NUAK1 | ENSG00000074590 | NCBI 9891

Details for: NUAK1

Gene ID: 9891

Symbol: NUAK1

Ensembl ID: ENSG00000074590

Description: NUAK family kinase 1

Associated with

Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through phosphorylation
(R-HSA-6804756)
Rna polymerase ii transcription
(R-HSA-73857)
Transcriptional regulation by tp53
(R-HSA-3700989)
Atp binding
(GO:0005524)
Cell adhesion
(GO:0007155)
Cytoplasm
(GO:0005737)
Dna damage response
(GO:0006974)
Fibrillar center
(GO:0001650)
Metal ion binding
(GO:0046872)
Microtubule cytoskeleton
(GO:0015630)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
P53 binding
(GO:0002039)
Protein binding
(GO:0005515)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Regulation of cell adhesion
(GO:0030155)
Regulation of cell population proliferation
(GO:0042127)
Regulation of cellular senescence
(GO:2000772)
Regulation of myosin-light-chain-phosphatase activity
(GO:0035507)
Regulation of signal transduction by p53 class mediator
(GO:1901796)

Other Information

Proteins

NUAK family SNF1-like kinase 1

Genular Protein ID: 2230900133

Symbol: NUAK1_HUMAN

Name: NUAK family SNF1-like kinase 1

UniProtKB Accession Codes:

O60285 A7MD39 Q96KA8

Database IDs:

Citations:

PubMed ID: 14976552

Title: LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.

PubMed ID: 14976552

DOI: 10.1038/sj.emboj.7600110

PubMed ID: 9628581

Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9628581

DOI: 10.1093/dnares/5.1.31

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12409306

Title: Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein.

PubMed ID: 12409306

DOI: 10.1074/jbc.m206025200

PubMed ID: 14982852

Title: ARK5 expression in colorectal cancer and its implications for tumor progression.

PubMed ID: 14982852

DOI: 10.1016/s0002-9440(10)63186-0

PubMed ID: 15060171

Title: ARK5 is a tumor invasion-associated factor downstream of Akt signaling.

PubMed ID: 15060171

DOI: 10.1128/mcb.24.8.3526-3535.2004

PubMed ID: 15273717

Title: Regulation of caspase-6 and FLIP by the AMPK family member ARK5.

PubMed ID: 15273717

DOI: 10.1038/sj.onc.1207963

PubMed ID: 16044163

Title: ARK5 is transcriptionally regulated by the Large-MAF family and mediates IGF-1-induced cell invasion in multiple myeloma: ARK5 as a new molecular determinant of malignant multiple myeloma.

PubMed ID: 16044163

DOI: 10.1038/sj.onc.1208844

PubMed ID: 16424013

Title: Overexpression of c-Maf contributes to T-cell lymphoma in both mice and human.

PubMed ID: 16424013

DOI: 10.1158/0008-5472.can-05-2154

PubMed ID: 16488889

Title: NDR2 acts as the upstream kinase of ARK5 during insulin-like growth factor-1 signaling.

PubMed ID: 16488889

DOI: 10.1074/jbc.m511354200

PubMed ID: 18254724

Title: Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains.

PubMed ID: 18254724

DOI: 10.1042/bj20080067

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19927127

Title: Regulation of ploidy and senescence by the AMPK-related kinase NUAK1.

PubMed ID: 19927127

DOI: 10.1038/emboj.2009.342

PubMed ID: 20354225

Title: New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion.

PubMed ID: 20354225

DOI: 10.1126/scisignal.2000616

PubMed ID: 21317932

Title: A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation.

PubMed ID: 21317932

DOI: 10.1038/onc.2011.19

PubMed ID: 25329316

Title: A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation.

PubMed ID: 25329316

DOI: 10.1371/journal.pgen.1004721

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 661
Mass: 74305
Checksum: 806F37D52CA4718F
Sequence:

MEGAAAPVAG DRPDLGLGAP GSPREAVAGA TAALEPRKPH GVKRHHHKHN LKHRYELQET 
LGKGTYGKVK RATERFSGRV VAIKSIRKDK IKDEQDMVHI RREIEIMSSL NHPHIISIYE 
VFENKDKIVI IMEYASKGEL YDYISERRRL SERETRHFFR QIVSAVHYCH KNGVVHRDLK 
LENILLDDNC NIKIADFGLS NLYQKDKFLQ TFCGSPLYAS PEIVNGRPYR GPEVDSWALG 
VLLYTLVYGT MPFDGFDHKN LIRQISSGEY REPTQPSDAR GLIRWMLMVN PDRRATIEDI 
ANHWWVNWGY KSSVCDCDAL HDSESPLLAR IIDWHHRSTG LQADTEAKMK GLAKPTTSEV 
MLERQRSLKK SKKENDFAQS GQDAVPESPS KLSSKRPKGI LKKRSNSEHR SHSTGFIEGV 
VGPALPSTFK MEQDLCRTGV LLPSSPEAEV PGKLSPKQSA TMPKKGILKK TQQRESGYYS 
SPERSESSEL LDSNDVMGSS IPSPSPPDPA RVTSHSLSCR RKGILKHSSK YSAGTMDPAL 
VSPEMPTLES LSEPGVPAEG LSRSYSRPSS VISDDSVLSS DSFDLLDLQE NRPARQRIRS 
CVSAENFLQI QDFEGLQNRP RPQYLKRYRN RLADSSFSLL TDMDDVTQVY KQALEICSKL 
N

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: NUAK1

Associated with

Other Information

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. PubMed ID: 14976552

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. PubMed ID: 9628581

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein. PubMed ID: 12409306

ARK5 expression in colorectal cancer and its implications for tumor progression. PubMed ID: 14982852

ARK5 is a tumor invasion-associated factor downstream of Akt signaling. PubMed ID: 15060171

Regulation of caspase-6 and FLIP by the AMPK family member ARK5. PubMed ID: 15273717

ARK5 is transcriptionally regulated by the Large-MAF family and mediates IGF-1-induced cell invasion in multiple myeloma: ARK5 as a new molecular determinant of malignant multiple myeloma. PubMed ID: 16044163

Overexpression of c-Maf contributes to T-cell lymphoma in both mice and human. PubMed ID: 16424013

NDR2 acts as the upstream kinase of ARK5 during insulin-like growth factor-1 signaling. PubMed ID: 16488889

Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains. PubMed ID: 18254724

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Regulation of ploidy and senescence by the AMPK-related kinase NUAK1. PubMed ID: 19927127

New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion. PubMed ID: 20354225

A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation. PubMed ID: 21317932

A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation. PubMed ID: 25329316

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846