Details for: CDK1

Gene ID: 983

Symbol: CDK1

Ensembl ID: ENSG00000170312

Description: cyclin dependent kinase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 49.3606
    Cell Significance Index: -12.5200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 35.7084
    Cell Significance Index: -14.7100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 27.8318
    Cell Significance Index: -13.1400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 26.6703
    Cell Significance Index: -10.8400
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 19.2356
    Cell Significance Index: 8.7600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.3748
    Cell Significance Index: -10.8600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.0433
    Cell Significance Index: -11.1500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.2634
    Cell Significance Index: -14.1000
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 4.9920
    Cell Significance Index: 3.8100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.2970
    Cell Significance Index: -13.0100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.1065
    Cell Significance Index: 22.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.7468
    Cell Significance Index: 172.8000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.4144
    Cell Significance Index: 41.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.3646
    Cell Significance Index: 160.9300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.9917
    Cell Significance Index: 34.4600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.9689
    Cell Significance Index: 20.2800
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.9324
    Cell Significance Index: 5.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9231
    Cell Significance Index: 100.4000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.7959
    Cell Significance Index: 25.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7889
    Cell Significance Index: 91.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5424
    Cell Significance Index: 107.6500
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.5098
    Cell Significance Index: 6.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4739
    Cell Significance Index: 258.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4637
    Cell Significance Index: 26.0200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.4480
    Cell Significance Index: 3.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4120
    Cell Significance Index: 67.0000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3986
    Cell Significance Index: 10.6800
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.3758
    Cell Significance Index: 2.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3636
    Cell Significance Index: 10.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2990
    Cell Significance Index: 17.9500
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: 0.2904
    Cell Significance Index: 2.6400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2744
    Cell Significance Index: 18.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2416
    Cell Significance Index: 12.5500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1843
    Cell Significance Index: 4.9300
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.1815
    Cell Significance Index: 0.5200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1584
    Cell Significance Index: 143.0000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1499
    Cell Significance Index: 7.8100
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.1474
    Cell Significance Index: 0.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1332
    Cell Significance Index: 3.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1217
    Cell Significance Index: 3.5100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1126
    Cell Significance Index: 21.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1098
    Cell Significance Index: 48.5400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0831
    Cell Significance Index: 51.9200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0614
    Cell Significance Index: 1.6400
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.0530
    Cell Significance Index: 0.4000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0469
    Cell Significance Index: 0.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0435
    Cell Significance Index: 1.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0388
    Cell Significance Index: 0.8400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0343
    Cell Significance Index: 0.7300
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.0339
    Cell Significance Index: 0.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0305
    Cell Significance Index: 3.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0188
    Cell Significance Index: 0.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0187
    Cell Significance Index: 2.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0065
    Cell Significance Index: -12.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0070
    Cell Significance Index: -3.9300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0079
    Cell Significance Index: -5.8800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0084
    Cell Significance Index: -6.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0107
    Cell Significance Index: -19.6900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0128
    Cell Significance Index: -19.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0145
    Cell Significance Index: -19.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0157
    Cell Significance Index: -11.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0190
    Cell Significance Index: -12.0800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0215
    Cell Significance Index: -0.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0262
    Cell Significance Index: -2.6800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0309
    Cell Significance Index: -14.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0330
    Cell Significance Index: -6.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0330
    Cell Significance Index: -11.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0347
    Cell Significance Index: -6.2600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0391
    Cell Significance Index: -6.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0434
    Cell Significance Index: -5.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0445
    Cell Significance Index: -12.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0539
    Cell Significance Index: -10.8100
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.0715
    Cell Significance Index: -0.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0803
    Cell Significance Index: -10.3700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0809
    Cell Significance Index: -9.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0819
    Cell Significance Index: -11.9100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0854
    Cell Significance Index: -9.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0873
    Cell Significance Index: -5.3500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0891
    Cell Significance Index: -1.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1253
    Cell Significance Index: -7.7000
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1261
    Cell Significance Index: -1.2000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1345
    Cell Significance Index: -3.9500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1348
    Cell Significance Index: -0.8000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1394
    Cell Significance Index: -2.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1422
    Cell Significance Index: -3.7400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1514
    Cell Significance Index: -11.9900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1544
    Cell Significance Index: -9.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1610
    Cell Significance Index: -10.1500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1642
    Cell Significance Index: -2.4800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1691
    Cell Significance Index: -11.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1805
    Cell Significance Index: -13.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1899
    Cell Significance Index: -14.5700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1956
    Cell Significance Index: -13.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2015
    Cell Significance Index: -9.4700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2305
    Cell Significance Index: -1.8800
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.2342
    Cell Significance Index: -2.1700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2415
    Cell Significance Index: -2.5000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2463
    Cell Significance Index: -12.9300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2487
    Cell Significance Index: -3.4500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2644
    Cell Significance Index: -4.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CDK1 is a member of the cyclin-dependent kinase (CDK) family, which is characterized by their ability to phosphorylate and activate downstream targets. CDK1 is unique in its ability to bind to multiple cyclins, including cyclin B, cyclin A, and cyclin C, and to phosphorylate and activate various mitotic proteins, such as separases and kinases. CDK1 is also involved in the regulation of transcription, cell cycle checkpoints, and apoptosis. **Pathways and Functions** CDK1 is involved in several key pathways, including: 1. **Activation of the APC/C complex**: CDK1 phosphorylates and activates the APC/C complex, which is responsible for the degradation of cyclin B and other mitotic proteins. 2. **Regulation of the G2/M transition**: CDK1 phosphorylates and activates cyclin B, which in turn activates the APC/C complex, driving the transition from the G2 phase to mitosis. 3. **Mitotic progression**: CDK1 phosphorylates and activates various mitotic proteins, including separases and kinases, to drive the progression of the cell cycle. 4. **Transcriptional regulation**: CDK1 phosphorylates and activates transcription factors, such as E2F, to regulate the expression of cell cycle genes. 5. **Apoptosis regulation**: CDK1 is involved in the regulation of apoptosis, particularly in response to DNA damage. **Clinical Significance** Dysregulation of CDK1 has been implicated in various diseases, including: 1. **Cancer**: CDK1 overexpression or mutations have been observed in various cancers, including breast, lung, and colon cancer. 2. **Neurodegenerative diseases**: CDK1 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Autoimmune diseases**: CDK1 has been implicated in the regulation of immune responses and has been associated with autoimmune diseases, such as multiple sclerosis. 4. **Developmental disorders**: CDK1 has been implicated in the regulation of cell proliferation and differentiation during development, and its dysregulation has been associated with developmental disorders, such as Down syndrome. In conclusion, CDK1 is a crucial regulator of the cell cycle, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms by which CDK1 regulates the cell cycle and to develop effective therapeutic strategies for the treatment of CDK1-related diseases.

Genular Protein ID: 3164957743

Symbol: CDK1_HUMAN

Name: Cyclin-dependent kinase 1

UniProtKB Accession Codes:

P06493 A8K7C4 C9J497 O60764

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 10 CPTC 1 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 ComplexPortal 4 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 10 DrugCentral 1 EC 3 ELM 1 EMBL 9 EMDB 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 82 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 2 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 37 RefSeq 4 Rhea 9 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3553962

Title: Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2.

PubMed ID: 3553962

DOI: 10.1038/327031a0

PubMed ID: 9515786

Title: T-loop deletion of CDC2 from breast cancer tissues eliminates binding to cyclin B1 and cyclin-dependent kinase inhibitor p21.

PubMed ID: 9515786

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3289755

Title: Activation of cdc2 protein kinase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement.

PubMed ID: 3289755

DOI: 10.1016/0092-8674(88)90175-4

PubMed ID: 2344612

Title: Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis.

PubMed ID: 2344612

DOI: 10.1016/0092-8674(90)90470-y

PubMed ID: 2188730

Title: Identification of cell cycle-regulated phosphorylation sites on nuclear lamin C.

PubMed ID: 2188730

DOI: 10.1016/0092-8674(90)90469-u

PubMed ID: 7569953

Title: Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15.

PubMed ID: 7569953

DOI: 10.1126/science.270.5233.86

PubMed ID: 9242535

Title: The Fanconi anemia polypeptide, FAC, binds to the cyclin-dependent kinase, cdc2.

PubMed ID: 9242535

PubMed ID: 9030781

Title: Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

PubMed ID: 9030781

DOI: 10.1111/j.1432-1033.1997.t01-2-00527.x

PubMed ID: 12775724

Title: RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis.

PubMed ID: 12775724

DOI: 10.1074/jbc.m302191200

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15145941

Title: Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region.

PubMed ID: 15145941

DOI: 10.1074/jbc.m404950200

PubMed ID: 16407259

Title: Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation.

PubMed ID: 16407259

DOI: 10.1074/jbc.m508162200

PubMed ID: 16371510

Title: Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-dependent kinase Cdk1.

PubMed ID: 16371510

DOI: 10.1091/mbc.e05-07-0621

PubMed ID: 18056467

Title: Cks1 regulates cdk1 expression: a novel role during mitotic entry in breast cancer cells.

PubMed ID: 18056467

DOI: 10.1158/0008-5472.can-06-4173

PubMed ID: 17459720

Title: TGFbeta regulates the expression and activities of G2 checkpoint kinases in human myeloid leukemia cells.

PubMed ID: 17459720

DOI: 10.1016/j.cyto.2007.03.009

PubMed ID: 16933150

Title: Microtubule deacetylases, SirT2 and HDAC6, in the nervous system.

PubMed ID: 16933150

DOI: 10.1007/s11064-006-9127-6

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18480403

Title: Rapid cycling and precocious termination of G1 phase in cells expressing CDK1AF.

PubMed ID: 18480403

DOI: 10.1091/mbc.e08-02-0172

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18356527

Title: Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons.

PubMed ID: 18356527

DOI: 10.1126/science.1152337

PubMed ID: 19202191

Title: Human CtIP mediates cell cycle control of DNA end resection and double strand break repair.

PubMed ID: 19202191

DOI: 10.1074/jbc.m808906200

PubMed ID: 19509060

Title: Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome.

PubMed ID: 19509060

DOI: 10.1242/jcs.042747

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20171170

Title: Mitotic phosphorylation of Aki1 at Ser208 by cyclin B1-Cdk1 complex.

PubMed ID: 20171170

DOI: 10.1016/j.bbrc.2010.02.103

PubMed ID: 20395957

Title: New Cdc2 Tyr 4 phosphorylation by dsRNA-activated protein kinase triggers Cdc2 polyubiquitination and G2 arrest under genotoxic stresses.

PubMed ID: 20395957

DOI: 10.1038/embor.2010.45

PubMed ID: 19917613

Title: The protein kinase Cdelta catalytic fragment is critical for maintenance of the G2/M DNA damage checkpoint.

PubMed ID: 19917613

DOI: 10.1074/jbc.m109.055392

PubMed ID: 20360007

Title: Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition.

PubMed ID: 20360007

DOI: 10.1074/jbc.m109.096552

PubMed ID: 19917720

Title: Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosis.

PubMed ID: 19917720

DOI: 10.1128/mcb.00882-09

PubMed ID: 20937773

Title: Cdk1/cyclin B1 controls Fas-mediated apoptosis by regulating caspase-8 activity.

PubMed ID: 20937773

DOI: 10.1128/mcb.00731-10

PubMed ID: 20935635

Title: Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2.

PubMed ID: 20935635

DOI: 10.1038/ncb2116

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406398

Title: Cep63 recruits Cdk1 to the centrosome: implications for regulation of mitotic entry, centrosome amplification, and genome maintenance.

PubMed ID: 21406398

DOI: 10.1158/0008-5472.can-10-2684

PubMed ID: 21063390

Title: CAMP (C13orf8, ZNF828) is a novel regulator of kinetochore-microtubule attachment.

PubMed ID: 21063390

DOI: 10.1038/emboj.2010.276

PubMed ID: 16236519

Title: Mammalian cyclin-dependent kinases.

PubMed ID: 16236519

DOI: 10.1016/j.tibs.2005.09.005

PubMed ID: 19364923

Title: The decision to enter mitosis: feedback and redundancy in the mitotic entry network.

PubMed ID: 19364923

DOI: 10.1083/jcb.200812045

PubMed ID: 19238148

Title: Cell cycle, CDKs and cancer: a changing paradigm.

PubMed ID: 19238148

DOI: 10.1038/nrc2602

PubMed ID: 21535261

Title: Cdc2: a monopotent or pluripotent CDK?

PubMed ID: 21535261

DOI: 10.1111/j.1365-2184.2011.00753.x

PubMed ID: 21517772

Title: Cyclin dependent kinase 1 inhibitors: a review of recent progress.

PubMed ID: 21517772

DOI: 10.2174/092986711795590110

PubMed ID: 21655336

Title: Checkpoint recovery in cells: how a molecular understanding can help in the fight against cancer.

PubMed ID: 21655336

DOI: 10.3410/b3-10

PubMed ID: 21516087

Title: EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy.

PubMed ID: 21516087

DOI: 10.1038/nm.2341

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23602554

Title: Phosphorylation of SAMHD1 by cyclin A2/CDK1 regulates its restriction activity toward HIV-1.

PubMed ID: 23602554

DOI: 10.1016/j.celrep.2013.03.017

PubMed ID: 23601106

Title: The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation.

PubMed ID: 23601106

DOI: 10.1016/j.chom.2013.03.005

PubMed ID: 23355470

Title: Tubulin polymerization promoting protein 1 (Tppp1) phosphorylation by Rho-associated coiled-coil kinase (rock) and cyclin-dependent kinase 1 (Cdk1) inhibits microtubule dynamics to increase cell proliferation.

PubMed ID: 23355470

DOI: 10.1074/jbc.m112.441048

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26549230

Title: Phosphorylation of the centrosomal protein, Cep169, by Cdk1 promotes its dissociation from centrosomes in mitosis.

PubMed ID: 26549230

DOI: 10.1016/j.bbrc.2015.11.004

PubMed ID: 25556658

Title: Dynamic phosphorylation of CENP-A at Ser68 orchestrates its cell-cycle-dependent deposition at centromeres.

PubMed ID: 25556658

DOI: 10.1016/j.devcel.2014.11.030

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27238018

Title: Circadian amplitude regulation via FBXW7-targeted REV-ERBalpha degradation.

PubMed ID: 27238018

DOI: 10.1016/j.cell.2016.05.012

PubMed ID: 27814491

Title: Nbs1 converts the human Mre11/Rad50 nuclease complex into an endo/exonuclease machine specific for protein-DNA adducts.

PubMed ID: 27814491

DOI: 10.1016/j.molcel.2016.10.010

PubMed ID: 26829474

Title: Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation.

PubMed ID: 26829474

DOI: 10.1038/nchembio.2017

PubMed ID: 28479321

Title: Ska3 Phosphorylated by Cdk1 Binds Ndc80 and Recruits Ska to Kinetochores to Promote Mitotic Progression.

PubMed ID: 28479321

DOI: 10.1016/j.cub.2017.03.060

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29606300

Title: Homozygous Mutations in WEE2 Cause Fertilization Failure and Female Infertility.

PubMed ID: 29606300

DOI: 10.1016/j.ajhg.2018.02.015

PubMed ID: 30139873

Title: An intrinsic S/G2 checkpoint enforced by ATR.

PubMed ID: 30139873

DOI: 10.1126/science.aap9346

PubMed ID: 31804178

Title: Molecular determinants of the Ska-Ndc80 interaction and their influence on microtubule tracking and force-coupling.

PubMed ID: 31804178

DOI: 10.7554/elife.49539

PubMed ID: 30723163

Title: The microtubule-associated protein EML3 regulates mitotic spindle assembly by recruiting the Augmin complex to spindle microtubules.

PubMed ID: 30723163

DOI: 10.1074/jbc.ra118.007164

PubMed ID: 30704899

Title: Pacer is a mediator of mTORC1 and GSK3-TIP60 signaling in regulation of autophagosome maturation and lipid metabolism.

PubMed ID: 30704899

DOI: 10.1016/j.molcel.2018.12.017

PubMed ID: 32351706

Title: Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis.

PubMed ID: 32351706

DOI: 10.1038/s41421-020-0162-2

PubMed ID: 31852787

Title: The Severe Fever with Thrombocytopenia Syndrome Virus NSs Protein Interacts with CDK1 To Induce G2 Cell Cycle Arrest and Positively Regulate Viral Replication.

PubMed ID: 31852787

DOI: 10.1128/jvi.01575-19

PubMed ID: 32491969

Title: Multisite phosphorylation determines the formation of Ska-Ndc80 macro-complexes that are essential for chromosome segregation during mitosis.

PubMed ID: 32491969

DOI: 10.1091/mbc.e19-10-0569

PubMed ID: 34741373

Title: CDK1/FBXW7 facilitates degradation and ubiquitination of MLST8 to inhibit progression of renal cell carcinoma.

PubMed ID: 34741373

DOI: 10.1111/cas.15188

PubMed ID: 37788673

Title: ATR promotes clearance of damaged DNA and damaged cells by rupturing micronuclei.

PubMed ID: 37788673

DOI: 10.1016/j.molcel.2023.09.003

Sequence Information:

  • Length: 297
  • Mass: 34095
  • Checksum: 942D79448EFE490A
  • Sequence:
    • MEDYTKIEKI GEGTYGVVYK GRHKTTGQVV AMKKIRLESE EEGVPSTAIR EISLLKELRH 
PNIVSLQDVL MQDSRLYLIF EFLSMDLKKY LDSIPPGQYM DSSLVKSYLY QILQGIVFCH 
SRRVLHRDLK PQNLLIDDKG TIKLADFGLA RAFGIPIRVY THEVVTLWYR SPEVLLGSAR 
YSTPVDIWSI GTIFAELATK KPLFHGDSEI DQLFRIFRAL GTPNNEVWPE VESLQDYKNT 
FPKWKPGSLA SHVKNLDENG LDLLSKMLIY DPAKRISGKM ALNHPYFNDL DNQIKKM

Genular Protein ID: 513095226

Symbol: I6L9I5_HUMAN

Name: N/A

UniProtKB Accession Codes:

I6L9I5

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 1 IntAct 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 2 RuleBase 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 225
  • Mass: 25939
  • Checksum: BC8E2B5334BA75B4
  • Sequence:
    • MEDYTKIEKI GEGTYGVVYK GRHKTTGQVV AMKKIRLESE EEGVPSTAIR EISLLKELRH 
PNIVSLQDVL MQDSRLYLIF EFLSMDLKKY LDSIPPGQYM DSSLVKSYLY QILQGIVFCH 
SRRVLHRDLK PQNLLIDDKG TIKLADFGLA RAFGIPIRVY THEVVTLWYR SPEVLLGSAR 
YSTPVDIWSI GTIFAELATK KPLFHGDSEI DQLFRIFRNF CFPVF

Genular Protein ID: 4179781507

Symbol: B7Z3D6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z3D6

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 2 SMART 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 109
  • Mass: 12467
  • Checksum: FF07749299FE27BB
  • Sequence:
    • MEDYTKIEKI GEGTYGVVYK GRHKTTGQVV AMKKIRLESE EEGVPSTAIR EISLLKELRH 
PNIVSLQDVL MQDSRLYLIF EFLSMDLKKY LDSIPPGQYM DSSLVKVKA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.