Details for: MELK

Gene ID: 9833

Symbol: MELK

Ensembl ID: ENSG00000165304

Description: maternal embryonic leucine zipper kinase

Associated with

Other Information

Genular Protein ID: 3526598611

Symbol: MELK_HUMAN

Name: Maternal embryonic leucine zipper kinase

UniProtKB Accession Codes:

Q14680 A6P3A7 A6P3A8 B1AMQ6 B7Z1E6 B7Z5M5 B7Z6Q7 B7Z6R8 B7Z6Y0 B7Z7Q1 D3DRP8 F5H0Y0 F5H2R4 F5H689 Q7L3C3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 7 CDD 3 CPTAC 2 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 5 EMBL 15 EPD 1 Ensembl 7 ExpressionAtlas 1 GO 19 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 37 PDBsum 31 PRO 1 PROSITE 4 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 Pumba 1 RNAct 1 RefSeq 16 Rhea 9 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8724849

Title: Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 8724849

DOI: 10.1093/dnares/3.1.17

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11802789

Title: Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38).

PubMed ID: 11802789

DOI: 10.1042/0264-6021:3610597

PubMed ID: 12400006

Title: Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation.

PubMed ID: 12400006

DOI: 10.1038/sj.onc.1205870

PubMed ID: 14699119

Title: Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1.

PubMed ID: 14699119

DOI: 10.1074/jbc.m311466200

PubMed ID: 14976552

Title: LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.

PubMed ID: 14976552

DOI: 10.1038/sj.emboj.7600110

PubMed ID: 16266996

Title: Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancers.

PubMed ID: 16266996

DOI: 10.1158/0008-5472.can-04-4531

PubMed ID: 15908796

Title: CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis.

PubMed ID: 15908796

DOI: 10.4161/cc.4.6.1716

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16628004

Title: M-phase MELK activity is regulated by MPF and MAPK.

PubMed ID: 16628004

DOI: 10.4161/cc.5.8.2683

PubMed ID: 16216881

Title: Substrate specificity and activity regulation of protein kinase MELK.

PubMed ID: 16216881

DOI: 10.1074/jbc.m507274200

PubMed ID: 16159311

Title: Cell-cycle-dependent cortical localization of pEg3 protein kinase in Xenopus and human cells.

PubMed ID: 16159311

DOI: 10.1042/bc20050041

PubMed ID: 17280616

Title: Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family.

PubMed ID: 17280616

DOI: 10.1186/bcr1650

PubMed ID: 17960622

Title: Maternal embryonic leucine zipper kinase transcript abundance correlates with malignancy grade in human astrocytomas.

PubMed ID: 17960622

DOI: 10.1002/ijc.23189

PubMed ID: 17722061

Title: Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells.

PubMed ID: 17722061

DOI: 10.1002/jnr.21471

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19671159

Title: Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer.

PubMed ID: 19671159

DOI: 10.1186/bcr2350

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20861186

Title: Maternal embryonic leucine zipper kinase is upregulated and required in mammary tumor-initiating cells in vivo.

PubMed ID: 20861186

DOI: 10.1158/0008-5472.can-10-1295

PubMed ID: 21145462

Title: Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids.

PubMed ID: 21145462

DOI: 10.1016/j.cell.2010.11.028

PubMed ID: 20420823

Title: Maternal embryonic leucine zipper kinase is stabilized in mitosis by phosphorylation and is partially degraded upon mitotic exit.

PubMed ID: 20420823

DOI: 10.1016/j.yexcr.2010.04.019

PubMed ID: 21806965

Title: Resistance of colorectal cancer cells to radiation and 5-FU is associated with MELK expression.

PubMed ID: 21806965

DOI: 10.1016/j.bbrc.2011.07.060

PubMed ID: 21558073

Title: Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway.

PubMed ID: 21558073

DOI: 10.1093/neuonc/nor023

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 651
  • Mass: 74642
  • Checksum: 57F05CDC6122E570
  • Sequence:
    • MKDYDELLKY YELHETIGTG GFAKVKLACH ILTGEMVAIK IMDKNTLGSD LPRIKTEIEA 
LKNLRHQHIC QLYHVLETAN KIFMVLEYCP GGELFDYIIS QDRLSEEETR VVFRQIVSAV 
AYVHSQGYAH RDLKPENLLF DEYHKLKLID FGLCAKPKGN KDYHLQTCCG SLAYAAPELI 
QGKSYLGSEA DVWSMGILLY VLMCGFLPFD DDNVMALYKK IMRGKYDVPK WLSPSSILLL 
QQMLQVDPKK RISMKNLLNH PWIMQDYNYP VEWQSKNPFI HLDDDCVTEL SVHHRNNRQT 
MEDLISLWQY DHLTATYLLL LAKKARGKPV RLRLSSFSCG QASATPFTDI KSNNWSLEDV 
TASDKNYVAG LIDYDWCEDD LSTGAATPRT SQFTKYWTES NGVESKSLTP ALCRTPANKL 
KNKENVYTPK SAVKNEEYFM FPEPKTPVNK NQHKREILTT PNRYTTPSKA RNQCLKETPI 
KIPVNSTGTD KLMTGVISPE RRCRSVELDL NQAHMEETPK RKGAKVFGSL ERGLDKVITV 
LTRSKRKGSA RDGPRRLKLH YNVTTTRLVN PDQLLNEIMS ILPKKHVDFV QKGYTLKCQT 
QSDFGKVTMQ FELEVCQLQK PDVVGIRRQR LKGDAWVYKR LVEDILSSCK V

Genular Protein ID: 3966552023

Symbol: B7Z1G6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z1G6

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 10 DNASU 1 EC 2 EMBL 2 GO 4 Gene3D 2 GenomeRNAi 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 3 RefSeq 1 Rhea 6 SMART 1 SUPFAM 2

Sequence Information:

  • Length: 571
  • Mass: 65648
  • Checksum: A8C887E4D8DA07A5
  • Sequence:
    • MMNFSNIMNY MKLLGQSDLP RIKTEIEALK NLRHQHICQL YHVLETANKI FMVLEENLLF 
DEYHKLKLID FGLCAKPKGN KDYHLQTCCG SLAYAAPELI QGKSYLGSEA DVWSMGILLY 
VLMCGFLPFD DDNVMALYKK IMRGKYDVPK WLSPSSILLL QQMLQVDPKK RISMKNLLNH 
PWIMQDYNYP VEWQSKNPFI HLDDDCVTEL SVHHRNNRQT MEDLISLWQY DHLTATYLLL 
LAKKARGKPV RLRLSSFSCG QASATPFTDI KSNNWSLEDV TASDKNYVAG LIDYDWCEDD 
LSTGAATPRT SQFTKYWTES NGVESKSLTP ALCRTPANKL KNKENVYTPK SAVKNEEYFM 
FPEPKTPVNK NQHKREILTT PNRYTTPSKA RNQCLKETPI KIPVNSTGTD KLMTGVISPE 
RRCRSVELDL NQAHMEETPK RKGAKVFGSL ERGLDKVITV LTRSKRKGSA RDGPRRLKLH 
YNVTTTRLVN PDQLLNEIMS ILPKKHVDFV QKGYTLKCQT QSDFGKVTMQ FELEVCQLQK 
PDVVGIRRQR LKGDAWVYKR LVEDILSSCK V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.