Details for: CDA

Gene ID: 978

Symbol: CDA

Ensembl ID: ENSG00000158825

Description: cytidine deaminase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 52.4606
    Cell Significance Index: -8.1600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 32.8808
    Cell Significance Index: -8.3400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 18.8380
    Cell Significance Index: -9.6900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.5899
    Cell Significance Index: -8.1300
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 3.2646
    Cell Significance Index: 12.5000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 2.3542
    Cell Significance Index: 20.2300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.1084
    Cell Significance Index: -8.3200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 2.0320
    Cell Significance Index: 64.2700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.8539
    Cell Significance Index: 40.1700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.3090
    Cell Significance Index: 22.0500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.9560
    Cell Significance Index: 14.3300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7715
    Cell Significance Index: 146.8300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.6779
    Cell Significance Index: 12.5300
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.6301
    Cell Significance Index: 4.1800
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.6037
    Cell Significance Index: 2.2500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4947
    Cell Significance Index: 5.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4628
    Cell Significance Index: 12.3800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.3509
    Cell Significance Index: 2.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3423
    Cell Significance Index: 33.8600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3423
    Cell Significance Index: 309.0900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2755
    Cell Significance Index: 16.5400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2426
    Cell Significance Index: 6.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1859
    Cell Significance Index: 30.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1780
    Cell Significance Index: 8.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1494
    Cell Significance Index: 81.5800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1381
    Cell Significance Index: 9.5500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1272
    Cell Significance Index: 2.0400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.1118
    Cell Significance Index: 0.9500
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.0958
    Cell Significance Index: 0.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0857
    Cell Significance Index: 2.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0844
    Cell Significance Index: 9.8400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0735
    Cell Significance Index: 99.8800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0690
    Cell Significance Index: 1.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0585
    Cell Significance Index: 11.6000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0549
    Cell Significance Index: 0.8100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0547
    Cell Significance Index: 0.7000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0336
    Cell Significance Index: 0.5200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0215
    Cell Significance Index: 0.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0093
    Cell Significance Index: 14.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0020
    Cell Significance Index: 0.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0018
    Cell Significance Index: 1.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0009
    Cell Significance Index: 1.7000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0025
    Cell Significance Index: -4.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0032
    Cell Significance Index: -0.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0035
    Cell Significance Index: -0.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0098
    Cell Significance Index: -1.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0105
    Cell Significance Index: -7.9200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0120
    Cell Significance Index: -5.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0135
    Cell Significance Index: -9.9900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0136
    Cell Significance Index: -8.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0142
    Cell Significance Index: -9.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0160
    Cell Significance Index: -4.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0164
    Cell Significance Index: -1.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0169
    Cell Significance Index: -9.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0172
    Cell Significance Index: -3.4600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0178
    Cell Significance Index: -6.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0204
    Cell Significance Index: -9.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0206
    Cell Significance Index: -3.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0362
    Cell Significance Index: -7.6200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0449
    Cell Significance Index: -6.1600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0454
    Cell Significance Index: -5.8200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0521
    Cell Significance Index: -1.1100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0532
    Cell Significance Index: -2.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0535
    Cell Significance Index: -9.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0551
    Cell Significance Index: -8.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0713
    Cell Significance Index: -9.2100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0731
    Cell Significance Index: -3.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0747
    Cell Significance Index: -7.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0846
    Cell Significance Index: -9.6900
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0887
    Cell Significance Index: -0.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0976
    Cell Significance Index: -7.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1102
    Cell Significance Index: -8.4600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1192
    Cell Significance Index: -1.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1228
    Cell Significance Index: -9.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1282
    Cell Significance Index: -8.6200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1299
    Cell Significance Index: -2.5400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1328
    Cell Significance Index: -5.4400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1457
    Cell Significance Index: -3.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1464
    Cell Significance Index: -9.0000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1499
    Cell Significance Index: -9.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1527
    Cell Significance Index: -4.8900
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.1533
    Cell Significance Index: -1.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1681
    Cell Significance Index: -7.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1717
    Cell Significance Index: -9.6400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1724
    Cell Significance Index: -2.4200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1749
    Cell Significance Index: -6.4200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1828
    Cell Significance Index: -4.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1880
    Cell Significance Index: -9.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1981
    Cell Significance Index: -10.2900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2030
    Cell Significance Index: -2.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2037
    Cell Significance Index: -9.0100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2050
    Cell Significance Index: -7.1800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2086
    Cell Significance Index: -7.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2100
    Cell Significance Index: -9.7900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2144
    Cell Significance Index: -7.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2146
    Cell Significance Index: -5.7500
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.2279
    Cell Significance Index: -2.3600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2286
    Cell Significance Index: -7.2800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2318
    Cell Significance Index: -3.8800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2396
    Cell Significance Index: -6.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CDA is a cytosolic enzyme that belongs to the cytidine deaminase family. It exhibits a high degree of specificity, primarily deaminating cytidine and uridine nucleotides into uracil and thymine, respectively. The enzyme is also known for its ability to hydrolyze nucleoside analogs, such as cytarabine, into their respective deoxynucleosides. CDA is highly expressed in various cell types, including immune cells, epithelial cells, and endothelial cells. **Pathways and Functions:** CDA plays a pivotal role in several cellular pathways, including: 1. **Immune response:** CDA is involved in the regulation of immune cell function, particularly in the deamination of nucleotides and the subsequent production of immune-modulating metabolites. 2. **Cell growth regulation:** CDA has been shown to inhibit cell growth and proliferation by deaminating nucleotides, thereby regulating cell cycle progression. 3. **Metabolism:** CDA participates in the metabolism of nucleotides, contributing to the salvage of nucleotides from the extracellular environment. 4. **Nucleotide salvage:** The enzyme is involved in the salvage of nucleotides from the extracellular environment, reducing the need for de novo synthesis. **Clinical Significance:** CDA has significant implications in various diseases and conditions, including: 1. **Immunodeficiency disorders:** Mutations in the CDA gene have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 2. **Cancer:** CDA has been implicated in the development and progression of certain cancers, including leukemia and lymphoma, where its ability to hydrolyze nucleoside analogs can contribute to chemotherapy resistance. 3. **Neurological disorders:** CDA has been linked to neurological disorders, such as Alzheimer's disease, where its involvement in nucleotide metabolism may contribute to disease progression. In conclusion, the CDA gene is a critical component of the immune system, regulating immune cell function, cell growth, and metabolism. Its dysregulation has significant implications in various diseases and conditions, highlighting the importance of further research into the mechanisms and functions of this enzyme. **References:** * [Insert relevant references to scientific articles, reviews, and studies on the CDA gene and its functions.]

Genular Protein ID: 865971040

Symbol: CDD_HUMAN

Name: Cytidine aminohydrolase

UniProtKB Accession Codes:

P32320

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 DrugCentral 1 EC 2 EMBL 9 Ensembl 1 EvolutionaryTrace 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 3 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7923172

Title: Human cytidine deaminase: purification of enzyme, cloning, and expression of its complementary DNA.

PubMed ID: 7923172

PubMed ID: 9878810

Title: Isolation and characterization of the gene coding for human cytidine deaminase.

PubMed ID: 9878810

DOI: 10.1016/s0167-4781(98)00235-8

PubMed ID: 9596658

Title: Growth inhibition of granulocyte-macrophage colony forming cells by human cytidine deaminase requires the catalytic function of the protein.

PubMed ID: 9596658

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8422236

Title: Cloning of a functional cDNA for human cytidine deaminase (CDD) and its use as a marker of monocyte/macrophage differentiation.

PubMed ID: 8422236

DOI: 10.1006/bbrc.1993.1001

PubMed ID: 15689149

Title: Structure of human cytidine deaminase bound to a potent inhibitor.

PubMed ID: 15689149

DOI: 10.1021/jm0496279

Sequence Information:

  • Length: 146
  • Mass: 16185
  • Checksum: AF33D09EE4E176B3
  • Sequence:
    • MAQKRPACTL KPECVQQLLV CSQEAKKSAY CPYSHFPVGA ALLTQEGRIF KGCNIENACY 
PLGICAERTA IQKAVSEGYK DFRAIAIASD MQDDFISPCG ACRQVMREFG TNWPVYMTKP 
DGTYIVMTVQ ELLPSSFGPE DLQKTQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.