Details for: LRBA

Gene ID: 987

Symbol: LRBA

Ensembl ID: ENSG00000198589

Description: LPS responsive beige-like anchor protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 451.0907
    Cell Significance Index: -70.1700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 258.8674
    Cell Significance Index: -65.6600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 156.2730
    Cell Significance Index: -73.7800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 149.1174
    Cell Significance Index: -60.5800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 132.9159
    Cell Significance Index: -68.3700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 109.9219
    Cell Significance Index: -73.7600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 63.7135
    Cell Significance Index: -60.8300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 59.3128
    Cell Significance Index: -73.1300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 24.8763
    Cell Significance Index: -66.6400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 22.0873
    Cell Significance Index: -48.3400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 21.8235
    Cell Significance Index: -67.0300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.7023
    Cell Significance Index: -73.8000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 15.7411
    Cell Significance Index: 2288.1600
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 8.1706
    Cell Significance Index: 50.4100
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 7.1468
    Cell Significance Index: 63.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 5.0518
    Cell Significance Index: 283.4800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 4.5410
    Cell Significance Index: 126.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.7064
    Cell Significance Index: 163.9500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.5517
    Cell Significance Index: 134.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.3598
    Cell Significance Index: 666.7700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.8322
    Cell Significance Index: 17.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.7120
    Cell Significance Index: 544.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.7046
    Cell Significance Index: 207.5500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.5946
    Cell Significance Index: 174.4600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.5198
    Cell Significance Index: 49.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.4865
    Cell Significance Index: 891.8800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.4627
    Cell Significance Index: 52.6400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.4119
    Cell Significance Index: 29.9200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.8567
    Cell Significance Index: 1284.1900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.8007
    Cell Significance Index: 48.2500
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.7501
    Cell Significance Index: 17.6600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6706
    Cell Significance Index: 181.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.5513
    Cell Significance Index: 985.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.5204
    Cell Significance Index: 2862.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2656
    Cell Significance Index: 36.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2102
    Cell Significance Index: 218.1700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.1886
    Cell Significance Index: 10.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.0608
    Cell Significance Index: 65.2000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.9625
    Cell Significance Index: 24.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9054
    Cell Significance Index: 41.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8360
    Cell Significance Index: 754.8100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7459
    Cell Significance Index: 91.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.6998
    Cell Significance Index: 1077.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.6905
    Cell Significance Index: 1273.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6453
    Cell Significance Index: 352.3900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.5561
    Cell Significance Index: 15.8700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5425
    Cell Significance Index: 13.0100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4732
    Cell Significance Index: 24.5800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.4657
    Cell Significance Index: 7.9800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4374
    Cell Significance Index: 11.6800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.3242
    Cell Significance Index: 147.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2246
    Cell Significance Index: 305.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2064
    Cell Significance Index: 9.7000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1251
    Cell Significance Index: 55.3300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1028
    Cell Significance Index: 16.7200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0973
    Cell Significance Index: 3.4200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0369
    Cell Significance Index: 0.5300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0267
    Cell Significance Index: 3.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0114
    Cell Significance Index: 0.5300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.0094
    Cell Significance Index: 0.9700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0105
    Cell Significance Index: -7.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0195
    Cell Significance Index: -3.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0281
    Cell Significance Index: -20.8500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0568
    Cell Significance Index: -35.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0797
    Cell Significance Index: -60.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0836
    Cell Significance Index: -14.2800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0892
    Cell Significance Index: -50.2800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1020
    Cell Significance Index: -10.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2012
    Cell Significance Index: -42.3800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2136
    Cell Significance Index: -4.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2181
    Cell Significance Index: -62.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2335
    Cell Significance Index: -32.0600
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.2938
    Cell Significance Index: -4.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2940
    Cell Significance Index: -21.9100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3075
    Cell Significance Index: -4.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3197
    Cell Significance Index: -41.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3212
    Cell Significance Index: -32.8100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3387
    Cell Significance Index: -5.7000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3431
    Cell Significance Index: -4.0900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3520
    Cell Significance Index: -5.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.4176
    Cell Significance Index: -53.5300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4508
    Cell Significance Index: -9.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4589
    Cell Significance Index: -52.5800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4726
    Cell Significance Index: -55.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5253
    Cell Significance Index: -27.5800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5482
    Cell Significance Index: -34.5500
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.5702
    Cell Significance Index: -5.9400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6329
    Cell Significance Index: -72.2500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.7195
    Cell Significance Index: -10.6200
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.7295
    Cell Significance Index: -7.3000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7307
    Cell Significance Index: -57.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.7370
    Cell Significance Index: -47.5500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7524
    Cell Significance Index: -16.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.8219
    Cell Significance Index: -58.1300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8487
    Cell Significance Index: -11.5800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.9659
    Cell Significance Index: -12.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9697
    Cell Significance Index: -59.4500
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.9824
    Cell Significance Index: -10.1800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.0391
    Cell Significance Index: -62.3800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.1040
    Cell Significance Index: -35.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** LRBA is a transmembrane protein that is responsive to lipopolysaccharide (LPS), a component of bacterial outer membranes. This responsiveness is mediated through the activation of the protein's signaling pathways, which ultimately lead to the regulation of immune response and cellular homeostasis. LRBA is also characterized by its ability to interact with various proteins, including protein kinases and transcription factors, which further underscore its role in regulating cellular processes. **Pathways and Functions** LRBA is involved in several key signaling pathways, including: 1. **Mitophagy**: LRBA plays a critical role in regulating mitophagy, a process by which damaged or dysfunctional mitochondria are degraded by autophagy. LRBA's interaction with mitochondrial proteins and signaling pathways regulates the efficiency of mitophagy, which is essential for maintaining cellular homeostasis and preventing neurodegenerative diseases. 2. **Immune Response**: LRBA's responsiveness to LPS triggers a signaling cascade that regulates immune response, including the activation of immune cells and the production of cytokines. This ensures that the immune system is able to respond appropriately to pathogens and maintain tissue homeostasis. 3. **Cellular Stress Response**: LRBA's interaction with stress-activated signaling pathways regulates the cellular response to stress, including heat shock, oxidative stress, and endoplasmic reticulum stress. 4. **Protein Degradation**: LRBA's interaction with the proteasome and other protein degradation pathways regulates the degradation of misfolded or damaged proteins, which is essential for maintaining protein homeostasis. **Clinical Significance** Dysregulation of LRBA has been implicated in various diseases, including: 1. **Neurodegenerative Diseases**: Mutations in LRBA have been associated with neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. LRBA's role in regulating mitophagy and cellular stress response suggests that dysregulation of this gene may contribute to the development of these diseases. 2. **Autoimmune Diseases**: LRBA's involvement in immune response and cellular homeostasis suggests that dysregulation of this gene may contribute to autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. 3. **Cancer**: LRBA's role in regulating protein degradation and cellular homeostasis suggests that dysregulation of this gene may contribute to tumorigenesis and cancer progression. In conclusion, LRBA is a critical regulator of immune response and cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining tissue homeostasis and preventing disease. Further research is needed to fully elucidate the role of LRBA in human disease and to develop therapeutic strategies to target this gene in the treatment of various diseases.

Genular Protein ID: 606413090

Symbol: LRBA_HUMAN

Name: Lipopolysaccharide-responsive and beige-like anchor protein

UniProtKB Accession Codes:

P50851 Q4W5J4 Q4W5L6 Q8NFQ0 Q9H2U3 Q9H2U4

Database IDs:

AGR 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 15 KEGG 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 7 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11254716

Title: Identification of a novel lipopolysaccharide-inducible gene with key features of both A kinase anchor proteins and chs1/beige proteins.

PubMed ID: 11254716

DOI: 10.4049/jimmunol.166.7.4586

PubMed ID: 12160729

Title: BCL8 is a novel, evolutionarily conserved human gene family encoding proteins with presumptive protein kinase A anchoring function.

PubMed ID: 12160729

DOI: 10.1006/geno.2002.6822

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 1505956

Title: Strategy for detecting cellular transcripts promoted by human endogenous long terminal repeats: identification of a novel gene (CDC4L) with homology to yeast CDC4.

PubMed ID: 1505956

DOI: 10.1016/0888-7543(92)90041-p

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 31263572

Title: Dominant TOM1 mutation associated with combined immunodeficiency and autoimmune disease.

PubMed ID: 31263572

DOI: 10.1038/s41525-019-0088-5

PubMed ID: 33773106

Title: ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system.

PubMed ID: 33773106

DOI: 10.1016/j.molcel.2021.03.001

PubMed ID: 15554694

Title: Crystal structure of the PH-BEACH domains of human LRBA/BGL.

PubMed ID: 15554694

DOI: 10.1021/bi049498y

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 22608502

Title: Deleterious mutations in LRBA are associated with a syndrome of immune deficiency and autoimmunity.

PubMed ID: 22608502

DOI: 10.1016/j.ajhg.2012.04.015

Sequence Information:

  • Length: 2863
  • Mass: 319108
  • Checksum: 58CD1F4314F685EE
  • Sequence:
    • MASEDNRVPS PPPTGDDGGG GGREETPTEG GALSLKPGLP IRGIRMKFAV LTGLVEVGEV 
SNRDIVETVF NLLVGGQFDL EMNFIIQEGE SINCMVDLLE KCDITCQAEV WSMFTAILKK 
SIRNLQVCTE VGLVEKVLGK IEKVDNMIAD LLVDMLGVLA SYNLTVRELK LFFSKLQGDK 
GRWPPHAGKL LSVLKHMPQK YGPDAFFNFP GKSAAAIALP PIAKWPYQNG FTFHTWLRMD 
PVNNINVDKD KPYLYCFRTS KGLGYSAHFV GGCLIVTSIK SKGKGFQHCV KFDFKPQKWY 
MVTIVHIYNR WKNSELRCYV NGELASYGEI TWFVNTSDTF DKCFLGSSET ADANRVFCGQ 
MTAVYLFSEA LNAAQIFAIY QLGLGYKGTF KFKAESDLFL AEHHKLLLYD GKLSSAIAFT 
YNPRATDAQL CLESSPKDNP SIFVHSPHAL MLQDVKAVLT HSIQSAMHSI GGVQVLFPLF 
AQLDYRQYLS DEIDLTICST LLAFIMELLK NSIAMQEQML ACKGFLVIGY SLEKSSKSHV 
SRAVLELCLA FSKYLSNLQN GMPLLKQLCD HVLLNPAIWI HTPAKVQLML YTYLSTEFIG 
TVNIYNTIRR VGTVLLIMHT LKYYYWAVNP QDRSGITPKG LDGPRPNQKE MLSLRAFLLM 
FIKQLVMKDS GVKEDELQAI LNYLLTMHED DNLMDVLQLL VALMSEHPNS MIPAFDQRNG 
LRVIYKLLAS KSEGIRVQAL KAMGYFLKHL APKRKAEVML GHGLFSLLAE RLMLQTNLIT 
MTTYNVLFEI LIEQIGTQVI HKQHPDPDSS VKIQNPQILK VIATLLRNSP QCPESMEVRR 
AFLSDMIKLF NNSRENRRSL LQCSVWQEWM LSLCYFNPKN SDEQKITEMV YAIFRILLYH 
AVKYEWGGWR VWVDTLSITH SKVTFEIHKE NLANIFREQQ GKVDEEIGLC SSTSVQAASG 
IRRDINVSVG SQQPDTKDSP VCPHFTTNGN ENSSIEKTSS LESASNIELQ TTNTSYEEMK 
AEQENQELPD EGTLEETLTN ETRNADDLEV SSDIIEAVAI SSNSFITTGK DSMTVSEVTA 
SISSPSEEDA SEMPEFLDKS IVEEEEDDDY VELKVEGSPT EEANLPTELQ DNSLSPAASE 
AGEKLDMFGN DDKLIFQEGK PVTEKQTDTE TQDSKDSGIQ TMTASGSSAM SPETTVSQIA 
VESDLGQMLE EGKKATNLTR ETKLINDCHG SVSEASSEQK IAKLDVSNVA TDTERLELKA 
SPNVEAPQPH RHVLEISRQH EQPGQGIAPD AVNGQRRDSR STVFRIPEFN WSQMHQRLLT 
DLLFSIETDI QMWRSHSTKT VMDFVNSSDN VIFVHNTIHL ISQVMDNMVM ACGGILPLLS 
AATSATHELE NIEPTQGLSI EASVTFLQRL ISLVDVLIFA SSLGFTEIEA EKSMSSGGIL 
RQCLRLVCAV AVRNCLECQQ HSQLKTRGDK ALKPMHSLIP LGKSAAKSPV DIVTGGISPV 
RDLDRLLQDM DINRLRAVVF RDIEDSKQAQ FLALAVVYFI SVLMVSKYRD ILEPQNERHS 
QSCTETGSEN ENVSLSEITP AAFSTLTTAS VEESESTSSA RRRDSGIGEE TATGLGSHVE 
VTPHTAPPGV SAGPDAISEV LSTLSLEVNK SPETKNDRGN DLDTKATPSV SVSKNVNVKD 
ILRSLVNIPA DGVTVDPALL PPACLGALGD LSVEQPVQFR SFDRSVIVAA KKSAVSPSTF 
NTSIPTNAVS VVSSVDSAQA SDMGGESPGS RSSNAKLPSV PTVDSVSQDP VSNMSITERL 
EHALEKAAPL LREIFVDFAP FLSRTLLGSH GQELLIEGTS LVCMKSSSSV VELVMLLCSQ 
EWQNSIQKNA GLAFIELVNE GRLLSQTMKD HLVRVANEAE FILSRQRAED IHRHAEFESL 
CAQYSADKRE DEKMCDHLIR AAKYRDHVTA TQLIQKIINI LTDKHGAWGN SAVSRPLEFW 
RLDYWEDDLR RRRRFVRNPL GSTHPEATLK TAVEHVCIFK LRENSKATDE DILAKGKQSI 
RSQALGNQNS ENEILLEGDD DTLSSVDEKD LENLAGPVSL STPAQLVAPS VVVKGTLSVT 
SSELYFEVDE EDPNFKKIDP KILAYTEGLH GKWLFTEIRS IFSRRYLLQN TALEIFMANR 
VAVMFNFPDP ATVKKVVNYL PRVGVGTSFG LPQTRRISLA SPRQLFKASN MTQRWQHREI 
SNFEYLMFLN TIAGRSYNDL NQYPVFPWVI TNYESEELDL TLPTNFRDLS KPIGALNPKR 
AAFFAERYES WEDDQVPKFH YGTHYSTASF VLAWLLRIEP FTTYFLNLQG GKFDHADRTF 
SSISRAWRNS QRDTSDIKEL IPEFYYLPEM FVNFNNYNLG VMDDGTVVSD VELPPWAKTS 
EEFVHINRLA LESEFVSCQL HQWIDLIFGY KQQGPEAVRA LNVFYYLTYE GAVNLNSITD 
PVLREAVEAQ IRSFGQTPSQ LLIEPHPPRG SAMQVSPLMF TDKAQQDVIM VLKFPSNSPV 
THVAANTQPG LATPAVITVT ANRLFAVNKW HNLPAHQGAV QDQPYQLPVE IDPLIASNTG 
MHRRQITDLL DQSIQVHSQC FVITSDNRYI LVCGFWDKSF RVYSTDTGRL IQVVFGHWDV 
VTCLARSESY IGGNCYILSG SRDATLLLWY WNGKCSGIGD NPGSETAAPR AILTGHDYEV 
TCAAVCAELG LVLSGSQEGP CLIHSMNGDL LRTLEGPENC LKPKLIQASR EGHCVIFYEN 
GLFCTFSVNG KLQATMETDD NIRAIQLSRD GQYLLTGGDR GVVVVRQVSD LKQLFAYPGC 
DAGIRAMALS YDQRCIISGM ASGSIVLFYN DFNRWHHEYQ TRY

Genular Protein ID: 768973502

Symbol: A0A494BZW2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A494BZW2

Database IDs:

ARBA 2 Antibodypedia 1 Bgee 1 CDD 2 CTD 1 ChiTaRS 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 Gene3D 5 GeneTree 1 HGNC 1 InterPro 15 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 4 PeptideAtlas 2 Pfam 7 Proteomes 2 ProteomicsDB 1 RefSeq 2 SAM 1 SMART 2 SMR 1 SUPFAM 5 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 2857
  • Mass: 318420
  • Checksum: 2E6E83ED76559E00
  • Sequence:
    • MASEDNRVPS PPPTGDDGGG GGREETPTEG GALSLKPGLP IRGIRMKFAV LTGLVEVGEV 
SNRDIVETVF NLLVGGQFDL EMNFIIQEGE SINCMVDLLE KCDITCQAEV WSMFTAILKK 
SIRNLQVCTE VGLVEKVLGK IEKVDNMIAD LLVDMLGVLA SYNLTVRELK LFFSKLQGDK 
GRWPPHAGKL LSVLKHMPQK YGPDAFFNFP GKSAAAIALP PIAKWPYQNG FTFHTWLRMD 
PVNNINVDKD KPYLYCFRTS KGLGYSAHFV GGCLIVTSIK SKGKGFQHCV KFDFKPQKWY 
MVTIVHIYNR WKNSELRCYV NGELASYGEI TWFVNTSDTF DKCFLGSSET ADANRVFCGQ 
MTAVYLFSEA LNAAQIFAIY QLGLGYKGTF KFKAESDLFL AEHHKLLLYD GKLSSAIAFT 
YNPRATDAQL CLESSPKDNP SIFVHSPHAL MLQDVKAVLT HSIQSAMHSI GGVQVLFPLF 
AQLDYRQYLS DEIDLTICST LLAFIMELLK NSIAMQEQML ACKGFLVIGY SLEKSSKSHV 
SRAVLELCLA FSKYLSNLQN GMPLLKQLCD HVLLNPAIWI HTPAKVQLML YTYLSTEFIG 
TVNIYNTIRR VGTVLLIMHT LKYYYWAVNP QDRSGITPKG LDGPRPNQKE MLSLRAFLLM 
FIKQLVMKDS GVKEDELQAI LNYLLTMHED DNLMDVLQLL VALMSEHPNS MIPAFDQRNG 
LRVIYKLLAS KSEGIRVQAL KAMGYFLKHL APKRKAEVML GHGLFSLLAE RLMLQTNLIT 
MTTYNVLFEI LIEQIGTQVI HKQHPDPDSS VKIQNPQILK VIATLLRNSP QCPESMEVRR 
AFLSDMIKLF NNSRENRRSL LQCSVWQEWM LSLCYFNPKN SDEQKITEMV YAIFRILLYH 
AVKYEWGGWR VWVDTLSITH SKVTFEIHKE NLANIFREQQ GKVDEEIGLC SSTSVQAASG 
IRRDINVSVG SQQPDTKDSP VCPHFTTNGN ENSSIEKTSS LESASNIELQ TTNTSYEEMK 
AEQENQELPD EGTLEETLTN ETRNADDLEV SSDIIEAVAI SSNSFITTGK DSMTVSEVTA 
SISSPSEEDA SEMPEFLDKS IVEEEEDDDY VELKVEGSPT EEANLPTELQ DNSLSPAASE 
AGEKLDMFGN DDKLIFQEGK PVTEKQTDTE TQDSKDSGIQ TMTASGSSAM SPETTVSQIA 
VESDLGQMLE EGKKATNLTR ETKLINDCHG SVSEASSEQK IAKLDVSNVA TDTERLELKA 
SPNVEAPQPH RHVLEISRQH EQPGQGIAPD AVNGQRRDSR STVFRIPEFN WSQMHQRLLT 
DLLFSIETDI QMWRSHSTKT VMDFVNSSDN VIFVHNTIHL ISQVMDNMVM ACGGILPLLS 
AATSATHELE NIEPTQGLSI EASVTFLQRL ISLVDVLIFA SSLGFTEIEA EKSMSSGGIL 
RQCLRLVCAV AVRNCLECQQ HSQLKTRGDK ALKPMHSLIP LGKSAAKSPV DIVTGGISPV 
RDLDRLLQDM DINRLRAVVF RDIEDSKQAQ FLALAVVYFI SVLMVSKYRD ILEPQNERHS 
QSCTETGSEN ENVSLSEITP AAFSTLTTAS VEESESTSSA RRRDSGIGEE TATGLGSHVE 
VTPHTAPPGV SAGPDAISEV LSTLSLEVNK SPETKNDRGN DLDTKATPSV SVSKNVNVKD 
ILRSLVNIPA DGVTVDPALL PPACLGALGD LSVEQPVQFR SFDRSVIVAA KKSAVSPSTF 
NTSIPTNAVS VVSSVDSAQA SDMGGESPGS RSSNAKLPSV PTVDSVSQDP VSNMSITERL 
EHALEKAAPL LREIFVDFAP FLSRTLLGSH GQELLIEGTS LVCMKSSSSV VELVMLLCSQ 
EWQNSIQKNA GLAFIELVNE GRLLSQTMKD HLVRVANEAE FILSRQRAED IHRHAEFESL 
CAQYSADKRE DEKMCDHLIR AAKYRDHVTA TQLIQKIINI LTDKHGAWGN SAVSRPLEFW 
RLDYWEDDLR RRRRFVRNPL GSTHPEATLK TAVEHATDED ILAKGKQSIR SQALGNQNSE 
NEILLEGDDD TLSSVDEKDL ENLAGPVSLS TPAQLVAPSV VVKGTLSVTS SELYFEVDEE 
DPNFKKIDPK ILAYTEGLHG KWLFTEIRSI FSRRYLLQNT ALEIFMANRV AVMFNFPDPA 
TVKKVVNYLP RVGVGTSFGL PQTRRISLAS PRQLFKASNM TQRWQHREIS NFEYLMFLNT 
IAGRSYNDLN QYPVFPWVIT NYESEELDLT LPTNFRDLSK PIGALNPKRA AFFAERYESW 
EDDQVPKFHY GTHYSTASFV LAWLLRIEPF TTYFLNLQGG KFDHADRTFS SISRAWRNSQ 
RDTSDIKELI PEFYYLPEMF VNFNNYNLGV MDDGTVVSDV ELPPWAKTSE EFVHINRLAL 
ESEFVSCQLH QWIDLIFGYK QQGPEAVRAL NVFYYLTYEG AVNLNSITDP VLREAVEAQI 
RSFGQTPSQL LIEPHPPRGS AMQVYLLLQS PLMFTDKAQQ DVIMVLKFPS NSPVTHVAAN 
TQPGLATPAV ITVTANRLFA VNKWHNLPAH QGAVQDQPYQ LPVEIDPLIA SNTGMHRRQI 
TDLLDQSIQV HSQCFVITSD NRYILVCGFW DKSFRVYSTD TGRLIQVVFG HWDVVTCLAR 
SESYIGGNCY ILSGSRDATL LLWYWNGKCS GIGDNPGSET AAPRAILTGH DYEVTCAAVC 
AELGLVLSGS QEGPCLIHSM NGDLLRTLEG PENCLKPKLI QASREGHCVI FYENGLFCTF 
SVNGKLQATM ETDDNIRAIQ LSRDGQYLLT GGDRGVVVVR QVSDLKQLFA YPGCDAGIRA 
MALSYDQRCI ISGMASGSIV LFYNDFNRWH HEYQTRY

Genular Protein ID: 2358593475

Symbol: A0A8V8TKR0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8V8TKR0

Database IDs:

ARBA 1 CDD 2 CTD 1 EMBL 7 Ensembl 2 Gene3D 3 GeneTree 1 HGNC 1 InterPro 9 NCBI Taxonomy 1 PANTHER 2 PROSITE 4 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMART 2 SMR 1 SUPFAM 3

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 758
  • Mass: 85863
  • Checksum: 897581EE75A492A9
  • Sequence:
    • MCTSEGWSGY KILAYTEGLH GKWLFTEIRS IFSRRYLLQN TALEIFMANR VAVMFNFPDP 
ATVKKVVNYL PRVGVGTSFG LPQTRRISLA SPRQLFKASN MTQRWQHREI SNFEYLMFLN 
TIAGRSYNDL NQYPVFPWVI TNYESEELDL TLPTNFRDLS KPIGALNPKR AAFFAERYES 
WEDDQVPKFH YGTHYSTASF VLAWLLRIEP FTTYFLNLQG GKFDHADRTF SSISRAWRNS 
QRDTSDIKEL IPEFYYLPEM FVNFNNYNLG VMDDGTVVSD VELPPWAKTS EEFVHINRLA 
LESEFVSCQL HQWIDLIFGY KQQGPEAVRA LNVFYYLTYE GAVNLNSITD PVLREAVEAQ 
IRSFGQTPSQ LLIEPHPPRG SAMQVYLLLQ SPLMFTDKAQ QDVIMVLKFP SNSPVTHVAA 
NTQPGLATPA VITVTANRLF AVNKWHNLPA HQGAVQDQPY QLPVEIDPLI ASNTGMHRRQ 
ITDLLDQSIQ VHSQCFVITS DNRYILVCGF WDKSFRVYST DTGRLIQVVF GHWDVVTCLA 
RSESYIGGNC YILSGSRDAT LLLWYWNGKC SGIGDNPGSE TAAPRAILTG HDYEVTCAAV 
CAELGLVLSG SQEGPCLIHS MNGDLLRTLE GPENCLKPKL IQASREGHCV IFYENGLFCT 
FSVNGKLQAT METDDNIRAI QLSRDGQYLL TGGDRGVVVV RQVSDLKQLF AYPGCDAGIR 
AMALSYDQRC IISGMASGSI VLFYNDFNRW HHEYQTRY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.