TOMM70 | ENSG00000154174 | NCBI 9868

Details for: TOMM70

Gene ID: 9868

Symbol: TOMM70

Ensembl ID: ENSG00000154174

Description: translocase of outer mitochondrial membrane 70

Associated with

Autophagy
(R-HSA-9612973)
Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-HSA-168928)
Deubiquitination
(R-HSA-5688426)
Disease
(R-HSA-1643685)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Macroautophagy
(R-HSA-1632852)
Metabolism of proteins
(R-HSA-392499)
Mitochondrial protein import
(R-HSA-1268020)
Mitophagy
(R-HSA-5205647)
Pink1-prkn mediated mitophagy
(R-HSA-5205685)
Post-translational protein modification
(R-HSA-597592)
Protein localization
(R-HSA-9609507)
Sars-cov-1 activates/modulates innate immune responses
(R-HSA-9692916)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 activates/modulates innate and adaptive immune responses
(R-HSA-9705671)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Selective autophagy
(R-HSA-9663891)
Ub-specific processing proteases
(R-HSA-5689880)
Viral infection pathways
(R-HSA-9824446)
Activation of innate immune response
(GO:0002218)
Cellular response to virus
(GO:0098586)
Extracellular exosome
(GO:0070062)
Membrane
(GO:0016020)
Mitochondrial membrane
(GO:0031966)
Mitochondrial outer membrane
(GO:0005741)
Mitochondrial outer membrane translocase complex
(GO:0005742)
Mitochondrion
(GO:0005739)
Mitochondrion targeting sequence binding
(GO:0030943)
Molecular adaptor activity
(GO:0060090)
Negative regulation of cell growth involved in cardiac muscle cell development
(GO:0061052)
Positive regulation of defense response to virus by host
(GO:0002230)
Positive regulation of interferon-beta production
(GO:0032728)
Positive regulation of protein targeting to mitochondrion
(GO:1903955)
Protein binding
(GO:0005515)
Protein import into mitochondrial matrix
(GO:0030150)
Protein insertion into mitochondrial inner membrane
(GO:0045039)
Protein insertion into mitochondrial outer membrane
(GO:0045040)
Protein targeting to mitochondrion
(GO:0006626)
Protein transmembrane transporter activity
(GO:0008320)
Regulation of apoptotic process
(GO:0042981)
Response to thyroxine
(GO:0097068)
Tom complex
(GO:0140596)

Other Information

Proteins

Mitochondrial precursor proteins import receptor

Genular Protein ID: 1957747780

Symbol: TOM70_HUMAN

Name: Mitochondrial precursor proteins import receptor

UniProtKB Accession Codes:

O94826 D3DN48

Database IDs:

Citations:

PubMed ID: 9872452

Title: Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9872452

DOI: 10.1093/dnares/5.5.277

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12526792

Title: Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70.

PubMed ID: 12526792

DOI: 10.1016/s0092-8674(02)01250-3

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18331822

Title: Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane.

PubMed ID: 18331822

DOI: 10.1016/j.bbrc.2008.02.150

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20628368

Title: Tom70 mediates activation of interferon regulatory factor 3 on mitochondria.

PubMed ID: 20628368

DOI: 10.1038/cr.2010.103

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25609812

Title: Tom70 mediates Sendai virus-induced apoptosis on mitochondria.

PubMed ID: 25609812

DOI: 10.1128/jvi.02959-14

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 32728199

Title: SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70.

PubMed ID: 32728199

DOI: 10.1038/s41423-020-0514-8

PubMed ID: 33723040

Title: Toxoplasma gondii association with host mitochondria requires key mitochondrial protein import machinery.

PubMed ID: 33723040

DOI: 10.1073/pnas.2013336118

PubMed ID: 35025629

Title: Mitochondria shed their outer membrane in response to infection-induced stress.

PubMed ID: 35025629

DOI: 10.1126/science.abi4343

PubMed ID: 33060197

Title: Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

PubMed ID: 33060197

DOI: 10.1126/science.abe9403

Sequence Information:

Length: 608
Mass: 67455
Checksum: 5AAF5CAAA8582480
Sequence:

MAASKPVEAA VVAAAVPSSG SGVGGGGTAG PGTGGLPRWQ LALAVGAPLL LGAGAIYLWS 
RQQRRREARG RGDASGLKRN SERKTPEGRA SPAPGSGHPE GPGAHLDMNS LDRAQAAKNK 
GNKYFKAGKY EQAIQCYTEA ISLCPTEKNV DLSTFYQNRA AAFEQLQKWK EVAQDCTKAV 
ELNPKYVKAL FRRAKAHEKL DNKKECLEDV TAVCILEGFQ NQQSMLLADK VLKLLGKEKA 
KEKYKNREPL MPSPQFIKSY FSSFTDDIIS QPMLKGEKSD EDKDKEGEAL EVKENSGYLK 
AKQYMEEENY DKIISECSKE IDAEGKYMAE ALLLRATFYL LIGNANAAKP DLDKVISLKE 
ANVKLRANAL IKRGSMYMQQ QQPLLSTQDF NMAADIDPQN ADVYHHRGQL KILLDQVEEA 
VADFDECIRL RPESALAQAQ KCFALYRQAY TGNNSSQIQA AMKGFEEVIK KFPRCAEGYA 
LYAQALTDQQ QFGKADEMYD KCIDLEPDNA TTYVHKGLLQ LQWKQDLDRG LELISKAIEI 
DNKCDFAYET MGTIEVQRGN MEKAIDMFNK AINLAKSEME MAHLYSLCDA AHAQTEVAKK 
YGLKPPTL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TOMM70

Associated with

Other Information

Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 9872452

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70. PubMed ID: 12526792

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. PubMed ID: 18331822

Phosphoproteome of resting human platelets. PubMed ID: 18088087

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Tom70 mediates activation of interferon regulatory factor 3 on mitochondria. PubMed ID: 20628368

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

Tom70 mediates Sendai virus-induced apoptosis on mitochondria. PubMed ID: 25609812

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70. PubMed ID: 32728199

Toxoplasma gondii association with host mitochondria requires key mitochondrial protein import machinery. PubMed ID: 33723040

Mitochondria shed their outer membrane in response to infection-induced stress. PubMed ID: 35025629

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. PubMed ID: 33060197