Details for: CDC5L

Gene ID: 988

Symbol: CDC5L

Ensembl ID: ENSG00000096401

Description: cell division cycle 5 like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 269.3107
    Cell Significance Index: -41.8900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 163.9309
    Cell Significance Index: -41.5800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 109.3360
    Cell Significance Index: -51.6200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 102.0536
    Cell Significance Index: -41.4600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 94.7442
    Cell Significance Index: -48.7400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 43.9909
    Cell Significance Index: -42.0000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 39.9852
    Cell Significance Index: -49.3000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.9064
    Cell Significance Index: -45.2900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.7875
    Cell Significance Index: -50.4600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.4576
    Cell Significance Index: -32.1200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.7499
    Cell Significance Index: -19.1500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.1364
    Cell Significance Index: 216.9000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.2399
    Cell Significance Index: 18.8200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.6945
    Cell Significance Index: 101.7300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.1180
    Cell Significance Index: 58.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0631
    Cell Significance Index: 145.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0511
    Cell Significance Index: 28.6100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0418
    Cell Significance Index: 187.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0341
    Cell Significance Index: 66.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9271
    Cell Significance Index: 113.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8373
    Cell Significance Index: 166.1600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8037
    Cell Significance Index: 21.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8030
    Cell Significance Index: 161.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7583
    Cell Significance Index: 414.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7529
    Cell Significance Index: 332.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6026
    Cell Significance Index: 27.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5665
    Cell Significance Index: 56.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4969
    Cell Significance Index: 178.2500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4904
    Cell Significance Index: 17.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4711
    Cell Significance Index: 33.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4667
    Cell Significance Index: 21.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4487
    Cell Significance Index: 21.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4452
    Cell Significance Index: 57.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4410
    Cell Significance Index: 12.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4214
    Cell Significance Index: 21.8900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4082
    Cell Significance Index: 48.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3937
    Cell Significance Index: 22.1000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3884
    Cell Significance Index: 8.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3641
    Cell Significance Index: 69.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3533
    Cell Significance Index: 22.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3436
    Cell Significance Index: 21.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3323
    Cell Significance Index: 7.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2468
    Cell Significance Index: 31.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2234
    Cell Significance Index: 38.1400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1987
    Cell Significance Index: 137.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1345
    Cell Significance Index: 7.0600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1308
    Cell Significance Index: 3.7500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0878
    Cell Significance Index: 0.9500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0825
    Cell Significance Index: 1.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0763
    Cell Significance Index: 2.6800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0425
    Cell Significance Index: 6.9200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0235
    Cell Significance Index: 44.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0167
    Cell Significance Index: 1.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0014
    Cell Significance Index: 0.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0007
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0120
    Cell Significance Index: -8.8800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0133
    Cell Significance Index: -8.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0142
    Cell Significance Index: -9.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0143
    Cell Significance Index: -21.9500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0164
    Cell Significance Index: -7.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0169
    Cell Significance Index: -31.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0322
    Cell Significance Index: -43.7500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0375
    Cell Significance Index: -28.3700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0506
    Cell Significance Index: -1.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0606
    Cell Significance Index: -34.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0737
    Cell Significance Index: -1.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0790
    Cell Significance Index: -8.0700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0887
    Cell Significance Index: -2.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1089
    Cell Significance Index: -22.9400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1150
    Cell Significance Index: -1.9300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1389
    Cell Significance Index: -3.7200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1430
    Cell Significance Index: -16.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1452
    Cell Significance Index: -41.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1548
    Cell Significance Index: -17.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1738
    Cell Significance Index: -25.2600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2575
    Cell Significance Index: -6.6200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3275
    Cell Significance Index: -37.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3428
    Cell Significance Index: -9.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3769
    Cell Significance Index: -25.3400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.3929
    Cell Significance Index: -42.7400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4067
    Cell Significance Index: -10.3900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4163
    Cell Significance Index: -5.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4427
    Cell Significance Index: -14.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4652
    Cell Significance Index: -36.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4675
    Cell Significance Index: -48.6800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5127
    Cell Significance Index: -12.3000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5142
    Cell Significance Index: -4.7400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5467
    Cell Significance Index: -13.6700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5484
    Cell Significance Index: -16.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6124
    Cell Significance Index: -27.0900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6219
    Cell Significance Index: -38.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6361
    Cell Significance Index: -17.0500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6466
    Cell Significance Index: -11.9500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7505
    Cell Significance Index: -28.4200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7870
    Cell Significance Index: -4.7600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.8506
    Cell Significance Index: -10.1400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.9591
    Cell Significance Index: -48.4700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.9739
    Cell Significance Index: -16.6900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.0201
    Cell Significance Index: -10.5600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.0662
    Cell Significance Index: -30.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The CDC5L gene exhibits several key characteristics that distinguish it from other genes. These include: 1. **Cell cycle regulation**: CDC5L is involved in the regulation of the cell cycle, particularly in the G2/M phase transition. 2. **Transcriptional regulation**: The CDC5L protein acts as a transcriptional activator, regulating the expression of genes involved in DNA damage response and repair. 3. **DNA damage response**: CDC5L is activated in response to DNA damage, leading to the activation of DNA repair pathways. 4. **Spliceosome regulation**: CDC5L is involved in the regulation of the spliceosome, a complex involved in pre-mRNA splicing. 5. **Wd40-repeat domain binding**: The CDC5L protein contains a Wd40-repeat domain, which is involved in protein-protein interactions and transcriptional regulation. **Pathways and Functions** The CDC5L gene is involved in several cellular pathways and functions, including: 1. **Cell cycle regulation**: CDC5L regulates the G2/M phase transition by interacting with the APC and other cell cycle regulators. 2. **DNA damage response**: CDC5L is activated in response to DNA damage, leading to the activation of DNA repair pathways, including non-homologous end joining (NHEJ) and homologous recombination (HR). 3. **Transcriptional regulation**: CDC5L regulates the expression of genes involved in DNA repair, cell cycle progression, and transcriptional regulation. 4. **Spliceosome regulation**: CDC5L regulates the spliceosome, a complex involved in pre-mRNA splicing. 5. **RNA metabolism**: CDC5L is involved in the regulation of RNA metabolism, including mRNA splicing and processing. **Clinical Significance** The CDC5L gene has significant clinical implications, particularly in the context of cancer and neurodegenerative diseases. Mutations in the CDC5L gene have been associated with: 1. **Cancer**: CDC5L is overexpressed in several types of cancer, including breast cancer, lung cancer, and colon cancer. 2. **Neurodegenerative diseases**: CDC5L is involved in the regulation of transcriptional programs involved in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Immune dysregulation**: CDC5L is involved in the regulation of immune responses, particularly in the context of autoimmunity and inflammation. In conclusion, the CDC5L gene is a critical regulator of the cell cycle and transcriptional processes, with significant implications for cancer and neurodegenerative diseases. Further research is needed to fully understand the mechanisms by which CDC5L regulates cellular processes and to develop therapeutic strategies targeting this gene.

Genular Protein ID: 4214608898

Symbol: CDC5L_HUMAN

Name: Cell division cycle 5-like protein

UniProtKB Accession Codes:

Q99459 Q76N46 Q99974

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 23 Ensembl 1 EvolutionaryTrace 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 27 PDBsum 27 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9038199

Title: Pombe Cdc5-related protein. A putative human transcription factor implicated in mitogen-activated signaling.

PubMed ID: 9038199

DOI: 10.1074/jbc.272.9.5833

PubMed ID: 9598309

Title: Rearrangement of the human CDC5L gene by a t(6;19)(p21;q13.1) in a patient with multicystic renal dysplasia.

PubMed ID: 9598309

DOI: 10.1006/geno.1998.5254

PubMed ID: 9632794

Title: Myb-related Schizosaccharomyces pombe cdc5p is structurally and functionally conserved in eukaryotes.

PubMed ID: 9632794

DOI: 10.1128/mcb.18.7.4097

PubMed ID: 9455477

Title: Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9455477

DOI: 10.1093/dnares/4.5.307

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8917598

Title: A cdc5+ homolog of a higher plant, Arabidopsis thaliana.

PubMed ID: 8917598

DOI: 10.1073/pnas.93.23.13371

PubMed ID: 10827081

Title: NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry.

PubMed ID: 10827081

DOI: 10.1074/jbc.m001676200

PubMed ID: 9468527

Title: A mammalian homolog of fission yeast Cdc5 regulates G2 progression and mitotic entry.

PubMed ID: 9468527

DOI: 10.1074/jbc.273.8.4666

PubMed ID: 9731529

Title: Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex.

PubMed ID: 9731529

DOI: 10.1038/1700

PubMed ID: 10570151

Title: Evidence that Myb-related CDC5 proteins are required for pre-mRNA splicing.

PubMed ID: 10570151

DOI: 10.1073/pnas.96.24.13789

PubMed ID: 11101529

Title: Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry.

PubMed ID: 11101529

DOI: 10.1093/emboj/19.23.6569

PubMed ID: 11082045

Title: Human Cdc5, a regulator of mitotic entry, can act as a site-specific DNA binding protein.

PubMed ID: 11082045

DOI: 10.1242/jcs.113.24.4523

PubMed ID: 11544257

Title: A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing.

PubMed ID: 11544257

DOI: 10.1074/jbc.m105453200

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 12927788

Title: hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing.

PubMed ID: 12927788

DOI: 10.1016/s0006-291x(03)01486-4

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18583928

Title: Cell cycle-dependent phosphorylation of human CDC5 regulates RNA processing.

PubMed ID: 18583928

DOI: 10.4161/cc.7.12.6017

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18722174

Title: Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1.

PubMed ID: 18722174

DOI: 10.1016/j.molcel.2008.07.009

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20176811

Title: Molecular architecture of the human Prp19/CDC5L complex.

PubMed ID: 20176811

DOI: 10.1128/mcb.01505-09

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21385873

Title: CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31.

PubMed ID: 21385873

DOI: 10.1074/jbc.m110.208769

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23022480

Title: Mpn1, mutated in poikiloderma with neutropenia protein 1, is a conserved 3'-to-5' RNA exonuclease processing U6 small nuclear RNA.

PubMed ID: 23022480

DOI: 10.1016/j.celrep.2012.08.031

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24332808

Title: PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.

PubMed ID: 24332808

DOI: 10.1016/j.molcel.2013.11.002

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 32484799

Title: Disease-associated CTNNBL1 mutation impairs somatic hypermutation by decreasing nuclear AID.

PubMed ID: 32484799

DOI: 10.1172/jci131297

PubMed ID: 28502770

Title: An Atomic Structure of the Human Spliceosome.

PubMed ID: 28502770

DOI: 10.1016/j.cell.2017.04.033

PubMed ID: 28076346

Title: Cryo-EM structure of a human spliceosome activated for step 2 of splicing.

PubMed ID: 28076346

DOI: 10.1038/nature21079

PubMed ID: 29361316

Title: Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex.

PubMed ID: 29361316

DOI: 10.1016/j.cell.2018.01.010

PubMed ID: 29360106

Title: Structure of the human activated spliceosome in three conformational states.

PubMed ID: 29360106

DOI: 10.1038/cr.2018.14

PubMed ID: 29301961

Title: Structure of a human catalytic step I spliceosome.

PubMed ID: 29301961

DOI: 10.1126/science.aar6401

PubMed ID: 30728453

Title: Structures of the human spliceosomes before and after release of the ligated exon.

PubMed ID: 30728453

DOI: 10.1038/s41422-019-0143-x

PubMed ID: 30705154

Title: A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation.

PubMed ID: 30705154

DOI: 10.1126/science.aaw5569

PubMed ID: 33509932

Title: Structure of the activated human minor spliceosome.

PubMed ID: 33509932

DOI: 10.1126/science.abg0879

Sequence Information:

  • Length: 802
  • Mass: 92251
  • Checksum: 3390F91EE7E79DA6
  • Sequence:
    • MPRIMIKGGV WRNTEDEILK AAVMKYGKNQ WSRIASLLHR KSAKQCKARW YEWLDPSIKK 
TEWSREEEEK LLHLAKLMPT QWRTIAPIIG RTAAQCLEHY EFLLDKAAQR DNEEETTDDP 
RKLKPGEIDP NPETKPARPD PIDMDEDELE MLSEARARLA NTQGKKAKRK AREKQLEEAR 
RLAALQKRRE LRAAGIEIQK KRKRKRGVDY NAEIPFEKKP ALGFYDTSEE NYQALDADFR 
KLRQQDLDGE LRSEKEGRDR KKDKQHLKRK KESDLPSAIL QTSGVSEFTK KRSKLVLPAP 
QISDAELQEV VKVGQASEIA RQTAEESGIT NSASSTLLSE YNVTNNSVAL RTPRTPASQD 
RILQEAQNLM ALTNVDTPLK GGLNTPLHES DFSGVTPQRQ VVQTPNTVLS TPFRTPSNGA 
EGLTPRSGTT PKPVINSTPG RTPLRDKLNI NPEDGMADYS DPSYVKQMER ESREHLRLGL 
LGLPAPKNDF EIVLPENAEK ELEEREIDDT YIEDAADVDA RKQAIRDAER VKEMKRMHKA 
VQKDLPRPSE VNETILRPLN VEPPLTDLQK SEELIKKEMI TMLHYDLLHH PYEPSGNKKG 
KTVGFGTNNS EHITYLEHNP YEKFSKEELK KAQDVLVQEM EVVKQGMSHG ELSSEAYNQV 
WEECYSQVLY LPGQSRYTRA NLASKKDRIE SLEKRLEINR GHMTTEAKRA AKMEKKMKIL 
LGGYQSRAMG LMKQLNDLWD QIEQAHLELR TFEELKKHED SAIPRRLECL KEDVQRQQER 
EKELQHRYAD LLLEKETLKS KF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.