Details for: EIF4A3
Associated with
Other Information
Genular Protein ID: 4157833595
Symbol: IF4A3_HUMAN
Name: Eukaryotic initiation factor 4A-III
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7788527
Title: Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.
PubMed ID: 7788527
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16625196
Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
PubMed ID: 16625196
DOI: 10.1038/nature04689
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10623621
Title: A human common nuclear matrix protein homologous to eukaryotic translation initiation factor 4A.
PubMed ID: 10623621
PubMed ID: 11991638
Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.
PubMed ID: 11991638
PubMed ID: 15034551
Title: eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay.
PubMed ID: 15034551
DOI: 10.1038/nsmb750
PubMed ID: 14730019
Title: eIF4A3 is a novel component of the exon junction complex.
PubMed ID: 14730019
DOI: 10.1261/rna.5230104
PubMed ID: 15715967
Title: Identification of NOM1, a nucleolar, eIF4A binding protein encoded within the chromosome 7q36 breakpoint region targeted in cases of pediatric acute myeloid leukemia.
PubMed ID: 15715967
PubMed ID: 16209946
Title: Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements.
PubMed ID: 16209946
PubMed ID: 16170325
Title: The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity.
PubMed ID: 16170325
DOI: 10.1038/nsmb990
PubMed ID: 16314458
Title: Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
PubMed ID: 16314458
DOI: 10.1261/rna.2155905
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16495234
Title: Mutational analysis of human eIF4AIII identifies regions necessary for exon junction complex formation and nonsense-mediated mRNA decay.
PubMed ID: 16495234
DOI: 10.1261/rna.2190706
PubMed ID: 17375189
Title: MLN51 stimulates the RNA-helicase activity of eIF4AIII.
PubMed ID: 17375189
PubMed ID: 18423201
Title: SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs.
PubMed ID: 18423201
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19409878
Title: Exon junction complex enhances translation of spliced mRNAs at multiple steps.
PubMed ID: 19409878
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22959432
Title: CWC22 connects pre-mRNA splicing and exon junction complex assembly.
PubMed ID: 22959432
PubMed ID: 22203037
Title: Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators.
PubMed ID: 22203037
DOI: 10.1128/mcb.06130-11
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22961380
Title: Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly.
PubMed ID: 22961380
DOI: 10.1038/nsmb.2380
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23236153
Title: Human spliceosomal protein CWC22 plays a role in coupling splicing to exon junction complex deposition and nonsense-mediated decay.
PubMed ID: 23236153
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23917022
Title: Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay.
PubMed ID: 23917022
DOI: 10.4161/rna.25827
PubMed ID: 24360810
Title: A noncoding expansion in EIF4A3 causes Richieri-Costa-Pereira syndrome, a craniofacial disorder associated with limb defects.
PubMed ID: 24360810
PubMed ID: 25220460
Title: The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex.
PubMed ID: 25220460
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 25772364
Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
PubMed ID: 25772364
PubMed ID: 25755297
Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
PubMed ID: 25755297
PubMed ID: 26382858
Title: mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3.
PubMed ID: 26382858
DOI: 10.1038/ncomms9192
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 30538148
Title: Human nuclear RNAi-defective 2 (NRDE2) is an essential RNA splicing factor.
PubMed ID: 30538148
PubMed ID: 16923391
Title: The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA.
PubMed ID: 16923391
PubMed ID: 16931718
Title: Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA.
PubMed ID: 16931718
PubMed ID: 19033377
Title: Mechanism of ATP turnover inhibition in the EJC.
PubMed ID: 19033377
DOI: 10.1261/rna.1283109
PubMed ID: 20479275
Title: Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex.
PubMed ID: 20479275
PubMed ID: 24218557
Title: Crystal structure of the human eIF4AIII-CWC22 complex shows how a DEAD-box protein is inhibited by a MIF4G domain.
PubMed ID: 24218557
PubMed ID: 28502770
Title: An Atomic Structure of the Human Spliceosome.
PubMed ID: 28502770
PubMed ID: 28076346
Title: Cryo-EM structure of a human spliceosome activated for step 2 of splicing.
PubMed ID: 28076346
DOI: 10.1038/nature21079
PubMed ID: 29301961
Title: Structure of a human catalytic step I spliceosome.
PubMed ID: 29301961
Sequence Information:
- Length: 411
- Mass: 46871
- Checksum: 3A21888CA96CA5EA
- Sequence:
MATTATMATS GSARKRLLKE EDMTKVEFET SEEVDVTPTF DTMGLREDLL RGIYAYGFEK PSAIQQRAIK QIIKGRDVIA QSQSGTGKTA TFSISVLQCL DIQVRETQAL ILAPTRELAV QIQKGLLALG DYMNVQCHAC IGGTNVGEDI RKLDYGQHVV AGTPGRVFDM IRRRSLRTRA IKMLVLDEAD EMLNKGFKEQ IYDVYRYLPP ATQVVLISAT LPHEILEMTN KFMTDPIRIL VKRDELTLEG IKQFFVAVER EEWKFDTLCD LYDTLTITQA VIFCNTKRKV DWLTEKMREA NFTVSSMHGD MPQKERESIM KEFRSGASRV LISTDVWARG LDVPQVSLII NYDLPNNREL YIHRIGRSGR YGRKGVAINF VKNDDIRILR DIEQYYSTQI DEMPMNVADL I
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.