Details for: LAPTM4A

Gene ID: 9741

Symbol: LAPTM4A

Ensembl ID: ENSG00000068697

Description: lysosomal protein transmembrane 4 alpha

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 4.84
    Marker Score: 6,310
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 4.64
    Marker Score: 7,148
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.54
    Marker Score: 3,253
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.52
    Marker Score: 153,679
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.14
    Marker Score: 54,667
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 4.11
    Marker Score: 10,435
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 4.06
    Marker Score: 5,874
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.99
    Marker Score: 3,122
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.83
    Marker Score: 7,204
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.57
    Marker Score: 8,992
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.57
    Marker Score: 23,194
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.52
    Marker Score: 3,000
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 3.41
    Marker Score: 8,935
  • Cell Name: basophil (CL0000767)
    Fold Change: 3.4
    Marker Score: 1,616
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.4
    Marker Score: 8,304
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.35
    Marker Score: 2,382
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.26
    Marker Score: 3,484
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.25
    Marker Score: 1,736
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.25
    Marker Score: 1,353
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 3.23
    Marker Score: 1,452
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.23
    Marker Score: 6,443
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 3.18
    Marker Score: 18,885
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 3.16
    Marker Score: 3,899
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.14
    Marker Score: 8,425
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.14
    Marker Score: 11,160
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 3.09
    Marker Score: 1,327
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.07
    Marker Score: 2,644
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 3.01
    Marker Score: 2,910
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.98
    Marker Score: 4,941
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.95
    Marker Score: 4,844
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.95
    Marker Score: 102,152
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.95
    Marker Score: 5,383
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.91
    Marker Score: 11,235
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.9
    Marker Score: 32,642
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.89
    Marker Score: 927
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.86
    Marker Score: 3,081
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.85
    Marker Score: 1,623
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.84
    Marker Score: 3,908
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.84
    Marker Score: 2,882
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.84
    Marker Score: 12,243
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.82
    Marker Score: 1,031
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.81
    Marker Score: 20,931
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.81
    Marker Score: 4,463
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.8
    Marker Score: 948
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.78
    Marker Score: 23,984
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.74
    Marker Score: 3,882
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.74
    Marker Score: 1,036
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.73
    Marker Score: 13,420
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.7
    Marker Score: 5,638
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.69
    Marker Score: 2,569
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.69
    Marker Score: 27,055
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.69
    Marker Score: 2,398
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.68
    Marker Score: 1,763
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.68
    Marker Score: 14,060
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.67
    Marker Score: 2,103
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.66
    Marker Score: 17,315
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.65
    Marker Score: 7,201
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.62
    Marker Score: 3,055
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.58
    Marker Score: 4,369
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.57
    Marker Score: 3,097
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.57
    Marker Score: 45,600
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.57
    Marker Score: 2,569
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.57
    Marker Score: 639
  • Cell Name: pericyte (CL0000669)
    Fold Change: 2.55
    Marker Score: 1,491
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.54
    Marker Score: 639
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 2.52
    Marker Score: 1,421
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.5
    Marker Score: 4,427
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.49
    Marker Score: 2,851
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.49
    Marker Score: 4,235
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.49
    Marker Score: 4,003
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.47
    Marker Score: 2,218
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.46
    Marker Score: 1,546
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.46
    Marker Score: 2,879
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.46
    Marker Score: 5,783
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.45
    Marker Score: 1,161
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.44
    Marker Score: 5,546
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.43
    Marker Score: 3,371
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.43
    Marker Score: 62,136
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.42
    Marker Score: 5,521
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.42
    Marker Score: 1,248
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.42
    Marker Score: 1,085
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.41
    Marker Score: 2,565
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.41
    Marker Score: 1,609
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.41
    Marker Score: 20,899
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 2.39
    Marker Score: 882
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.39
    Marker Score: 677
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.39
    Marker Score: 3,083
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.37
    Marker Score: 946
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.36
    Marker Score: 20,748
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 2.36
    Marker Score: 583
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.36
    Marker Score: 542
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.34
    Marker Score: 3,407
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.34
    Marker Score: 2,524
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.34
    Marker Score: 2,477
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 2.33
    Marker Score: 808
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.33
    Marker Score: 556
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.33
    Marker Score: 1,469
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.33
    Marker Score: 2,611
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.32
    Marker Score: 826
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.32
    Marker Score: 736

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LAPTM4A is a transmembrane protein that localizes to the lysosome and late endosome membranes. It exhibits a unique structure, consisting of two transmembrane domains and two cytoplasmic domains. The protein interacts with various cellular components, including proteins and lipids, to regulate lysosomal function, membrane dynamics, and cellular signaling pathways. LAPTM4A is also involved in the regulation of protein degradation, autophagy, and apoptosis. **Pathways and Functions:** LAPTM4A is involved in several key cellular pathways, including: 1. **Golgi apparatus pathway**: LAPTM4A regulates the trafficking of proteins and lipids within the Golgi apparatus, ensuring proper cellular function and membrane dynamics. 2. **Late endosome membrane pathway**: LAPTM4A interacts with other proteins to regulate the formation and function of late endosomes, which are involved in protein degradation and autophagy. 3. **Lysosomal membrane pathway**: LAPTM4A maintains the integrity and function of lysosomal membranes, regulating the escape of toxic molecules and the uptake of nutrients. 4. **Protein binding pathway**: LAPTM4A interacts with various proteins, including receptors, enzymes, and adaptor proteins, to regulate cellular signaling and function. **Functions:** LAPTM4A performs several critical functions, including: 1. **Regulation of lysosomal function**: LAPTM4A maintains the integrity and function of lysosomal membranes, ensuring proper protein degradation and autophagy. 2. **Modulation of immune responses**: LAPTM4A interacts with immune cells and regulates the production of cytokines and chemokines, influencing immune responses. 3. **Cellular signaling**: LAPTM4A regulates cellular signaling pathways, including those involved in cell growth, differentiation, and survival. 4. **Autophagy and apoptosis**: LAPTM4A regulates autophagy and apoptosis, influencing cellular homeostasis and survival. **Clinical Significance:** Dysregulation of LAPTM4A has been implicated in various diseases, including: 1. **Cancer**: LAPTM4A is overexpressed in several types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis. 2. **Cardiovascular diseases**: LAPTM4A is involved in the development of cardiovascular diseases, including atherosclerosis and heart failure. 3. **Autoimmune disorders**: LAPTM4A is associated with autoimmune disorders, including rheumatoid arthritis and lupus. 4. **Neurodegenerative diseases**: LAPTM4A is involved in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. In conclusion, LAPTM4A is a multifunctional protein that plays a critical role in maintaining cellular homeostasis, regulating lysosomal function, and modulating immune responses. Its dysregulation has significant clinical implications, highlighting the importance of further research into the mechanisms and functions of LAPTM4A.

Genular Protein ID: 2641744935

Symbol: LAP4A_HUMAN

Name: Lysosomal-associated transmembrane protein 4A

UniProtKB Accession Codes:

Q15012 Q6UW22

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7788527

Title: Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7788527

DOI: 10.1093/dnares/2.1.37

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25732826

Title: An organellar nalpha-acetyltransferase, naa60, acetylates cytosolic N termini of transmembrane proteins and maintains Golgi integrity.

PubMed ID: 25732826

DOI: 10.1016/j.celrep.2015.01.053

Sequence Information:

  • Length: 233
  • Mass: 26801
  • Checksum: 9BB76152B6E1365E
  • Sequence:
    • MVSMSFKRNR SDRFYSTRCC GCCHVRTGTI ILGTWYMVVN LLMAILLTVE VTHPNSMPAV 
NIQYEVIGNY YSSERMADNA CVLFAVSVLM FIISSMLVYG AISYQVGWLI PFFCYRLFDF 
VLSCLVAISS LTYLPRIKEY LDQLPDFPYK DDLLALDSSC LLFIVLVFFA LFIIFKAYLI 
NCVWNCYKYI NNRNVPEIAV YPAFEAPPQY VLPTYEMAVK MPEKEPPPPY LPA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.