Details for: MTSS1

Gene ID: 9788

Symbol: MTSS1

Ensembl ID: ENSG00000170873

Description: MTSS I-BAR domain containing 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 4.7
    Marker Score: 25,230
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 4.47
    Marker Score: 10,274
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 4.33
    Marker Score: 22,741
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 4.29
    Marker Score: 14,385
  • Cell Name: granule cell (CL0000120)
    Fold Change: 4.12
    Marker Score: 31,047
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 3.48
    Marker Score: 2,288
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 3.4
    Marker Score: 11,126
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.21
    Marker Score: 108,450
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 3.03
    Marker Score: 1,456
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.93
    Marker Score: 13,559
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.74
    Marker Score: 40,937
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.72
    Marker Score: 862
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.69
    Marker Score: 1,562
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.58
    Marker Score: 19,809
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.57
    Marker Score: 1,429
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.54
    Marker Score: 1,341
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.51
    Marker Score: 2,888
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.5
    Marker Score: 55,861
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.5
    Marker Score: 5,976
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.49
    Marker Score: 94,692
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.45
    Marker Score: 5,909
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 2.44
    Marker Score: 2,000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.42
    Marker Score: 10,014
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.38
    Marker Score: 47,338
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.35
    Marker Score: 86,728
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.27
    Marker Score: 8,771
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.23
    Marker Score: 3,144
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.19
    Marker Score: 2,704
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.13
    Marker Score: 1,194
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.12
    Marker Score: 1,056
  • Cell Name: podocyte (CL0000653)
    Fold Change: 2.11
    Marker Score: 779
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.1
    Marker Score: 4,045
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.09
    Marker Score: 2,312
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.05
    Marker Score: 2,320
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.04
    Marker Score: 3,980
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.99
    Marker Score: 2,128
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.98
    Marker Score: 762
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.95
    Marker Score: 1,950
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.93
    Marker Score: 4,056
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.93
    Marker Score: 2,080
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.91
    Marker Score: 691
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.89
    Marker Score: 33,497
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.86
    Marker Score: 1,833
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.85
    Marker Score: 17,429
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.83
    Marker Score: 1,215
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.81
    Marker Score: 1,605
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.8
    Marker Score: 3,670
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.8
    Marker Score: 565
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.8
    Marker Score: 1,695
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.8
    Marker Score: 18,573
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.8
    Marker Score: 753
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.78
    Marker Score: 9,562
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.75
    Marker Score: 107,625
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.75
    Marker Score: 15,022
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.72
    Marker Score: 1,029
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.69
    Marker Score: 1,615
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.69
    Marker Score: 16,094
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.69
    Marker Score: 6,001
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.68
    Marker Score: 1,292
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.67
    Marker Score: 10,734
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.67
    Marker Score: 2,005
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.63
    Marker Score: 6,630
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.62
    Marker Score: 944
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.6
    Marker Score: 5,503
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.59
    Marker Score: 825
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.59
    Marker Score: 5,639
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.59
    Marker Score: 874
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.57
    Marker Score: 6,782
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.56
    Marker Score: 11,626
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.51
    Marker Score: 485
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.5
    Marker Score: 6,272
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.5
    Marker Score: 730
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.47
    Marker Score: 2,270
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.46
    Marker Score: 2,961
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.45
    Marker Score: 1,366
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166,381
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.45
    Marker Score: 872
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.45
    Marker Score: 2,047
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.45
    Marker Score: 3,530
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.44
    Marker Score: 2,631
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.43
    Marker Score: 835
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.42
    Marker Score: 573
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.42
    Marker Score: 11,071
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.42
    Marker Score: 3,336
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.42
    Marker Score: 501
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.41
    Marker Score: 1,756
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.41
    Marker Score: 1,059
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.4
    Marker Score: 322
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.39
    Marker Score: 5,821
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.36
    Marker Score: 2,228
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.34
    Marker Score: 2,340
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.34
    Marker Score: 485
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.33
    Marker Score: 1,716
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.33
    Marker Score: 496
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.33
    Marker Score: 797
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.33
    Marker Score: 1,009
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.32
    Marker Score: 811
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.32
    Marker Score: 774
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.32
    Marker Score: 1,140
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.31
    Marker Score: 20,481

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MTSS1 is a gene that contains an I-BAR (I-Band and Ankyrin Repeat) domain, which is a characteristic feature of proteins involved in actin cytoskeleton organization. The gene's expression is widespread, with significant levels detected in stellate neurons, macroglial cells, and various other cell types. MTSS1 is also known as Metastasis suppressor YGL-1, suggesting its potential role in tumor suppression. The gene's involvement in actin cytoskeleton organization and cellular processes highlights its importance in maintaining cellular homeostasis. **Pathways and Functions** MTSS1 is involved in several signaling pathways, including: 1. **Actin cytoskeleton organization**: MTSS1 regulates the assembly of actin filaments and the organization of the actin cytoskeleton, which is essential for cell shape, movement, and intracellular transport. 2. **Cell adhesion**: MTSS1 interacts with other proteins to regulate cell adhesion, which is critical for tissue morphogenesis and maintenance. 3. **Epithelial cell proliferation**: MTSS1 regulates epithelial cell proliferation, differentiation, and morphogenesis, particularly in the context of renal tubule development. 4. **Negative regulation of epithelial cell proliferation**: MTSS1 acts as a negative regulator of epithelial cell proliferation, which prevents excessive cell growth and tumor formation. 5. **Positive regulation of actin filament bundle assembly**: MTSS1 promotes the assembly of actin filament bundles, which is essential for cell movement and intracellular transport. **Clinical Significance** The dysregulation of MTSS1 has been implicated in various pathological conditions, including: 1. **Cancer**: MTSS1's tumor suppressor function suggests its potential role in preventing cancer development and progression. 2. **Renal tubule disorders**: MTSS1's involvement in renal tubule morphogenesis and epithelial cell proliferation highlights its potential role in renal tubule disorders, such as polycystic kidney disease. 3. **Neurological disorders**: MTSS1's expression in neurons and glial cells suggests its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, MTSS1 is a multifaceted gene that plays a crucial role in actin cytoskeleton organization, cellular processes, and tissue homeostasis. Its dysregulation has been implicated in various pathological conditions, highlighting the importance of further research into the gene's functions and its role in human disease.

Genular Protein ID: 3360827487

Symbol: MTSS1_HUMAN

Name: Metastasis suppressor YGL-1

UniProtKB Accession Codes:

O43312 J3KNK6 Q8TCA2 Q96RX2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DisProt 1 ELM 1 EMBL 6 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 3 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9455477

Title: Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9455477

DOI: 10.1093/dnares/4.5.307

PubMed ID: 12082544

Title: MIM, a potential metastasis suppressor gene in bladder cancer.

PubMed ID: 12082544

DOI: 10.1038/sj.neo.7900231

PubMed ID: 12570871

Title: MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta.

PubMed ID: 12570871

DOI: 10.1042/bj20021962

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

Sequence Information:

  • Length: 755
  • Mass: 82251
  • Checksum: 76FEE3224CBA9287
  • Sequence:
    • MEAVIEKECS ALGGLFQTII SDMKGSYPVW EDFINKAGKL QSQLRTTVVA AAAFLDAFQK 
VADMATNTRG GTREIGSALT RMCMRHRSIE AKLRQFSSAL IDCLINPLQE QMEEWKKVAN 
QLDKDHAKEY KKARQEIKKK SSDTLKLQKK AKKGRGDIQP QLDSALQDVN DKYLLLEETE 
KQAVRKALIE ERGRFCTFIS MLRPVIEEEI SMLGEITHLQ TISEDLKSLT MDPHKLPSSS 
EQVILDLKGS DYSWSYQTPP SSPSTTMSRK SSVCSSLNSV NSSDSRSSGS HSHSPSSHYR 
YRSSNLAQQA PVRLSSVSSH DSGFISQDAF QSKSPSPMPP EAPNQLSNGF SHYSLSSESH 
VGPTGAGLFP HCLPASRLLP RVTSVHLPDY AHYYTIGPGM FPSSQIPSWK DWAKPGPYDQ 
PLVNTLQRRK EKREPDPNGG GPTTASGPPA AAEEAQRPRS MTVSAATRPG EEMEACEELA 
LALSRGLQLD TQRSSRDSLQ CSSGYSTQTT TPCCSEDTIP SQVSDYDYFS VSGDQEADQQ 
EFDKSSTIPR NSDISQSYRR MFQAKRPAST AGLPTTLGPA MVTPGVATIR RTPSTKPSVR 
RGTIGAGPIP IKTPVIPVKT PTVPDLPGVL PAPPDGPEER GEHSPESPSV GEGPQGVTSM 
PSSMWSGQAS VNPPLPGPKP SIPEEHRQAI PESEAEDQER EPPSATVSPG QIPESDPADL 
SPRDTPQGED MLNAIRRGVK LKKTTTNDRS APRFS

Genular Protein ID: 3169435260

Symbol: A5YM41_HUMAN

Name: N/A

UniProtKB Accession Codes:

A5YM41

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 730
  • Mass: 79081
  • Checksum: 27D9B4143B18F0BD
  • Sequence:
    • MEAVIEKECS ALGGLFQTII SDMKGSYPVW EDFINKAGKL QSQLRTTVVA AAAFLDAFQK 
VADMATNTRG GTREIGSALT RMCMRHRSIE AKLRQFSSAL IDCLINPLQE QMEEWKKVAN 
QLDKDHAKEY KKARQEIKKK SSDTLKLQKK AKKGRGDIQP QLDSALQDVN DKYLLLEETE 
KQAVRKALIE ERGRFCTFIS MLRPVIEEEI SMLGEITHLQ TISEDLKSLT MDPHKLPSSS 
EQVILDLKGS DYSWSYQTPP SSPSTTMSRK SSVCSSLNSV NSSDSRSSGS HSHSPSSHYR 
YRSSNLAQQA PVRLSSVSSH DSGFISQDAF QSKSPSPMPP EAPNQNSSSS ASSEASETCQ 
SVSECSSPTS VSSGSTMGAW VSTEKDWAKP GPYDQPLVNT LQRRKEKREP DPNGGGPTTA 
SGPPAAAEEA HRPRSMTVSA ATRPGEEMEA CGELALALSR GLQLDTQRSS RDSLQCSSGY 
STQTTTPCCS EDTIPSQVSD YDYFSVSGDQ EADQQEFDKS STIPRNSDIS QSYRRMFQAK 
RPASTAGLPT TLGPAMVTPG VATIRRTPST KPSVRRGTIG AGPIPIKTPV IPVKTPTVPD 
LPGVLPAPPD GPEERGEHSP ESPSVGEGPQ GVTSMPSSMW SGQASVNPPL PGPKPSIPEE 
HRQAIPESEA EDQEREPPSA TVSPGQIPES DPADLSPRDT PQGEDMLNAI RRGVKLKKTT 
TNDRSAPRFS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.