Details for: EFCAB14

Gene ID: 9813

Symbol: EFCAB14

Ensembl ID: ENSG00000159658

Description: EF-hand calcium binding domain 14

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.47
    Marker Score: 6,219
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.9
    Marker Score: 2,804
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.82
    Marker Score: 2,576
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.78
    Marker Score: 11,372
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.73
    Marker Score: 1,631
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.64
    Marker Score: 1,728
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.61
    Marker Score: 1,707
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.55
    Marker Score: 4,157
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.51
    Marker Score: 2,507
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.47
    Marker Score: 3,325
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166,603
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.43
    Marker Score: 1,234
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.39
    Marker Score: 1,093
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.38
    Marker Score: 8,972
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.37
    Marker Score: 3,123
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.35
    Marker Score: 3,321
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.34
    Marker Score: 897
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.31
    Marker Score: 457
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.27
    Marker Score: 1,324
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.25
    Marker Score: 524
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.24
    Marker Score: 1,598
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.23
    Marker Score: 6,485
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.23
    Marker Score: 496
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.23
    Marker Score: 868
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.22
    Marker Score: 1,343
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.19
    Marker Score: 1,070
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.19
    Marker Score: 295
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.18
    Marker Score: 283
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.17
    Marker Score: 339
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.17
    Marker Score: 547
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.16
    Marker Score: 29,683
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.16
    Marker Score: 266
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.16
    Marker Score: 8,603
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.15
    Marker Score: 498
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.15
    Marker Score: 672
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.15
    Marker Score: 284
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.15
    Marker Score: 1,824
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.14
    Marker Score: 1,837
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.14
    Marker Score: 272
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.11
    Marker Score: 1,126
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.11
    Marker Score: 1,058
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.1
    Marker Score: 9,560
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.1
    Marker Score: 1,171
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.09
    Marker Score: 238
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.09
    Marker Score: 5,228
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.09
    Marker Score: 1,043
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.08
    Marker Score: 765
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.08
    Marker Score: 3,696
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.05
    Marker Score: 1,057
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.05
    Marker Score: 4,388
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.05
    Marker Score: 948
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.05
    Marker Score: 58,462
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.04
    Marker Score: 2,198
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.04
    Marker Score: 431
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.04
    Marker Score: 1,036
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.04
    Marker Score: 537
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.03
    Marker Score: 255
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.03
    Marker Score: 863
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.03
    Marker Score: 385
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.03
    Marker Score: 202
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.03
    Marker Score: 1,121
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.03
    Marker Score: 2,055
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.03
    Marker Score: 8,867
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.03
    Marker Score: 3,241
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 1.02
    Marker Score: 255
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.02
    Marker Score: 416
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.02
    Marker Score: 376
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.02
    Marker Score: 1,095
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.02
    Marker Score: 606
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1
    Marker Score: 3,948
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1
    Marker Score: 1,780
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1
    Marker Score: 916
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1
    Marker Score: 3,127
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,573
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.99
    Marker Score: 343
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.99
    Marker Score: 1,143
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,794
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.99
    Marker Score: 225
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.99
    Marker Score: 247
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.99
    Marker Score: 1,527
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.99
    Marker Score: 1,063
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.99
    Marker Score: 300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.98
    Marker Score: 672
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.98
    Marker Score: 983
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,358
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.98
    Marker Score: 1,061
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.98
    Marker Score: 215
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.98
    Marker Score: 224
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.97
    Marker Score: 248
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.97
    Marker Score: 218
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.97
    Marker Score: 1,849
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.97
    Marker Score: 301
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.97
    Marker Score: 661
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.97
    Marker Score: 3,749
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.97
    Marker Score: 1,132
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.97
    Marker Score: 391
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.96
    Marker Score: 254
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.96
    Marker Score: 305
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.96
    Marker Score: 362

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EFCAB14 is a calcium-binding protein that contains an EF-hand calcium-binding domain, which is a characteristic of calcium-binding proteins. This domain allows the protein to bind to calcium ions, regulating its availability and activity within the cell. EFCAB14 is also characterized by its tissue-specific expression, with highest levels found in the kidney, bladder, and stomach, where it is likely involved in maintaining calcium homeostasis. Furthermore, its expression in different cell types suggests a diverse range of cellular functions, including cell signaling, differentiation, and possibly even cell growth. **Pathways and Functions:** EFCAB14 is involved in several cellular pathways, including calcium ion binding, which is critical for maintaining calcium homeostasis within cells. The EF-hand calcium-binding domain of EFCAB14 allows it to bind to calcium ions, regulating their availability and activity within the cell. This domain is also involved in cell signaling pathways, where it may interact with other proteins to regulate cellular responses to changes in calcium levels. Additionally, EFCAB14 may play a role in cell differentiation and growth, as its expression is found in various cell types, including those involved in tissue development and maintenance. **Clinical Significance:** EFCAB14 has implications for various diseases related to calcium homeostasis and cellular function. For example, alterations in calcium homeostasis have been implicated in the pathogenesis of several diseases, including osteoporosis, hypertension, and cardiovascular disease. Furthermore, disruptions in calcium homeostasis have been linked to certain types of cancer, including breast and prostate cancer. EFCAB14 may play a role in these diseases, either by regulating calcium homeostasis or by interacting with other proteins to modulate cellular responses to changes in calcium levels. Therefore, further research is needed to fully understand the role of EFCAB14 in human disease and to explore its potential as a therapeutic target. In conclusion, EFCAB14 is a calcium-binding protein that plays a critical role in maintaining calcium homeostasis within cells. Its tissue-specific expression and involvement in various cellular pathways suggest a broad range of cellular functions, including cell signaling, differentiation, and growth. Further research is needed to fully understand the role of EFCAB14 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 4248759092

Symbol: EFC14_HUMAN

Name: EF-hand calcium-binding domain-containing protein 14

UniProtKB Accession Codes:

O75071 D3DQ23 Q5SXB8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 CarbonylDB 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 1 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9455484

Title: Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.

PubMed ID: 9455484

DOI: 10.1093/dnares/4.5.345

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25787250

Title: Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas.

PubMed ID: 25787250

DOI: 10.1073/pnas.1503696112

Sequence Information:

  • Length: 495
  • Mass: 55031
  • Checksum: 81170A5169D4B46F
  • Sequence:
    • MKKRKELNAL IGLAGDSRRK KPKKGPSSHR LLRTEPPDSD SESSSEEEEE FGVVGNRSRF 
AKGDYLRCCK ICYPLCGFVI LAACVVACVG LVWMQVALKE DLDALKEKFR TMESNQKSSF 
QEIPKLNEEL LSKQKQLEKI ESGEMGLNKV WINITEMNKQ ISLLTSAVNH LKANVKSAAD 
LISLPTTVEG LQKSVASIGN TLNSVHLAVE ALQKTVDEHK KTMELLQSDM NQHFLKETPG 
SNQIIPSPSA TSELDNKTHS ENLKQDILYL HNSLEEVNSA LVGYQRQNDL KLEGMNETVS 
NLTQRVNLIE SDVVAMSKVE KKANLSFSMM GDRSATLKRQ SLDQVTNRTD TVKIQSIKKE 
DSSNSQVSKL REKLQLISAL TNKPESNRPP ETADEEQVES FTSKPSALPK FSQFLGDPVE 
KAAQLRPISL PGVSSTEDLQ DLFRKTGQDV DGKLTYQEIW TSLGSAMPEP ESLRAFDSDG 
DGRYSFLELR VALGI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.