Details for: FCHSD2

Gene ID: 9873

Symbol: FCHSD2

Ensembl ID: ENSG00000137478

Description: FCH and double SH3 domains 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 4.24
    Marker Score: 1,531
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 3.95
    Marker Score: 2,140
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.81
    Marker Score: 67,644
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.69
    Marker Score: 4,467
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.59
    Marker Score: 121,293
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 3.43
    Marker Score: 1,705
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 3.4
    Marker Score: 2,793
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.29
    Marker Score: 73,628
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.92
    Marker Score: 5,621
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.9
    Marker Score: 3,906
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.77
    Marker Score: 12,835
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.75
    Marker Score: 11,448
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.73
    Marker Score: 14,685
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.69
    Marker Score: 3,915
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.68
    Marker Score: 5,877
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.66
    Marker Score: 1,479
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.56
    Marker Score: 2,443
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.54
    Marker Score: 1,519
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.54
    Marker Score: 1,478
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.49
    Marker Score: 37,290
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.48
    Marker Score: 18,980
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.47
    Marker Score: 93,869
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.46
    Marker Score: 48,977
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.46
    Marker Score: 2,833
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.41
    Marker Score: 9,975
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.4
    Marker Score: 51,203
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.37
    Marker Score: 2,537
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2.35
    Marker Score: 1,771
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.32
    Marker Score: 1,359
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.31
    Marker Score: 85,077
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.3
    Marker Score: 1,137
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.3
    Marker Score: 9,606
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.28
    Marker Score: 7,639
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.23
    Marker Score: 2,761
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.23
    Marker Score: 5,117
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.19
    Marker Score: 7,800
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.18
    Marker Score: 915
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.17
    Marker Score: 7,110
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.17
    Marker Score: 8,371
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.14
    Marker Score: 5,126
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.09
    Marker Score: 19,644
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.02
    Marker Score: 2,512
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.96
    Marker Score: 14,785
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.94
    Marker Score: 20,011
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.93
    Marker Score: 2,186
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.92
    Marker Score: 740
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.9
    Marker Score: 1,252
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.87
    Marker Score: 593
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.86
    Marker Score: 589
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.84
    Marker Score: 113,406
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.84
    Marker Score: 538
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.84
    Marker Score: 1,032
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.83
    Marker Score: 2,579
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.83
    Marker Score: 675
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.82
    Marker Score: 15,640
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.82
    Marker Score: 29,192
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.8
    Marker Score: 7,346
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.8
    Marker Score: 1,047
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.73
    Marker Score: 1,534
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.72
    Marker Score: 2,882
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.71
    Marker Score: 622
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.69
    Marker Score: 463
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.67
    Marker Score: 804
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.64
    Marker Score: 915
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.62
    Marker Score: 1,128
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.62
    Marker Score: 4,062
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.6
    Marker Score: 514
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.59
    Marker Score: 15,105
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.58
    Marker Score: 2,748
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.57
    Marker Score: 1,360
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.54
    Marker Score: 392
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.54
    Marker Score: 1,657
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.5
    Marker Score: 567
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.5
    Marker Score: 1,812
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.49
    Marker Score: 468
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.49
    Marker Score: 2,305
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.48
    Marker Score: 3,101
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.48
    Marker Score: 7,756
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.47
    Marker Score: 405
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.45
    Marker Score: 1,119
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.4
    Marker Score: 1,066
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.39
    Marker Score: 914
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.37
    Marker Score: 355
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.36
    Marker Score: 2,774
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.34
    Marker Score: 1,674
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.34
    Marker Score: 20,961
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.34
    Marker Score: 1,256
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.33
    Marker Score: 3,803
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.33
    Marker Score: 454
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.31
    Marker Score: 1,134
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.29
    Marker Score: 483
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.29
    Marker Score: 1,267
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.27
    Marker Score: 3,768
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.26
    Marker Score: 8,081
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 1.23
    Marker Score: 324
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.22
    Marker Score: 1,221
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.19
    Marker Score: 1,318
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.19
    Marker Score: 5,122
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.17
    Marker Score: 704
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.17
    Marker Score: 1,650

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The FCHSD2 protein is distinguished by its unique domain structure, which enables it to interact with multiple partners and participate in diverse cellular processes. The F-BAR domain, a hallmark of FCHSD2, is capable of binding to phosphatidylinositol-3,4,5-trisphosphate (PIP3) and phosphatidylinositol-3,4-bisphosphate (PIBP), thereby regulating actin filament polymerization. The two SH3 domains, on the other hand, facilitate protein-protein interactions, enabling the protein to bind to various partners and modulate cellular processes. **Pathways and Functions** The FCHSD2 protein is involved in several key cellular pathways, including: 1. **Clathrin-dependent endocytosis**: FCHSD2 regulates the formation and dynamics of clathrin-coated pits, which are essential for endocytosis and the uptake of nutrients and waste products. 2. **Actin filament polymerization**: The FCHSD2 protein modulates actin filament polymerization, a process crucial for cell motility, shape changes, and the establishment of cellular structures. 3. **Protein transport**: FCHSD2 participates in protein transport across the plasma membrane, a process essential for cell signaling, communication, and the regulation of cellular processes. 4. **Stereocilium shaft formation**: In the context of stereocilia, FCHSD2 plays a critical role in the formation and maintenance of the shaft, a structure essential for sensory function. **Clinical Significance** Dysregulation of the FCHSD2 gene has been implicated in various diseases, including: 1. **Neuromuscular disorders**: Mutations in the FCHSD2 gene have been linked to neuromuscular disorders, such as Charcot-Marie-Tooth disease, a condition characterized by peripheral nerve degeneration. 2. **Neurodegenerative diseases**: FCHSD2 has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, where disruptions in endocytosis and protein transport contribute to disease progression. 3. **Cancer**: Alterations in the FCHSD2 gene have been observed in various cancers, including breast cancer, where FCHSD2 regulates cell migration and invasion. In conclusion, the FCHSD2 gene is a critical component of various cellular processes, including endocytosis, actin filament polymerization, and protein transport. Dysregulation of this gene has been implicated in a range of diseases, highlighting the importance of FCHSD2 in maintaining cellular homeostasis and overall health.

Genular Protein ID: 2757216951

Symbol: FCSD2_HUMAN

Name: F-BAR and double SH3 domains protein 2

UniProtKB Accession Codes:

O94868 B4DNI3 Q7L8J9 Q8WVM2 Q96FV7 Q9UF77

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 1 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14627983

Title: Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains.

PubMed ID: 14627983

DOI: 10.1038/sj.onc.1206996

PubMed ID: 9872452

Title: Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9872452

DOI: 10.1093/dnares/5.5.277

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15067381

Title: Identification and characterization of human FCHSD1 and FCHSD2 genes in silico.

PubMed ID: 15067381

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30249660

Title: Role for ERK1/2-dependent activation of FCHSD2 in cancer cell-selective regulation of clathrin-mediated endocytosis.

PubMed ID: 30249660

DOI: 10.1073/pnas.1810209115

PubMed ID: 29887380

Title: A Flat BAR Protein Promotes Actin Polymerization at the Base of Clathrin-Coated Pits.

PubMed ID: 29887380

DOI: 10.1016/j.cell.2018.05.020

Sequence Information:

  • Length: 740
  • Mass: 84276
  • Checksum: 3AF4DAC3CAD24C28
  • Sequence:
    • MQPPPRKVKV TQELKNIQVE QMTKLQAKHQ AECDLLEDMR TFSQKKAAIE REYAQGMQKL 
ASQYLKRDWP GVKADDRNDY RSMYPVWKSF LEGTMQVAQS RMNICENYKN FISEPARTVR 
SLKEQQLKRC VDQLTKIQTE LQETVKDLAK GKKKYFETEQ MAHAVREKAD IEAKSKLSLF 
QSRISLQKAS VKLKARRSEC NSKATHARND YLLTLAAANA HQDRYYQTDL VNIMKALDGN 
VYDHLKDYLI AFSRTELETC QAVQNTFQFL LENSSKVVRD YNLQLFLQEN AVFHKPQPFQ 
FQPCDSDTSR QLESETGTTE EHSLNKEARK WATRVAREHK NIVHQQRVLN DLECHGAAVS 
EQSRAELEQK IDEARENIRK AEIIKLKAEA RLDLLKQIGV SVDTWLKSAM NQVMEELENE 
RWARPPAVTS NGTLHSLNAD TEREEGEEFE DNMDVFDDSS SSPSGTLRNY PLTCKVVYSY 
KASQPDELTI EEHEVLEVIE DGDMEDWVKA RNKVGQVGYV PEKYLQFPTS NSLLSMLQSL 
AALDSRSHTS SNSTEAELVS GSLNGDASVC FVKALYDYEG QTDDELSFPE GAIIRILNKE 
NQDDDGFWEG EFNGRIGVFP SVLVEELSAS ENGDTPWMRE IQISPSPKPH ASLPPLPLYD 
QPPSSPYPSP DKRSSLYFPR SPSANEKSLH AESPGFSQAS RHTPETSYGK LRPVRAAPPP 
PTQNHRRPAE KIEDVEITLV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.