Genular: Defining Cellular Identity and Function

Details for: FAM30A

Gene ID: 9834

Symbol: FAM30A

Ensembl ID: ENSG00000226777

Description: family with sequence similarity 30 member A

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

Description

**Key Characteristics:** 1. **Widespread Expression:** FAM30A is expressed in a diverse range of cell types, including thymocytes, glutamatergic neurons, and hematopoietic stem cells. 2. **Cell-Specific Expression:** FAM30A exhibits cell-specific expression patterns, suggesting that it plays distinct roles in different cell types. 3. **Conserved Sequence:** FAM30A shares sequence homology with other family members, indicating a conserved evolutionary function. 4. **Regulatory Role:** FAM30A is involved in regulating cellular processes, including proliferation, differentiation, and survival. **Pathways and Functions:** 1. **Immune System Development:** FAM30A is essential for thymocyte development and function, influencing the maturation of T cells and the regulation of immune responses. 2. **Neurotransmission:** FAM30A is expressed in glutamatergic neurons, where it may play a role in regulating neurotransmitter release and synaptic plasticity. 3. **Cellular Differentiation:** FAM30A is involved in the differentiation of hematopoietic stem cells into various immune cell types, including B cells and T cells. 4. **Apoptosis Regulation:** FAM30A may regulate apoptosis in certain cell types, influencing the balance between cell survival and death. **Clinical Significance:** 1. **Immunodeficiency Disorders:** FAM30A mutations have been linked to immunodeficiency disorders, highlighting its critical role in immune system development and function. 2. **Cancer:** FAM30A expression has been observed in various types of cancer, including leukemia and lymphoma, suggesting potential roles in tumorigenesis and cancer progression. 3. **Neurological Disorders:** FAM30A expression in neurons has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, suggesting potential involvement in neurodegenerative processes. 4. **Infectious Diseases:** FAM30A may play a role in the regulation of immune responses to infectious diseases, influencing the efficacy of vaccination and treatment strategies. In conclusion, FAM30A is a multifaceted gene that plays critical roles in various biological processes, including immune system development, cellular differentiation, and neurotransmission. Further research is necessary to fully elucidate the mechanisms by which FAM30A regulates these processes and to explore its clinical significance in different diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.