ELMO1 | ENSG00000155849 | NCBI 9844

Details for: ELMO1

Gene ID: 9844

Symbol: ELMO1

Ensembl ID: ENSG00000155849

Description: engulfment and cell motility 1

Associated with

Disease
(R-HSA-1643685)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Hiv infection
(R-HSA-162906)
Host interactions of hiv factors
(R-HSA-162909)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania phagocytosis
(R-HSA-9664417)
Nef and signal transduction
(R-HSA-164944)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Ptk6 regulates rho gtpases, ras gtpase and map kinases
(R-HSA-8849471)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by ptk6
(R-HSA-8848021)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by vegf
(R-HSA-194138)
Signal transduction
(R-HSA-162582)
The role of nef in hiv-1 replication and disease pathogenesis
(R-HSA-164952)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Viral infection pathways
(R-HSA-9824446)
Actin cytoskeleton organization
(GO:0030036)
Actin filament organization
(GO:0007015)
Apoptotic process
(GO:0006915)
Cell motility
(GO:0048870)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Guanyl-nucleotide exchange factor activity
(GO:0005085)
Guanyl-nucleotide exchange factor complex
(GO:0032045)
Membrane
(GO:0016020)
Phagocytosis, engulfment
(GO:0006911)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Rac protein signal transduction
(GO:0016601)
Sh3 domain binding
(GO:0017124)

Other Information

Proteins

Engulfment and cell motility protein 1

Genular Protein ID: 3097563350

Symbol: ELMO1_HUMAN

Name: Engulfment and cell motility protein 1

UniProtKB Accession Codes:

Q92556 A4D1X6 Q29R79 Q6ZTJ0 Q96PB0 Q9H0I1

Database IDs:

Citations:

PubMed ID: 11595183

Title: CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration.

PubMed ID: 11595183

DOI: 10.1016/s0092-8674(01)00520-7

PubMed ID: 9179496

Title: Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins.

PubMed ID: 9179496

DOI: 10.1093/dnares/4.1.53

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12029088

Title: Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1.

PubMed ID: 12029088

DOI: 10.1074/jbc.m202783200

PubMed ID: 12134158

Title: Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex.

PubMed ID: 12134158

DOI: 10.1038/ncb824

PubMed ID: 15952790

Title: Identification of tyrosine residues on ELMO1 that are phosphorylated by the Src-family kinase Hck.

PubMed ID: 15952790

DOI: 10.1021/bi0500832

PubMed ID: 17881735

Title: Interaction of ezrin with the novel guanine nucleotide exchange factor PLEKHG6 promotes RhoG-dependent apical cytoskeleton rearrangements in epithelial cells.

PubMed ID: 17881735

DOI: 10.1091/mbc.e06-12-1144

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24567399

Title: G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates.

PubMed ID: 24567399

DOI: 10.1073/pnas.1313886111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 20869035

Title: BMPER mutation in diaphanospondylodysostosis identified by ancestral autozygosity mapping and targeted high-throughput sequencing.

PubMed ID: 20869035

DOI: 10.1016/j.ajhg.2010.08.015

Sequence Information:

Length: 727
Mass: 83829
Checksum: 053DCA73D2B0A4C6
Sequence:

MPPPADIVKV AIEWPGAYPK LMEIDQKKPL SAIIKEVCDG WSLANHEYFA LQHADSSNFY 
ITEKNRNEIK NGTILRLTTS PAQNAQQLHE RIQSSSMDAK LEALKDLASL SRDVTFAQEF 
INLDGISLLT QMVESGTERY QKLQKIMKPC FGDMLSFTLT AFVELMDHGI VSWDTFSVAF 
IKKIASFVNK SAIDISILQR SLAILESMVL NSHDLYQKVA QEITIGQLIP HLQGSDQEIQ 
TYTIAVINAL FLKAPDERRQ EMANILAQKQ LRSIILTHVI RAQRAINNEM AHQLYVLQVL 
TFNLLEDRMM TKMDPQDQAQ RDIIFELRRI AFDAESEPNN SSGSMEKRKS MYTRDYKKLG 
FINHVNPAMD FTQTPPGMLA LDNMLYFAKH HQDAYIRIVL ENSSREDKHE CPFGRSSIEL 
TKMLCEILKV GELPSETCND FHPMFFTHDR SFEEFFCICI QLLNKTWKEM RATSEDFNKV 
MQVVKEQVMR ALTTKPSSLD QFKSKLQNLS YTEILKIRQS ERMNQEDFQS RPILELKEKI 
QPEILELIKQ QRLNRLVEGT CFRKLNARRR QDKFWYCRLS PNHKVLHYGD LEESPQGEVP 
HDSLQDKLPV ADIKAVVTGK DCPHMKEKGA LKQNKEVLEL AFSILYDSNC QLNFIAPDKH 
EYCIWTDGLN ALLGKDMMSD LTRNDLDTLL SMEIKLRLLD LENIQIPDAP PPIPKEPSNY 
DFVYDCN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ELMO1

Associated with

Other Information

CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration. PubMed ID: 11595183

Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. PubMed ID: 9179496

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. PubMed ID: 11230166

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human chromosome 7: DNA sequence and biology. PubMed ID: 12690205

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1. PubMed ID: 12029088

Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex. PubMed ID: 12134158

Identification of tyrosine residues on ELMO1 that are phosphorylated by the Src-family kinase Hck. PubMed ID: 15952790

Interaction of ezrin with the novel guanine nucleotide exchange factor PLEKHG6 promotes RhoG-dependent apical cytoskeleton rearrangements in epithelial cells. PubMed ID: 17881735

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates. PubMed ID: 24567399

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

BMPER mutation in diaphanospondylodysostosis identified by ancestral autozygosity mapping and targeted high-throughput sequencing. PubMed ID: 20869035