Details for: AREL1

Gene ID: 9870

Symbol: AREL1

Ensembl ID: ENSG00000119682

Description: apoptosis resistant E3 ubiquitin protein ligase 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.47
    Marker Score: 3,234
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,679
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.21
    Marker Score: 4,925
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.19
    Marker Score: 347
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.18
    Marker Score: 1,828
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.11
    Marker Score: 9,549
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.1
    Marker Score: 1,928
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.07
    Marker Score: 10,153
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.06
    Marker Score: 64,919
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.05
    Marker Score: 1,155
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,762
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,986
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,401
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.97
    Marker Score: 9,163
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.95
    Marker Score: 399
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,406
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.95
    Marker Score: 34,913
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 486
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 441
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.92
    Marker Score: 9,479
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,721
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.89
    Marker Score: 19,008
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5,001
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.88
    Marker Score: 1,782
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,294
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.87
    Marker Score: 3,644
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.85
    Marker Score: 5,124
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.84
    Marker Score: 3,234
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.83
    Marker Score: 12,964
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.83
    Marker Score: 759
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.79
    Marker Score: 906
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.78
    Marker Score: 411
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,252
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 582
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.74
    Marker Score: 11,126
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.73
    Marker Score: 14,591
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 379
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.73
    Marker Score: 27,743
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.73
    Marker Score: 199
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.72
    Marker Score: 207
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.71
    Marker Score: 1,374
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2,948
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.69
    Marker Score: 5,324
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 627
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.68
    Marker Score: 2,809
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.68
    Marker Score: 765
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.67
    Marker Score: 724
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.67
    Marker Score: 403
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.64
    Marker Score: 375
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.63
    Marker Score: 1,332
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.63
    Marker Score: 542
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.61
    Marker Score: 1,023
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.61
    Marker Score: 339
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.61
    Marker Score: 294
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.6
    Marker Score: 408
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.59
    Marker Score: 237
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.58
    Marker Score: 19,484
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.57
    Marker Score: 182
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.57
    Marker Score: 581
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.57
    Marker Score: 2,628
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.56
    Marker Score: 560
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.56
    Marker Score: 809
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.56
    Marker Score: 697
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.55
    Marker Score: 343
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 431
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.54
    Marker Score: 761
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.53
    Marker Score: 261
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.53
    Marker Score: 11,797
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.53
    Marker Score: 406
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.52
    Marker Score: 193
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.52
    Marker Score: 236
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.52
    Marker Score: 317
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.52
    Marker Score: 1,382
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.51
    Marker Score: 1,232
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.51
    Marker Score: 853
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.51
    Marker Score: 130
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.51
    Marker Score: 302
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.48
    Marker Score: 153
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.47
    Marker Score: 1,343
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.47
    Marker Score: 311
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.47
    Marker Score: 3,000
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.47
    Marker Score: 1,654
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.47
    Marker Score: 134
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.46
    Marker Score: 443
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.46
    Marker Score: 157
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.46
    Marker Score: 1,989
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.46
    Marker Score: 1,159
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.46
    Marker Score: 231
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.46
    Marker Score: 492
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.45
    Marker Score: 487
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.45
    Marker Score: 479
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.45
    Marker Score: 821
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.45
    Marker Score: 90
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.44
    Marker Score: 295
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.44
    Marker Score: 165
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.44
    Marker Score: 304
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.43
    Marker Score: 157

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** AREL1 is an E3 ubiquitin protein ligase, a class of enzymes responsible for catalyzing the transfer of ubiquitin molecules to target proteins. This process is a crucial mechanism for protein degradation, modification, and regulation. AREL1 is distinct from other E3 ubiquitin ligases due to its resistance to apoptosis, a process of programmed cell death. This characteristic suggests that AREL1 plays a role in maintaining cellular homeostasis and preventing excessive cell death. **Pathways and Functions:** AREL1 is involved in several key pathways, including: 1. **Adaptive Immune System:** AREL1 is expressed in non-immune cells, but its role in the adaptive immune system is still unclear. However, its involvement in antigen processing and presentation suggests that it may play a role in modulating the immune response. 2. **Antigen Processing: Ubiquitination & Proteasome Degradation:** AREL1 is involved in the ubiquitination of proteins, which is a critical step in the degradation of proteins by the proteasome. 3. **Apoptotic Process:** As mentioned earlier, AREL1 is resistant to apoptosis, suggesting that it may play a role in preventing excessive cell death. 4. **Class I MHC Mediated Antigen Processing & Presentation:** AREL1 is involved in the processing and presentation of antigens to the immune system via Class I MHC molecules. 5. **Regulation of Inflammatory Response:** AREL1 may play a role in regulating the inflammatory response by modulating the activity of immune cells and the production of cytokines. **Clinical Significance:** While the exact clinical significance of AREL1 is still unclear, its involvement in various cellular processes suggests that it may play a role in the development and progression of various diseases. For example: 1. **Neurological Disorders:** AREL1's role in neuronal function and survival suggests that it may be involved in the development and progression of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer:** AREL1's resistance to apoptosis and its role in protein degradation and modification suggest that it may be involved in the development and progression of cancer. 3. **Ophthalmic Diseases:** AREL1's expression in corneal epithelial cells suggests that it may play a role in the development and progression of ophthalmic diseases, such as corneal dystrophies. In conclusion, AREL1 is a complex gene with a multifaceted role in various cellular processes. Further research is needed to fully elucidate its function and clinical significance. However, its involvement in antigen processing, apoptosis, and protein degradation suggests that it may play a critical role in maintaining cellular homeostasis and regulating the immune response.

Genular Protein ID: 3371547595

Symbol: AREL1_HUMAN

Name: N/A

UniProtKB Accession Codes:

O15033 B4E2C7 Q7LDY1 Q8IYY9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 5 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 12 Gene3D 4 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9205841

Title: Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9205841

DOI: 10.1093/dnares/4.2.141

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23479728

Title: Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTS.

PubMed ID: 23479728

DOI: 10.1074/jbc.m112.436113

PubMed ID: 25752577

Title: Assembly and specific recognition of K29- and K33-linked polyubiquitin.

PubMed ID: 25752577

DOI: 10.1016/j.molcel.2015.01.042

PubMed ID: 31578312

Title: KIAA0317 regulates pulmonary inflammation through SOCS2 degradation.

PubMed ID: 31578312

DOI: 10.1172/jci.insight.129110

Sequence Information:

  • Length: 823
  • Mass: 94223
  • Checksum: 9E26273B529DB477
  • Sequence:
    • MFYVIGGITV SVVAFFFTIK FLFELAARVV SFLQNEDRER RGDRTIYDYV RGNYLDPRSC 
KVSWDWKDPY EVGHSMAFRV HLFYKNGQPF PAHRPVGLRV HISHVELAVE IPVTQEVLQE 
PNSNVVKVAF TVRKAGRYEI TVKLGGLNVA YSPYYKIFQP GMVVPSKTKI VCHFSTLVLT 
CGQPHTLQIV PRDEYDNPTN NSMSLRDEHN YTLSIHELGP QEEESTGVSF EKSVTSNRQT 
FQVFLRLTLH SRGCFHACIS YQNQPINNGE FDIIVLSEDE KNIVERNVST SGVSIYFEAY 
LYNATNCSST PWHLPPMHMT SSQRRPSTAV DEEDEDSPSE CHTPEKVKKP KKVYCYVSPK 
QFSVKEFYLK IIPWRLYTFR VCPGTKFSYL GPDPVHKLLT LVVDDGIQPP VELSCKERNI 
LAATFIRSLH KNIGGSETFQ DKVNFFQREL RQVHMKRPHS KVTLKVSRHA LLESSLKATR 
NFSISDWSKN FEVVFQDEEA LDWGGPRREW FELICKALFD TTNQLFTRFS DNNQALVHPN 
PNRPAHLRLK MYEFAGRLVG KCLYESSLGG AYKQLVRARF TRSFLAQIIG LRMHYKYFET 
DDPEFYKSKV CFILNNDMSE MELVFAEEKY NKSGQLDKVV ELMTGGAQTP VTNANKIFYL 
NLLAQYRLAS QVKEEVEHFL KGLNELVPEN LLAIFDENEL ELLMCGTGDI SVSDFKAHAV 
VVGGSWHFRE KVMRWFWTVV SSLTQEELAR LLQFTTGSSQ LPPGGFAALC PSFQIIAAPT 
HSTLPTAHTC FNQLCLPTYD SYEEVHRMLQ LAISEGCEGF GML

Genular Protein ID: 3623467778

Symbol: A0A7P0T811_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A7P0T811

Database IDs:

ARBA 4 AlphaFoldDB 1 Bgee 1 CDD 1 CTD 1 EC 1 EMBL 4 EPD 1 Ensembl 2 GO 1 Gene3D 3 GeneTree 1 HGNC 1 InterPro 4 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 2

Citations:

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

Sequence Information:

  • Length: 813
  • Mass: 93100
  • Checksum: 96E1A9E552400CFF
  • Sequence:
    • MFYVIGGITV SVVAFFFTIK FLFELAARVV SFLQNEDRER RGDRTIYDYV RGNYLDPRSC 
KVSWDWKDPY ELFYKNGQPF PAHRPVGLRV HISHVELAVE IPVTQEVLQE PNSNVVKVAF 
TVRKAGRYEI TVKLGGLNVA YSPYYKIFQP GMVVPSKTKI VCHFSTLVLT CGQPHTLQIV 
PRDEYDNPTN NSMSLRDEHN YTLSIHELGP QEEESTGVSF EKSVTSNRQT FQVFLRLTLH 
SRGCFHACIS YQNQPINNGE FDIIVLSEDE KNIVERNVST SGVSIYFEAY LYNATNCSST 
PWHLPPMHMT SSQRRPSTAV DEEDEDSPSE CHTPEKVKKP KKVYCYVSPK QFSVKEFYLK 
IIPWRLYTFR VCPGTKFSYL GPDPVHKLLT LVVDDGIQPP VELSCKERNI LAATFIRSLH 
KNIGGSETFQ DKVNFFQREL RQVHMKRPHS KVTLKVSRHA LLESSLKATR NFSISDWSKN 
FEVVFQDEEA LDWGGPRREW FELICKALFD TTNQLFTRFS DNNQALVHPN PNRPAHLRLK 
MYEFAGRLVG KCLYESSLGG AYKQLVRARF TRSFLAQIIG LRMHYKYFET DDPEFYKSKV 
CFILNNDMSE MELVFAEEKY NKSGQLDKVV ELMTGGAQTP VTNANKIFYL NLLAQYRLAS 
QVKEEVEHFL KGLNELVPEN LLAIFDENEL ELLMCGTGDI SVSDFKAHAV VVGGSWHFRE 
KVMRWFWTVV SSLTQEELAR LLQFTTGSSQ LPPGGFAALC PSFQIIAAPT HSTLPTAHTC 
FNQLCLPTYD SYEEVHRMLQ LAISEGCEGF GML

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.