Details for: PCDHA9

Gene ID: 9752

Symbol: PCDHA9

Ensembl ID: ENSG00000204961

Description: protocadherin alpha 9

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.99
    Marker Score: 162,086
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.22
    Marker Score: 2,239
  • Cell Name: T cell (CL0000084)
    Fold Change: 1.71
    Marker Score: 2,941
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1,176
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.57
    Marker Score: 1,568
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.32
    Marker Score: 553
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 861
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.19
    Marker Score: 492
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,683
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,822
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.11
    Marker Score: 303
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.11
    Marker Score: 508
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.09
    Marker Score: 2,250
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.03
    Marker Score: 543
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,834
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,059
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 514
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 467
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.95
    Marker Score: 1,804
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 378
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,352
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 330
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,740
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.88
    Marker Score: 834
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.87
    Marker Score: 277
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,293
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.83
    Marker Score: 303
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.76
    Marker Score: 439
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.73
    Marker Score: 1,173
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 467
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.72
    Marker Score: 1,472
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.72
    Marker Score: 211
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.67
    Marker Score: 1,595
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.65
    Marker Score: 517
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.64
    Marker Score: 203
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.57
    Marker Score: 210
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 176
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.54
    Marker Score: 602
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.5
    Marker Score: 301
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.49
    Marker Score: 7,619
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.47
    Marker Score: 165
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.47
    Marker Score: 2,817
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.45
    Marker Score: 116
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.43
    Marker Score: 333
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.41
    Marker Score: 415
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.39
    Marker Score: 125
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.38
    Marker Score: 181
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.37
    Marker Score: 574
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.36
    Marker Score: 3,384
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.35
    Marker Score: 3,038
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.34
    Marker Score: 234
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.34
    Marker Score: 2,879
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.33
    Marker Score: 3,115
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.32
    Marker Score: 1,343
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.31
    Marker Score: 1,206
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.3
    Marker Score: 696
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.29
    Marker Score: 11,105
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.28
    Marker Score: 5,623
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.27
    Marker Score: 2,105
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.27
    Marker Score: 9,893
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.27
    Marker Score: 16,345
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.26
    Marker Score: 113
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.25
    Marker Score: 3,733
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.24
    Marker Score: 118
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.24
    Marker Score: 144
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.24
    Marker Score: 306
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.23
    Marker Score: 107
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.21
    Marker Score: 66
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.21
    Marker Score: 259
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.18
    Marker Score: 122
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.16
    Marker Score: 99
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.15
    Marker Score: 69
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.14
    Marker Score: 39
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.14
    Marker Score: 134
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.12
    Marker Score: 158
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.11
    Marker Score: 42
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.1
    Marker Score: 2,161
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.1
    Marker Score: 100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.1
    Marker Score: 88
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.1
    Marker Score: 57
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.1
    Marker Score: 58
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.09
    Marker Score: 89
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.09
    Marker Score: 264
  • Cell Name: S cone cell (CL0003050)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.09
    Marker Score: 39
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.08
    Marker Score: 94
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.08
    Marker Score: 31
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.08
    Marker Score: 54
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.07
    Marker Score: 69
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.07
    Marker Score: 126
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.07
    Marker Score: 121
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.07
    Marker Score: 81

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PCDHA9 exhibits homophilic cell adhesion properties, meaning it binds to itself, facilitating cell-to-cell interactions. This gene is specifically expressed in a range of cell types, including glutamatergic neurons, blood vessel endothelial cells, T cells, colon goblet cells, and intestinal epithelial cells. The expression pattern of PCDHA9 suggests its involvement in tissue development, immune function, and epithelial homeostasis. **Pathways and Functions:** PCDHA9 is involved in several cellular pathways, including: 1. **Calcium ion binding**: PCDHA9 interacts with calcium ions, which play a crucial role in cell signaling and adhesion. 2. **Cell adhesion**: PCDHA9 mediates homophilic cell adhesion, influencing cell-to-cell interactions and tissue organization. 3. **Nervous system development**: PCDHA9 is expressed in neural cells, suggesting its involvement in the development and maintenance of the nervous system. 4. **Plasma membrane**: PCDHA9 is localized to the plasma membrane, where it can interact with other adhesion molecules and signaling pathways. The functional significance of PCDHA9 is multifaceted: 1. **Cell adhesion and migration**: PCDHA9 contributes to cell migration and adhesion, which are essential processes in development, immune responses, and tissue repair. 2. **Cell signaling**: PCDHA9 may modulate cell signaling pathways, influencing cell growth, differentiation, and survival. 3. **Tissue organization**: PCDHA9 helps maintain tissue architecture and organization, particularly in epithelial tissues. **Clinical Significance:** The clinical significance of PCDHA9 is an area of active research. Alterations in PCDHA9 expression have been linked to various diseases, including: 1. **Neurological disorders**: Changes in PCDHA9 expression have been observed in neurodegenerative diseases, such as Alzheimer's and Parkinson's. 2. **Cancer**: PCDHA9 has been implicated in cancer progression, particularly in epithelial-derived cancers. 3. **Inflammatory diseases**: PCDHA9 may play a role in the development and progression of inflammatory diseases, such as atherosclerosis and rheumatoid arthritis. In conclusion, PCDHA9 is a critical gene involved in cell adhesion, development, and immune function. Further research is needed to elucidate the mechanisms by which PCDHA9 regulates cellular processes and to understand its role in disease pathology. As an expert immunologist, I emphasize the importance of investigating PCDHA9 in the context of human disease and developing strategies to modulate its expression and function.

Genular Protein ID: 2602219355

Symbol: PCDA9_HUMAN

Name: Protocadherin alpha-9

UniProtKB Accession Codes:

Q9Y5H5 O15053 Q2M3S5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 4 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 2 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10380929

Title: A striking organization of a large family of human neural cadherin-like cell adhesion genes.

PubMed ID: 10380929

DOI: 10.1016/s0092-8674(00)80789-8

PubMed ID: 9205841

Title: Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9205841

DOI: 10.1093/dnares/4.2.141

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 950
  • Mass: 102402
  • Checksum: AA1783B20D963957
  • Sequence:
    • MLYSSRGDPE GQPLLLSLLI LAMWVVGSGQ LHYSVPEEAE HGTFVGRIAQ DLGLELAELV 
PRLFQLDSKG RGDLLEVNLQ NGILFVNSRI DREELCGRSA ECSIHLEVIV DRPLQVFHVD 
VEVKDINDNP PVFPATQKNL FIAESRPLDS RFPLEGASDA DIGENALLTY RLSPNEYFFL 
DVPTSNQQVK PLGLVLRKLL DREETPELHL LLTATDGGKP ELTGTVQLLI TVLDNNDNAP 
VFDRTLYTVK LPENVSIGTL VIHPNASDLD EGLNGDIIYS FSSDVSPDIK SKFHMDPLSG 
AITVIGHMDF EESRAHKIPV EAVDKGFPPL AGHCTLLVEV VDVNDNAPQL TIKTLSVPVK 
EDAQLGTVIA LISVIDLDAD ANGQVTCSLT PHVPFKLVST YKNYYSLVLD RALDRESVSA 
YELVVTARDG GSPSLWATAR VSVEVADVND NAPAFAQSEY TVFVKENNPP GCHIFTVSAR 
DADAQENALV SYSLVERRLG ERSLSSYVSV HAESGKVYAL QPLDHEELEL LQFQVSARDA 
GVPPLGSNVT LQVFVLDEND NAPALLTPRM RGTDGAVSEM VLRSVGAGVV VGKVRAVDAD 
SGYNAWLSYE LQPETASASI PFRVGLYTGE ISTTRALDET DAPRQRLLVL VKDHGEPALT 
ATATVLVSLV ESGQAPKSSS RASVGATGPE VTLVDVNVYL IIAICAVSSL LVLTLLLYTV 
LRCSAMPTEG ECAPGKPTLV CSSAVGSWSY SQQRRQRVCS GEGKQKTDLM AFSPGLSPCA 
GSTERTGEPS ASSDSTGKPR QPNPDWRYSA SLRAGMHSSV HLEEAGILRA GPGGPDQQWP 
TVSSATPEPE AGEVSPPVGA GVNSNSWTFK YGPGNPKQSG PGELPDKFII PGSPAIISIR 
QEPTNSQIDK SDFITFGKKE ETKKKKKKKK GNKTQEKKEK GNSTTDNSDQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.