Details for: ZNF518A

Gene ID: 9849

Symbol: ZNF518A

Ensembl ID: ENSG00000177853

Description: zinc finger protein 518A

Associated with

  • Chromatin organization
    (GO:0006325)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Metal ion binding
    (GO:0046872)
  • Nucleus
    (GO:0005634)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 3.79
    Marker Score: 50,400
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.61
    Marker Score: 1,265
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.46
    Marker Score: 52,559
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.36
    Marker Score: 3,175
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.11
    Marker Score: 8,821
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 2.09
    Marker Score: 5,901
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.07
    Marker Score: 2,501
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.05
    Marker Score: 600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.02
    Marker Score: 30,198
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2
    Marker Score: 39,839
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.96
    Marker Score: 74,345
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.94
    Marker Score: 7,489
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.92
    Marker Score: 14,729
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.91
    Marker Score: 70,443
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.89
    Marker Score: 1,683
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.84
    Marker Score: 17,330
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.81
    Marker Score: 1,059
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.78
    Marker Score: 1,174
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.78
    Marker Score: 109,348
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.7
    Marker Score: 7,055
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.7
    Marker Score: 16,156
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.68
    Marker Score: 485
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.67
    Marker Score: 14,358
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.67
    Marker Score: 1,841
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.66
    Marker Score: 1,912
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.66
    Marker Score: 3,191
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.63
    Marker Score: 1,258
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.58
    Marker Score: 920
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.58
    Marker Score: 7,301
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.58
    Marker Score: 2,265
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.55
    Marker Score: 4,434
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.54
    Marker Score: 810
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.52
    Marker Score: 4,076
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.5
    Marker Score: 786
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.5
    Marker Score: 51,881
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.47
    Marker Score: 545
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.44
    Marker Score: 456
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.43
    Marker Score: 800
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.42
    Marker Score: 410
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.42
    Marker Score: 2,192
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.39
    Marker Score: 3,047
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.39
    Marker Score: 1,322
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.38
    Marker Score: 3,314
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.38
    Marker Score: 1,107
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.37
    Marker Score: 1,712
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.37
    Marker Score: 573
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.35
    Marker Score: 1,454
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.34
    Marker Score: 542
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.33
    Marker Score: 746
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.33
    Marker Score: 1,421
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.32
    Marker Score: 417
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.3
    Marker Score: 1,317
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.29
    Marker Score: 468
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.29
    Marker Score: 639
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.24
    Marker Score: 662
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.21
    Marker Score: 1,520
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.18
    Marker Score: 454
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.18
    Marker Score: 817
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.16
    Marker Score: 772
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.14
    Marker Score: 1,211
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.14
    Marker Score: 1,014
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.14
    Marker Score: 2,380
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.13
    Marker Score: 310
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.13
    Marker Score: 1,896
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.13
    Marker Score: 4,009
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.12
    Marker Score: 3,989
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.12
    Marker Score: 4,391
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.12
    Marker Score: 417
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.11
    Marker Score: 660
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.09
    Marker Score: 345
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.09
    Marker Score: 1,130
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.08
    Marker Score: 629
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.08
    Marker Score: 2,549
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.08
    Marker Score: 2,660
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.08
    Marker Score: 14,224
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.07
    Marker Score: 6,911
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.05
    Marker Score: 247
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.05
    Marker Score: 357
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.04
    Marker Score: 23,340
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.04
    Marker Score: 1,116
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.03
    Marker Score: 9,008
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.02
    Marker Score: 696
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.02
    Marker Score: 3,765
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.01
    Marker Score: 547
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1
    Marker Score: 942
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1
    Marker Score: 2,030
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1
    Marker Score: 372
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.99
    Marker Score: 577
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.99
    Marker Score: 1,397
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.99
    Marker Score: 244
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.98
    Marker Score: 4,249
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.98
    Marker Score: 341
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.98
    Marker Score: 250
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.98
    Marker Score: 555
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,386
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.98
    Marker Score: 2,233
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.98
    Marker Score: 2,467
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.98
    Marker Score: 1,106
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.96
    Marker Score: 535

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** ZNF518A acts as a transcription factor, binding to specific DNA sequences and regulating the expression of target genes. Its ability to interact with RNA polymerase II is crucial for its function in transcriptional regulation. 2. **Chromatin Organization:** ZNF518A is involved in maintaining chromatin organization, which is essential for proper gene expression and cellular function. Its ability to bind metal ions and interact with chromatin suggests a role in regulating chromatin structure and dynamics. 3. **Cell Type-Specific Expression:** ZNF518A is highly expressed in specific cell types, including cardiac muscle cells, astrocytes, and lens epithelial cells. This cell type-specific expression suggests that ZNF518A plays distinct roles in different tissues. 4. **Metal Ion Binding:** ZNF518A's ability to bind metal ions suggests a role in regulating metal ion homeostasis and potentially interacting with other proteins that require metal ions for their function. **Pathways and Functions:** 1. **Chromatin Organization:** ZNF518A interacts with chromatin to regulate its structure and dynamics, which is essential for proper gene expression and cellular function. 2. **Transcriptional Regulation:** ZNF518A regulates transcription by binding to specific DNA sequences and interacting with RNA polymerase II, which is crucial for its function in gene expression. 3. **Metal Ion Binding:** ZNF518A's ability to bind metal ions suggests a role in regulating metal ion homeostasis and potentially interacting with other proteins that require metal ions for their function. 4. **Cellular Homeostasis:** ZNF518A's expression in cardiac muscle cells, astrocytes, and lens epithelial cells suggests that it plays a role in maintaining cellular homeostasis and function in these tissues. **Clinical Significance:** While ZNF518A's role in disease is not yet fully understood, its involvement in transcriptional regulation and chromatin organization suggests that it may play a role in various diseases, including: 1. **Cardiovascular Disease:** ZNF518A's expression in cardiac muscle cells suggests that it may play a role in maintaining cardiac function and potentially contributing to cardiovascular disease. 2. **Neurological Disorders:** ZNF518A's expression in astrocytes and neurons suggests that it may play a role in maintaining neural function and potentially contributing to neurological disorders, such as Alzheimer's disease. 3. **Cancer:** ZNF518A's ability to regulate transcription and chromatin organization suggests that it may play a role in cancer development and progression. In conclusion, ZNF518A is a transcription factor protein that plays a crucial role in regulating gene expression and chromatin organization across various cell types. Its clinical significance is still being explored, but its involvement in transcriptional regulation and chromatin organization suggests that it may play a role in various diseases. Further studies are needed to fully understand the role of ZNF518A in disease and to explore its potential as a therapeutic target.

Genular Protein ID: 1485929471

Symbol: Z518A_HUMAN

Name: Zinc finger protein 518A

UniProtKB Accession Codes:

Q6AHZ1 A0PJI5 O15044 Q32MP4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 27 SAM 1 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9205841

Title: Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9205841

DOI: 10.1093/dnares/4.2.141

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 1483
  • Mass: 166782
  • Checksum: 8202CFBDD12F9CB0
  • Sequence:
    • MPSEQKQLFC DEKQTTLKKD YDVKNEIVDR SAPKPKISGS IHYALKNVKI DLPKINIPNE 
VLLKHEVDKY RKLFQSKQQT ARKSISIKTV SCVEECTLLH KSERAEEEGV KMSAKILNFS 
CLKCRDNTRY SPNDLQKHFQ MWHHGELPSY PCEMCNFSAN DFQVFKQHRR THRSTLVKCD 
ICNNESVYTL LNLTKHFTST HCVNGNFQCE KCKFSTQDVG TFVQHIHRHN EIHYKCGKCH 
HVCFTKGELQ KHLHIHSGTF PFTCQYCSYG ATRREHLVRH VITLHKEHLY AKEKLEKDKY 
EKRMAKTSAG LKLILKRYKI GASRKTFWKR KKINSGSDRS IEKNTQVLKK MNKTQTKSED 
QSHVVQEHLS EEKDERLHCE NNDKAPESES EKPTPLSTGQ GNRAEEGPNA SSGFMKTAVL 
GPTLKNVMMK NNKLAVSPNY NATFMGFKMM DGKQHIVLKL VPIKQNVCSP GSQSGAAKDG 
TANLQPQTLD TNGFLTGVTT ELNDTVYMKA ATPFSCSSSI LSGKASSEKE MTLISQRNNM 
LQTMDYEKSV SSLSATSELV TASVNLTTKF ETRDNVDFWG NHLTQSHPEV LGTTIKSPDK 
VNCVAKPNAY NSGDMHNYCI NYGNCELPVE SSNQGSLPFH NYSKVNNSNK RRRFSGTAVY 
ENPQRESSSS KTVVQQPISE SFLSLVRQES SKPDSLLASI SLLNDKDGTL KAKSEIEEQY 
VLEKGQNIDG QNLYSNENQN LECATEKSKW EDFSNVDSPM MPRITSVFSL QSQQASEFLP 
PEVNQLLQDV LKIKPDVKQD SSNTPNKGLP LHCDQSFQKH EREGKIVESS KDFKVQGIFP 
VPPGSVGINV PTNDLNLKFG KEKQVSSIPQ DVRDSEKMPR ISGFGTLLKT QSDAIITQQL 
VKDKLRATTQ NLGSFYMQSP LLNSEQKKTI IVQTSKGFLI PLNITNKPGL PVIPGNALPL 
VNSQGIPASL FVNKKPGMVL TLNNGKLEGV SAVKTEGAPA RGTVTKEPCK TPILKVEPNN 
NCLTPGLCSS IGSCLSMKSS SENTLPLKGP YILKPTSSVK AVLIPNMLSE QQSTKLNISD 
SVKQQNEIFP KPPLYTFLPD GKQAVFLKCV MPNKTELLKP KLVQNSTYQN IQPKKPEGTP 
QRILLKIFNP VLNVTAANNL SVSNSASSLQ KDNVPSNQII GGEQKEPESR DALPFLLDDL 
MPANEIVITS TATCPESSEE PICVSDCSES RVLRCKTNCR IERNFNRKKT SKKIFSKTKT 
HGSKDSETAF VSRNRNCKRK CRDSYQEPPR RKATLHRKCK EKAKPEDVRE TFGFSRPRLS 
KDSIRTLRLF PFSSKQLVKC PRRNQPVVVL NHPDADAPEV VSVMKTIAKF NGHVLKVSLS 
KRTINALLKP VCYNPPKTTY DDFSKRHKTF KPVSSVKERF VLKLTLKKTS KNNYQIVKTT 
SENILKAKFN CWFCGRVFDN QDTWAGHGQR HLMEATRDWN MLE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.