Details for: CDK11B
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 5.81rCSI 8.21%PRS 47.8
-
CSI 5.49rCSI 5.28%PRS 38.83
-
CSI 5.22rCSI 5.32%PRS 50.45
-
CSI 4.33rCSI 3.29%PRS 48.57
-
CSI 4.21rCSI 15.24%PRS 56.83
-
CSI 3.77rCSI 5.38%PRS 40.92
-
CSI 3.45rCSI 2.59%PRS 41.1
-
CSI 3.4rCSI 2.86%PRS 55.04
-
CSI 3.25rCSI 2.26%PRS 45.88
-
CSI 3.24rCSI 2.56%PRS 27.42
-
CSI 3.21rCSI 4.85%PRS 39.69
-
CSI 2.83rCSI 3.89%PRS 58.89
-
CSI 2.79rCSI 1.88%PRS 47.36
-
CSI 2.73rCSI 2.18%PRS 59.4
-
CSI 2.64rCSI 2.75%PRS 69.98
-
CSI 2.56rCSI 1.79%PRS 39.98
-
CSI 2.55rCSI 1.98%PRS 53.79
-
CSI 2.52rCSI 2.48%PRS 53.02
-
CSI 2.5rCSI 3.9%PRS 65.48
-
CSI 2.44rCSI 2.14%PRS 47.56
-
CSI 2.42rCSI 3.69%PRS 54.46
-
CSI 2.41rCSI 3%PRS 40.67
-
CSI 2.41rCSI 3.9%PRS 37.18
-
CSI 2.37rCSI 3.47%PRS 40.88
-
CSI 2.34rCSI 7.51%PRS 46.49
-
CSI 2.33rCSI 3.45%PRS 42.63
-
CSI 2.31rCSI 1.61%PRS 50.31
-
CSI 2.3rCSI 4.31%PRS 29.36
-
CSI 2.28rCSI 2.9%PRS 43.11
-
CSI 2.27rCSI 2.43%PRS 36.09
-
CSI 2.22rCSI 2.68%PRS 44.93
-
CSI 2.21rCSI 3.37%PRS 42.58
-
CSI 2.19rCSI 1.63%PRS 50.83
-
CSI 2.19rCSI 2.04%PRS 38.02
-
CSI 2.15rCSI 1.54%PRS 50.2
-
CSI 2.08rCSI 3%PRS 48.21
-
CSI 2.05rCSI 4.68%PRS 37.7
-
CSI 2.03rCSI 1.92%PRS 39.3
-
CSI 2.03rCSI 1.59%PRS 44.21
-
CSI 2.02rCSI 1.19%PRS 51.84
-
CSI 2.01rCSI 3.44%PRS 59.21
-
CSI 1.99rCSI 1.55%PRS 38.18
-
CSI 1.98rCSI 1.48%PRS 52.46
-
CSI 1.94rCSI 3.74%PRS 68.09
-
CSI 1.93rCSI 4.12%PRS 53.29
-
CSI 1.91rCSI 3.43%PRS 32.44
-
CSI 1.9rCSI 1.26%PRS 42.32
-
CSI 1.89rCSI 1.98%PRS 38.83
-
CSI 1.89rCSI 1.74%PRS 44.87
-
CSI 1.89rCSI 3.79%PRS 29.37
-
CSI 1.86rCSI 1.41%PRS 49.74
-
CSI 1.83rCSI 2.06%PRS 54.06
-
CSI 1.83rCSI 1.36%PRS 56.45
-
CSI 1.81rCSI 2.6%PRS 46.04
-
CSI 1.81rCSI 3.45%PRS 54.73
-
CSI 1.79rCSI 2.4%PRS 46.09
-
CSI 1.79rCSI 3.19%PRS 54.25
-
CSI 1.77rCSI 2.41%PRS 42.66
-
CSI 1.75rCSI 1.83%PRS 38.13
-
CSI 1.71rCSI 1.51%PRS 28.77
-
CSI 1.71rCSI 1.52%PRS 37.6
-
CSI 1.63rCSI 2.86%PRS 31.43
-
CSI 1.58rCSI 6.14%PRS 57.7
-
CSI 1.57rCSI 3.26%PRS 36.75
-
CSI 1.57rCSI 2.71%PRS 30.09
-
CSI 1.56rCSI 1.83%PRS 52.6
-
CSI 1.55rCSI 4.02%PRS 34.96
-
CSI 1.53rCSI 1.4%PRS 52.78
-
CSI 1.53rCSI 3.05%PRS 56.05
-
CSI 1.53rCSI 2.33%PRS 35.34
-
CSI 1.51rCSI 2.33%PRS 36.4
-
CSI 1.49rCSI 1.23%PRS 39.01
-
CSI 1.49rCSI 3.93%PRS 44.93
-
CSI 1.48rCSI 2.43%PRS 43.15
-
CSI 1.48rCSI 2.53%PRS 47.48
-
CSI 1.44rCSI 1.67%PRS 29.48
-
CSI 1.44rCSI 1.8%PRS 47.29
-
CSI 1.43rCSI 3.27%PRS 32.8
-
CSI 1.43rCSI 2.18%PRS 55.81
-
CSI 1.42rCSI 1.77%PRS 49.25
-
CSI 1.41rCSI 1.69%PRS 24.63
-
CSI 1.4rCSI 1.87%PRS 39.98
-
CSI 1.39rCSI 1.44%PRS 43.62
-
CSI 1.39rCSI 5.61%PRS 36.92
-
CSI 1.37rCSI 4.05%PRS 42.5
-
CSI 1.36rCSI 1.18%PRS 46.64
-
CSI 1.35rCSI 1.42%PRS 35.82
-
CSI 1.35rCSI 1.61%PRS 57.86
-
CSI 1.34rCSI 1.67%PRS 23.37
-
CSI 1.33rCSI 3.17%PRS 50.7
-
CSI 1.33rCSI 3.68%PRS 35.6
-
CSI 1.32rCSI 1.22%PRS 39.32
-
CSI 1.31rCSI 2.7%PRS 60.94
-
CSI 1.3rCSI 1.17%PRS 35.15
-
CSI 1.3rCSI 2.91%PRS 25.22
-
CSI 1.28rCSI 1.96%PRS 46.92
-
CSI 1.25rCSI 1.47%PRS 42.07
-
CSI 1.19rCSI 1.89%PRS 32.42
-
CSI 1.16rCSI 3.33%PRS 54.52
-
CSI 1.15rCSI 1.15%PRS 33.04
-
CSI 0.3rCSI 1.7%PRS 49.3%
-
CSI 0.4rCSI 1.4%PRS 23.7%
-
CSI 0.5rCSI 1.1%PRS 37.3%
-
CSI 0.5rCSI 1.4%PRS 40.9%
-
CSI 0.5rCSI 2.4%PRS 48.5%
-
CSI 0.5rCSI 1.5%PRS 53.3%
-
CSI 0.5rCSI 2.9%PRS 53.4%
-
CSI 0.6rCSI 0.5%PRS 42.0%
-
CSI 0.6rCSI 1.3%PRS 28.3%
-
CSI 0.6rCSI 2.2%PRS 25.6%
-
CSI 0.6rCSI 2.6%PRS 58.0%
-
CSI 0.6rCSI 1.7%PRS 53.0%
-
CSI 0.6rCSI 2.0%PRS 25.7%
-
CSI 0.7rCSI 1.6%PRS 24.0%
-
CSI 0.7rCSI 1.1%PRS 30.2%
-
CSI 0.7rCSI 3.2%PRS 36.9%
-
CSI 0.7rCSI 1.9%PRS 46.9%
-
CSI 0.8rCSI 1.0%PRS 56.9%
-
CSI 0.8rCSI 1.4%PRS 36.6%
-
CSI 0.8rCSI 0.7%PRS 59.7%
-
CSI 0.9rCSI 1.2%PRS 50.9%
-
CSI 0.9rCSI 3.9%PRS 33.0%
-
CSI 0.9rCSI 1.2%PRS 25.5%
-
CSI 1.0rCSI 2.2%PRS 44.2%
-
CSI 1.0rCSI 0.8%PRS 36.7%
-
CSI 1.0rCSI 1.7%PRS 41.4%
-
CSI 1.1rCSI 0.9%PRS 38.7%
-
CSI 1.1rCSI 2.8%PRS 30.1%
-
CSI 1.1rCSI 2.4%PRS 47.9%
-
CSI 1.1rCSI 1.5%PRS 32.9%
-
CSI 1.1rCSI 3.7%PRS 41.8%
-
CSI 1.2rCSI 1.2%PRS 33.0%
-
CSI 1.2rCSI 3.3%PRS 54.5%
-
CSI 1.2rCSI 1.9%PRS 32.4%
-
CSI 1.3rCSI 1.5%PRS 42.1%
-
CSI 1.3rCSI 2.0%PRS 46.9%
-
CSI 1.3rCSI 2.9%PRS 25.2%
-
CSI 1.3rCSI 1.2%PRS 35.2%
-
CSI 1.3rCSI 2.7%PRS 60.9%
-
CSI 1.3rCSI 1.2%PRS 39.3%
-
CSI 1.3rCSI 3.7%PRS 35.6%
-
CSI 1.3rCSI 3.2%PRS 50.7%
-
CSI 1.3rCSI 1.7%PRS 23.4%
-
CSI 1.4rCSI 1.6%PRS 57.9%
-
CSI 1.4rCSI 1.4%PRS 35.8%
-
CSI 1.4rCSI 1.2%PRS 46.6%
-
CSI 1.4rCSI 4.1%PRS 42.5%
-
CSI 1.4rCSI 5.6%PRS 36.9%
-
CSI 1.4rCSI 1.4%PRS 43.6%
-
CSI 1.4rCSI 1.9%PRS 40.0%
-
CSI 1.4rCSI 1.7%PRS 24.6%
-
CSI 1.4rCSI 1.8%PRS 49.3%
-
CSI 1.4rCSI 2.2%PRS 55.8%
-
CSI 1.4rCSI 3.3%PRS 32.8%
-
CSI 1.4rCSI 1.8%PRS 47.3%
-
CSI 1.4rCSI 1.7%PRS 29.5%
-
CSI 1.5rCSI 2.5%PRS 47.5%
-
CSI 1.5rCSI 2.4%PRS 43.2%
-
CSI 1.5rCSI 3.9%PRS 44.9%
-
CSI 1.5rCSI 1.2%PRS 39.0%
-
CSI 1.5rCSI 2.3%PRS 36.4%
-
CSI 1.5rCSI 2.3%PRS 35.3%
-
CSI 1.5rCSI 3.1%PRS 56.1%
-
CSI 1.5rCSI 1.4%PRS 52.8%
-
CSI 1.6rCSI 4.0%PRS 35.0%
-
CSI 1.6rCSI 1.8%PRS 52.6%
-
CSI 1.6rCSI 2.7%PRS 30.1%
-
CSI 1.6rCSI 3.3%PRS 36.8%
-
CSI 1.6rCSI 6.1%PRS 57.7%
-
CSI 1.6rCSI 2.9%PRS 31.4%
-
CSI 1.7rCSI 1.5%PRS 37.6%
-
CSI 1.7rCSI 1.5%PRS 28.8%
-
CSI 1.8rCSI 1.8%PRS 38.1%
-
CSI 1.8rCSI 2.4%PRS 42.7%
-
CSI 1.8rCSI 3.2%PRS 54.3%
-
CSI 1.8rCSI 2.4%PRS 46.1%
-
CSI 1.8rCSI 3.5%PRS 54.7%
-
CSI 1.8rCSI 2.6%PRS 46.0%
-
CSI 1.8rCSI 1.4%PRS 56.5%
-
CSI 1.8rCSI 2.1%PRS 54.1%
-
CSI 1.9rCSI 1.4%PRS 49.7%
-
CSI 1.9rCSI 3.8%PRS 29.4%
-
CSI 1.9rCSI 1.7%PRS 44.9%
-
CSI 1.9rCSI 2.0%PRS 38.8%
-
CSI 1.9rCSI 1.3%PRS 42.3%
-
CSI 1.9rCSI 3.4%PRS 32.4%
-
CSI 1.9rCSI 4.1%PRS 53.3%
-
CSI 1.9rCSI 3.7%PRS 68.1%
-
CSI 2.0rCSI 1.5%PRS 52.5%
-
CSI 2.0rCSI 1.6%PRS 38.2%
-
CSI 2.0rCSI 3.4%PRS 59.2%
-
CSI 2.0rCSI 1.2%PRS 51.8%
-
CSI 2.0rCSI 1.6%PRS 44.2%
-
CSI 2.0rCSI 1.9%PRS 39.3%
-
CSI 2.1rCSI 4.7%PRS 37.7%
-
CSI 2.1rCSI 3.0%PRS 48.2%
-
CSI 2.2rCSI 1.5%PRS 50.2%
-
CSI 2.2rCSI 2.0%PRS 38.0%
-
CSI 2.2rCSI 1.6%PRS 50.8%
-
CSI 2.2rCSI 3.4%PRS 42.6%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1467043720
Symbol: CD11B_HUMAN
Name: Cyclin-dependent kinase 11B
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2217177
Title: Increased expression of a 58-kDa protein kinase leads to changes in the CHO cell cycle.
PubMed ID: 2217177
PubMed ID: 2006197
PubMed ID: 1639388
Title: Structure and expression of the human p58clk-1 protein kinase chromosomal gene.
PubMed ID: 1639388
PubMed ID: 8195233
Title: Molecular cloning and expression of alternatively spliced PITSLRE protein kinase isoforms.
PubMed ID: 8195233
PubMed ID: 9750192
Title: Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2.
PubMed ID: 9750192
DOI: 10.1101/gr.8.9.929
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9580558
Title: The RNP protein, RNPS1, associates with specific isoforms of the p34cdc2-related PITSLRE protein kinases in vivo.
PubMed ID: 9580558
PubMed ID: 10882096
Title: Identification and characterization of a novel cell cycle-regulated internal ribosome entry site.
PubMed ID: 10882096
PubMed ID: 14511641
Title: The cyclin-dependent kinase 11(p46) isoform interacts with RanBPM.
PubMed ID: 14511641
PubMed ID: 12501247
PubMed ID: 12624090
Title: The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis.
PubMed ID: 12624090
PubMed ID: 15883043
Title: The cyclin-dependent kinase 11 interacts with 14-3-3 proteins.
PubMed ID: 15883043
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 16327805
Title: Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics.
PubMed ID: 16327805
DOI: 10.1038/nsmb1028
PubMed ID: 18216018
Title: Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: influence of cyclin L isoforms on splice site selection.
PubMed ID: 18216018
PubMed ID: 18220336
Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
PubMed ID: 18220336
DOI: 10.1021/pr0705441
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25965346
Title: SP-R210 (Myo18A) isoforms as intrinsic modulators of macrophage priming and activation.
PubMed ID: 25965346
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 34696162
Title: HSV-1 ICP22 Is a Selective Viral Repressor of Cellular RNA Polymerase II-Mediated Transcription Elongation.
PubMed ID: 34696162
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 795
- Mass: 92620
- Checksum: 8CCB0E688E66DF47
- Sequence:
MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE GELRDHRMEI TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKAHHR KDEKRKEKRR HRSHSAEGGK HARVKEKERE HERRKRHREE QDKARREWER QKRREMAREH SRRERDRLEQ LERKRERERK MREQQKEQRE QKERERRAEE RRKEREARRE VSAHHRTMRE DYSDKVKASH WSRSPPRPPR ERFELGDGRK PGEARPAPAQ KPAQLKEEKM EERDLLSDLQ DISDSERKTS SAESSSAESG SGSEEEEEEE EEEEEEGSTS EESEEEEEEE EEEEEETGSN SEEASEQSAE EVSEEEMSED EERENENHLL VVPESRFDRD SGESEEAEEE VGEGTPQSSA LTEGDYVPDS PALSPIELKQ ELPKYLPALQ GCRSVEEFQC LNRIEEGTYG VVYRAKDKKT DEIVALKRLK MEKEKEGFPI TSLREINTIL KAQHPNIVTV REIVVGSNMD KIYIVMNYVE HDLKSLMETM KQPFLPGEVK TLMIQLLRGV KHLHDNWILH RDLKTSNLLL SHAGILKVGD FGLAREYGSP LKAYTPVVVT LWYRAPELLL GAKEYSTAVD MWSVGCIFGE LLTQKPLFPG KSEIDQINKV FKDLGTPSEK IWPGYSELPA VKKMTFSEHP YNNLRKRFGA LLSDQGFDLM NKFLTYFPGR RISAEDGLKH EYFRETPLPI DPSMFPTWPA KSEQQRVKRG TSPRPPEGGL GYSQLGDDDL KETGFHLTTT NQGASAAGPG FSLKF
Genular Protein ID: 2503595159
Symbol: B4DII1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 210
- Mass: 25014
- Checksum: 799B855A2F80FC75
- Sequence:
MSQSDDRDSK RDSLEEGELR DHRMEITIRN SPYRREDSME DRGEEDDSLA IKPPQQMSRK EKAHHRKDEK RKEKRRHRSH SAEGGKHARV KEKEREHERR KRHREEQDKA RREWERQKRR EMAREHSRRE SVCTSPNDER GLQRQSESQP LESQPASAAA GAVRVGRRPE ASKRRENGRK GPAVRLTGHQ RQREEDQLGR VLVSGIRLRF