Details for: CDK11B

Gene ID: 984

Symbol: CDK11B

Ensembl ID: ENSG00000248333

Description: cyclin dependent kinase 11B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 141.8880
    Cell Significance Index: -22.0700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 94.9759
    Cell Significance Index: -24.0900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 58.7805
    Cell Significance Index: -23.8800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 57.4851
    Cell Significance Index: -27.1400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 52.1594
    Cell Significance Index: -26.8300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 40.4607
    Cell Significance Index: -27.1500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.3890
    Cell Significance Index: -24.2400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.2984
    Cell Significance Index: -26.2600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.5339
    Cell Significance Index: -25.5400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.9069
    Cell Significance Index: -27.2600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.6385
    Cell Significance Index: -20.3900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.4471
    Cell Significance Index: -14.1100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.8287
    Cell Significance Index: 24.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.4562
    Cell Significance Index: 41.9600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2057
    Cell Significance Index: 131.1500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.0780
    Cell Significance Index: 56.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9042
    Cell Significance Index: 19.5900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8333
    Cell Significance Index: 37.7700
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.6748
    Cell Significance Index: 5.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6629
    Cell Significance Index: 16.5700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6177
    Cell Significance Index: 111.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5428
    Cell Significance Index: 66.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5307
    Cell Significance Index: 14.4500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5215
    Cell Significance Index: 51.5900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.4845
    Cell Significance Index: 4.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4703
    Cell Significance Index: 64.5900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4434
    Cell Significance Index: 11.8400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4324
    Cell Significance Index: 390.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4205
    Cell Significance Index: 83.4400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4071
    Cell Significance Index: 14.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4039
    Cell Significance Index: 26.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4012
    Cell Significance Index: 219.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3364
    Cell Significance Index: 39.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3150
    Cell Significance Index: 63.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2953
    Cell Significance Index: 84.9600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2871
    Cell Significance Index: 126.9200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2770
    Cell Significance Index: 4.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2407
    Cell Significance Index: 15.1700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2215
    Cell Significance Index: 36.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2117
    Cell Significance Index: 9.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2029
    Cell Significance Index: 10.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2022
    Cell Significance Index: 9.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1981
    Cell Significance Index: 25.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1739
    Cell Significance Index: 33.1000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1645
    Cell Significance Index: 1.5200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1545
    Cell Significance Index: 290.8600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.1492
    Cell Significance Index: 1.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1456
    Cell Significance Index: 4.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1265
    Cell Significance Index: 8.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1080
    Cell Significance Index: 38.7400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1061
    Cell Significance Index: 8.1400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0743
    Cell Significance Index: 3.9000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0433
    Cell Significance Index: 27.5300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0342
    Cell Significance Index: 0.7100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0324
    Cell Significance Index: 0.6900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0298
    Cell Significance Index: 45.9000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0237
    Cell Significance Index: 43.7000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0104
    Cell Significance Index: 14.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0036
    Cell Significance Index: 0.6200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0021
    Cell Significance Index: -1.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0052
    Cell Significance Index: -0.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0062
    Cell Significance Index: -0.1300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0095
    Cell Significance Index: -0.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0119
    Cell Significance Index: -8.6900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0146
    Cell Significance Index: -6.6500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0178
    Cell Significance Index: -0.6200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0236
    Cell Significance Index: -0.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0267
    Cell Significance Index: -1.6400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0294
    Cell Significance Index: -21.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0397
    Cell Significance Index: -5.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0431
    Cell Significance Index: -24.3100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0462
    Cell Significance Index: -28.8500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0562
    Cell Significance Index: -1.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0691
    Cell Significance Index: -7.0600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0782
    Cell Significance Index: -1.3400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0834
    Cell Significance Index: -2.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0841
    Cell Significance Index: -6.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0972
    Cell Significance Index: -14.1300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1039
    Cell Significance Index: -1.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1306
    Cell Significance Index: -14.9600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1349
    Cell Significance Index: -15.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1438
    Cell Significance Index: -30.2900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1661
    Cell Significance Index: -2.7800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1806
    Cell Significance Index: -7.9900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1984
    Cell Significance Index: -13.3400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2426
    Cell Significance Index: -9.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2446
    Cell Significance Index: -25.4700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2764
    Cell Significance Index: -1.6700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2811
    Cell Significance Index: -7.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2878
    Cell Significance Index: -22.7900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3007
    Cell Significance Index: -8.6200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3089
    Cell Significance Index: -7.9400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3418
    Cell Significance Index: -7.3100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3689
    Cell Significance Index: -4.0100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3708
    Cell Significance Index: -4.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3809
    Cell Significance Index: -23.3500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3889
    Cell Significance Index: -5.7400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4767
    Cell Significance Index: -14.0400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.5082
    Cell Significance Index: -8.7600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5099
    Cell Significance Index: -13.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CDK11B is a member of the cyclin-dependent kinase (CDK) family, which is essential for the regulation of the cell cycle. CDK11B is specifically implicated in the G2/M transition and the mitotic cell cycle, suggesting its role in promoting cell proliferation and division. The kinase activity of CDK11B is also linked to the recruitment of mitotic centrosome proteins and complexes, highlighting its involvement in the proper formation and function of the mitotic spindle. In addition to its role in the cell cycle, CDK11B is also implicated in apoptosis, a process of programmed cell death. The kinase activity of CDK11B is required for the regulation of DNA-templated transcription, suggesting its role in the regulation of gene expression. **Pathways and Functions** CDK11B is involved in multiple signaling pathways, including: 1. **Apoptotic process**: CDK11B regulates apoptosis by phosphorylating and activating pro-apoptotic proteins, thereby promoting cell death. 2. **Cell cycle**: CDK11B is essential for the progression of the cell cycle, particularly during the G2/M transition and the mitotic cell cycle. 3. **Centrosome maturation**: CDK11B regulates the maturation of centrosomes, which are essential for the formation of the mitotic spindle. 4. **Cyclin-dependent protein serine/threonine kinase activity**: CDK11B is a member of the cyclin-dependent kinase family and regulates the phosphorylation of downstream targets. 5. **Protein binding**: CDK11B interacts with various proteins, including cyclins, CDKs, and transcription factors, to regulate cellular processes. **Clinical Significance** CDK11B has been implicated in several diseases, including: 1. **Cancer**: Overexpression of CDK11B has been observed in various types of cancer, including breast, lung, and pancreatic cancer, suggesting its role in tumorigenesis. 2. **Neurodegenerative diseases**: CDK11B has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, suggesting its role in the regulation of neuronal function and survival. 3. **Developmental disorders**: CDK11B is required for the proper development and differentiation of multiple cell types, including oogonial cells and primordial germ cells, suggesting its role in developmental disorders such as infertility and developmental delay. In conclusion, CDK11B is a serine/threonine kinase that plays a crucial role in regulating various cellular processes, including cell cycle progression, apoptosis, and transcription. Its significance in human disease highlights the importance of further research into the functions and regulation of CDK11B.

Genular Protein ID: 1467043720

Symbol: CD11B_HUMAN

Name: Cyclin-dependent kinase 11B

UniProtKB Accession Codes:

P21127 B7ZVY7 J3KTL7 J3QR29 J3QR44 O95265 Q12817 Q12818 Q12819 Q12820 Q12822 Q8N530 Q9NZS5 Q9UBJ0 Q9UBQ1 Q9UBR0 Q9UNY2 Q9UP57 Q9UP58 Q9UP59

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CPTAC 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 ComplexPortal 4 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 3 EMBL 80 Ensembl 3 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 6 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 10 Pumba 1 RNAct 1 Reactome 1 RefSeq 7 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2217177

Title: Increased expression of a 58-kDa protein kinase leads to changes in the CHO cell cycle.

PubMed ID: 2217177

DOI: 10.1073/pnas.87.19.7467

PubMed ID: 2006197

Title:

PubMed ID: 2006197

DOI: 10.1073/pnas.88.6.2612-e

PubMed ID: 1639388

Title: Structure and expression of the human p58clk-1 protein kinase chromosomal gene.

PubMed ID: 1639388

DOI: 10.1016/0888-7543(92)90132-c

PubMed ID: 8195233

Title: Molecular cloning and expression of alternatively spliced PITSLRE protein kinase isoforms.

PubMed ID: 8195233

DOI: 10.1016/s0021-9258(17)40749-6

PubMed ID: 9750192

Title: Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2.

PubMed ID: 9750192

DOI: 10.1101/gr.8.9.929

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9580558

Title: The RNP protein, RNPS1, associates with specific isoforms of the p34cdc2-related PITSLRE protein kinases in vivo.

PubMed ID: 9580558

DOI: 10.1242/jcs.111.11.1495

PubMed ID: 10882096

Title: Identification and characterization of a novel cell cycle-regulated internal ribosome entry site.

PubMed ID: 10882096

DOI: 10.1016/s1097-2765(00)80239-7

PubMed ID: 14511641

Title: The cyclin-dependent kinase 11(p46) isoform interacts with RanBPM.

PubMed ID: 14511641

DOI: 10.1016/j.bbrc.2003.08.116

PubMed ID: 12501247

Title: CDK11 complexes promote pre-mRNA splicing.

PubMed ID: 12501247

DOI: 10.1074/jbc.m210057200

PubMed ID: 12624090

Title: The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis.

PubMed ID: 12624090

DOI: 10.1074/jbc.m300818200

PubMed ID: 15883043

Title: The cyclin-dependent kinase 11 interacts with 14-3-3 proteins.

PubMed ID: 15883043

DOI: 10.1016/j.bbrc.2005.04.078

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16327805

Title: Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics.

PubMed ID: 16327805

DOI: 10.1038/nsmb1028

PubMed ID: 18216018

Title: Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: influence of cyclin L isoforms on splice site selection.

PubMed ID: 18216018

DOI: 10.1074/jbc.m708188200

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25965346

Title: SP-R210 (Myo18A) isoforms as intrinsic modulators of macrophage priming and activation.

PubMed ID: 25965346

DOI: 10.1371/journal.pone.0126576

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 34696162

Title: HSV-1 ICP22 Is a Selective Viral Repressor of Cellular RNA Polymerase II-Mediated Transcription Elongation.

PubMed ID: 34696162

DOI: 10.3390/vaccines9101054

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 795
  • Mass: 92620
  • Checksum: 8CCB0E688E66DF47
  • Sequence:
    • MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE GELRDHRMEI 
TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKAHHR KDEKRKEKRR HRSHSAEGGK 
HARVKEKERE HERRKRHREE QDKARREWER QKRREMAREH SRRERDRLEQ LERKRERERK 
MREQQKEQRE QKERERRAEE RRKEREARRE VSAHHRTMRE DYSDKVKASH WSRSPPRPPR 
ERFELGDGRK PGEARPAPAQ KPAQLKEEKM EERDLLSDLQ DISDSERKTS SAESSSAESG 
SGSEEEEEEE EEEEEEGSTS EESEEEEEEE EEEEEETGSN SEEASEQSAE EVSEEEMSED 
EERENENHLL VVPESRFDRD SGESEEAEEE VGEGTPQSSA LTEGDYVPDS PALSPIELKQ 
ELPKYLPALQ GCRSVEEFQC LNRIEEGTYG VVYRAKDKKT DEIVALKRLK MEKEKEGFPI 
TSLREINTIL KAQHPNIVTV REIVVGSNMD KIYIVMNYVE HDLKSLMETM KQPFLPGEVK 
TLMIQLLRGV KHLHDNWILH RDLKTSNLLL SHAGILKVGD FGLAREYGSP LKAYTPVVVT 
LWYRAPELLL GAKEYSTAVD MWSVGCIFGE LLTQKPLFPG KSEIDQINKV FKDLGTPSEK 
IWPGYSELPA VKKMTFSEHP YNNLRKRFGA LLSDQGFDLM NKFLTYFPGR RISAEDGLKH 
EYFRETPLPI DPSMFPTWPA KSEQQRVKRG TSPRPPEGGL GYSQLGDDDL KETGFHLTTT 
NQGASAAGPG FSLKF

Genular Protein ID: 2503595159

Symbol: B4DII1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DII1

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 210
  • Mass: 25014
  • Checksum: 799B855A2F80FC75
  • Sequence:
    • MSQSDDRDSK RDSLEEGELR DHRMEITIRN SPYRREDSME DRGEEDDSLA IKPPQQMSRK 
EKAHHRKDEK RKEKRRHRSH SAEGGKHARV KEKEREHERR KRHREEQDKA RREWERQKRR 
EMAREHSRRE SVCTSPNDER GLQRQSESQP LESQPASAAA GAVRVGRRPE ASKRRENGRK 
GPAVRLTGHQ RQREEDQLGR VLVSGIRLRF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.