Details for: IP6K1

Gene ID: 9807

Symbol: IP6K1

Ensembl ID: ENSG00000176095

Description: inositol hexakisphosphate kinase 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.73
    Marker Score: 63,644
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.71
    Marker Score: 105,161
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.71
    Marker Score: 33,977
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.66
    Marker Score: 62,987
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.65
    Marker Score: 15,566
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.65
    Marker Score: 2,882
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.64
    Marker Score: 6,689
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.63
    Marker Score: 24,376
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.62
    Marker Score: 6,264
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.6
    Marker Score: 15,233
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.6
    Marker Score: 13,732
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.6
    Marker Score: 12,234
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.59
    Marker Score: 6,589
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.48
    Marker Score: 15,317
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.39
    Marker Score: 6,451
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.38
    Marker Score: 2,133
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.35
    Marker Score: 1,559
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.29
    Marker Score: 540
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.23
    Marker Score: 2,705
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.19
    Marker Score: 25,410
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.17
    Marker Score: 2,245
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.15
    Marker Score: 1,245
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.14
    Marker Score: 1,425
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.07
    Marker Score: 1,182
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.06
    Marker Score: 634
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.06
    Marker Score: 1,044
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.06
    Marker Score: 16,571
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.04
    Marker Score: 299
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.03
    Marker Score: 10,391
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,672
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,897
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.99
    Marker Score: 453
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.99
    Marker Score: 314
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,389
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.97
    Marker Score: 510
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.96
    Marker Score: 17,116
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.96
    Marker Score: 261
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.95
    Marker Score: 32,230
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.94
    Marker Score: 552
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,393
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.94
    Marker Score: 328
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.94
    Marker Score: 1,011
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.92
    Marker Score: 1,953
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.92
    Marker Score: 707
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.91
    Marker Score: 2,147
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.91
    Marker Score: 1,288
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.9
    Marker Score: 527
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.9
    Marker Score: 545
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,699
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.9
    Marker Score: 20,001
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.89
    Marker Score: 1,007
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.89
    Marker Score: 846
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.88
    Marker Score: 429
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.88
    Marker Score: 492
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,294
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.87
    Marker Score: 2,490
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.87
    Marker Score: 322
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.87
    Marker Score: 1,409
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.87
    Marker Score: 307
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.86
    Marker Score: 1,759
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.86
    Marker Score: 3,065
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4,803
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.84
    Marker Score: 1,013
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.84
    Marker Score: 504
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.84
    Marker Score: 2,003
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.84
    Marker Score: 3,095
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.84
    Marker Score: 269
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.83
    Marker Score: 413
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.82
    Marker Score: 1,189
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.81
    Marker Score: 746
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.81
    Marker Score: 760
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.81
    Marker Score: 237
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.81
    Marker Score: 1,014
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.8
    Marker Score: 300
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.8
    Marker Score: 692
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.8
    Marker Score: 545
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 320
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.79
    Marker Score: 836
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.79
    Marker Score: 4,708
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.79
    Marker Score: 804
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.79
    Marker Score: 4,727
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.78
    Marker Score: 488
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.77
    Marker Score: 867
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 587
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.77
    Marker Score: 265
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.76
    Marker Score: 1,276
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.75
    Marker Score: 2,587
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.74
    Marker Score: 795
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.74
    Marker Score: 167
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.74
    Marker Score: 786
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.74
    Marker Score: 11,871
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.74
    Marker Score: 1,304
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.74
    Marker Score: 637
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.73
    Marker Score: 295
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.72
    Marker Score: 770
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.72
    Marker Score: 392

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** IP6K1 is primarily expressed in the nervous system, with high levels detected in GABAergic cortical interneurons, L2/3-6 intratelencephalic projecting glutamatergic neurons, and other neural cells. 2. **Enzymatic Activity:** IP6K1 possesses a unique enzymatic activity, catalyzing the phosphorylation of inositol hexakisphosphate (IP6) to produce inositol pentakisphosphate (IP5). 3. **Regulation of Thermogenesis:** IP6K1 has been shown to negatively regulate cold-induced thermogenesis, suggesting a potential role in energy homeostasis and thermoregulation. 4. **Protein Synthesis:** IP6K1 is involved in the synthesis of IP6, which is a precursor to various polyphosphates, including IP4, IP5, and IP6. These polyphosphates play critical roles in cellular metabolism, protein synthesis, and signaling pathways. **Pathways and Functions:** 1. **Inositol Phosphate Biosynthesis:** IP6K1 is a key enzyme in the biosynthesis of inositol hexakisphosphate (IP6), which is then converted into various polyphosphates, including IP4, IP5, and IP6. 2. **Protein Synthesis:** IP6K1's activity is essential for the synthesis of IP6, which is a precursor to various polyphosphates involved in protein synthesis, including the synthesis of pyrophosphates and inositol hexakisphosphate. 3. **Phosphorylation and Signaling:** IP6K1's enzymatic activity is involved in the phosphorylation of various substrates, including proteins and lipids, which can modulate signaling pathways and cellular responses. 4. **Metabolic Regulation:** IP6K1 plays a role in regulating cellular metabolism, particularly in the context of energy homeostasis and thermoregulation. **Clinical Significance:** 1. **Neurological Disorders:** IP6K1's involvement in GABAergic cortical interneurons suggests potential implications for neurological disorders, such as epilepsy, autism, and schizophrenia. 2. **Thermoregulation:** IP6K1's regulation of cold-induced thermogenesis may have therapeutic implications for conditions characterized by abnormal thermoregulation, such as hypothyroidism. 3. **Cancer:** IP6K1's role in protein synthesis and metabolism may have implications for cancer research, particularly in the context of energy metabolism and polyphosphate metabolism. In conclusion, IP6K1 is a multifaceted enzyme that plays a critical role in various cellular processes, including immune regulation, cellular metabolism, and protein synthesis. Further research is needed to fully elucidate the functions of IP6K1 and its potential implications for human health and disease.

Genular Protein ID: 2511985733

Symbol: IP6K1_HUMAN

Name: Inositol hexakisphosphate kinase 1

UniProtKB Accession Codes:

Q92551 A8K157 A8MUX4 Q7L3I7 Q96E38

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 8 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 Rhea 2 SAM 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9039502

Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.

PubMed ID: 9039502

DOI: 10.1093/dnares/3.5.321

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11502751

Title: Identification and characterization of a novel inositol hexakisphosphate kinase.

PubMed ID: 11502751

DOI: 10.1074/jbc.m106842200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 441
  • Mass: 50236
  • Checksum: 6DFB2F88E1F91EE9
  • Sequence:
    • MCVCQTMEVG QYGKNASRAG DRGVLLEPFI HQVGGHSSMM RYDDHTVCKP LISREQRFYE 
SLPPEMKEFT PEYKGVVSVC FEGDSDGYIN LVAYPYVESE TVEQDDTTER EQPRRKHSRR 
SLHRSGSGSD HKEEKASLSL ETSESSQEAK SPKVELHSHS EVPFQMLDGN SGLSSEKISH 
NPWSLRCHKQ QLSRMRSESK DRKLYKFLLL ENVVHHFKYP CVLDLKMGTR QHGDDASAEK 
AARQMRKCEQ STSATLGVRV CGMQVYQLDT GHYLCRNKYY GRGLSIEGFR NALYQYLHNG 
LDLRRDLFEP ILSKLRGLKA VLERQASYRF YSSSLLVIYD GKECRAESCL DRRSEMRLKH 
LDMVLPEVAS SCGPSTSPSN TSPEAGPSSQ PKVDVRMIDF AHSTFKGFRD DPTVHDGPDR 
GYVFGLENLI SIMEQMRDEN Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.