Details for: CDK1

Gene ID: 983

Symbol: CDK1

Ensembl ID: ENSG00000170312

Description: cyclin dependent kinase 1

Associated with

Other Information

Genular Protein ID: 3164957743

Symbol: CDK1_HUMAN

Name: Cyclin-dependent kinase 1

UniProtKB Accession Codes:

P06493 A8K7C4 C9J497 O60764

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 10 CPTC 1 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 ComplexPortal 4 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 10 DrugCentral 1 EC 3 ELM 1 EMBL 9 EMDB 1 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 78 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 2 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 12 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 37 RefSeq 4 Rhea 9 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3553962

Title: Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2.

PubMed ID: 3553962

DOI: 10.1038/327031a0

PubMed ID: 9515786

Title: T-loop deletion of CDC2 from breast cancer tissues eliminates binding to cyclin B1 and cyclin-dependent kinase inhibitor p21.

PubMed ID: 9515786

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3289755

Title: Activation of cdc2 protein kinase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement.

PubMed ID: 3289755

DOI: 10.1016/0092-8674(88)90175-4

PubMed ID: 7569953

Title: Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15.

PubMed ID: 7569953

DOI: 10.1126/science.270.5233.86

PubMed ID: 9242535

Title: The Fanconi anemia polypeptide, FAC, binds to the cyclin-dependent kinase, cdc2.

PubMed ID: 9242535

PubMed ID: 9030781

Title: Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

PubMed ID: 9030781

DOI: 10.1111/j.1432-1033.1997.t01-2-00527.x

PubMed ID: 12775724

Title: RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis.

PubMed ID: 12775724

DOI: 10.1074/jbc.m302191200

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15145941

Title: Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region.

PubMed ID: 15145941

DOI: 10.1074/jbc.m404950200

PubMed ID: 16407259

Title: Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation.

PubMed ID: 16407259

DOI: 10.1074/jbc.m508162200

PubMed ID: 16371510

Title: Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-dependent kinase Cdk1.

PubMed ID: 16371510

DOI: 10.1091/mbc.e05-07-0621

PubMed ID: 18056467

Title: Cks1 regulates cdk1 expression: a novel role during mitotic entry in breast cancer cells.

PubMed ID: 18056467

DOI: 10.1158/0008-5472.can-06-4173

PubMed ID: 17459720

Title: TGFbeta regulates the expression and activities of G2 checkpoint kinases in human myeloid leukemia cells.

PubMed ID: 17459720

DOI: 10.1016/j.cyto.2007.03.009

PubMed ID: 16933150

Title: Microtubule deacetylases, SirT2 and HDAC6, in the nervous system.

PubMed ID: 16933150

DOI: 10.1007/s11064-006-9127-6

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18480403

Title: Rapid cycling and precocious termination of G1 phase in cells expressing CDK1AF.

PubMed ID: 18480403

DOI: 10.1091/mbc.e08-02-0172

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18356527

Title: Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons.

PubMed ID: 18356527

DOI: 10.1126/science.1152337

PubMed ID: 19509060

Title: Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome.

PubMed ID: 19509060

DOI: 10.1242/jcs.042747

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20171170

Title: Mitotic phosphorylation of Aki1 at Ser208 by cyclin B1-Cdk1 complex.

PubMed ID: 20171170

DOI: 10.1016/j.bbrc.2010.02.103

PubMed ID: 20395957

Title: New Cdc2 Tyr 4 phosphorylation by dsRNA-activated protein kinase triggers Cdc2 polyubiquitination and G2 arrest under genotoxic stresses.

PubMed ID: 20395957

DOI: 10.1038/embor.2010.45

PubMed ID: 19917613

Title: The protein kinase Cdelta catalytic fragment is critical for maintenance of the G2/M DNA damage checkpoint.

PubMed ID: 19917613

DOI: 10.1074/jbc.m109.055392

PubMed ID: 20360007

Title: Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition.

PubMed ID: 20360007

DOI: 10.1074/jbc.m109.096552

PubMed ID: 19917720

Title: Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosis.

PubMed ID: 19917720

DOI: 10.1128/mcb.00882-09

PubMed ID: 20937773

Title: Cdk1/cyclin B1 controls Fas-mediated apoptosis by regulating caspase-8 activity.

PubMed ID: 20937773

DOI: 10.1128/mcb.00731-10

PubMed ID: 20935635

Title: Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2.

PubMed ID: 20935635

DOI: 10.1038/ncb2116

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406398

Title: Cep63 recruits Cdk1 to the centrosome: implications for regulation of mitotic entry, centrosome amplification, and genome maintenance.

PubMed ID: 21406398

DOI: 10.1158/0008-5472.can-10-2684

PubMed ID: 21063390

Title: CAMP (C13orf8, ZNF828) is a novel regulator of kinetochore-microtubule attachment.

PubMed ID: 21063390

DOI: 10.1038/emboj.2010.276

PubMed ID: 16236519

Title: Mammalian cyclin-dependent kinases.

PubMed ID: 16236519

DOI: 10.1016/j.tibs.2005.09.005

PubMed ID: 19364923

Title: The decision to enter mitosis: feedback and redundancy in the mitotic entry network.

PubMed ID: 19364923

DOI: 10.1083/jcb.200812045

PubMed ID: 19238148

Title: Cell cycle, CDKs and cancer: a changing paradigm.

PubMed ID: 19238148

DOI: 10.1038/nrc2602

PubMed ID: 21535261

Title: Cdc2: a monopotent or pluripotent CDK?

PubMed ID: 21535261

DOI: 10.1111/j.1365-2184.2011.00753.x

PubMed ID: 21517772

Title: Cyclin dependent kinase 1 inhibitors: a review of recent progress.

PubMed ID: 21517772

DOI: 10.2174/092986711795590110

PubMed ID: 21655336

Title: Checkpoint recovery in cells: how a molecular understanding can help in the fight against cancer.

PubMed ID: 21655336

DOI: 10.3410/b3-10

PubMed ID: 21516087

Title: EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy.

PubMed ID: 21516087

DOI: 10.1038/nm.2341

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23602554

Title: Phosphorylation of SAMHD1 by cyclin A2/CDK1 regulates its restriction activity toward HIV-1.

PubMed ID: 23602554

DOI: 10.1016/j.celrep.2013.03.017

PubMed ID: 23601106

Title: The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation.

PubMed ID: 23601106

DOI: 10.1016/j.chom.2013.03.005

PubMed ID: 23355470

Title: Tubulin polymerization promoting protein 1 (Tppp1) phosphorylation by Rho-associated coiled-coil kinase (rock) and cyclin-dependent kinase 1 (Cdk1) inhibits microtubule dynamics to increase cell proliferation.

PubMed ID: 23355470

DOI: 10.1074/jbc.m112.441048

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26549230

Title: Phosphorylation of the centrosomal protein, Cep169, by Cdk1 promotes its dissociation from centrosomes in mitosis.

PubMed ID: 26549230

DOI: 10.1016/j.bbrc.2015.11.004

PubMed ID: 25556658

Title: Dynamic phosphorylation of CENP-A at Ser68 orchestrates its cell-cycle-dependent deposition at centromeres.

PubMed ID: 25556658

DOI: 10.1016/j.devcel.2014.11.030

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27238018

Title: Circadian amplitude regulation via FBXW7-targeted REV-ERBalpha degradation.

PubMed ID: 27238018

DOI: 10.1016/j.cell.2016.05.012

PubMed ID: 26829474

Title: Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation.

PubMed ID: 26829474

DOI: 10.1038/nchembio.2017

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30723163

Title: The microtubule-associated protein EML3 regulates mitotic spindle assembly by recruiting the Augmin complex to spindle microtubules.

PubMed ID: 30723163

DOI: 10.1074/jbc.ra118.007164

PubMed ID: 30704899

Title: Pacer is a mediator of mTORC1 and GSK3-TIP60 signaling in regulation of autophagosome maturation and lipid metabolism.

PubMed ID: 30704899

DOI: 10.1016/j.molcel.2018.12.017

PubMed ID: 32351706

Title: Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis.

PubMed ID: 32351706

DOI: 10.1038/s41421-020-0162-2

PubMed ID: 31852787

Title: The Severe Fever with Thrombocytopenia Syndrome Virus NSs Protein Interacts with CDK1 To Induce G2 Cell Cycle Arrest and Positively Regulate Viral Replication.

PubMed ID: 31852787

DOI: 10.1128/jvi.01575-19

PubMed ID: 34741373

Title: CDK1/FBXW7 facilitates degradation and ubiquitination of MLST8 to inhibit progression of renal cell carcinoma.

PubMed ID: 34741373

DOI: 10.1111/cas.15188

Sequence Information:

  • Length: 297
  • Mass: 34095
  • Checksum: 942D79448EFE490A
  • Sequence:
    • MEDYTKIEKI GEGTYGVVYK GRHKTTGQVV AMKKIRLESE EEGVPSTAIR EISLLKELRH 
PNIVSLQDVL MQDSRLYLIF EFLSMDLKKY LDSIPPGQYM DSSLVKSYLY QILQGIVFCH 
SRRVLHRDLK PQNLLIDDKG TIKLADFGLA RAFGIPIRVY THEVVTLWYR SPEVLLGSAR 
YSTPVDIWSI GTIFAELATK KPLFHGDSEI DQLFRIFRAL GTPNNEVWPE VESLQDYKNT 
FPKWKPGSLA SHVKNLDENG LDLLSKMLIY DPAKRISGKM ALNHPYFNDL DNQIKKM

Genular Protein ID: 4179781507

Symbol: B7Z3D6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z3D6

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 DNASU 1 EMBL 2 GO 3 Genevisible 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 2 SMART 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 109
  • Mass: 12467
  • Checksum: FF07749299FE27BB
  • Sequence:
    • MEDYTKIEKI GEGTYGVVYK GRHKTTGQVV AMKKIRLESE EEGVPSTAIR EISLLKELRH 
PNIVSLQDVL MQDSRLYLIF EFLSMDLKKY LDSIPPGQYM DSSLVKVKA

Genular Protein ID: 513095226

Symbol: I6L9I5_HUMAN

Name: N/A

UniProtKB Accession Codes:

I6L9I5

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 GenomeRNAi 1 IntAct 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 2 RuleBase 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 225
  • Mass: 25939
  • Checksum: BC8E2B5334BA75B4
  • Sequence:
    • MEDYTKIEKI GEGTYGVVYK GRHKTTGQVV AMKKIRLESE EEGVPSTAIR EISLLKELRH 
PNIVSLQDVL MQDSRLYLIF EFLSMDLKKY LDSIPPGQYM DSSLVKSYLY QILQGIVFCH 
SRRVLHRDLK PQNLLIDDKG TIKLADFGLA RAFGIPIRVY THEVVTLWYR SPEVLLGSAR 
YSTPVDIWSI GTIFAELATK KPLFHGDSEI DQLFRIFRNF CFPVF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.