Details for: ACYP2

Gene ID: 98

Symbol: ACYP2

Ensembl ID: ENSG00000170634

Description: acylphosphatase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 406.1198
    Cell Significance Index: -63.1700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 234.2659
    Cell Significance Index: -59.4200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 150.1890
    Cell Significance Index: -61.8700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 124.0991
    Cell Significance Index: -58.5900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 104.0222
    Cell Significance Index: -53.5100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 52.0943
    Cell Significance Index: -64.2300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.5713
    Cell Significance Index: -49.7500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.9630
    Cell Significance Index: -37.1300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.3835
    Cell Significance Index: -64.6500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 10.6276
    Cell Significance Index: 273.1800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 5.7569
    Cell Significance Index: 140.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 4.0857
    Cell Significance Index: 313.5300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 3.8122
    Cell Significance Index: 61.5100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 3.0501
    Cell Significance Index: 59.5300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.9879
    Cell Significance Index: 37.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.9059
    Cell Significance Index: 128.5400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.8516
    Cell Significance Index: 46.9900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.8348
    Cell Significance Index: 107.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.3336
    Cell Significance Index: 468.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.2765
    Cell Significance Index: 451.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.1165
    Cell Significance Index: 759.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.9875
    Cell Significance Index: 111.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.6408
    Cell Significance Index: 110.3300
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 1.6065
    Cell Significance Index: 20.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3798
    Cell Significance Index: 18.8300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.9558
    Cell Significance Index: 58.7500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.9394
    Cell Significance Index: 6.3700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8849
    Cell Significance Index: 143.9300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8832
    Cell Significance Index: 96.0700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.8820
    Cell Significance Index: 25.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8722
    Cell Significance Index: 101.6500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.7668
    Cell Significance Index: 18.3900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7529
    Cell Significance Index: 45.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7456
    Cell Significance Index: 134.4100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.7166
    Cell Significance Index: 12.2800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7016
    Cell Significance Index: 18.8000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.6658
    Cell Significance Index: 9.3100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.6338
    Cell Significance Index: 7.5600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.6253
    Cell Significance Index: 1177.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6063
    Cell Significance Index: 74.5500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5871
    Cell Significance Index: 69.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5840
    Cell Significance Index: 16.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5137
    Cell Significance Index: 26.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.4699
    Cell Significance Index: 638.9500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4602
    Cell Significance Index: 292.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.4328
    Cell Significance Index: 196.4200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.3922
    Cell Significance Index: 5.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3729
    Cell Significance Index: 17.3900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3591
    Cell Significance Index: 552.8000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3388
    Cell Significance Index: 23.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3098
    Cell Significance Index: 40.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3027
    Cell Significance Index: 558.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2367
    Cell Significance Index: 104.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2059
    Cell Significance Index: 112.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1720
    Cell Significance Index: 29.3700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1380
    Cell Significance Index: 124.5700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1357
    Cell Significance Index: 13.4200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.1247
    Cell Significance Index: 1.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1196
    Cell Significance Index: 5.6200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1060
    Cell Significance Index: 2.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0768
    Cell Significance Index: 1.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0688
    Cell Significance Index: 9.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0639
    Cell Significance Index: 12.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0471
    Cell Significance Index: 1.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0244
    Cell Significance Index: 1.5400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0174
    Cell Significance Index: 1.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0183
    Cell Significance Index: -2.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0361
    Cell Significance Index: -27.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0455
    Cell Significance Index: -33.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0501
    Cell Significance Index: -37.0800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0816
    Cell Significance Index: -2.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0847
    Cell Significance Index: -47.7600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0934
    Cell Significance Index: -0.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1035
    Cell Significance Index: -64.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1217
    Cell Significance Index: -12.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1416
    Cell Significance Index: -6.4200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1448
    Cell Significance Index: -15.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1729
    Cell Significance Index: -9.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1827
    Cell Significance Index: -52.5600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1907
    Cell Significance Index: -13.4900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2232
    Cell Significance Index: -3.7600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2512
    Cell Significance Index: -5.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2849
    Cell Significance Index: -60.0200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3079
    Cell Significance Index: -3.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3233
    Cell Significance Index: -8.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3845
    Cell Significance Index: -44.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3942
    Cell Significance Index: -50.5300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4494
    Cell Significance Index: -29.0000
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.5914
    Cell Significance Index: -5.2500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5946
    Cell Significance Index: -47.0900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6168
    Cell Significance Index: -13.0900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.6640
    Cell Significance Index: -8.3800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.7162
    Cell Significance Index: -5.8400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7560
    Cell Significance Index: -19.8800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.7620
    Cell Significance Index: -10.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.7627
    Cell Significance Index: -21.9800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.7737
    Cell Significance Index: -11.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7746
    Cell Significance Index: -24.8100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.8645
    Cell Significance Index: -45.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8678
    Cell Significance Index: -27.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** ACYP2 is expressed in a wide range of cell types, including skeletal muscle fibers, cardiac myocytes, astrocytes, and specialized cells in the retina and lens. 2. **Protein Binding:** ACYP2 interacts with identical proteins, suggesting a potential role in protein-protein interactions and cellular signaling. 3. **Metabolic Process:** The gene is involved in phosphate-containing compound metabolic processes, indicating a possible role in energy metabolism and cellular homeostasis. 4. **Acylphosphatase Activity:** ACYP2 is associated with acylphosphatase activity, a crucial enzymatic process in cellular detoxification and metabolism. **Pathways and Functions:** 1. **Acylphosphatase Activity:** ACYP2 is involved in the hydrolysis of acylphosphates, a process essential for cellular detoxification and metabolism. 2. **Protein Binding:** The gene's protein-binding capabilities suggest a role in protein-protein interactions, cellular signaling, and regulation of cellular processes. 3. **Phosphate-Containing Compound Metabolic Process:** ACYP2 is involved in the metabolism of phosphate-containing compounds, which is critical for energy metabolism and cellular homeostasis. 4. **Identical Protein Binding:** The gene's ability to bind identical proteins implies a potential role in protein-protein interactions and regulation of cellular processes. **Clinical Significance:** 1. **Disease Association:** Further research is necessary to establish a link between ACYP2 and various diseases, including immunological disorders and metabolic disorders. 2. **Therapeutic Targeting:** The identification of ACYP2 as a potential therapeutic target could lead to the development of novel treatments for diseases associated with its dysregulation. 3. **Immunological Implications:** The gene's expression in immune cells and its involvement in protein-protein interactions suggest a potential role in immunological processes and disease. In conclusion, the ACYP2 gene is a complex and multifaceted molecule with far-reaching implications for our understanding of cellular biology and immunology. Further investigation into its functions, pathways, and clinical significance is essential to unlock its full potential and harness its therapeutic potential.

Genular Protein ID: 1215561022

Symbol: ACYP2_HUMAN

Name: Acylphosphatase-2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6100723

Title: Human skeletal muscle acylphosphatase: the primary structure.

PubMed ID: 6100723

PubMed ID: 7796909

Title: Cloning and expression of the cDNA coding for the erythrocyte isoenzyme of human acylphosphatase.

PubMed ID: 7796909

DOI: 10.1016/0014-5793(95)00553-l

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 99
  • Mass: 11140
  • Checksum: AEDE40E45B6207A0
  • Sequence:
  • MSTAQSLKSV DYEVFGRVQG VCFRMYTEDE ARKIGVVGWV KNTSKGTVTG QVQGPEDKVN 
    SMKSWLSKVG SPSSRIDRTN FSNEKTISKL EYSNFSIRY

Genular Protein ID: 3299284269

Symbol: E9PF46_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 69
  • Mass: 7547
  • Checksum: C54BF41423348128
  • Sequence:
  • MSTAQSLKSV DYEVFGRVQG VCFRMYTEDE ARKIGVVGWV KNTSKGTVTG QVQGPEDKVN 
    SMLECSGLI

Genular Protein ID: 4172812464

Symbol: F8WA34_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 70
  • Mass: 7544
  • Checksum: 0958C7DB1C582A22
  • Sequence:
  • MSTAQSLKSV DYEVFGRVQG VCFRMYTEDE ARKIGVVGWV KNTSKGTVTG QVQGPEDKVN 
    SMNSSAPEAG

Genular Protein ID: 2730098521

Symbol: U3KQL2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 172
  • Mass: 19578
  • Checksum: DA9BF16D9EFB0676
  • Sequence:
  • MLLTQSLFGG LFPRTRETMR RYKVSLFYLG CSRTPNVKLS SCLGLPCCWD YSYKFIQLSE 
    FGFGQVIIVS EEPWKENISC SSTTFIKSTI CLSVCFRMYT EDEARKIGVV GWVKNTSKGT 
    VTGQVQGPED KVNSMKSWLS KVGSPSSRID RTNFSNEKTI SKLEYSNFSI RY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.