells.

PubMed ID: 12361598

DOI: 10.1016/s1534-5807(02)00258-7

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 16760425

Title: CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability.

PubMed ID: 16760425

DOI: 10.1091/mbc.e06-04-0371

PubMed ID: 17719545

Title: Cep97 and CP110 suppress a cilia assembly program.

PubMed ID: 17719545

DOI: 10.1016/j.cell.2007.06.027

PubMed ID: 17681131

Title: Plk4-induced centriole biogenesis in human cells.

PubMed ID: 17681131

DOI: 10.1016/j.devcel.2007.07.002

PubMed ID: 18694559

Title: CP110 suppresses primary cilia formation through its interaction with CEP290, a protein deficient in human ciliary disease.

PubMed ID: 18694559

DOI: 10.1016/j.devcel.2008.07.004

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19460342

Title: Cep76, a centrosomal protein that specifically restrains centriole reduplication.

PubMed ID: 19460342

DOI: 10.1016/j.devcel.2009.03.004

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20596027

Title: SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation.

PubMed ID: 20596027

DOI: 10.1038/nature09140

PubMed ID: 21620453

Title: Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesis.

PubMed ID: 21620453

DOI: 10.1016/j.cell.2011.04.028

PubMed ID: 22885064

Title: A proteome-wide screen for mammalian SxIP motif-containing microtubule plus-end tracking proteins.

PubMed ID: 22885064

DOI: 10.1016/j.cub.2012.07.047

PubMed ID: 22441691

Title: Neurl4, a novel daughter centriole protein, prevents formation of ectopic microtubule organizing centres.

PubMed ID: 22441691

DOI: 10.1038/embor.2012.40

PubMed ID: 22261722

Title: Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture.

PubMed ID: 22261722

DOI: 10.1074/mcp.m111.014233

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23486064

Title: USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110.

PubMed ID: 23486064

DOI: 10.1038/nature11941

PubMed ID: 24421332

Title: The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly.

PubMed ID: 24421332

DOI: 10.1083/jcb.201304153

PubMed ID: 26304236

Title: Specific CP110 phosphorylation sites mediate anaphase catastrophe after CDK2 inhibition: evidence for cooperation with USP33 knockdown.

PubMed ID: 26304236

DOI: 10.1158/1535-7163.mct-15-0443

PubMed ID: 30375385

Title: M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole.

PubMed ID: 30375385

DOI: 10.1038/s41467-018-06990-9

PubMed ID: 35301795

Title: ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis.

PubMed ID: 35301795

DOI: 10.15252/embr.202154090

Sequence Information:

Length: 1012
Mass: 113424
Checksum: 5459F655CFB9DFD0
Sequence:

MEEYEKFCEK SLARIQEASL STESFLPAQS ESISLIRFHG VAILSPLLNI EKRKEMQQEK 
QKALDVEARK QVNRKKALLT RVQEILDNVQ VRKAPNASDF DQWEMETVYS NSEVRNLNVP 
ATFPNSFPSH TEHSTAAKLD KIAGILPLDN EDQCKTDGID LARDSEGFNS PKQCDSSNIS 
HVENEAFPKT SSATPQETLI SDGPFSVNEQ QDLPLLAEVI PDPYVMSLQN LMKKSKEYIE 
REQSRRSLRG SINRIVNESH LDKEHDAVEV ADCVKEKGQL TGKHCVSVIP DKPSLNKSNV 
LLQGASTQAS SMSMPVLASF SKVDIPIRTG HPTVLESNSD FKVIPTFVTE NNVIKSLTGS 
YAKLPSPEPS MSPKMHRRRS RTSSACHILI NNPINACELS PKGKEQAMDL IIQDTDENTN 
VPEIMPKLPT DLAGVCSSKV YVGKNTSEVK EDVVLGKSNQ VCQSSGNHLE NKVTHGLVTV 
EGQLTSDERG AHIMNSTCAA MPKLHEPYAS SQCIASPNFG TVSGLKPASM LEKNCSLQTE 
LNKSYDVKNP SPLLMQNQNT RQQMDTPMVS CGNEQFLDNS FEKVKRRLDL DIDGLQKENC 
PYVITSGITE QERQHLPEKR YPKGSGFVNK NKMLGTSSKE SEELLKSKML AFEEMRKRLE 
EQHAQQLSLL IAEQEREQER LQKEIEEQEK MLKEKKAMTA EASELDINNA VELEWRKISD 
SSLLETMLSQ ADSLHTSNSN SSGFTNSAMQ YSFVSANEAP FYLWGSSTSG LTKLSVTRPF 
GRAKTRWSQV FSLEIQAKFN KITAVAKGFL TRRLMQTDKL KQLRQTVKDT MEFIRSFQSE 
APLKRGIVSA QDASLQERVL AQLRAALYGI HDIFFVMDAA ERMSILHHDR EVRKEKMLRQ 
MDKMKSPRVA LSAATQKSLD RKKYMKAAEM GMPNKKFLVK QNPSETRVLQ PNQGQNAPVH 
RLLSRQGTPK TSVKGVVQNR QKPSQSRVPN RVPVSGVYAG KIQRKRPNVA TI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CCP110

Associated with

Other Information

Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 9455477

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. PubMed ID: 10493829

The sequence and analysis of duplication-rich human chromosome 16. PubMed ID: 15616553

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells. PubMed ID: 12361598

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability. PubMed ID: 16760425

Cep97 and CP110 suppress a cilia assembly program. PubMed ID: 17719545

Plk4-induced centriole biogenesis in human cells. PubMed ID: 17681131

CP110 suppresses primary cilia formation through its interaction with CEP290, a protein deficient in human ciliary disease. PubMed ID: 18694559

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Cep76, a centrosomal protein that specifically restrains centriole reduplication. PubMed ID: 19460342

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation. PubMed ID: 20596027

Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesis. PubMed ID: 21620453

A proteome-wide screen for mammalian SxIP motif-containing microtubule plus-end tracking proteins. PubMed ID: 22885064

Neurl4, a novel daughter centriole protein, prevents formation of ectopic microtubule organizing centres. PubMed ID: 22441691

Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture. PubMed ID: 22261722

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110. PubMed ID: 23486064

The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly. PubMed ID: 24421332

Specific CP110 phosphorylation sites mediate anaphase catastrophe after CDK2 inhibition: evidence for cooperation with USP33 knockdown. PubMed ID: 26304236

M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole. PubMed ID: 30375385

ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis. PubMed ID: 35301795