Details for: CD81

Gene ID: 975

Symbol: CD81

Ensembl ID: ENSG00000110651

Description: CD81 molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 708.2185
    Cell Significance Index: -110.1600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 427.7265
    Cell Significance Index: -108.4900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 287.4395
    Cell Significance Index: -118.4100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 236.9511
    Cell Significance Index: -111.8700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 227.3683
    Cell Significance Index: -92.3700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 205.5269
    Cell Significance Index: -105.7200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 98.6182
    Cell Significance Index: -94.1600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 89.5247
    Cell Significance Index: -110.3800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 39.1585
    Cell Significance Index: -104.9000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 28.2536
    Cell Significance Index: -111.4900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 26.3458
    Cell Significance Index: -57.6600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 24.2100
    Cell Significance Index: -74.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 8.4184
    Cell Significance Index: 438.5000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 7.7594
    Cell Significance Index: 211.2100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 7.3868
    Cell Significance Index: 170.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 6.9497
    Cell Significance Index: 954.3900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.2104
    Cell Significance Index: 149.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.8678
    Cell Significance Index: 226.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 4.6306
    Cell Significance Index: 569.3700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 4.3145
    Cell Significance Index: 777.7700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.0205
    Cell Significance Index: 259.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.8545
    Cell Significance Index: 2105.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.3065
    Cell Significance Index: 108.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.2642
    Cell Significance Index: 1001.0500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.2308
    Cell Significance Index: 157.7700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.0481
    Cell Significance Index: 18.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.9098
    Cell Significance Index: 99.2100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.8987
    Cell Significance Index: 21.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.8874
    Cell Significance Index: 222.5900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.6886
    Cell Significance Index: 21.6300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.1932
    Cell Significance Index: 21.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.1257
    Cell Significance Index: 145.4300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9922
    Cell Significance Index: 127.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7399
    Cell Significance Index: 55.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.6010
    Cell Significance Index: 102.6200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5989
    Cell Significance Index: 41.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5687
    Cell Significance Index: 112.8600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5168
    Cell Significance Index: 466.6200
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.4819
    Cell Significance Index: 2.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.3957
    Cell Significance Index: 290.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3415
    Cell Significance Index: 64.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3381
    Cell Significance Index: 67.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3284
    Cell Significance Index: 117.8000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2546
    Cell Significance Index: 4.9700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1063
    Cell Significance Index: 200.1200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0579
    Cell Significance Index: 0.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0150
    Cell Significance Index: 11.3700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0021
    Cell Significance Index: 0.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0326
    Cell Significance Index: -1.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0352
    Cell Significance Index: -0.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0508
    Cell Significance Index: -37.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0747
    Cell Significance Index: -137.7000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0756
    Cell Significance Index: -52.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0839
    Cell Significance Index: -53.2600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0842
    Cell Significance Index: -8.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0875
    Cell Significance Index: -134.7500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0921
    Cell Significance Index: -57.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1043
    Cell Significance Index: -141.8300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1087
    Cell Significance Index: -1.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1179
    Cell Significance Index: -19.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1258
    Cell Significance Index: -70.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1576
    Cell Significance Index: -71.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2336
    Cell Significance Index: -49.2000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2869
    Cell Significance Index: -32.7500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.3066
    Cell Significance Index: -30.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3191
    Cell Significance Index: -36.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3312
    Cell Significance Index: -95.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3428
    Cell Significance Index: -21.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5133
    Cell Significance Index: -59.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5797
    Cell Significance Index: -84.2700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.6406
    Cell Significance Index: -9.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7101
    Cell Significance Index: -39.8500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8671
    Cell Significance Index: -23.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.9130
    Cell Significance Index: -70.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.0149
    Cell Significance Index: -105.6800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.0298
    Cell Significance Index: -8.6500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.0308
    Cell Significance Index: -52.0900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.1018
    Cell Significance Index: -87.2600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.2536
    Cell Significance Index: -26.0100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.2658
    Cell Significance Index: -51.8700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.2674
    Cell Significance Index: -33.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.3242
    Cell Significance Index: -89.0400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.4457
    Cell Significance Index: -91.1200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.6535
    Cell Significance Index: -34.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.8035
    Cell Significance Index: -110.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.8428
    Cell Significance Index: -51.5000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.9247
    Cell Significance Index: -26.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.9301
    Cell Significance Index: -101.3400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.9395
    Cell Significance Index: -32.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -2.0283
    Cell Significance Index: -91.9400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -2.2148
    Cell Significance Index: -32.6900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.2561
    Cell Significance Index: -82.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.2903
    Cell Significance Index: -101.3100
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -2.2924
    Cell Significance Index: -47.8100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.4820
    Cell Significance Index: -63.8000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -2.5810
    Cell Significance Index: -89.6900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -2.6933
    Cell Significance Index: -101.9900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -2.8060
    Cell Significance Index: -59.7600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.9004
    Cell Significance Index: -85.4300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -2.9319
    Cell Significance Index: -93.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CD81 is a type II transmembrane glycoprotein, consisting of an extracellular domain, a transmembrane domain, and an intracellular domain. It is characterized by its ability to form tetraspanin-enriched microdomains (TEMDs) with other tetraspanins, which are involved in cell-cell interactions and signaling. CD81 is also known for its ability to bind to various ligands, including cholesterol, lipids, and proteins, which are involved in cell adhesion, migration, and signaling. **Pathways and Functions** CD81 is involved in several signaling pathways, including: 1. **Adaptive Immune Response**: CD81 plays a key role in the adaptive immune response, particularly in the activation and proliferation of T cells, B cells, and natural killer cells. 2. **Innate Immune Response**: CD81 is involved in the innate immune response, particularly in the recognition and elimination of pathogens and foreign substances. 3. **Cell Adhesion and Migration**: CD81 is involved in cell adhesion and migration, particularly in the migration of immune cells to sites of inflammation. 4. **Signaling Pathways**: CD81 is involved in various signaling pathways, including the MAPK cascade, PI3K/AKT pathway, and NF-κB pathway. Some of the key functions of CD81 include: 1. **Regulation of Complement Cascade**: CD81 is involved in the regulation of the complement cascade, which is a part of the innate immune response. 2. **Regulation of Macrophage Migration**: CD81 is involved in the regulation of macrophage migration, which is important for the clearance of pathogens and foreign substances. 3. **Regulation of Protein Stability**: CD81 is involved in the regulation of protein stability, particularly in the regulation of the stability of immune-related proteins. 4. **Regulation of T-cell Activation**: CD81 is involved in the regulation of T-cell activation, particularly in the activation of CD4+ T cells. **Clinical Significance** CD81 has been implicated in various diseases, including: 1. **Cancer**: CD81 is overexpressed in several types of cancer, including leukemia, lymphoma, and breast cancer. 2. **Autoimmune Diseases**: CD81 is involved in autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Infectious Diseases**: CD81 is involved in infectious diseases, such as HIV and influenza. 4. **Neurological Disorders**: CD81 is involved in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, CD81 is a multifunctional protein that plays a critical role in the immune system. Its dysregulation has been implicated in various diseases, highlighting the importance of CD81 in maintaining immune homeostasis. Further research is needed to fully understand the role of CD81 in immune function and disease.

Genular Protein ID: 787470037

Symbol: CD81_HUMAN

Name: CD81 antigen

UniProtKB Accession Codes:

P60033 P18582 Q5U0J6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 40 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 16 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1695320

Title: TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins.

PubMed ID: 1695320

DOI: 10.1128/mcb.10.8.4007-4015.1990

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2398277

Title: TAPA-1, the target of an antiproliferative antibody, is associated on the cell surface with the Leu-13 antigen.

PubMed ID: 2398277

PubMed ID: 1860863

Title: Structure and membrane topology of TAPA-1.

PubMed ID: 1860863

DOI: 10.1016/s0021-9258(18)98728-4

PubMed ID: 1383329

Title: The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules.

PubMed ID: 1383329

PubMed ID: 8409388

Title: The TAPA-1 molecule is associated on the surface of B cells with HLA-DR molecules.

PubMed ID: 8409388

PubMed ID: 8766544

Title: Ligation of TAPA-1 (CD81) or major histocompatibility complex class II in co-cultures of human B and T lymphocytes enhances interleukin-4 synthesis by antigen-specific CD4+ T cells.

PubMed ID: 8766544

DOI: 10.1002/eji.1830260706

PubMed ID: 11504738

Title: EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily.

PubMed ID: 11504738

DOI: 10.1074/jbc.m107338200

PubMed ID: 12913001

Title: Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor.

PubMed ID: 12913001

DOI: 10.1074/jbc.m305289200

PubMed ID: 12796480

Title: Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes.

PubMed ID: 12796480

DOI: 10.1083/jcb.200212031

PubMed ID: 12970454

Title: CD81-dependent binding of hepatitis C virus E1E2 heterodimers.

PubMed ID: 12970454

DOI: 10.1128/jvi.77.19.10677-10683.2003

PubMed ID: 12483205

Title: Hepatocyte CD81 is required for Plasmodium falciparum and Plasmodium yoelii sporozoite infectivity.

PubMed ID: 12483205

DOI: 10.1038/nm808

PubMed ID: 15161911

Title: B cell signaling is regulated by induced palmitoylation of CD81.

PubMed ID: 15161911

DOI: 10.1074/jbc.m404410200

PubMed ID: 15004227

Title: Dynamic regulation of a GPCR-tetraspanin-G protein complex on intact cells: central role of CD81 in facilitating GPR56-Galpha q/11 association.

PubMed ID: 15004227

DOI: 10.1091/mbc.e03-12-0886

PubMed ID: 16449649

Title: Building of the tetraspanin web: distinct structural domains of CD81 function in different cellular compartments.

PubMed ID: 16449649

DOI: 10.1128/mcb.26.4.1373-1385.2006

PubMed ID: 20375010

Title: Claudin association with CD81 defines hepatitis C virus entry.

PubMed ID: 20375010

DOI: 10.1074/jbc.m110.104836

PubMed ID: 20237408

Title: CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency.

PubMed ID: 20237408

DOI: 10.1172/jci39748

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21930792

Title: SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling.

PubMed ID: 21930792

DOI: 10.1128/mcb.05817-11

PubMed ID: 21516087

Title: EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy.

PubMed ID: 21516087

DOI: 10.1038/nm.2341

PubMed ID: 22307619

Title: Complementary costimulation of human T-cell subpopulations by cluster of differentiation 28 (CD28) and CD81.

PubMed ID: 22307619

DOI: 10.1073/pnas.1121307109

PubMed ID: 23858057

Title: CD81 controls sustained T cell activation signaling and defines the maturation stages of cognate immunological synapses.

PubMed ID: 23858057

DOI: 10.1128/mcb.00302-13

PubMed ID: 26354436

Title: The Interferon-induced Transmembrane Proteins, IFITM1, IFITM2, and IFITM3 Inhibit Hepatitis C Virus Entry.

PubMed ID: 26354436

DOI: 10.1074/jbc.m115.657346

PubMed ID: 27993971

Title: The CD9, CD81, and CD151 EC2 domains bind to the classical RGD-binding site of integrin alphavbeta3.

PubMed ID: 27993971

DOI: 10.1042/bcj20160998

PubMed ID: 28871089

Title: CD81 association with SAMHD1 enhances HIV-1 reverse transcription by increasing dNTP levels.

PubMed ID: 28871089

DOI: 10.1038/s41564-017-0019-0

PubMed ID: 11226150

Title: CD81 extracellular domain 3D structure: insight into the tetraspanin superfamily structural motifs.

PubMed ID: 11226150

DOI: 10.1093/emboj/20.1.12

PubMed ID: 12437138

Title: Subunit association and conformational flexibility in the head subdomain of human CD81 large extracellular loop.

PubMed ID: 12437138

DOI: 10.1515/bc.2002.164

PubMed ID: 26116703

Title: An intramolecular bond at cluster of differentiation 81 ectodomain is important for hepatitis C virus entry.

PubMed ID: 26116703

DOI: 10.1096/fj.15-272880

PubMed ID: 27881302

Title: Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket.

PubMed ID: 27881302

DOI: 10.1016/j.cell.2016.09.056

PubMed ID: 27916518

Title: Mechanism of Structural Tuning of the Hepatitis C Virus Human Cellular Receptor CD81 Large Extracellular Loop.

PubMed ID: 27916518

DOI: 10.1016/j.str.2016.11.003

Sequence Information:

  • Length: 236
  • Mass: 25809
  • Checksum: EB9BD7671AC91B4A
  • Sequence:
    • MGVEGCTKCI KYLLFVFNFV FWLAGGVILG VALWLRHDPQ TTNLLYLELG DKPAPNTFYV 
GIYILIAVGA VMMFVGFLGC YGAIQESQCL LGTFFTCLVI LFACEVAAGI WGFVNKDQIA 
KDVKQFYDQA LQQAVVDDDA NNAKAVVKTF HETLDCCGSS TLTALTTSVL KNNLCPSGSN 
IISNLFKEDC HQKIDDLFSG KLYLIGIAAI VVAVIMIFEM ILSMVLCCGI RNSSVY

Genular Protein ID: 1912742821

Symbol: E9PJK1_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PJK1 E9PM31

Database IDs:

ARBA 2 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 4 GO 1 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 2 InterPro 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 3 RefSeq 2 SAM 1 SUPFAM 1 UCSC 2 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 165
  • Mass: 17963
  • Checksum: AABF8E4548B76329
  • Sequence:
    • MMFVGFLGCY GAIQESQCLL GTFFTCLVIL FACEVAAGIW GFVNKDQIAK DVKQFYDQAL 
QQAVVDDDAN NAKAVVKTFH ETLDCCGSST LTALTTSVLK NNLCPSGSNI ISNLFKEDCH 
QKIDDLFSGK LYLIGIAAIV VAVIMIFEMI LSMVLCCGIR NSSVY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.