GAB2 | ENSG00000033327 | NCBI 9846

Details for: GAB2

Gene ID: 9846

Symbol: GAB2

Ensembl ID: ENSG00000033327

Description: GRB2 associated binding protein 2

Associated with

Axon guidance
(R-HSA-422475)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Cytokine signaling in immune system
(R-HSA-1280215)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fgfr1 mutant receptor activation
(R-HSA-1839124)
Flt3 signaling
(R-HSA-9607240)
Flt3 signaling in disease
(R-HSA-9682385)
Igf1r signaling cascade
(R-HSA-2428924)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Insulin receptor signalling cascade
(R-HSA-74751)
Interleukin-2 family signaling
(R-HSA-451927)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-HSA-512988)
Interleukin-15 signaling
(R-HSA-8983432)
Interleukin receptor shc signaling
(R-HSA-912526)
Intracellular signaling by second messengers
(R-HSA-9006925)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Nervous system development
(R-HSA-9675108)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k cascade
(R-HSA-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Ret signaling
(R-HSA-8853659)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Signaling by csf1 (m-csf) in myeloid cells
(R-HSA-9680350)
Signaling by csf3 (g-csf)
(R-HSA-9674555)
Signaling by cytosolic fgfr1 fusion mutants
(R-HSA-1839117)
Signaling by fgfr1 in disease
(R-HSA-5655302)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by flt3 fusion proteins
(R-HSA-9703465)
Signaling by flt3 itd and tkd mutants
(R-HSA-9703648)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by interleukins
(R-HSA-449147)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by scf-kit
(R-HSA-1433557)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Stat5 activation
(R-HSA-9645135)
Stat5 activation downstream of flt3 itd mutants
(R-HSA-9702518)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Membrane raft
(GO:0045121)
Osteoclast differentiation
(GO:0030316)
Phosphatidylinositol-3,4,5-trisphosphate binding
(GO:0005547)
Phosphatidylinositol-3,4-bisphosphate binding
(GO:0043325)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Plasma membrane
(GO:0005886)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of mast cell degranulation
(GO:0043306)
Protein binding
(GO:0005515)
Signal transduction
(GO:0007165)
Transmembrane receptor protein tyrosine kinase adaptor activity
(GO:0005068)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)

Other Information

Proteins

GRB2-associated-binding protein 2

Genular Protein ID: 2720071261

Symbol: GAB2_HUMAN

Name: GRB2-associated-binding protein 2

UniProtKB Accession Codes:

Q9UQC2 A2RRM2 A6NEW9 A7MD36 O60317

Database IDs:

Citations:

PubMed ID: 10068651

Title: Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors.

PubMed ID: 10068651

PubMed ID: 9628581

Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9628581

DOI: 10.1093/dnares/5.1.31

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15010462

Title: Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells.

PubMed ID: 15010462

DOI: 10.1074/jbc.m305783200

PubMed ID: 15750601

Title: The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis.

PubMed ID: 15750601

DOI: 10.1038/nm1203

PubMed ID: 19172738

Title: Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein.

PubMed ID: 19172738

DOI: 10.1038/emboj.2008.159

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23478294

Title: Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis.

PubMed ID: 23478294

DOI: 10.1038/cr.2013.33

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 19523899

Title: Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2.

PubMed ID: 19523899

DOI: 10.1016/j.str.2009.03.017

Sequence Information:

Length: 676
Mass: 74458
Checksum: 107623FD07D884C9
Sequence:

MSGGGDVVCT GWLRKSPPEK KLRRYAWKKR WFILRSGRMS GDPDVLEYYK NDHSKKPLRI 
INLNFCEQVD AGLTFNKKEL QDSFVFDIKT SERTFYLVAE TEEDMNKWVQ SICQICGFNQ 
AEESTDSLRN VSSAGHGPRS SPAELSSSSQ HLLRERKSSA PSHSSQPTLF TFEPPVSNHM 
QPTLSTSAPQ EYLYLHQCIS RRAENARSAS FSQGTRASFL MRSDTAVQKL AQGNGHCVNG 
ISGQVHGFYS LPKPSRHNTE FRDSTYDLPR SLASHGHTKG SLTGSETDNE DVYTFKTPSN 
TLCREFGDLL VDNMDVPATP LSAYQIPRTF TLDKNHNAMT VATPGDSAIA PPPRPPKPSQ 
AETPRWGSPQ QRPPISENSR SVAATIPRRN TLPAMDNSRL HRASSCETYE YPQRGGESAG 
RSAESMSDGV GSFLPGKMIV GRSDSTNSED NYVPMNPGSS TLLAMERAGD NSQSVYIPMS 
PGAHHFDSLG YPSTTLPVHR GPSRGSEIQP PPVNRNLKPD RKAKPTPLDL RNNTVIDELP 
FKSPITKSWS RANHTFNSSS SQYCRPISTQ SITSTDSGDS EENYVPMQNP VSASPVPSGT 
NSPAPKKSTG SVDYLALDFQ PSSPSPHRKP STSSVTSDEK VDYVQVDKEK TQALQNTMQE 
WTDVRQSSEP SKGAKL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: GAB2

Associated with

Other Information

Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors. PubMed ID: 10068651

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. PubMed ID: 9628581

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells. PubMed ID: 15010462

The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis. PubMed ID: 15750601

Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. PubMed ID: 19172738

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Initial characterization of the human central proteome. PubMed ID: 21269460

Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis. PubMed ID: 23478294

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. PubMed ID: 19523899