Details for: CD81

Gene ID: 975

Symbol: CD81

Ensembl ID: ENSG00000110651

Description: CD81 molecule

Associated with

Other Information

Genular Protein ID: 787470037

Symbol: CD81_HUMAN

Name: CD81 antigen

UniProtKB Accession Codes:

P60033 P18582 Q5U0J6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 1 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 40 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 35 PDBsum 16 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1695320

Title: TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins.

PubMed ID: 1695320

DOI: 10.1128/mcb.10.8.4007-4015.1990

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2398277

Title: TAPA-1, the target of an antiproliferative antibody, is associated on the cell surface with the Leu-13 antigen.

PubMed ID: 2398277

PubMed ID: 1860863

Title: Structure and membrane topology of TAPA-1.

PubMed ID: 1860863

DOI: 10.1016/s0021-9258(18)98728-4

PubMed ID: 1383329

Title: The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules.

PubMed ID: 1383329

PubMed ID: 8409388

Title: The TAPA-1 molecule is associated on the surface of B cells with HLA-DR molecules.

PubMed ID: 8409388

PubMed ID: 8766544

Title: Ligation of TAPA-1 (CD81) or major histocompatibility complex class II in co-cultures of human B and T lymphocytes enhances interleukin-4 synthesis by antigen-specific CD4+ T cells.

PubMed ID: 8766544

DOI: 10.1002/eji.1830260706

PubMed ID: 11504738

Title: EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily.

PubMed ID: 11504738

DOI: 10.1074/jbc.m107338200

PubMed ID: 12913001

Title: Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor.

PubMed ID: 12913001

DOI: 10.1074/jbc.m305289200

PubMed ID: 12796480

Title: Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes.

PubMed ID: 12796480

DOI: 10.1083/jcb.200212031

PubMed ID: 12970454

Title: CD81-dependent binding of hepatitis C virus E1E2 heterodimers.

PubMed ID: 12970454

DOI: 10.1128/jvi.77.19.10677-10683.2003

PubMed ID: 12483205

Title: Hepatocyte CD81 is required for Plasmodium falciparum and Plasmodium yoelii sporozoite infectivity.

PubMed ID: 12483205

DOI: 10.1038/nm808

PubMed ID: 15161911

Title: B cell signaling is regulated by induced palmitoylation of CD81.

PubMed ID: 15161911

DOI: 10.1074/jbc.m404410200

PubMed ID: 15004227

Title: Dynamic regulation of a GPCR-tetraspanin-G protein complex on intact cells: central role of CD81 in facilitating GPR56-Galpha q/11 association.

PubMed ID: 15004227

DOI: 10.1091/mbc.e03-12-0886

PubMed ID: 16449649

Title: Building of the tetraspanin web: distinct structural domains of CD81 function in different cellular compartments.

PubMed ID: 16449649

DOI: 10.1128/mcb.26.4.1373-1385.2006

PubMed ID: 20375010

Title: Claudin association with CD81 defines hepatitis C virus entry.

PubMed ID: 20375010

DOI: 10.1074/jbc.m110.104836

PubMed ID: 20237408

Title: CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency.

PubMed ID: 20237408

DOI: 10.1172/jci39748

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21930792

Title: SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling.

PubMed ID: 21930792

DOI: 10.1128/mcb.05817-11

PubMed ID: 21516087

Title: EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy.

PubMed ID: 21516087

DOI: 10.1038/nm.2341

PubMed ID: 22307619

Title: Complementary costimulation of human T-cell subpopulations by cluster of differentiation 28 (CD28) and CD81.

PubMed ID: 22307619

DOI: 10.1073/pnas.1121307109

PubMed ID: 23858057

Title: CD81 controls sustained T cell activation signaling and defines the maturation stages of cognate immunological synapses.

PubMed ID: 23858057

DOI: 10.1128/mcb.00302-13

PubMed ID: 26354436

Title: The Interferon-induced Transmembrane Proteins, IFITM1, IFITM2, and IFITM3 Inhibit Hepatitis C Virus Entry.

PubMed ID: 26354436

DOI: 10.1074/jbc.m115.657346

PubMed ID: 27993971

Title: The CD9, CD81, and CD151 EC2 domains bind to the classical RGD-binding site of integrin alphavbeta3.

PubMed ID: 27993971

DOI: 10.1042/bcj20160998

PubMed ID: 28871089

Title: CD81 association with SAMHD1 enhances HIV-1 reverse transcription by increasing dNTP levels.

PubMed ID: 28871089

DOI: 10.1038/s41564-017-0019-0

PubMed ID: 11226150

Title: CD81 extracellular domain 3D structure: insight into the tetraspanin superfamily structural motifs.

PubMed ID: 11226150

DOI: 10.1093/emboj/20.1.12

PubMed ID: 12437138

Title: Subunit association and conformational flexibility in the head subdomain of human CD81 large extracellular loop.

PubMed ID: 12437138

DOI: 10.1515/bc.2002.164

PubMed ID: 26116703

Title: An intramolecular bond at cluster of differentiation 81 ectodomain is important for hepatitis C virus entry.

PubMed ID: 26116703

DOI: 10.1096/fj.15-272880

PubMed ID: 27881302

Title: Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket.

PubMed ID: 27881302

DOI: 10.1016/j.cell.2016.09.056

PubMed ID: 27916518

Title: Mechanism of Structural Tuning of the Hepatitis C Virus Human Cellular Receptor CD81 Large Extracellular Loop.

PubMed ID: 27916518

DOI: 10.1016/j.str.2016.11.003

Sequence Information:

  • Length: 236
  • Mass: 25809
  • Checksum: EB9BD7671AC91B4A
  • Sequence:
    • MGVEGCTKCI KYLLFVFNFV FWLAGGVILG VALWLRHDPQ TTNLLYLELG DKPAPNTFYV 
GIYILIAVGA VMMFVGFLGC YGAIQESQCL LGTFFTCLVI LFACEVAAGI WGFVNKDQIA 
KDVKQFYDQA LQQAVVDDDA NNAKAVVKTF HETLDCCGSS TLTALTTSVL KNNLCPSGSN 
IISNLFKEDC HQKIDDLFSG KLYLIGIAAI VVAVIMIFEM ILSMVLCCGI RNSSVY

Genular Protein ID: 1912742821

Symbol: E9PJK1_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PJK1 E9PM31

Database IDs:

ARBA 2 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 EPD 1 Ensembl 4 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 2 InterPro 2 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 2 SAM 1 SUPFAM 1 UCSC 2 VEuPathDB 1

Citations:

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 165
  • Mass: 17963
  • Checksum: AABF8E4548B76329
  • Sequence:
    • MMFVGFLGCY GAIQESQCLL GTFFTCLVIL FACEVAAGIW GFVNKDQIAK DVKQFYDQAL 
QQAVVDDDAN NAKAVVKTFH ETLDCCGSST LTALTTSVLK NNLCPSGSNI ISNLFKEDCH 
QKIDDLFSGK LYLIGIAAIV VAVIMIFEMI LSMVLCCGIR NSSVY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.