Details for: KEAP1
Associated with
Other Information
Genular Protein ID: 4226704217
Symbol: KEAP1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8590280
Title: Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.
PubMed ID: 8590280
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14585973
Title: Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress.
PubMed ID: 14585973
PubMed ID: 15379550
Title: Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein.
PubMed ID: 15379550
DOI: 10.1021/bi0494166
PubMed ID: 15572695
Title: Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.
PubMed ID: 15572695
PubMed ID: 15983046
Title: Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway.
PubMed ID: 15983046
PubMed ID: 15601839
Title: BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase.
PubMed ID: 15601839
PubMed ID: 15657435
Title: Nuclear oncoprotein prothymosin alpha is a partner of Keap1: implications for expression of oxidative stress-protecting genes.
PubMed ID: 15657435
PubMed ID: 19489739
Title: Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1.
PubMed ID: 19489739
DOI: 10.1042/bj20090471
PubMed ID: 16006525
Title: Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2.
PubMed ID: 16006525
PubMed ID: 16687406
Title: Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function.
PubMed ID: 16687406
PubMed ID: 17046835
Title: PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex.
PubMed ID: 17046835
PubMed ID: 17127771
Title: Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3.
PubMed ID: 17127771
PubMed ID: 18251510
Title: Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3.
PubMed ID: 18251510
DOI: 10.1021/tx700302s
PubMed ID: 18387606
Title: PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria.
PubMed ID: 18387606
PubMed ID: 19424503
Title: Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level.
PubMed ID: 19424503
PubMed ID: 20495340
Title: Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy.
PubMed ID: 20495340
PubMed ID: 20452972
Title: p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription.
PubMed ID: 20452972
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23274085
Title: Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.
PubMed ID: 23274085
PubMed ID: 24089205
Title: Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites.
PubMed ID: 24089205
DOI: 10.1038/nature12606
PubMed ID: 26517842
Title: Client proteins and small molecule inhibitors display distinct binding preferences for constitutive and stress-induced HSP90 isoforms and their conformationally restricted mutants.
PubMed ID: 26517842
PubMed ID: 24630991
Title: The Marburg virus VP24 protein interacts with Keap1 to activate the cytoprotective antioxidant response pathway.
PubMed ID: 24630991
PubMed ID: 28380357
Title: Keap1/cullin3 modulates p62/SQSTM1 activity via UBA domain ubiquitination.
PubMed ID: 28380357
PubMed ID: 29590092
Title: Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
PubMed ID: 29590092
DOI: 10.1038/nature25986
PubMed ID: 30323285
Title: A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling.
PubMed ID: 30323285
PubMed ID: 28842501
Title: Stress-sensing mechanisms and the physiological roles of the Keap1-Nrf2 system during cellular stress.
PubMed ID: 28842501
PubMed ID: 15583386
Title: Crystallization and initial crystallographic analysis of the Kelch domain from human Keap1.
PubMed ID: 15583386
PubMed ID: 16204884
Title: Conserved solvent and side-chain interactions in the 1.35 Angstrom structure of the Kelch domain of Keap1.
PubMed ID: 16204884
PubMed ID: 16888629
Title: Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling.
PubMed ID: 16888629
PubMed ID: 24896564
Title: Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO.
PubMed ID: 24896564
PubMed ID: 16507366
Title: Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer.
PubMed ID: 16507366
PubMed ID: 17020408
Title: Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer.
PubMed ID: 17020408
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
Sequence Information:
- Length: 624
- Mass: 69666
- Checksum: CE180F3897BB8C97
- Sequence:
MQPDPRPSGA GACCRFLPLQ SQCPEGAGDA VMYASTECKA EVTPSQHGNR TFSYTLEDHT KQAFGIMNEL RLSQQLCDVT LQVKYQDAPA AQFMAHKVVL ASSSPVFKAM FTNGLREQGM EVVSIEGIHP KVMERLIEFA YTASISMGEK CVLHVMNGAV MYQIDSVVRA CSDFLVQQLD PSNAIGIANF AEQIGCVELH QRAREYIYMH FGEVAKQEEF FNLSHCQLVT LISRDDLNVR CESEVFHACI NWVKYDCEQR RFYVQALLRA VRCHSLTPNF LQMQLQKCEI LQSDSRCKDY LVKIFEELTL HKPTQVMPCR APKVGRLIYT AGGYFRQSLS YLEAYNPSDG TWLRLADLQV PRSGLAGCVV GGLLYAVGGR NNSPDGNTDS SALDCYNPMT NQWSPCAPMS VPRNRIGVGV IDGHIYAVGG SHGCIHHNSV ERYEPERDEW HLVAPMLTRR IGVGVAVLNR LLYAVGGFDG TNRLNSAECY YPERNEWRMI TAMNTIRSGA GVCVLHNCIY AAGGYDGQDQ LNSVERYDVE TETWTFVAPM KHRRSALGIT VHQGRIYVLG GYDGHTFLDS VECYDPDTDT WSEVTRMTSG RSGVGVAVTM EPCRKQIDQQ NCTC
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.