Details for: CD151

Gene ID: 977

Symbol: CD151

Ensembl ID: ENSG00000177697

Description: CD151 molecule (Raph blood group)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 337.8439
    Cell Significance Index: -52.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 211.3992
    Cell Significance Index: -53.6200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 122.9447
    Cell Significance Index: -58.0500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 109.8593
    Cell Significance Index: -56.5100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 87.7020
    Cell Significance Index: -58.8500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 45.2977
    Cell Significance Index: -55.8500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.9778
    Cell Significance Index: -48.1600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.2244
    Cell Significance Index: -56.1300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.4566
    Cell Significance Index: -38.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 10.3922
    Cell Significance Index: 1211.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.1059
    Cell Significance Index: 238.0600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 4.6007
    Cell Significance Index: 81.3000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.5554
    Cell Significance Index: 28.0400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.9240
    Cell Significance Index: 31.3300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.7127
    Cell Significance Index: 24.9800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.4911
    Cell Significance Index: 28.3000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.2330
    Cell Significance Index: 33.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.1469
    Cell Significance Index: 1172.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.0467
    Cell Significance Index: 96.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.0188
    Cell Significance Index: 277.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.0064
    Cell Significance Index: 149.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.7102
    Cell Significance Index: 37.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.6319
    Cell Significance Index: 210.8300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.5149
    Cell Significance Index: 35.0000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.4404
    Cell Significance Index: 8.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3866
    Cell Significance Index: 137.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.2641
    Cell Significance Index: 558.8800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2337
    Cell Significance Index: 222.3900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.1678
    Cell Significance Index: 40.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1314
    Cell Significance Index: 139.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.1139
    Cell Significance Index: 142.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.0490
    Cell Significance Index: 179.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0076
    Cell Significance Index: 52.3400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.0040
    Cell Significance Index: 71.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9429
    Cell Significance Index: 851.3500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9220
    Cell Significance Index: 26.5700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.8699
    Cell Significance Index: 11.1400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8276
    Cell Significance Index: 22.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7561
    Cell Significance Index: 20.1900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6245
    Cell Significance Index: 16.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5897
    Cell Significance Index: 16.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4509
    Cell Significance Index: 85.8000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.2027
    Cell Significance Index: 23.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1905
    Cell Significance Index: 144.2000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1539
    Cell Significance Index: 0.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1320
    Cell Significance Index: 26.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1074
    Cell Significance Index: 17.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0789
    Cell Significance Index: 2.7700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0728
    Cell Significance Index: 1.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0676
    Cell Significance Index: 13.5700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0673
    Cell Significance Index: 46.5300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0583
    Cell Significance Index: 1.6700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0535
    Cell Significance Index: 0.9000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0186
    Cell Significance Index: 35.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0035
    Cell Significance Index: -4.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0088
    Cell Significance Index: -6.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0124
    Cell Significance Index: -1.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0179
    Cell Significance Index: -27.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0188
    Cell Significance Index: -34.5900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0201
    Cell Significance Index: -14.9200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0326
    Cell Significance Index: -20.3500
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.0384
    Cell Significance Index: -0.8000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0476
    Cell Significance Index: -0.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0500
    Cell Significance Index: -31.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0508
    Cell Significance Index: -3.9000
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.0658
    Cell Significance Index: -0.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0691
    Cell Significance Index: -24.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0758
    Cell Significance Index: -42.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0868
    Cell Significance Index: -39.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1013
    Cell Significance Index: -11.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1255
    Cell Significance Index: -26.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1537
    Cell Significance Index: -44.2100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1544
    Cell Significance Index: -10.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2398
    Cell Significance Index: -7.6800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2490
    Cell Significance Index: -6.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2912
    Cell Significance Index: -42.3300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3190
    Cell Significance Index: -16.7500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3716
    Cell Significance Index: -4.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4197
    Cell Significance Index: -49.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4556
    Cell Significance Index: -29.3900
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.4590
    Cell Significance Index: -2.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4904
    Cell Significance Index: -22.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5165
    Cell Significance Index: -53.7800
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.5599
    Cell Significance Index: -2.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6296
    Cell Significance Index: -35.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6607
    Cell Significance Index: -40.6100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6721
    Cell Significance Index: -53.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6750
    Cell Significance Index: -9.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7440
    Cell Significance Index: -45.6200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7809
    Cell Significance Index: -15.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.8037
    Cell Significance Index: -20.0900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.8129
    Cell Significance Index: -23.8700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8324
    Cell Significance Index: -55.9700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.8605
    Cell Significance Index: -15.9100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8680
    Cell Significance Index: -54.7100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.9125
    Cell Significance Index: -19.1000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.9220
    Cell Significance Index: -15.8000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9591
    Cell Significance Index: -28.2500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -1.0301
    Cell Significance Index: -10.6600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.0905
    Cell Significance Index: -28.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane glycoprotein:** CD151 is a transmembrane protein composed of four extracellular Ig-like domains and six intracellular transmembrane domains. 2. **Tetraspanin family member:** CD151 is a member of the tetraspanin family, which consists of four transmembrane proteins that interact with each other and other molecules to regulate cell-cell and cell-extracellular matrix interactions. 3. **Cell adhesion and migration:** CD151 plays a crucial role in cell adhesion, migration, and the organization of the extracellular matrix, influencing the assembly of collagen fibrils, cell junctions, and focal adhesions. 4. **Multiple ligands and interactors:** CD151 interacts with multiple cell surface receptors and molecules, including integrins, laminins, and collagen, to regulate various cellular processes. **Pathways and Functions:** 1. **Cell-cell communication:** CD151 interacts with other tetraspanins and cell surface receptors to regulate cell-cell communication and the formation of cell junctions. 2. **Cell adhesion:** CD151 mediates cell adhesion to the extracellular matrix through its interaction with integrins and laminins. 3. **Extracellular matrix organization:** CD151 regulates the assembly of collagen fibrils and the organization of the extracellular matrix, influencing tissue structure and function. 4. **Cell migration:** CD151 plays a crucial role in cell migration, influencing the formation of focal adhesions and the regulation of cell movement. 5. **Wound healing:** CD151 has been implicated in wound healing, influencing the organization of the extracellular matrix and the migration of cells to the wound site. **Clinical Significance:** 1. **Cancer:** CD151 has been implicated in various types of cancer, including breast, lung, and colon cancer, where it may contribute to tumor progression and metastasis. 2. **Cardiovascular disorders:** CD151 has been linked to cardiovascular disorders, including atherosclerosis and heart failure, where it may influence the organization of the extracellular matrix and cell migration. 3. **Inflammatory conditions:** CD151 has been implicated in inflammatory conditions, including rheumatoid arthritis and multiple sclerosis, where it may contribute to tissue damage and inflammation. 4. **Regenerative medicine:** CD151 has been identified as a potential target for regenerative medicine, where it may be used to promote tissue repair and regeneration. In conclusion, CD151 is a multifaceted gene involved in various cellular processes, including cell adhesion, migration, and extracellular matrix organization. Its dysregulation has been implicated in several diseases, and further research is needed to fully elucidate its role in human health and disease.

Genular Protein ID: 4057369447

Symbol: CD151_HUMAN

Name: CD151 antigen

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7632941

Title: Molecular cloning of cDNA encoding a novel platelet-endothelial cell tetra-span antigen, PETA-3.

PubMed ID: 7632941

PubMed ID: 8627808

Title: SFA-1, a novel cellular gene induced by human T-cell leukemia virus type 1, is a member of the transmembrane 4 superfamily.

PubMed ID: 8627808

DOI: 10.1128/jvi.70.5.3258-3263.1996

PubMed ID: 11181065

Title: Genomic organization, amplification, fine mapping, and intragenic polymorphisms of the human hemidesmosomal tetraspanin CD151 gene.

PubMed ID: 11181065

DOI: 10.1006/bbrc.2001.4384

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11907260

Title: Palmitoylation of tetraspanin proteins: modulation of CD151 lateral interactions, subcellular distribution, and integrin-dependent cell morphology.

PubMed ID: 11907260

DOI: 10.1091/mbc.01-05-0275

PubMed ID: 15265795

Title: CD151, the first member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin.

PubMed ID: 15265795

DOI: 10.1182/blood-2004-04-1512

PubMed ID: 17045834

Title: Activation of the phosphatidylinositol 3-kinase/protein kinase Akt pathway mediates CD151-induced endothelial cell proliferation and cell migration.

PubMed ID: 17045834

DOI: 10.1016/j.biocel.2006.09.001

PubMed ID: 18713730

Title: The single subunit transmembrane E3 ligase gene related to anergy in lymphocytes (GRAIL) captures and then ubiquitinates transmembrane proteins across the cell membrane.

PubMed ID: 18713730

DOI: 10.1074/jbc.m805092200

PubMed ID: 18852263

Title: Tetraspanin CD151 regulates glycosylation of (alpha)3(beta)1 integrin.

PubMed ID: 18852263

DOI: 10.1074/jbc.m806394200

PubMed ID: 18508921

Title: DHHC2 affects palmitoylation, stability, and functions of tetraspanins CD9 and CD151.

PubMed ID: 18508921

DOI: 10.1091/mbc.e07-11-1164

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22843693

Title: Tetraspanin CD151 stimulates adhesion-dependent activation of Ras, Rac, and Cdc42 by facilitating molecular association between beta1 integrins and small GTPases.

PubMed ID: 22843693

DOI: 10.1074/jbc.m111.314443

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24723389

Title: Tetraspanins CD9 and CD151 at the immune synapse support T-cell integrin signaling.

PubMed ID: 24723389

DOI: 10.1002/eji.201344235

PubMed ID: 24553111

Title: The tetraspanin CD151 in papillomavirus infection.

PubMed ID: 24553111

DOI: 10.3390/v6020893

PubMed ID: 27147745

Title: Tetraspanin CD151 Promotes Initial Events in Human Cytomegalovirus Infection.

PubMed ID: 27147745

DOI: 10.1128/jvi.00145-16

PubMed ID: 27993971

Title: The CD9, CD81, and CD151 EC2 domains bind to the classical RGD-binding site of integrin alphavbeta3.

PubMed ID: 27993971

DOI: 10.1042/bcj20160998

PubMed ID: 31488507

Title: Tetraspanin CD151 and integrin alpha3beta1 contribute to the stabilization of integrin alpha6beta4-containing cell-matrix adhesions.

PubMed ID: 31488507

DOI: 10.1242/jcs.235366

PubMed ID: 32978478

Title: The tetraspanin CD151 marks a unique population of activated human T cells.

PubMed ID: 32978478

DOI: 10.1038/s41598-020-72719-8

PubMed ID: 35067832

Title: JAM-A interacts with alpha3beta1 integrin and tetraspanins CD151 and CD9 to regulate collective cell migration of polarized epithelial cells.

PubMed ID: 35067832

DOI: 10.1007/s00018-022-04140-5

Sequence Information:

  • Length: 253
  • Mass: 28295
  • Checksum: 0C8FE4CF2C3C286D
  • Sequence:
  • MGEFNEKKTT CGTVCLKYLL FTYNCCFWLA GLAVMAVGIW TLALKSDYIS LLASGTYLAT 
    AYILVVAGTV VMVTGVLGCC ATFKERRNLL RLYFILLLII FLLEIIAGIL AYAYYQQLNT 
    ELKENLKDTM TKRYHQPGHE AVTSAVDQLQ QEFHCCGSNN SQDWRDSEWI RSQEAGGRVV 
    PDSCCKTVVA LCGQRDHASN IYKVEGGCIT KLETFIQEHL RVIGAVGIGI ACVQVFGMIF 
    TCCLYRSLKL EHY

Genular Protein ID: 1807719036

Symbol: Q6ZNZ0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 179
  • Mass: 18926
  • Checksum: 6A18B6EC57335AC1
  • Sequence:
  • MGEFNEKKTT CGTVCLKYLL FTYNCCFWLA GLAVMAVGIW TLALKSDYIS LLASGTYLAT 
    AYILVVAGTV VMVTGVLGCC ATFKERRNLL RLVRRAQGHG VGVVQMGPRR LSLQALNLCL 
    AVLTWGGVTV LPHLPSPVGP HVPAGPAEGR HQLRKKASGR VAAPQPPPGA WGAGVGTLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.