Details for: GAB2

Gene ID: 9846

Symbol: GAB2

Ensembl ID: ENSG00000033327

Description: GRB2 associated binding protein 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 4.52
    Marker Score: 6,361
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 3.74
    Marker Score: 1,351
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 3.07
    Marker Score: 1,525
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.6
    Marker Score: 6,214
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.4
    Marker Score: 2,984
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 2.35
    Marker Score: 775
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.31
    Marker Score: 77,866
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.29
    Marker Score: 87,053
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.21
    Marker Score: 9,143
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.19
    Marker Score: 4,222
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.13
    Marker Score: 78,407
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.08
    Marker Score: 1,164
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.05
    Marker Score: 1,014
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.98
    Marker Score: 1,102
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.96
    Marker Score: 9,076
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.92
    Marker Score: 19,822
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.9
    Marker Score: 37,864
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.86
    Marker Score: 29,892
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.86
    Marker Score: 1,608
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.83
    Marker Score: 39,099
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.79
    Marker Score: 523
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.78
    Marker Score: 15,306
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.75
    Marker Score: 26,180
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.73
    Marker Score: 3,526
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.73
    Marker Score: 16,465
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.69
    Marker Score: 619
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.69
    Marker Score: 104,075
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.64
    Marker Score: 1,081
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.64
    Marker Score: 1,343
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.6
    Marker Score: 670
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.59
    Marker Score: 12,212
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.59
    Marker Score: 925
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.59
    Marker Score: 6,471
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.58
    Marker Score: 1,372
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.55
    Marker Score: 498
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.54
    Marker Score: 2,373
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.51
    Marker Score: 5,852
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.51
    Marker Score: 1,741
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.49
    Marker Score: 6,219
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,970
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.39
    Marker Score: 755
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.39
    Marker Score: 1,717
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.39
    Marker Score: 472
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.38
    Marker Score: 357
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.33
    Marker Score: 364
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.29
    Marker Score: 497
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.29
    Marker Score: 2,158
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.25
    Marker Score: 2,955
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.23
    Marker Score: 4,127
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.22
    Marker Score: 19,064
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.18
    Marker Score: 6,197
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.17
    Marker Score: 773
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.14
    Marker Score: 25,372
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.13
    Marker Score: 360
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.12
    Marker Score: 657
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.12
    Marker Score: 375
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.11
    Marker Score: 1,934
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.09
    Marker Score: 2,633
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.08
    Marker Score: 339
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.08
    Marker Score: 10,144
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.08
    Marker Score: 1,028
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.08
    Marker Score: 398
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.07
    Marker Score: 281
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.05
    Marker Score: 18,683
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.05
    Marker Score: 587
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.04
    Marker Score: 1,104
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.01
    Marker Score: 6,614
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1
    Marker Score: 6,026
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,759
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,984
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1
    Marker Score: 996
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,402
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.98
    Marker Score: 1,181
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.97
    Marker Score: 565
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.97
    Marker Score: 2,730
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.96
    Marker Score: 1,201
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.96
    Marker Score: 1,398
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 452
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,409
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.94
    Marker Score: 240
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.92
    Marker Score: 647
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,729
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.9
    Marker Score: 1,910
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5,037
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.88
    Marker Score: 425
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.87
    Marker Score: 1,057
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.86
    Marker Score: 446
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.84
    Marker Score: 46,853
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.82
    Marker Score: 433
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 620
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.81
    Marker Score: 3,398
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.81
    Marker Score: 2,010
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 322
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.8
    Marker Score: 4,296
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.79
    Marker Score: 378
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.79
    Marker Score: 379
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.78
    Marker Score: 295

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** GAB2 is a 65-kDa protein that contains two SH2 domains and one SH3 domain. These domains enable GAB2 to interact with various signaling molecules, including receptor tyrosine kinases, phosphatidylinositol 3-kinase (PI3K), and Akt. GAB2's ability to bind to multiple partners allows it to modulate the activity of multiple signaling pathways, making it a key regulator of cellular responses to various stimuli. GAB2's expression is tissue-specific, with high levels found in immune cells, neurons, and epithelial cells. **Pathways and Functions** GAB2 is involved in several key signaling pathways, including: 1. **PI3K/Akt signaling pathway**: GAB2 binds to PI3K and Akt, modulating their activity and contributing to cell survival, proliferation, and differentiation. 2. **Cytokine signaling**: GAB2 interacts with cytokine receptors, such as IL-2R and IL-15R, to regulate cytokine-mediated responses. 3. **Receptor tyrosine kinase signaling**: GAB2 binds to receptor tyrosine kinases, such as Flt3 and FGFR1, to modulate their activity and regulate cell proliferation and differentiation. 4. **Immune system signaling**: GAB2 is expressed in immune cells, where it plays a role in regulating immune responses, including mast cell degranulation and immune cell proliferation. **Clinical Significance** GAB2's involvement in disease has been implicated in various conditions, including: 1. **Cancer**: GAB2's aberrant signaling can contribute to tumorigenesis, tumor progression, and resistance to therapy. 2. **Immunological disorders**: GAB2's dysregulation has been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Neurological disorders**: GAB2's role in neuronal signaling and development has been implicated in neurological disorders, such as autism spectrum disorder and schizophrenia. 4. **Cardiovascular disease**: GAB2's involvement in cardiovascular signaling has been linked to cardiac dysfunction and atherosclerosis. In conclusion, GAB2 is a multifunctional adaptor protein that plays a crucial role in various cellular processes, including signal transduction, cell proliferation, and differentiation. Its dysregulation has been implicated in various diseases, highlighting the importance of GAB2 in maintaining cellular homeostasis and preventing disease.

Genular Protein ID: 2720071261

Symbol: GAB2_HUMAN

Name: GRB2-associated-binding protein 2

UniProtKB Accession Codes:

Q9UQC2 A2RRM2 A6NEW9 A7MD36 O60317

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 7 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 10 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 17 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10068651

Title: Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors.

PubMed ID: 10068651

PubMed ID: 9628581

Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9628581

DOI: 10.1093/dnares/5.1.31

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15010462

Title: Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells.

PubMed ID: 15010462

DOI: 10.1074/jbc.m305783200

PubMed ID: 15750601

Title: The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis.

PubMed ID: 15750601

DOI: 10.1038/nm1203

PubMed ID: 19172738

Title: Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein.

PubMed ID: 19172738

DOI: 10.1038/emboj.2008.159

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23478294

Title: Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis.

PubMed ID: 23478294

DOI: 10.1038/cr.2013.33

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 19523899

Title: Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2.

PubMed ID: 19523899

DOI: 10.1016/j.str.2009.03.017

Sequence Information:

  • Length: 676
  • Mass: 74458
  • Checksum: 107623FD07D884C9
  • Sequence:
    • MSGGGDVVCT GWLRKSPPEK KLRRYAWKKR WFILRSGRMS GDPDVLEYYK NDHSKKPLRI 
INLNFCEQVD AGLTFNKKEL QDSFVFDIKT SERTFYLVAE TEEDMNKWVQ SICQICGFNQ 
AEESTDSLRN VSSAGHGPRS SPAELSSSSQ HLLRERKSSA PSHSSQPTLF TFEPPVSNHM 
QPTLSTSAPQ EYLYLHQCIS RRAENARSAS FSQGTRASFL MRSDTAVQKL AQGNGHCVNG 
ISGQVHGFYS LPKPSRHNTE FRDSTYDLPR SLASHGHTKG SLTGSETDNE DVYTFKTPSN 
TLCREFGDLL VDNMDVPATP LSAYQIPRTF TLDKNHNAMT VATPGDSAIA PPPRPPKPSQ 
AETPRWGSPQ QRPPISENSR SVAATIPRRN TLPAMDNSRL HRASSCETYE YPQRGGESAG 
RSAESMSDGV GSFLPGKMIV GRSDSTNSED NYVPMNPGSS TLLAMERAGD NSQSVYIPMS 
PGAHHFDSLG YPSTTLPVHR GPSRGSEIQP PPVNRNLKPD RKAKPTPLDL RNNTVIDELP 
FKSPITKSWS RANHTFNSSS SQYCRPISTQ SITSTDSGDS EENYVPMQNP VSASPVPSGT 
NSPAPKKSTG SVDYLALDFQ PSSPSPHRKP STSSVTSDEK VDYVQVDKEK TQALQNTMQE 
WTDVRQSSEP SKGAKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.