Details for: CD79B

Gene ID: 974

Symbol: CD79B

Ensembl ID: ENSG00000007312

Description: CD79b molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: centroblast (CL0009112)
    Fold Change: 46.8740
    Cell Significance Index: 109.3600
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 39.7634
    Cell Significance Index: -6.1900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 25.4272
    Cell Significance Index: -10.3300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 23.0955
    Cell Significance Index: -11.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 10.3516
    Cell Significance Index: 363.7400
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 5.9969
    Cell Significance Index: 18.4900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 5.4083
    Cell Significance Index: 637.8000
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 4.9262
    Cell Significance Index: 22.0300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.9223
    Cell Significance Index: 123.0500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.9069
    Cell Significance Index: -6.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 4.6656
    Cell Significance Index: 134.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.5667
    Cell Significance Index: 294.6200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.6545
    Cell Significance Index: -9.7900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.2496
    Cell Significance Index: 57.4700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.1707
    Cell Significance Index: 63.7500
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.9331
    Cell Significance Index: 9.6700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.8119
    Cell Significance Index: -7.1500
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.7866
    Cell Significance Index: 10.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.7273
    Cell Significance Index: 78.3000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.5714
    Cell Significance Index: 34.0500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.5074
    Cell Significance Index: -4.6300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.4801
    Cell Significance Index: 22.9000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.2768
    Cell Significance Index: 26.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2103
    Cell Significance Index: 230.3300
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.1743
    Cell Significance Index: 5.8900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.0460
    Cell Significance Index: 18.4900
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 1.0261
    Cell Significance Index: 4.8200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9178
    Cell Significance Index: 90.8000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.8226
    Cell Significance Index: 9.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8028
    Cell Significance Index: 724.8800
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.7518
    Cell Significance Index: 6.6100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7462
    Cell Significance Index: 19.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4417
    Cell Significance Index: 71.8500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3626
    Cell Significance Index: 39.4400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2041
    Cell Significance Index: 14.1200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.1071
    Cell Significance Index: 0.9000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0610
    Cell Significance Index: 3.6700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.0459
    Cell Significance Index: 0.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0038
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0051
    Cell Significance Index: -3.7700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0086
    Cell Significance Index: -6.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0097
    Cell Significance Index: -4.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0134
    Cell Significance Index: -7.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0140
    Cell Significance Index: -7.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0143
    Cell Significance Index: -5.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0240
    Cell Significance Index: -3.0800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0279
    Cell Significance Index: -0.2800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0313
    Cell Significance Index: -1.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0336
    Cell Significance Index: -9.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0341
    Cell Significance Index: -6.7700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0371
    Cell Significance Index: -7.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0392
    Cell Significance Index: -5.3900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0453
    Cell Significance Index: -0.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0465
    Cell Significance Index: -5.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0470
    Cell Significance Index: -8.0200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0479
    Cell Significance Index: -0.7000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0505
    Cell Significance Index: -0.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0508
    Cell Significance Index: -9.1600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0524
    Cell Significance Index: -6.7700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0603
    Cell Significance Index: -3.1400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0630
    Cell Significance Index: -0.6700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0674
    Cell Significance Index: -4.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0703
    Cell Significance Index: -8.0600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0721
    Cell Significance Index: -2.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0751
    Cell Significance Index: -9.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0756
    Cell Significance Index: -3.5600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0822
    Cell Significance Index: -5.0400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0896
    Cell Significance Index: -1.1600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0964
    Cell Significance Index: -9.8500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0968
    Cell Significance Index: -7.4300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1064
    Cell Significance Index: -1.1200
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.1075
    Cell Significance Index: -0.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1147
    Cell Significance Index: -8.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1165
    Cell Significance Index: -7.3400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1272
    Cell Significance Index: -3.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1306
    Cell Significance Index: -3.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1381
    Cell Significance Index: -7.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1416
    Cell Significance Index: -6.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1627
    Cell Significance Index: -8.4500
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.1628
    Cell Significance Index: -1.5400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1632
    Cell Significance Index: -10.0300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1639
    Cell Significance Index: -2.4700
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1869
    Cell Significance Index: -2.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1888
    Cell Significance Index: -8.3500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1955
    Cell Significance Index: -2.3100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1990
    Cell Significance Index: -6.9700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2205
    Cell Significance Index: -8.3500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2208
    Cell Significance Index: -7.2300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2228
    Cell Significance Index: -8.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2269
    Cell Significance Index: -4.7500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2333
    Cell Significance Index: -7.4300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2507
    Cell Significance Index: -3.6400
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.2540
    Cell Significance Index: -3.8000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2600
    Cell Significance Index: -3.7400
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.2731
    Cell Significance Index: -1.7100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2807
    Cell Significance Index: -7.6400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2861
    Cell Significance Index: -6.9300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2881
    Cell Significance Index: -3.9200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2892
    Cell Significance Index: -7.7500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2909
    Cell Significance Index: -4.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CD79B is a transmembrane signaling receptor that is part of the BCR complex, which consists of the CD79A alpha chain and the CD79B beta chain. The CD79B beta chain is responsible for the signal transduction downstream of the BCR complex upon antigen binding. CD79B is also involved in the regulation of B cell receptor signaling through interactions with other proteins, such as CD22. Its expression is restricted to B cells, with high levels detected in germinal center B cells and memory B cells. **Pathways and Functions** The CD79B gene is involved in several key pathways and functions: 1. **Adaptive Immune Response**: CD79B plays a crucial role in the adaptive immune response by facilitating the recognition and response to antigens through the BCR complex. 2. **Antigen-Activated BCR Signaling**: Upon antigen binding, the CD79B beta chain initiates signal transduction cascades that lead to the activation of B cells. 3. **B Cell Differentiation**: CD79B is required for the differentiation of B cells from progenitor cells to mature B cells. 4. **B Cell Receptor Signaling Pathway**: CD79B is part of the BCR signaling pathway, which is essential for the activation and proliferation of B cells. 5. **CD22-Mediated BCR Regulation**: CD79B interacts with CD22, a co-receptor that modulates BCR signaling and regulation. **Clinical Significance** CD79B has been implicated in various immune-related disorders and viral infections, including: 1. **Autoimmune Diseases**: Dysregulation of CD79B has been linked to autoimmune diseases, such as autoimmune hemolytic anemia and rheumatoid arthritis. 2. **Viral Infections**: CD79B has been shown to be involved in the recognition and response to viral infections, such as SARS-CoV. 3. **Cancer**: CD79B has been implicated in the development and progression of certain types of cancer, such as Burkitt lymphoma. 4. **Immunodeficiency Disorders**: Mutations in the CD79B gene have been associated with immunodeficiency disorders, such as X-linked lymphoproliferative disease. In conclusion, CD79B is a critical component of the BCR complex, playing a pivotal role in the adaptive immune response and B cell differentiation. Its dysregulation has been implicated in various immune-related disorders and viral infections, making it a potential target for therapeutic interventions.

Genular Protein ID: 1559800519

Symbol: CD79B_HUMAN

Name: B-cell antigen receptor complex-associated protein beta chain

UniProtKB Accession Codes:

P40259 Q53FS2 Q9BU06

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 DrugCentral 1 ELM 1 EMBL 10 EMDB 4 Ensembl 3 EvolutionaryTrace 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1534761

Title: Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29.

PubMed ID: 1534761

DOI: 10.1002/eji.1830220641

PubMed ID: 8486355

Title: Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB).

PubMed ID: 8486355

DOI: 10.1006/geno.1993.1157

PubMed ID: 8419481

Title: The human Ig-beta cDNA sequence, a homologue of murine B29, is identical in B cell and plasma cell lines producing all the human Ig isotypes.

PubMed ID: 8419481

PubMed ID: 7913081

Title: The complete sequence of the human CD79b (Ig beta/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism.

PubMed ID: 7913081

DOI: 10.1007/bf00188178

PubMed ID: 7643857

Title: Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells.

PubMed ID: 7643857

DOI: 10.1016/0161-5890(95)00023-8

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7514267

Title: Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex.

PubMed ID: 7514267

DOI: 10.1016/0161-5890(94)90061-2

PubMed ID: 8617796

Title: Cooperativity and segregation of function within the Ig-alpha/beta heterodimer of the B cell antigen receptor complex.

PubMed ID: 8617796

DOI: 10.1074/jbc.271.9.5158

PubMed ID: 9057631

Title: B-cell antigen receptor-induced apoptosis requires both Ig alpha and Ig beta.

PubMed ID: 9057631

PubMed ID: 12097390

Title: B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-alpha and Ig-beta.

PubMed ID: 12097390

DOI: 10.4049/jimmunol.169.2.865

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 20696394

Title: Structural and functional studies of Igalphabeta and its assembly with the B cell antigen receptor.

PubMed ID: 20696394

DOI: 10.1016/j.str.2010.04.019

PubMed ID: 35981043

Title: Cryo-EM structure of the human IgM B cell receptor.

PubMed ID: 35981043

DOI: 10.1126/science.abo3923

PubMed ID: 17675462

Title: A hypomorphic mutation in Igbeta (CD79b) in a patient with immunodeficiency and a leaky defect in B cell development.

PubMed ID: 17675462

DOI: 10.4049/jimmunol.179.4.2055

Sequence Information:

  • Length: 229
  • Mass: 26048
  • Checksum: C467175567D10883
  • Sequence:
    • MARLALSPVP SHWMVALLLL LSAEPVPAAR SEDRYRNPKG SACSRIWQSP RFIARKRGFT 
VKMHCYMNSA SGNVSWLWKQ EMDENPQQLK LEKGRMEESQ NESLATLTIQ GIRFEDNGIY 
FCQQKCNNTS EVYQGCGTEL RVMGFSTLAQ LKQRNTLKDG IIMIQTLLII LFIIVPIFLL 
LDKDDSKAGM EEDHTYEGLD IDQTATYEDI VTLRTGEVKW SVGEHPGQE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.