CKAP5 | ENSG00000175216 | NCBI 9793

Details for: CKAP5

Gene ID: 9793

Symbol: CKAP5

Ensembl ID: ENSG00000175216

Description: cytoskeleton associated protein 5

Associated with

Amplification of signal from the kinetochores
(R-HSA-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-HSA-141444)
Anchoring of the basal body to the plasma membrane
(R-HSA-5620912)
Aurka activation by tpx2
(R-HSA-8854518)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Centrosome maturation
(R-HSA-380287)
Cilium assembly
(R-HSA-5617833)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
G2/m transition
(R-HSA-69275)
Loss of nlp from mitotic centrosomes
(R-HSA-380259)
Loss of proteins required for interphase microtubule organization from the centrosome
(R-HSA-380284)
Mitotic anaphase
(R-HSA-68882)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Recruitment of mitotic centrosome proteins and complexes
(R-HSA-380270)
Recruitment of numa to mitotic centrosomes
(R-HSA-380320)
Regulation of plk1 activity at g2/m transition
(R-HSA-2565942)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Cadherin binding
(GO:0045296)
Cell division
(GO:0051301)
Centrosome
(GO:0005813)
Centrosome cycle
(GO:0007098)
Centrosome duplication
(GO:0051298)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Establishment or maintenance of microtubule cytoskeleton polarity
(GO:0030951)
Kinetochore
(GO:0000776)
Membrane
(GO:0016020)
Microtubule binding
(GO:0008017)
Microtubule cytoskeleton
(GO:0015630)
Microtubule depolymerization
(GO:0007019)
Microtubule plus-end
(GO:0035371)
Microtubule plus-end binding
(GO:0051010)
Microtubule plus end polymerase
(GO:0061863)
Microtubule polymerization
(GO:0046785)
Mitotic spindle organization
(GO:0007052)
Nucleolus
(GO:0005730)
Plasma membrane
(GO:0005886)
Positive regulation of microtubule nucleation
(GO:0090063)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Ribonucleoprotein complex binding
(GO:0043021)
Rna transport
(GO:0050658)
Spindle organization
(GO:0007051)
Spindle pole
(GO:0000922)

Other Information

Proteins

Cytoskeleton-associated protein 5

Genular Protein ID: 3579639692

Symbol: CKAP5_HUMAN

Name: Cytoskeleton-associated protein 5

UniProtKB Accession Codes:

Q14008 Q05D70 Q0VAX7 Q0VAX8 Q14668 Q2TA89 Q6NSH4

Database IDs:

Citations:

PubMed ID: 8536682

Title: Characterization of the cDNA and pattern of expression of a new gene over-expressed in human hepatomas and colonic tumors.

PubMed ID: 8536682

DOI: 10.1111/j.1432-1033.1995.406_b.x

PubMed ID: 7788527

Title: Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7788527

DOI: 10.1093/dnares/2.1.37

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8832653

Title: Expression of the tumor over-expressed ch-TOG gene in human and baboon brain.

PubMed ID: 8832653

DOI: 10.1016/0304-3940(96)12789-0

PubMed ID: 9570755

Title: The TOGp protein is a new human microtubule-associated protein homologous to the Xenopus XMAP215.

PubMed ID: 9570755

DOI: 10.1242/jcs.111.10.1371

PubMed ID: 11903063

Title: Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells.

PubMed ID: 11903063

DOI: 10.1042/0264-6021:3630195

PubMed ID: 12569123

Title: The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells.

PubMed ID: 12569123

DOI: 10.1101/gad.245603

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15703215

Title: The microtubule-associated protein tumor overexpressed gene binds to the RNA trafficking protein heterogeneous nuclear ribonucleoprotein A2.

PubMed ID: 15703215

DOI: 10.1091/mbc.e04-08-0709

PubMed ID: 18809577

Title: MCAK-independent functions of ch-Tog/XMAP215 in microtubule plus-end dynamics.

PubMed ID: 18809577

DOI: 10.1128/mcb.01040-08

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21297582

Title: A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging.

PubMed ID: 21297582

DOI: 10.1038/emboj.2011.15

PubMed ID: 21646404

Title: SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase.

PubMed ID: 21646404

DOI: 10.1083/jcb.201012179

PubMed ID: 23251535

Title: Dissecting the nanoscale distributions and functions of microtubule-end-binding proteins EB1 and ch-TOG in interphase HeLa cells.

PubMed ID: 23251535

DOI: 10.1371/journal.pone.0051442

PubMed ID: 23532825

Title: Specific removal of TACC3-ch-TOG-clathrin at metaphase deregulates kinetochore fiber tension.

PubMed ID: 23532825

DOI: 10.1242/jcs.124834

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25596274

Title: TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation.

PubMed ID: 25596274

DOI: 10.1242/bio.201410843

PubMed ID: 27156448

Title: A TOG protein confers tension sensitivity to kinetochore-microtubule attachments.

PubMed ID: 27156448

DOI: 10.1016/j.cell.2016.04.030

PubMed ID: 24966168

Title: The XMAP215 family drives microtubule polymerization using a structurally diverse TOG array.

PubMed ID: 24966168

DOI: 10.1091/mbc.e13-08-0501

Sequence Information:

Length: 2032
Mass: 225495
Checksum: B2BBFB1CF2ED688B
Sequence:

MGDDSEWLKL PVDQKCEHKL WKARLSGYEE ALKIFQKIKD EKSPEWSKFL GLIKKFVTDS 
NAVVQLKGLE AALVYVENAH VAGKTTGEVV SGVVSKVFNQ PKAKAKELGI EICLMYIEIE 
KGEAVQEELL KGLDNKNPKI IVACIETLRK ALSEFGSKII LLKPIIKVLP KLFESREKAV 
RDEAKLIAVE IYRWIRDALR PPLQNINSVQ LKELEEEWVK LPTSAPRPTR FLRSQQELEA 
KLEQQQSAGG DAEGGGDDGD EVPQIDAYEL LEAVEILSKL PKDFYDKIEA KKWQERKEAL 
ESVEVLIKNP KLEAGDYADL VKALKKVVGK DTNVMLVALA AKCLTGLAVG LRKKFGQYAG 
HVVPTILEKF KEKKPQVVQA LQEAIDAIFL TTTLQNISED VLAVMDNKNP TIKQQTSLFI 
ARSFRHCTAS TLPKSLLKPF CAALLKHIND SAPEVRDAAF EALGTALKVV GEKAVNPFLA 
DVDKLKLDKI KECSEKVELI HGKKAGLAAD KKEFKPLPGR TAASGAAGDK DTKDISAPKP 
GPLKKAPAAK AGGPPKKGKP AAPGGAGNTG TKNKKGLETK EIVEPELSIE VCEEKASAVL 
PPTCIQLLDS SNWKERLACM EEFQKAVELM DRTEMPCQAL VRMLAKKPGW KETNFQVMQM 
KLHIVALIAQ KGNFSKTSAQ VVLDGLVDKI GDVKCGNNAK EAMTAIAEAC MLPWTAEQVV 
SMAFSQKNPK NQSETLNWLS NAIKEFGFSG LNVKAFISNV KTALAATNPA VRTAAITLLG 
VMYLYVGPSL RMFFEDEKPA LLSQIDAEFE KMQGQSPPAP TRGISKHSTS GTDEGEDGDE 
PDDGSNDVVD LLPRTEISDK ITSELVSKIG DKNWKIRKEG LDEVAGIIND AKFIQPNIGE 
LPTALKGRLN DSNKILVQQT LNILQQLAVA MGPNIKQHVK NLGIPIITVL GDSKNNVRAA 
ALATVNAWAE QTGMKEWLEG EDLSEELKKE NPFLRQELLG WLAEKLPTLR STPTDLILCV 
PHLYSCLEDR NGDVRKKAQD ALPFFMMHLG YEKMAKATGK LKPTSKDQVL AMLEKAKVNM 
PAKPAPPTKA TSKPMGGSAP AKFQPASAPA EDCISSSTEP KPDPKKAKAP GLSSKAKSAQ 
GKKMPSKTSL KEDEDKSGPI FIVVPNGKEQ RMKDEKGLKV LKWNFTTPRD EYIEQLKTQM 
SSCVAKWLQD EMFHSDFQHH NKALAVMVDH LESEKEGVIG CLDLILKWLT LRFFDTNTSV 
LMKALEYLKL LFTLLSEEEY HLTENEASSF IPYLVVKVGE PKDVIRKDVR AILNRMCLVY 
PASKMFPFIM EGTKSKNSKQ RAECLEELGC LVESYGMNVC QPTPGKALKE IAVHIGDRDN 
AVRNAALNTI VTVYNVHGDQ VFKLIGNLSE KDMSMLEERI KRSAKRPSAA PIKQVEEKPQ 
RAQNISSNAN MLRKGPAEDM SSKLNQARSM SGHPEAAQMV RREFQLDLDE IENDNGTVRC 
EMPELVQHKL DDIFEPVLIP EPKIRAVSPH FDDMHSNTAS TINFIISQVA SGDINTSIQA 
LTQIDEVLRQ EDKAEAMSGH IDQFLIATFM QLRLIYNTHM ADEKLEKDEI IKLYSCIIGN 
MISLFQIESL AREASTGVLK DLMHGLITLM LDSRIEDLEE GQQVIRSVNL LVVKVLEKSD 
QTNILSALLV LLQDSLLATA SSPKFSELVM KCLWRMVRLL PDTINSINLD RILLDIHIFM 
KVFPKEKLKQ CKSEFPIRTL KTLLHTLCKL KGPKILDHLT MIDNKNESEL EAHLCRMMKH 
SMDQTGSKSD KETEKGASRI DEKSSKAKVN DFLAEIFKKI GSKENTKEGL AELYEYKKKY 
SDADIEPFLK NSSQFFQSYV ERGLRVIEME REGKGRISTS TGISPQMEVT CVPTPTSTVS 
SIGNTNGEEV GPSVYLERLK ILRQRCGLDN TKQDDRPPLT SLLSKPAVPT VASSTDMLHS 
KLSQLRESRE QHQHSDLDSN QTHSSGTVTS SSSTANIDDL KKRLERIKSS RK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CKAP5

Associated with

Other Information

Characterization of the cDNA and pattern of expression of a new gene over-expressed in human hepatomas and colonic tumors. PubMed ID: 8536682

Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. PubMed ID: 7788527

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Expression of the tumor over-expressed ch-TOG gene in human and baboon brain. PubMed ID: 8832653

The TOGp protein is a new human microtubule-associated protein homologous to the Xenopus XMAP215. PubMed ID: 9570755

Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells. PubMed ID: 11903063

The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells. PubMed ID: 12569123

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

The microtubule-associated protein tumor overexpressed gene binds to the RNA trafficking protein heterogeneous nuclear ribonucleoprotein A2. PubMed ID: 15703215

MCAK-independent functions of ch-Tog/XMAP215 in microtubule plus-end dynamics. PubMed ID: 18809577

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging. PubMed ID: 21297582

SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase. PubMed ID: 21646404

Dissecting the nanoscale distributions and functions of microtubule-end-binding proteins EB1 and ch-TOG in interphase HeLa cells. PubMed ID: 23251535

Specific removal of TACC3-ch-TOG-clathrin at metaphase deregulates kinetochore fiber tension. PubMed ID: 23532825

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation. PubMed ID: 25596274

A TOG protein confers tension sensitivity to kinetochore-microtubule attachments. PubMed ID: 27156448

The XMAP215 family drives microtubule polymerization using a structurally diverse TOG array. PubMed ID: 24966168