Details for: PPP1R26

Gene ID: 9858

Symbol: PPP1R26

Ensembl ID: ENSG00000196422

Description: protein phosphatase 1 regulatory subunit 26

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,810
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,033
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 498
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,734
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,171
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,279
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.81
    Marker Score: 1,909
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,268
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 387
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 558
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 287
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 648
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,858
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.57
    Marker Score: 379
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.55
    Marker Score: 8,599
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 437
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.52
    Marker Score: 481
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.52
    Marker Score: 332
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.5
    Marker Score: 522
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.49
    Marker Score: 1,694
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.48
    Marker Score: 2,853
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.45
    Marker Score: 4,567
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.39
    Marker Score: 795
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.38
    Marker Score: 646
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.38
    Marker Score: 927
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.38
    Marker Score: 364
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.37
    Marker Score: 371
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.37
    Marker Score: 248
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.37
    Marker Score: 642
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.36
    Marker Score: 198
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.36
    Marker Score: 1,455
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.36
    Marker Score: 3,690
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.35
    Marker Score: 520
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.35
    Marker Score: 145
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.34
    Marker Score: 11,668
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.34
    Marker Score: 1,403
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.34
    Marker Score: 2,920
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.34
    Marker Score: 1,241
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.33
    Marker Score: 78
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.33
    Marker Score: 626
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.32
    Marker Score: 683
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.32
    Marker Score: 198
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.32
    Marker Score: 721
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.31
    Marker Score: 117
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.31
    Marker Score: 19,172
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.31
    Marker Score: 348
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.31
    Marker Score: 835
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.3
    Marker Score: 763
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.3
    Marker Score: 681
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.3
    Marker Score: 11,062
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.29
    Marker Score: 773
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.29
    Marker Score: 182
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.29
    Marker Score: 162
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.29
    Marker Score: 287
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.28
    Marker Score: 10,796
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.28
    Marker Score: 338
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.28
    Marker Score: 131
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.28
    Marker Score: 243
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.28
    Marker Score: 295
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.28
    Marker Score: 525
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.27
    Marker Score: 290
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.27
    Marker Score: 141
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.27
    Marker Score: 967
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.27
    Marker Score: 112
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.26
    Marker Score: 1,668
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.26
    Marker Score: 209
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.26
    Marker Score: 475
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.26
    Marker Score: 997
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.25
    Marker Score: 81
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.25
    Marker Score: 274
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.25
    Marker Score: 168
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.25
    Marker Score: 1,028
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.25
    Marker Score: 100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.24
    Marker Score: 377
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.24
    Marker Score: 400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.24
    Marker Score: 5,111
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.24
    Marker Score: 567
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.24
    Marker Score: 83
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.24
    Marker Score: 63
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.24
    Marker Score: 222
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.23
    Marker Score: 234
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.23
    Marker Score: 1,530
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.23
    Marker Score: 74
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.23
    Marker Score: 158
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.23
    Marker Score: 1,062
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.22
    Marker Score: 116
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.22
    Marker Score: 227
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.22
    Marker Score: 2,111
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.22
    Marker Score: 50
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.22
    Marker Score: 350
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.22
    Marker Score: 311
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.22
    Marker Score: 81

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Regulatory Subunit of PP1**: PPP1R26 is a regulatory subunit of PP1, which is a multifunctional phosphatase that dephosphorylates and thereby regulates a wide range of substrates, including proteins, lipids, and carbohydrates. 2. **Specific Expression Patterns**: PPP1R26 is primarily expressed in cells of the cerebral cortex, forebrain radial glial cells, and intestinal epithelial cells. This specificity suggests that PPP1R26 plays distinct roles in different tissues and cell types. 3. **Inhibition of PP1 Activity**: PPP1R26 acts as a negative regulator of PP1 activity, which is essential for maintaining cellular homeostasis and preventing excessive or uncontrolled PP1 activity. **Pathways and Functions:** 1. **Nucleolus**: PPP1R26 is involved in regulating the activity of PP1 in the nucleolus, where it plays a critical role in ribosome biogenesis and cell cycle progression. 2. **Protein Binding**: PPP1R26 interacts with various proteins, including PP1 itself, to regulate its activity and specificity. 3. **Protein Phosphatase Inhibitor Activity**: PPP1R26 possesses phosphatase inhibitor activity, which allows it to modulate PP1 activity and prevent excessive phosphatase activity. 4. **Cellular Homeostasis**: PPP1R26 plays a crucial role in maintaining cellular homeostasis by regulating PP1 activity, which is essential for cell cycle progression, gene expression, and signal transduction. **Clinical Significance:** 1. **Neurological Disorders**: Alterations in PPP1R26 expression or function have been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. 2. **Intestinal Diseases**: PPP1R26 has been linked to intestinal diseases, such as inflammatory bowel disease (IBD) and colon cancer, where its dysregulation can contribute to disease pathogenesis. 3. **Cancer Therapeutics**: Understanding the role of PPP1R26 in cancer cell biology may lead to the development of novel cancer therapeutics that target PP1 activity. 4. **Personalized Medicine**: Further studies on PPP1R26 expression and function may enable the development of personalized medicine approaches, where PPP1R26 status can be used to predict disease risk or response to therapy. In conclusion, PPP1R26 is a critical regulator of cellular processes through its role as a regulatory subunit of PP1. Further research on PPP1R26 is necessary to fully elucidate its functions and clinical significance, which may lead to the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 3944781461

Symbol: PPR26_HUMAN

Name: Protein phosphatase 1 regulatory subunit 26

UniProtKB Accession Codes:

Q5T8A7 Q86WU0 Q8WVV0 Q9Y4D3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 5 GO 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 10 SAM 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9734811

Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9734811

DOI: 10.1093/dnares/5.3.169

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16053918

Title: KIAA0649, a 1A6/DRIM-interacting protein with the oncogenic potential.

PubMed ID: 16053918

DOI: 10.1016/j.bbrc.2005.06.179

PubMed ID: 19389623

Title: Docking motif-guided mapping of the interactome of protein phosphatase-1.

PubMed ID: 19389623

DOI: 10.1016/j.chembiol.2009.02.012

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 1209
  • Mass: 127351
  • Checksum: B30872DE87E37E93
  • Sequence:
    • MFLMNASPVV ALQSKWEAFG PPGSCRFPRC FSEADEGVES ASVSARVQML ISTLQRDGAA 
RGTSDERAAQ RGHRAEGCHD ARPAAKPTVH KEPPALAVCG LVADFDPMGE EETTDFGPLV 
LDSDSDDSVD RDIEEAIQEY LKAKSGAAQP GAGGAQPGAA QPSRAAGGGS RCKPEPAHGS 
APTALCPPKL VPGSGGGPGS QVGSSKDQGS ASPVSVSSDD SFEQSIRAEI EQFLNEKRQH 
ETQKCDGSVE KKPDTNENSA KSLLKSHQEP PTKVVHRQGL LGVQKEFAFR KPPRLAKMNV 
QPRSLRSKVT TTQENEGSTK PATPCRPSEA AQNKGGIKRS ASAARRGKRV MSAAQASEAS 
DSSSDDGIEE AIQLYQLQKT RKEADGDLPQ RVQLREERAP DPPAHSTSSA TKSALPETHR 
KTPSKKKLVA TKTMDPGPGG LDTDHAPKLL KETKAPPPAS PASRSEFVER SSCRADTSAE 
LMCAEAILDI SKTILPAPVE GSDGSLSASP LFYSPNVPSR SDGDSSSVDS DDSIEQEIRT 
FLALKAQSGS LLARGESCPQ AAQGPLLPPG LNSQTGGHKT PLSKTPDPLL GCKRKRRGGG 
HVRPSTPKKM QEVVKDGSQD ADHSQGRAEP GHERRDLPIQ GKASEALGGE GTARGPGDTR 
MSQGQGKTDE ARRLDEKESS EDKSSSLDSD EDLDTAIKDL LRSKRKLKKR CREPRAACRK 
KVRFSTAQTH FLEQLGGLRR DWKDRGPPVL KSCLSKSKRD SGEGPGKKPP SVFGSTAERM 
RQEGAASQDA ALAFRVRRPA SASASEGNPF PRESQGPAPS PGSLSDDSSS VDSNDSIELE 
IRKFLAEKAK ESVSSSEVQA EGPTALGTGG PARPEVLCRK EPAPPPGVCT RSQRARGVPH 
LAEGLRGTES AGAQGTAGLF SQGGKGLPAA PARGDPVPPR STSGGVSAKG LSVSRRNVYV 
HKDQSPRGAE PAAKSAFGQL PSCATAGTEA GGARGTFHMG CGSPSFLTPS PGAERDAGAQ 
ADRTPPWSDF AHQSRLPSPW VLRSEGRDAV WRGGVGSERD KGSEGPARGL PSLPLAGFSP 
LLSTQLFHFG KGVSWGGRQA GLFSPHLGLP LQGPSFSAFR EAQAGPSPVF GSPHLLAKKD 
GGPWPTRKAQ AGLSLHDRRS SGSEESILDL RYRRRVNRDD QEQDALGSDA SDFSDTSTED 
SGGSSVVKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.