Details for: ACYP2

Gene ID: 98

Symbol: ACYP2

Ensembl ID: ENSG00000170634

Description: acylphosphatase 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 4.42
    Marker Score: 11057
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.62
    Marker Score: 80934
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.75
    Marker Score: 58798.5
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.69
    Marker Score: 11269.5
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.56
    Marker Score: 6138.5
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.55
    Marker Score: 810
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.52
    Marker Score: 3383
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.49
    Marker Score: 3017
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.48
    Marker Score: 1449
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.45
    Marker Score: 4722
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.42
    Marker Score: 5319
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.38
    Marker Score: 42307
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.3
    Marker Score: 2647
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.29
    Marker Score: 10599
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.27
    Marker Score: 952
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.27
    Marker Score: 8076
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.27
    Marker Score: 86114
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.26
    Marker Score: 44918
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.25
    Marker Score: 9331
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.24
    Marker Score: 82810
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.24
    Marker Score: 654
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.23
    Marker Score: 1244
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.19
    Marker Score: 1438.5
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.17
    Marker Score: 16630
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.17
    Marker Score: 32400
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.13
    Marker Score: 2648
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2.13
    Marker Score: 1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.06
    Marker Score: 4358
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.06
    Marker Score: 1356
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2
    Marker Score: 633
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.99
    Marker Score: 1596
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.99
    Marker Score: 122417
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.99
    Marker Score: 18705
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.99
    Marker Score: 1105
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.98
    Marker Score: 1155
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.94
    Marker Score: 7487
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.93
    Marker Score: 19933
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.91
    Marker Score: 1036
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.9
    Marker Score: 1643
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.89
    Marker Score: 5389
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.85
    Marker Score: 1762.5
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.84
    Marker Score: 1277
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.84
    Marker Score: 2031
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.84
    Marker Score: 17444
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.83
    Marker Score: 7432
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.81
    Marker Score: 663.5
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.77
    Marker Score: 1364
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.77
    Marker Score: 932
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.76
    Marker Score: 15119
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.75
    Marker Score: 1553.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.75
    Marker Score: 1514
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.74
    Marker Score: 475
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.73
    Marker Score: 58282.5
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.72
    Marker Score: 2885
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.7
    Marker Score: 1830
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.65
    Marker Score: 5415
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.58
    Marker Score: 2435
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.56
    Marker Score: 756
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.49
    Marker Score: 506
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.49
    Marker Score: 1837.5
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.48
    Marker Score: 23765
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.48
    Marker Score: 734
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.45
    Marker Score: 537
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.43
    Marker Score: 9218
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.42
    Marker Score: 744
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.41
    Marker Score: 529
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.41
    Marker Score: 511
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.39
    Marker Score: 441
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.39
    Marker Score: 4671
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.38
    Marker Score: 5767.5
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.38
    Marker Score: 1559.5
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.37
    Marker Score: 7380.5
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.36
    Marker Score: 391
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.34
    Marker Score: 342
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.34
    Marker Score: 1898
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.34
    Marker Score: 1434
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.33
    Marker Score: 5744
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3
    Marker Score: 20344
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.29
    Marker Score: 6918
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.28
    Marker Score: 337
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.27
    Marker Score: 658
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.27
    Marker Score: 626.5
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.27
    Marker Score: 1761
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.27
    Marker Score: 1781
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.26
    Marker Score: 456.5
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.26
    Marker Score: 327
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.25
    Marker Score: 748
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.25
    Marker Score: 9419
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.25
    Marker Score: 6552
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.24
    Marker Score: 2929
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.24
    Marker Score: 745
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.24
    Marker Score: 4247
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.22
    Marker Score: 1799
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.22
    Marker Score: 403
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.21
    Marker Score: 678
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.21
    Marker Score: 2779
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.19
    Marker Score: 1390.5
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.19
    Marker Score: 30370.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.18
    Marker Score: 4202
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 1.17
    Marker Score: 352

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Other Information

**Key characteristics:** - ACYP2 is a protein of the serine/threonine family. - It is expressed in a variety of cell types. - It is involved in the regulation of phosphate metabolism. **Pathways and functions:** - ACYP2 is involved in the regulation of phosphate metabolism. - It is expressed in skeletal muscle fiber, regular ventricular cardiac myocyte, astrocyte of the cerebral cortex, pigmented epithelial cell, oligodendrocyte, A2 amacrine cell, anterior lens cell, lens epithelial cell, secondary lens fiber, and kidney interstitial fibroblast. - It is involved in the regulation of muscle contraction and relaxation. - It is involved in the regulation of cardiac function. - It is involved in the regulation of energy metabolism. **Clinical significance:** - Mutations in ACYP2 have been linked to a number of human diseases, including hyperphosphatemia, hypocalcemia, and diabetic retinopathy. - ACYP2 is a potential therapeutic target for these diseases.

Genular Protein ID: 1215561022

Symbol: ACYP2_HUMAN

Name: Acylphosphatase-2

UniProtKB Accession Codes:

P14621

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 5 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 2 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 Rhea 1 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6100723

Title: Human skeletal muscle acylphosphatase: the primary structure.

PubMed ID: 6100723

PubMed ID: 7796909

Title: Cloning and expression of the cDNA coding for the erythrocyte isoenzyme of human acylphosphatase.

PubMed ID: 7796909

DOI: 10.1016/0014-5793(95)00553-l

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 99
  • Mass: 11140
  • Checksum: AEDE40E45B6207A0
  • Sequence:
    • MSTAQSLKSV DYEVFGRVQG VCFRMYTEDE ARKIGVVGWV KNTSKGTVTG QVQGPEDKVN 
SMKSWLSKVG SPSSRIDRTN FSNEKTISKL EYSNFSIRY

Genular Protein ID: 2730098521

Symbol: U3KQL2_HUMAN

Name: N/A

UniProtKB Accession Codes:

U3KQL2

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EC 1 EMBL 5 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 4 MANE-Select 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PhylomeDB 1 Proteomes 2 RefSeq 1 Rhea 1 RuleBase 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 172
  • Mass: 19578
  • Checksum: DA9BF16D9EFB0676
  • Sequence:
    • MLLTQSLFGG LFPRTRETMR RYKVSLFYLG CSRTPNVKLS SCLGLPCCWD YSYKFIQLSE 
FGFGQVIIVS EEPWKENISC SSTTFIKSTI CLSVCFRMYT EDEARKIGVV GWVKNTSKGT 
VTGQVQGPED KVNSMKSWLS KVGSPSSRID RTNFSNEKTI SKLEYSNFSI RY

Genular Protein ID: 4172812464

Symbol: F8WA34_HUMAN

Name: N/A

UniProtKB Accession Codes:

F8WA34

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CTD 1 ChEBI 5 ChiTaRS 1 EC 1 EMBL 5 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 4 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 1 RuleBase 2 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 70
  • Mass: 7544
  • Checksum: 0958C7DB1C582A22
  • Sequence:
    • MSTAQSLKSV DYEVFGRVQG VCFRMYTEDE ARKIGVVGWV KNTSKGTVTG QVQGPEDKVN 
SMNSSAPEAG

Genular Protein ID: 3299284269

Symbol: E9PF46_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PF46

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CTD 1 ChEBI 5 ChiTaRS 1 EC 1 EMBL 5 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 1 RuleBase 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 69
  • Mass: 7547
  • Checksum: C54BF41423348128
  • Sequence:
    • MSTAQSLKSV DYEVFGRVQG VCFRMYTEDE ARKIGVVGWV KNTSKGTVTG QVQGPEDKVN 
SMLECSGLI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.