CD79B | ENSG00000007312 | NCBI 974

Details for: CD79B

Gene ID: 974

Symbol: CD79B

Ensembl ID: ENSG00000007312

Description: CD79b molecule

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Disease
(R-HSA-1643685)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Potential therapeutics for sars
(R-HSA-9679191)
Sars-cov infections
(R-HSA-9679506)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
B cell differentiation
(GO:0030183)
B cell receptor complex
(GO:0019815)
B cell receptor signaling pathway
(GO:0050853)
External side of plasma membrane
(GO:0009897)
Extracellular exosome
(GO:0070062)
Identical protein binding
(GO:0042802)
Igm b cell receptor complex
(GO:0071755)
Immune response
(GO:0006955)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Signal transduction
(GO:0007165)
Transmembrane signaling receptor activity
(GO:0004888)

Other Information

Proteins

B-cell antigen receptor complex-associated protein beta chain

Genular Protein ID: 1559800519

Symbol: CD79B_HUMAN

Name: B-cell antigen receptor complex-associated protein beta chain

UniProtKB Accession Codes:

P40259 Q53FS2 Q9BU06

Database IDs:

Citations:

PubMed ID: 1534761

Title: Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29.

PubMed ID: 1534761

DOI: 10.1002/eji.1830220641

PubMed ID: 8486355

Title: Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB).

PubMed ID: 8486355

DOI: 10.1006/geno.1993.1157

PubMed ID: 8419481

Title: The human Ig-beta cDNA sequence, a homologue of murine B29, is identical in B cell and plasma cell lines producing all the human Ig isotypes.

PubMed ID: 8419481

PubMed ID: 7913081

Title: The complete sequence of the human CD79b (Ig beta/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism.

PubMed ID: 7913081

DOI: 10.1007/bf00188178

PubMed ID: 7643857

Title: Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells.

PubMed ID: 7643857

DOI: 10.1016/0161-5890(95)00023-8

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7514267

Title: Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex.

PubMed ID: 7514267

DOI: 10.1016/0161-5890(94)90061-2

PubMed ID: 8617796

Title: Cooperativity and segregation of function within the Ig-alpha/beta heterodimer of the B cell antigen receptor complex.

PubMed ID: 8617796

DOI: 10.1074/jbc.271.9.5158

PubMed ID: 9057631

Title: B-cell antigen receptor-induced apoptosis requires both Ig alpha and Ig beta.

PubMed ID: 9057631

PubMed ID: 12097390

Title: B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-alpha and Ig-beta.

PubMed ID: 12097390

DOI: 10.4049/jimmunol.169.2.865

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 20696394

Title: Structural and functional studies of Igalphabeta and its assembly with the B cell antigen receptor.

PubMed ID: 20696394

DOI: 10.1016/j.str.2010.04.019

PubMed ID: 35981043

Title: Cryo-EM structure of the human IgM B cell receptor.

PubMed ID: 35981043

DOI: 10.1126/science.abo3923

PubMed ID: 17675462

Title: A hypomorphic mutation in Igbeta (CD79b) in a patient with immunodeficiency and a leaky defect in B cell development.

PubMed ID: 17675462

DOI: 10.4049/jimmunol.179.4.2055

Sequence Information:

Length: 229
Mass: 26048
Checksum: C467175567D10883
Sequence:

MARLALSPVP SHWMVALLLL LSAEPVPAAR SEDRYRNPKG SACSRIWQSP RFIARKRGFT 
VKMHCYMNSA SGNVSWLWKQ EMDENPQQLK LEKGRMEESQ NESLATLTIQ GIRFEDNGIY 
FCQQKCNNTS EVYQGCGTEL RVMGFSTLAQ LKQRNTLKDG IIMIQTLLII LFIIVPIFLL 
LDKDDSKAGM EEDHTYEGLD IDQTATYEDI VTLRTGEVKW SVGEHPGQE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CD79B

Associated with

Other Information

Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29. PubMed ID: 1534761

Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB). PubMed ID: 8486355

The human Ig-beta cDNA sequence, a homologue of murine B29, is identical in B cell and plasma cell lines producing all the human Ig isotypes. PubMed ID: 8419481

The complete sequence of the human CD79b (Ig beta/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism. PubMed ID: 7913081

Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells. PubMed ID: 7643857

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex. PubMed ID: 7514267

Cooperativity and segregation of function within the Ig-alpha/beta heterodimer of the B cell antigen receptor complex. PubMed ID: 8617796

B-cell antigen receptor-induced apoptosis requires both Ig alpha and Ig beta. PubMed ID: 9057631

B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-alpha and Ig-beta. PubMed ID: 12097390

Initial characterization of the human central proteome. PubMed ID: 21269460

Structural and functional studies of Igalphabeta and its assembly with the B cell antigen receptor. PubMed ID: 20696394

Cryo-EM structure of the human IgM B cell receptor. PubMed ID: 35981043

A hypomorphic mutation in Igbeta (CD79b) in a patient with immunodeficiency and a leaky defect in B cell development. PubMed ID: 17675462