ARHGEF11 | ENSG00000132694 | NCBI 9826

Details for: ARHGEF11

Gene ID: 9826

Symbol: ARHGEF11

Ensembl ID: ENSG00000132694

Description: Rho guanine nucleotide exchange factor 11

Associated with

Axon guidance
(R-HSA-422475)
Cdc42 gtpase cycle
(R-HSA-9013148)
Cell death signalling via nrage, nrif and nade
(R-HSA-204998)
Death receptor signaling
(R-HSA-73887)
Developmental biology
(R-HSA-1266738)
G alpha (12/13) signalling events
(R-HSA-416482)
Gpcr downstream signalling
(R-HSA-388396)
Nervous system development
(R-HSA-9675108)
Nrage signals death through jnk
(R-HSA-193648)
P75 ntr receptor-mediated signalling
(R-HSA-193704)
Rac1 gtpase cycle
(R-HSA-9013149)
Rhoa gtpase cycle
(R-HSA-8980692)
Rhob gtpase cycle
(R-HSA-9013026)
Rhoc gtpase cycle
(R-HSA-9013106)
Rho gtpase cycle
(R-HSA-9012999)
Sema4d induced cell migration and growth-cone collapse
(R-HSA-416572)
Sema4d in semaphorin signaling
(R-HSA-400685)
Semaphorin interactions
(R-HSA-373755)
Signaling by gpcr
(R-HSA-372790)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Actin cytoskeleton organization
(GO:0030036)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Establishment of cell polarity
(GO:0030010)
G protein-coupled receptor binding
(GO:0001664)
G protein-coupled receptor signaling pathway
(GO:0007186)
Gtpase activator activity
(GO:0005096)
Guanyl-nucleotide exchange factor activity
(GO:0005085)
Nucleoplasm
(GO:0005654)
Plasma membrane
(GO:0005886)
Positive regulation of dna-templated transcription
(GO:0045893)
Protein binding
(GO:0005515)
Regulation of cell growth
(GO:0001558)
Regulation of small gtpase mediated signal transduction
(GO:0051056)
Rho protein signal transduction
(GO:0007266)
Striated muscle contraction
(GO:0006941)

Other Information

Proteins

Rho guanine nucleotide exchange factor 11

Genular Protein ID: 340648950

Symbol: ARHGB_HUMAN

Name: Rho guanine nucleotide exchange factor 11

UniProtKB Accession Codes:

O15085 D3DVD0 Q5VY40 Q6PFW2

Database IDs:

Citations:

PubMed ID: 9205841

Title: Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9205841

DOI: 10.1093/dnares/4.2.141

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10526156

Title: Rho-specific binding and guanine nucleotide exchange catalysis by KIAA0380, a dbl family member.

PubMed ID: 10526156

DOI: 10.1016/s0014-5793(99)01270-3

PubMed ID: 10026210

Title: A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho.

PubMed ID: 10026210

DOI: 10.1074/jbc.274.9.5868

PubMed ID: 12372594

Title: B plexins activate Rho through PDZ-RhoGEF.

PubMed ID: 12372594

DOI: 10.1016/s0014-5793(02)03323-9

PubMed ID: 12183458

Title: Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF.

PubMed ID: 12183458

DOI: 10.1074/jbc.m206005200

PubMed ID: 10900204

Title: Functions of a rho-specific guanine nucleotide exchange factor in neurite retraction. Possible role of a proline-rich motif of KIAA0380 in localization.

PubMed ID: 10900204

DOI: 10.1074/jbc.m003726200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20844236

Title: HGAL, a germinal center specific protein, decreases lymphoma cell motility by modulation of the RhoA signaling pathway.

PubMed ID: 20844236

DOI: 10.1182/blood-2010-04-281568

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21670212

Title: PDZ-RhoGEF ubiquitination by Cullin3-KLHL20 controls neurotrophin-induced neurite outgrowth.

PubMed ID: 21670212

DOI: 10.1083/jcb.201103015

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 11470431

Title: Structure of the RGS-like domain from PDZ-RhoGEF: linking heterotrimeric g protein-coupled signaling to Rho GTPases.

PubMed ID: 11470431

DOI: 10.1016/s0969-2126(01)00620-7

Sequence Information:

Length: 1522
Mass: 167704
Checksum: CA16E125B9F8A4AA
Sequence:

MSVRLPQSID RLSSLSSLGD SAPERKSPSH HRQPSDASET TGLVQRCVII QKDQHGFGFT 
VSGDRIVLVQ SVRPGGAAMK AGVKEGDRII KVNGTMVTNS SHLEVVKLIK SGAYVALTLL 
GSSPSSMGIS GLQQDPSPAG APRITSVIPS PPPPPPLPPP QRITGPKPLQ DPEVQKHATQ 
ILRNMLRQEE KELQDILPLY GDTSQRPSEG RLSLDSQEGD SGLDSGTERF PSLSESLMNR 
NSVLSDPGLD SPRTSPVIMA RVAQHHRRQG SDAAVPSTGD QGVDQSPKPL IIGPEEDYDP 
GYFNNESDII FQDLEKLKSR PAHLGVFLRY IFSQADPSPL LFYLCAEVYQ QASPKDSRSL 
GKDIWNIFLE KNAPLRVKIP EMLQAEIDSR LRNSEDARGV LCEAQEAAMP EIQEQIHDYR 
TKRTLGLGSL YGENDLLDLD GDPLRERQVA EKQLAALGDI LSKYEEDRSA PMDFALNTYM 
SHAGIRLREA RPSNTAEKAQ SAPDKDKWLP FFPKTKKSSN SKKEKDALED KKRNPILKYI 
GKPKSSSQST FHIPLSPVEV KPGNVRNIIQ HFENNQQYDA PEPGTQRLST GSFPEDLLES 
DSSRSEIRLG RSESLKGREE MKRSRKAENV PRSRSDVDMD AAAEATRLHQ SASSSTSSLS 
TRSLENPTPP FTPKMGRRSI ESPSLGFCTD TLLPHLLEDD LGQLSDLEPE PDAQNWQHTV 
GKDVVAGLTQ REIDRQEVIN ELFVTEASHL RTLRVLDLIF YQRMKKENLM PREELARLFP 
NLPELIEIHN SWCEAMKKLR EEGPIIKEIS DLMLARFDGP AREELQQVAA QFCSYQSIAL 
ELIKTKQRKE SRFQLFMQEA ESHPQCRRLQ LRDLIISEMQ RLTKYPLLLE SIIKHTEGGT 
SEHEKLCRAR DQCREILKYV NEAVKQTENR HRLEGYQKRL DATALERASN PLAAEFKSLD 
LTTRKMIHEG PLTWRISKDK TLDLHVLLLE DLLVLLQKQD EKLLLKCHSK TAVGSSDSKQ 
TFSPVLKLNA VLIRSVATDK RAFFIICTSK LGPPQIYELV ALTSSDKNTW MELLEEAVRN 
ATRHPGAAPM PVHPPPPGPR EPAQQGPTPS RVELDDSDVF HGEPEPEELP GGTGSQQRVQ 
GKHQVLLEDP EQEGSAEEEE LGVLPCPSTS LDGENRGIRT RNPIHLAFPG PLFMEGLADS 
ALEDVENLRH LILWSLLPGH TMETQAAQEP EDDLTPTPSV ISVTSHPWDP GSPGQAPPGG 
EGDNTQLAGL EGERPEQEDM GLCSLEHLPP RTRNSGIWES PELDRNLAED ASSTEAAGGY 
KVVRKAEVAG SKVVPALPES GQSEPGPPEV EGGTKATGNC FYVSMPSGPP DSSTDHSEAP 
MSPPQPDSLP AGQTEPQPQL QGGNDDPRRP SRSPPSLALR DVGMIFHTIE QLTLKLNRLK 
DMELAHRELL KSLGGESSGG TTPVGSFHTE AARWTDGSLS PPAKEPLASD SRNSHELGPC 
PEDGSDAPLE DSTADAAASP GP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ARHGEF11

Associated with

Other Information

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. PubMed ID: 9205841

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Rho-specific binding and guanine nucleotide exchange catalysis by KIAA0380, a dbl family member. PubMed ID: 10526156

A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho. PubMed ID: 10026210

B plexins activate Rho through PDZ-RhoGEF. PubMed ID: 12372594

Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF. PubMed ID: 12183458

Functions of a rho-specific guanine nucleotide exchange factor in neurite retraction. Possible role of a proline-rich motif of KIAA0380 in localization. PubMed ID: 10900204

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

HGAL, a germinal center specific protein, decreases lymphoma cell motility by modulation of the RhoA signaling pathway. PubMed ID: 20844236

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

PDZ-RhoGEF ubiquitination by Cullin3-KLHL20 controls neurotrophin-induced neurite outgrowth. PubMed ID: 21670212

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Structure of the RGS-like domain from PDZ-RhoGEF: linking heterotrimeric g protein-coupled signaling to Rho GTPases. PubMed ID: 11470431