LRBA | ENSG00000198589 | NCBI 987

Details for: LRBA

Gene ID: 987

Symbol: LRBA

Ensembl ID: ENSG00000198589

Description: LPS responsive beige-like anchor protein

Associated with

Cytosol
(GO:0005829)
Endoplasmic reticulum membrane
(GO:0005789)
Golgi apparatus
(GO:0005794)
Lysosomal membrane
(GO:0005765)
Membrane
(GO:0016020)
Mitophagy
(GO:0000423)
Molecular_function
(GO:0003674)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein localization
(GO:0008104)
Protein localization to phagophore assembly site
(GO:0034497)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.89
Cell Significance Index: 2
Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.5
Cell Significance Index: 2
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.41
Cell Significance Index: 2
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.41
Cell Significance Index: 2
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.33
Cell Significance Index: 1
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.29
Cell Significance Index: 1
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.21
Cell Significance Index: 1
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.19
Cell Significance Index: 2
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.18
Cell Significance Index: 1
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 1.13
Cell Significance Index: 1
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.1
Cell Significance Index: 1
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.06
Cell Significance Index: 1
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.05
Cell Significance Index: 1
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 1.05
Cell Significance Index: 1
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 1.05
Cell Significance Index: 1
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.03
Cell Significance Index: 1
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 1.03
Cell Significance Index: 1
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: preadipocyte (CL0002334)
Fold Change: 1
Cell Significance Index: 1
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 1
Cell Significance Index: 1
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1
Cell Significance Index: 1
Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: 1
Cell Significance Index: 1
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1
Cell Significance Index: 1
Cell Name: cell (CL0000000)
Fold Change: 1
Cell Significance Index: 1
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 1
Cell Significance Index: 1
Cell Name: epidermal cell (CL0000362)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neuron (CL0000540)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: adipocyte of breast (CL0002617)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: astrocyte (CL0000127)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: perivascular cell (CL4033054)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neural cell (CL0002319)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: glioblast (CL0000030)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: flat midget bipolar cell (CL4033033)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: invaginating midget bipolar cell (CL4033034)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: malignant cell (CL0001064)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: Merkel cell (CL0000242)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: microglial cell (CL0000129)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: diffuse bipolar 1 cell (CL4033027)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.98
Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** LRBA is a transmembrane protein that is responsive to lipopolysaccharide (LPS), a component of bacterial outer membranes. This responsiveness is mediated through the activation of the protein's signaling pathways, which ultimately lead to the regulation of immune response and cellular homeostasis. LRBA is also characterized by its ability to interact with various proteins, including protein kinases and transcription factors, which further underscore its role in regulating cellular processes. **Pathways and Functions** LRBA is involved in several key signaling pathways, including: 1. **Mitophagy**: LRBA plays a critical role in regulating mitophagy, a process by which damaged or dysfunctional mitochondria are degraded by autophagy. LRBA's interaction with mitochondrial proteins and signaling pathways regulates the efficiency of mitophagy, which is essential for maintaining cellular homeostasis and preventing neurodegenerative diseases. 2. **Immune Response**: LRBA's responsiveness to LPS triggers a signaling cascade that regulates immune response, including the activation of immune cells and the production of cytokines. This ensures that the immune system is able to respond appropriately to pathogens and maintain tissue homeostasis. 3. **Cellular Stress Response**: LRBA's interaction with stress-activated signaling pathways regulates the cellular response to stress, including heat shock, oxidative stress, and endoplasmic reticulum stress. 4. **Protein Degradation**: LRBA's interaction with the proteasome and other protein degradation pathways regulates the degradation of misfolded or damaged proteins, which is essential for maintaining protein homeostasis. **Clinical Significance** Dysregulation of LRBA has been implicated in various diseases, including: 1. **Neurodegenerative Diseases**: Mutations in LRBA have been associated with neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. LRBA's role in regulating mitophagy and cellular stress response suggests that dysregulation of this gene may contribute to the development of these diseases. 2. **Autoimmune Diseases**: LRBA's involvement in immune response and cellular homeostasis suggests that dysregulation of this gene may contribute to autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. 3. **Cancer**: LRBA's role in regulating protein degradation and cellular homeostasis suggests that dysregulation of this gene may contribute to tumorigenesis and cancer progression. In conclusion, LRBA is a critical regulator of immune response and cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining tissue homeostasis and preventing disease. Further research is needed to fully elucidate the role of LRBA in human disease and to develop therapeutic strategies to target this gene in the treatment of various diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.