Details for: ADGRE5

Gene ID: 976

Symbol: ADGRE5

Ensembl ID: ENSG00000123146

Description: adhesion G protein-coupled receptor E5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 68.7988
    Cell Significance Index: -27.9500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 55.3962
    Cell Significance Index: -28.5000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 52.3805
    Cell Significance Index: -24.7300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 37.0182
    Cell Significance Index: -24.8400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.4425
    Cell Significance Index: -28.1100
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 15.1444
    Cell Significance Index: 40.5700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.6413
    Cell Significance Index: -23.4700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.5065
    Cell Significance Index: -14.2400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.0283
    Cell Significance Index: -13.4700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.7033
    Cell Significance Index: 86.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.9756
    Cell Significance Index: 127.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.7894
    Cell Significance Index: 291.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.2533
    Cell Significance Index: 146.0600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1983
    Cell Significance Index: 130.3400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0352
    Cell Significance Index: 62.1500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.8490
    Cell Significance Index: 22.7100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6316
    Cell Significance Index: 43.6800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5628
    Cell Significance Index: 16.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5440
    Cell Significance Index: 15.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4508
    Cell Significance Index: 246.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4229
    Cell Significance Index: 41.8300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4016
    Cell Significance Index: 8.7000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3855
    Cell Significance Index: 348.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3812
    Cell Significance Index: 9.5300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3177
    Cell Significance Index: 4.7600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2384
    Cell Significance Index: 47.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2366
    Cell Significance Index: 10.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2237
    Cell Significance Index: 17.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1934
    Cell Significance Index: 36.8000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.1626
    Cell Significance Index: 1.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1153
    Cell Significance Index: 20.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1050
    Cell Significance Index: 3.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0967
    Cell Significance Index: 11.9000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0824
    Cell Significance Index: 11.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0712
    Cell Significance Index: 2.0400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0322
    Cell Significance Index: 1.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0291
    Cell Significance Index: 3.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0151
    Cell Significance Index: 11.4300
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0046
    Cell Significance Index: 0.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0023
    Cell Significance Index: -0.3900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0042
    Cell Significance Index: -6.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0063
    Cell Significance Index: -11.8800
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0083
    Cell Significance Index: -0.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0127
    Cell Significance Index: -23.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0168
    Cell Significance Index: -22.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0170
    Cell Significance Index: -2.1900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0184
    Cell Significance Index: -0.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0257
    Cell Significance Index: -11.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0283
    Cell Significance Index: -0.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0315
    Cell Significance Index: -6.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0327
    Cell Significance Index: -1.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0343
    Cell Significance Index: -0.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0376
    Cell Significance Index: -27.8600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0388
    Cell Significance Index: -28.4800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0405
    Cell Significance Index: -25.7400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0428
    Cell Significance Index: -18.9200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0429
    Cell Significance Index: -15.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0474
    Cell Significance Index: -2.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0480
    Cell Significance Index: -29.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0492
    Cell Significance Index: -27.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0561
    Cell Significance Index: -6.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0741
    Cell Significance Index: -21.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0854
    Cell Significance Index: -8.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1049
    Cell Significance Index: -12.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1308
    Cell Significance Index: -27.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1596
    Cell Significance Index: -23.2000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1651
    Cell Significance Index: -8.6000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1768
    Cell Significance Index: -1.8300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2057
    Cell Significance Index: -21.4200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2153
    Cell Significance Index: -5.5000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.2256
    Cell Significance Index: -1.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2306
    Cell Significance Index: -10.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2745
    Cell Significance Index: -20.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2884
    Cell Significance Index: -7.7000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2947
    Cell Significance Index: -5.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3174
    Cell Significance Index: -19.4600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3334
    Cell Significance Index: -23.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3531
    Cell Significance Index: -23.7400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3970
    Cell Significance Index: -25.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3997
    Cell Significance Index: -11.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4116
    Cell Significance Index: -25.3000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4158
    Cell Significance Index: -21.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4195
    Cell Significance Index: -23.5400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4431
    Cell Significance Index: -11.3900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4595
    Cell Significance Index: -3.8600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4673
    Cell Significance Index: -19.1500
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.4750
    Cell Significance Index: -4.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5337
    Cell Significance Index: -23.6100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5694
    Cell Significance Index: -9.5300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5785
    Cell Significance Index: -20.2700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.5971
    Cell Significance Index: -14.5700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6267
    Cell Significance Index: -13.0000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6338
    Cell Significance Index: -24.0000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6341
    Cell Significance Index: -14.6500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6415
    Cell Significance Index: -23.5500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6491
    Cell Significance Index: -21.2500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.6511
    Cell Significance Index: -12.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6615
    Cell Significance Index: -17.4000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.6617
    Cell Significance Index: -18.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6735
    Cell Significance Index: -21.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ADGRE5 is a member of the G protein-coupled receptor (GPCR) family and shares structural and functional similarities with other GPCRs. It is characterized by its ability to bind to ligands, which triggers the activation of G-proteins, leading to the modulation of downstream signaling pathways. ADGRE5 is specifically expressed in immune cells, including monocytes, T cells, and dendritic cells, and is involved in various immune responses, including inflammation and immune system development. **Pathways and Functions:** ADGRE5 is involved in several signaling pathways that regulate immune cell functions, including: 1. Adenylate cyclase-activating GPCR signaling pathway: ADGRE5 activates adenylate cyclase, leading to the production of cAMP, which regulates various immune cell functions, including cell proliferation, differentiation, and survival. 2. Calcium ion binding: ADGRE5 regulates calcium ion homeostasis, which is essential for immune cell function, including cell signaling, proliferation, and differentiation. 3. Cell-cell signaling: ADGRE5 is involved in cell-cell communication, regulating the interaction between immune cells and other cells, including endothelial cells, epithelial cells, and other immune cells. 4. Cell adhesion: ADGRE5 regulates cell adhesion, which is essential for immune cell migration, invasion, and trafficking. 5. Immune response: ADGRE5 is involved in various immune responses, including the regulation of cytokine production, chemokine secretion, and the activation of immune cells, including neutrophils and macrophages. **Clinical Significance:** ADGRE5 has been implicated in various diseases, including: 1. Inflammatory disorders: ADGRE5 has been shown to play a role in the development of inflammatory disorders, including rheumatoid arthritis, lupus, and multiple sclerosis. 2. Cancer: ADGRE5 has been implicated in the progression of various cancers, including breast cancer, lung cancer, and colon cancer. 3. Autoimmune disorders: ADGRE5 has been shown to play a role in the development of autoimmune disorders, including type 1 diabetes, multiple sclerosis, and rheumatoid arthritis. 4. Infectious diseases: ADGRE5 has been implicated in the regulation of immune responses to infectious diseases, including HIV, tuberculosis, and influenza. In conclusion, ADGRE5 is a novel adhesion G protein-coupled receptor that plays a crucial role in immune response and inflammation. Its involvement in various signaling pathways and its expression in immune cells make it an important target for the development of novel therapeutic strategies for various diseases. Further research is needed to fully elucidate the role of ADGRE5 in human health and disease.

Genular Protein ID: 1276686024

Symbol: AGRE5_HUMAN

Name: Adhesion G protein-coupled receptor E5 subunit alpha

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7636245

Title: Expression cloning and chromosomal mapping of the leukocyte activation antigen CD97, a new seven-span transmembrane molecule of the secretion receptor superfamily with an unusual extracellular domain.

PubMed ID: 7636245

PubMed ID: 8786105

Title: Structure of the human CD97 gene: exon shuffling has generated a new type of seven-span transmembrane molecule related to the secretin receptor superfamily.

PubMed ID: 8786105

DOI: 10.1006/geno.1996.0092

PubMed ID: 8955192

Title: CD97 is a processed, seven-transmembrane, heterodimeric receptor associated with inflammation.

PubMed ID: 8955192

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11297558

Title: Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex.

PubMed ID: 11297558

DOI: 10.1074/jbc.m101770200

PubMed ID: 12829604

Title: The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans.

PubMed ID: 12829604

DOI: 10.1182/blood-2002-11-3540

PubMed ID: 14647991

Title: The EGF-TM7 family: a postgenomic view.

PubMed ID: 14647991

DOI: 10.1007/s00251-003-0625-2

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 835
  • Mass: 91869
  • Checksum: 06DDDE9178BC494B
  • Sequence:
  • MGGRVFLAFC VWLTLPGAET QDSRGCARWC PQNSSCVNAT ACRCNPGFSS FSEIITTPTE 
    TCDDINECAT PSKVSCGKFS DCWNTEGSYD CVCSPGYEPV SGAKTFKNES ENTCQDVDEC 
    QQNPRLCKSY GTCVNTLGSY TCQCLPGFKF IPEDPKVCTD VNECTSGQNP CHSSTHCLNN 
    VGSYQCRCRP GWQPIPGSPN GPNNTVCEDV DECSSGQHQC DSSTVCFNTV GSYSCRCRPG 
    WKPRHGIPNN QKDTVCEDMT FSTWTPPPGV HSQTLSRFFD KVQDLGRDSK TSSAEVTIQN 
    VIKLVDELME APGDVEALAP PVRHLIATQL LSNLEDIMRI LAKSLPKGPF TYISPSNTEL 
    TLMIQERGDK NVTMGQSSAR MKLNWAVAAG AEDPGPAVAG ILSIQNMTTL LANASLNLHS 
    KKQAELEEIY ESSIRGVQLR RLSAVNSIFL SHNNTKELNS PILFAFSHLE SSDGEAGRDP 
    PAKDVMPGPR QELLCAFWKS DSDRGGHWAT EGCQVLGSKN GSTTCQCSHL SSFAILMAHY 
    DVEDWKLTLI TRVGLALSLF CLLLCILTFL LVRPIQGSRT TIHLHLCICL FVGSTIFLAG 
    IENEGGQVGL RCRLVAGLLH YCFLAAFCWM SLEGLELYFL VVRVFQGQGL STRWLCLIGY 
    GVPLLIVGVS AAIYSKGYGR PRYCWLDFEQ GFLWSFLGPV TFIILCNAVI FVTTVWKLTQ 
    KFSEINPDMK KLKKARALTI TAIAQLFLLG CTWVFGLFIF DDRSLVLTYV FTILNCLQGA 
    FLYLLHCLLN KKVREEYRKW ACLVAGGSKY SEFTSTTSGT GHNQTRALRA SESGI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.