Details for: SPCS2

Gene ID: 9789

Symbol: SPCS2

Ensembl ID: ENSG00000118363

Description: signal peptidase complex subunit 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 4.43
    Marker Score: 3,777
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.03
    Marker Score: 102,945
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.94
    Marker Score: 2,626
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.9
    Marker Score: 7,083
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.85
    Marker Score: 7,177
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.82
    Marker Score: 7,567
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.76
    Marker Score: 1,100
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.76
    Marker Score: 4,569
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.71
    Marker Score: 10,460
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.71
    Marker Score: 4,941
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.68
    Marker Score: 92,894
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.65
    Marker Score: 11,443
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.6
    Marker Score: 5,926
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.6
    Marker Score: 4,883
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 2.58
    Marker Score: 950
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.57
    Marker Score: 4,123
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.56
    Marker Score: 25,400
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.55
    Marker Score: 7,055
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.55
    Marker Score: 2,586
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.54
    Marker Score: 1,058
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.52
    Marker Score: 4,009
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.52
    Marker Score: 1,436
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.49
    Marker Score: 1,450
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.49
    Marker Score: 5,193
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.46
    Marker Score: 3,208
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.46
    Marker Score: 27,727
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.45
    Marker Score: 28,450
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 2.43
    Marker Score: 1,062
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.43
    Marker Score: 6,356
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.42
    Marker Score: 4,287
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.38
    Marker Score: 20,534
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.38
    Marker Score: 569
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.38
    Marker Score: 2,779
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.37
    Marker Score: 31,281
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.35
    Marker Score: 754
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.35
    Marker Score: 1,682
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.34
    Marker Score: 6,843
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.34
    Marker Score: 3,318
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.34
    Marker Score: 3,389
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.32
    Marker Score: 3,945
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.31
    Marker Score: 576
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.31
    Marker Score: 1,819
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.29
    Marker Score: 791
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.29
    Marker Score: 576
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.29
    Marker Score: 1,529
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.29
    Marker Score: 12,033
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.28
    Marker Score: 6,197
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.28
    Marker Score: 953
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.26
    Marker Score: 5,133
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.26
    Marker Score: 2,395
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.25
    Marker Score: 839
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.25
    Marker Score: 2,399
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.24
    Marker Score: 1,913
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.24
    Marker Score: 10,986
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.24
    Marker Score: 4,542
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.23
    Marker Score: 14,529
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.23
    Marker Score: 5,666
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.23
    Marker Score: 57,000
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.22
    Marker Score: 1,393
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.22
    Marker Score: 2,491
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.22
    Marker Score: 4,429
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.21
    Marker Score: 22,284
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.2
    Marker Score: 9,024
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.2
    Marker Score: 2,073
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.2
    Marker Score: 8,659
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.2
    Marker Score: 1,131
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.19
    Marker Score: 2,314
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.18
    Marker Score: 3,582
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.18
    Marker Score: 14,184
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.17
    Marker Score: 1,275
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.17
    Marker Score: 3,078
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.17
    Marker Score: 2,050
  • Cell Name: basophil (CL0000767)
    Fold Change: 2.16
    Marker Score: 1,028
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.16
    Marker Score: 732
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.16
    Marker Score: 2,591
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.15
    Marker Score: 3,166
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.15
    Marker Score: 1,924
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 2.14
    Marker Score: 2,851
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.14
    Marker Score: 2,588
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.14
    Marker Score: 1,344
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.14
    Marker Score: 6,752
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.14
    Marker Score: 2,298
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.13
    Marker Score: 2,436
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.13
    Marker Score: 614
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.12
    Marker Score: 1,667
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 2.11
    Marker Score: 522
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.11
    Marker Score: 2,082
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 2.11
    Marker Score: 736
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 2.11
    Marker Score: 735
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 2.11
    Marker Score: 2,035
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.11
    Marker Score: 1,774
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.1
    Marker Score: 998
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.1
    Marker Score: 7,767
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.09
    Marker Score: 1,262
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.09
    Marker Score: 13,356
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 2.09
    Marker Score: 549
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.09
    Marker Score: 2,692
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.08
    Marker Score: 1,482
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.08
    Marker Score: 947
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.08
    Marker Score: 2,082

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Signal Peptidase Complex Subunit 2 (SPCS2)**: SPCS2 is a subunit of the signal peptidase complex, which plays a crucial role in protein processing and secretion. 2. **Cellular Expression**: SPCS2 is significantly expressed in various cell types, including IgA plasma cells, fibroblasts, and secretory cells. 3. **Protein Targeting**: SPCS2 is involved in the targeting of proteins to the ER, where they undergo maturation and secretion. 4. **Peptide Hormone Metabolism**: SPCS2 is involved in the synthesis, secretion, and inactivation of various peptide hormones, including glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and ghrelin. **Pathways and Functions:** 1. **Signal Peptidase Complex**: SPCS2 is a subunit of the signal peptidase complex, responsible for protein processing and secretion. 2. **Endoplasmic Reticulum Membrane**: SPCS2 is involved in the targeting of proteins to the ER, where they undergo maturation and secretion. 3. **Incretin Synthesis and Secretion**: SPCS2 is involved in the synthesis, secretion, and inactivation of GLP-1, GIP, and ghrelin. 4. **Viral Infection Pathways**: SPCS2 is involved in the maturation and secretion of viral proteins, including those of the respiratory syncytial virus (RSV). 5. **Immune Response**: SPCS2 is involved in the processing and secretion of immune-related peptides, including those involved in the regulation of immune responses. **Clinical Significance:** 1. **Diabetes**: SPCS2 has been implicated in the regulation of glucose metabolism and insulin secretion, making it a potential therapeutic target for the treatment of diabetes. 2. **Infectious Diseases**: SPCS2 has been implicated in the maturation and secretion of viral proteins, making it a potential target for the treatment of infectious diseases, including RSV. 3. **Immunological Disorders**: SPCS2 has been implicated in the processing and secretion of immune-related peptides, making it a potential therapeutic target for the treatment of immunological disorders, including autoimmune diseases. 4. **Cancer**: SPCS2 has been implicated in the regulation of protein processing and secretion, making it a potential therapeutic target for the treatment of cancer. In conclusion, SPCS2 plays a crucial role in protein processing and secretion, and its dysregulation has been implicated in various diseases, including diabetes, infectious diseases, immunological disorders, and cancer. Further research is needed to fully understand the mechanisms of SPCS2 and its potential therapeutic applications.

Genular Protein ID: 3448540498

Symbol: SPCS2_HUMAN

Name: Signal peptidase complex subunit 2

UniProtKB Accession Codes:

Q15005 Q15507 Q3KQT0 Q641R4 Q6FG65 Q6IRX0 Q6P1P4 Q96HU9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 2 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SAM 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7788527

Title: Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7788527

DOI: 10.1093/dnares/2.1.37

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 34388369

Title: Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage.

PubMed ID: 34388369

DOI: 10.1016/j.molcel.2021.07.031

Sequence Information:

  • Length: 226
  • Mass: 25003
  • Checksum: C1EDF687E9F7A57A
  • Sequence:
    • MAAAAVQGGR SGGSGGCSGA GGASNCGTGS GRSGLLDKWK IDDKPVKIDK WDGSAVKNSL 
DDSAKKVLLE KYKYVENFGL IDGRLTICTI SCFFAIVALI WDYMHPFPES KPVLALCVIS 
YFVMMGILTI YTSYKEKSIF LVAHRKDPTG MDPDDIWQLS SSLKRFDDKY TLKLTFISGR 
TKQQREAEFT KSIAKFFDHS GTLVMDAYEP EISRLHDSLA IERKIK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.