Details for: ACYP2

Gene ID: 98

Symbol: ACYP2

Ensembl ID: ENSG00000170634

Description: acylphosphatase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.23
    Cell Significance Index: 2
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.17
    Cell Significance Index: 1
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.17
    Cell Significance Index: 1
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.09
    Cell Significance Index: 1
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.09
    Cell Significance Index: 1
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.08
    Cell Significance Index: 1
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.06
    Cell Significance Index: 1
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.05
    Cell Significance Index: 1
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.05
    Cell Significance Index: 1
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.05
    Cell Significance Index: 1
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.04
    Cell Significance Index: 1
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.03
    Cell Significance Index: 1
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.03
    Cell Significance Index: 1
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.02
    Cell Significance Index: 1
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: cell (CL0000000)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.99
    Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** ACYP2 is expressed in a wide range of cell types, including skeletal muscle fibers, cardiac myocytes, astrocytes, and specialized cells in the retina and lens. 2. **Protein Binding:** ACYP2 interacts with identical proteins, suggesting a potential role in protein-protein interactions and cellular signaling. 3. **Metabolic Process:** The gene is involved in phosphate-containing compound metabolic processes, indicating a possible role in energy metabolism and cellular homeostasis. 4. **Acylphosphatase Activity:** ACYP2 is associated with acylphosphatase activity, a crucial enzymatic process in cellular detoxification and metabolism. **Pathways and Functions:** 1. **Acylphosphatase Activity:** ACYP2 is involved in the hydrolysis of acylphosphates, a process essential for cellular detoxification and metabolism. 2. **Protein Binding:** The gene's protein-binding capabilities suggest a role in protein-protein interactions, cellular signaling, and regulation of cellular processes. 3. **Phosphate-Containing Compound Metabolic Process:** ACYP2 is involved in the metabolism of phosphate-containing compounds, which is critical for energy metabolism and cellular homeostasis. 4. **Identical Protein Binding:** The gene's ability to bind identical proteins implies a potential role in protein-protein interactions and regulation of cellular processes. **Clinical Significance:** 1. **Disease Association:** Further research is necessary to establish a link between ACYP2 and various diseases, including immunological disorders and metabolic disorders. 2. **Therapeutic Targeting:** The identification of ACYP2 as a potential therapeutic target could lead to the development of novel treatments for diseases associated with its dysregulation. 3. **Immunological Implications:** The gene's expression in immune cells and its involvement in protein-protein interactions suggest a potential role in immunological processes and disease. In conclusion, the ACYP2 gene is a complex and multifaceted molecule with far-reaching implications for our understanding of cellular biology and immunology. Further investigation into its functions, pathways, and clinical significance is essential to unlock its full potential and harness its therapeutic potential.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.