MAML1 | ENSG00000161021 | NCBI 9794

Details for: MAML1

Gene ID: 9794

Symbol: MAML1

Ensembl ID: ENSG00000161021

Description: mastermind like transcriptional coactivator 1

Associated with

Constitutive signaling by notch1 hd+pest domain mutants
(R-HSA-2894862)
Constitutive signaling by notch1 pest domain mutants
(R-HSA-2644606)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Formation of paraxial mesoderm
(R-HSA-9793380)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Notch-hlh transcription pathway
(R-HSA-350054)
Notch1 intracellular domain regulates transcription
(R-HSA-2122947)
Notch2 intracellular domain regulates transcription
(R-HSA-2197563)
Notch3 intracellular domain regulates transcription
(R-HSA-9013508)
Notch4 intracellular domain regulates transcription
(R-HSA-9013695)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Regulation of beta-cell development
(R-HSA-186712)
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
(R-HSA-210744)
Rna polymerase ii transcription
(R-HSA-73857)
Runx3 regulates notch signaling
(R-HSA-8941856)
Signaling by notch
(R-HSA-157118)
Signaling by notch1
(R-HSA-1980143)
Signaling by notch1 hd+pest domain mutants in cancer
(R-HSA-2894858)
Signaling by notch1 in cancer
(R-HSA-2644603)
Signaling by notch1 pest domain mutants in cancer
(R-HSA-2644602)
Signaling by notch2
(R-HSA-1980145)
Signaling by notch3
(R-HSA-9012852)
Signaling by notch4
(R-HSA-9013694)
Signal transduction
(R-HSA-162582)
Transcriptional regulation by runx3
(R-HSA-8878159)
Atrioventricular node cell development
(GO:0060928)
Atrioventricular node development
(GO:0003162)
Maml1-rbp-jkappa- icn1 complex
(GO:0002193)
Myoblast differentiation
(GO:0045445)
Notch signaling pathway
(GO:0007219)
Nuclear speck
(GO:0016607)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Peptide antigen binding
(GO:0042605)
Positive regulation of myotube differentiation
(GO:0010831)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transcription of notch receptor target
(GO:0007221)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Transcription coactivator activity
(GO:0003713)

Other Information

Proteins

Mastermind-like protein 1

Genular Protein ID: 743634770

Symbol: MAML1_HUMAN

Name: Mastermind-like protein 1

UniProtKB Accession Codes:

Q92585 Q9NZ12

Database IDs:

Citations:

PubMed ID: 8724849

Title: Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 8724849

DOI: 10.1093/dnares/3.1.17

PubMed ID: 11101851

Title: MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.

PubMed ID: 11101851

DOI: 10.1038/82644

PubMed ID: 11390662

Title: A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of Notch and a CSL protein to build a transcriptional activator complex on target promoters.

PubMed ID: 11390662

DOI: 10.1128/mcb.21.13.4337-4346.2001

PubMed ID: 12050117

Title: Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex.

PubMed ID: 12050117

DOI: 10.1101/gad.991602

PubMed ID: 15546612

Title: Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.

PubMed ID: 15546612

DOI: 10.1016/j.molcel.2004.10.014

PubMed ID: 17317671

Title: The notch regulator MAML1 interacts with p53 and functions as a coactivator.

PubMed ID: 17317671

DOI: 10.1074/jbc.m608974200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 16530044

Title: Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.

PubMed ID: 16530044

DOI: 10.1016/j.cell.2005.12.037

Sequence Information:

Length: 1016
Mass: 108054
Checksum: C683CB81B73A2A61
Sequence:

MVLPTCPMAE FALPRHSAVM ERLRRRIELC RRHHSTCEAR YEAVSPERLE LERQHTFALH 
QRCIQAKAKR AGKHRQPPAA TAPAPAAPAP RLDAADGPEH GRPATHLHDT VKRNLDSATS 
PQNGDQQNGY GDLFPGHKKT RREAPLGVAI SSNGLPPASP LGQSDKPSGA DALQSSGKHS 
LGLDSLNKKR LADSSLHLNG GSNPSESFPL SLNKELKQEP VEDLPCMITG TVGSISQSNL 
MPDLNLNEQE WKELIEELNR SVPDEDMKDL FNEDFEEKKD PESSGSATQT PLAQDINIKT 
EFSPAAFEQE QLGSPQVRAG SAGQTFLGPS SAPVSTDSPS LGGSQTLFHT SGQPRADNPS 
PNLMPASAQA QNAQRALAGV VLPSQGPGGA SELSSAHQLQ QIAAKQKREQ MLQNPQQATP 
APAPGQMSTW QQTGPSHSSL DVPYPMEKPA SPSSYKQDFT NSKLLMMPSV NKSSPRPGGP 
YLQPSHVNLL SHQPPSNLNQ NSANNQGSVL DYGNTKPLSH YKADCGQGSP GSGQSKPALM 
AYLPQQLSHI SHEQNSLFLM KPKPGNMPFR SLVPPGQEQN PSSVPVQAQA TSVGTQPPAV 
SVASSHNSSP YLSSQQQAAV MKQHQLLLDQ QKQREQQQKH LQQQQFLQRQ QHLLAEQEKQ 
QFQRHLTRPP PQYQDPTQGS FPQQVGQFTG SSAAVPGMNT LGPSNSSCPR VFPQAGNLMP 
MGPGHASVSS LPTNSGQQDR GVAQFPGSQN MPQSSLYGMA SGITQIVAQP PPQATNGHAH 
IPRQTNVGQN TSVSAAYGQN SLGSSGLSQQ HNKGTLNPGL TKPPVPRVSP AMGGQNSSWQ 
HQGMPNLSGQ TPGNSNVSPF TAASSFHMQQ QAHLKMSSPQ FSQAVPNRPM APMSSAAAVG 
SLLPPVSAQQ RTSAPAPAPP PTAPQQGLPG LSPAGPELGA FSQSPASQMG GRAGLHCTQA 
YPVRTAGQEL PFAYSGQPGG SGLSSVAGHT DLIDSLLKNR TSEEWMSDLD DLLGSQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: MAML1

Associated with

Other Information

Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. PubMed ID: 8724849

MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. PubMed ID: 11101851

A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of Notch and a CSL protein to build a transcriptional activator complex on target promoters. PubMed ID: 11390662

Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex. PubMed ID: 12050117

Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. PubMed ID: 15546612

The notch regulator MAML1 interacts with p53 and functions as a coactivator. PubMed ID: 17317671

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. PubMed ID: 16530044