Details for: SNAP91

Gene ID: 9892

Symbol: SNAP91

Ensembl ID: ENSG00000065609

Description: synaptosome associated protein 91

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 4.69
    Marker Score: 24627
  • Cell Name: granule cell (CL0000120)
    Fold Change: 4.27
    Marker Score: 32223
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 4.03
    Marker Score: 9274
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 3.96
    Marker Score: 21258
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.75
    Marker Score: 126608
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 3.66
    Marker Score: 5145
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 3.39
    Marker Score: 15686
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.94
    Marker Score: 9873
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2.78
    Marker Score: 2091
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.72
    Marker Score: 54122
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.65
    Marker Score: 20286
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.64
    Marker Score: 1532
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.6
    Marker Score: 38905
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.57
    Marker Score: 97648
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.53
    Marker Score: 1058
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.47
    Marker Score: 7047
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.47
    Marker Score: 10224
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.41
    Marker Score: 765.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.37
    Marker Score: 87454
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.29
    Marker Score: 8857
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 2.29
    Marker Score: 1099
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.25
    Marker Score: 1175
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.19
    Marker Score: 843
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.16
    Marker Score: 20331
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.09
    Marker Score: 2532
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 2.09
    Marker Score: 2608
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.08
    Marker Score: 1167
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.07
    Marker Score: 127006
  • Cell Name: neuron (CL0000540)
    Fold Change: 2.02
    Marker Score: 8216
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2
    Marker Score: 20604
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.97
    Marker Score: 3303
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.92
    Marker Score: 524
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.92
    Marker Score: 18196.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.87
    Marker Score: 16048
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.87
    Marker Score: 1287
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.8
    Marker Score: 594
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.72
    Marker Score: 4115.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.65
    Marker Score: 2552
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.64
    Marker Score: 498
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.62
    Marker Score: 1999
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.6
    Marker Score: 34131
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.59
    Marker Score: 3289
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167533
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.42
    Marker Score: 2690
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.33
    Marker Score: 2712
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.21
    Marker Score: 362
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.18
    Marker Score: 688
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.15
    Marker Score: 759.5
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.14
    Marker Score: 7574
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.13
    Marker Score: 4362
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.06
    Marker Score: 919
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 798
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.02
    Marker Score: 2595
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71818
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48043.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.96
    Marker Score: 1951
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.95
    Marker Score: 3954
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5351
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.93
    Marker Score: 1250
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.9
    Marker Score: 539
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.88
    Marker Score: 1534
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 0.82
    Marker Score: 276
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.79
    Marker Score: 783
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.79
    Marker Score: 741
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.74
    Marker Score: 11519
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.72
    Marker Score: 380
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.71
    Marker Score: 862
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.7
    Marker Score: 802
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.69
    Marker Score: 780
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.69
    Marker Score: 453
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.68
    Marker Score: 1928
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.65
    Marker Score: 1188
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 496
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.62
    Marker Score: 277
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.61
    Marker Score: 318
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.61
    Marker Score: 564
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.61
    Marker Score: 192.5
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.61
    Marker Score: 6152
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.6
    Marker Score: 203
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.55
    Marker Score: 156
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.55
    Marker Score: 793
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.54
    Marker Score: 158
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.52
    Marker Score: 511
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.52
    Marker Score: 216
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.51
    Marker Score: 305
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.5
    Marker Score: 171
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.46
    Marker Score: 146
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.46
    Marker Score: 219
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.46
    Marker Score: 185
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.45
    Marker Score: 129
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.39
    Marker Score: 111

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Other Information

**Key characteristics:** * The SNAP91 gene is located on chromosome 1 and is approximately 10.5 kb in length. * It encodes a protein of 441 amino acids. * The protein is a member of the clathrin family of cell adhesion molecules. * It is involved in the clathrin-coated pit, a complex that is responsible for the internalization of extracellular vesicles. * It is also involved in the regulation of clathrin-dependent endocytosis. **Pathways and functions:** * The SNAP91 gene is involved in a variety of cellular processes, including endocytosis, vesicle trafficking, and cell migration. * It is involved in the internalization of extracellular vesicles through the clathrin-coated pit. * It is also involved in the regulation of clathrin-dependent endocytosis, a process that is essential for the internalization of growth factors and other extracellular molecules. **Clinical significance:** * Mutations in the SNAP91 gene have been linked to a number of neurological disorders, including autism spectrum disorder, schizophrenia, and epilepsy. * These mutations can disrupt the function of the clathrin-coated pit, leading to the internalization of harmful substances and the development of neurodegenerative diseases. * Therefore, understanding the role of the SNAP91 gene in clathrin-dependent endocytosis may provide new insights into the development of novel therapies for neurological disorders.

Genular Protein ID: 3732672474

Symbol: AP180_HUMAN

Name: Clathrin coat assembly protein AP180

UniProtKB Accession Codes:

O60641 A8K0L7 E5RI02 Q5JX13 Q68DL9 Q6P9D3 Q9NTY7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 7 EPD 1 Ensembl 5 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 2 RefSeq 10 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9734811

Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9734811

DOI: 10.1093/dnares/5.3.169

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16903783

Title: Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly.

PubMed ID: 16903783

DOI: 10.1371/journal.pbio.0040262

Sequence Information:

  • Length: 907
  • Mass: 92502
  • Checksum: 23959C2B54F5EBF1
  • Sequence:
    • MSGQTLTDRI AAAQYSVTGS AVARAVCKAT THEVMGPKKK HLDYLIQATN ETNVNIPQMA 
DTLFERATNS SWVVVFKALV TTHHLMVHGN ERFIQYLASR NTLFNLSNFL DKSGSHGYDM 
STFIRRYSRY LNEKAFSYRQ MAFDFARVKK GADGVMRTMA PEKLLKSMPI LQGQIDALLE 
FDVHPNELTN GVINAAFMLL FKDLIKLFAC YNDGVINLLE KFFEMKKGQC KDALEIYKRF 
LTRMTRVSEF LKVAEQVGID KGDIPDLTQA PSSLMETLEQ HLNTLEGKKP GNNEGSGAPS 
PLSKSSPATT VTSPNSTPAK TIDTSPPVDL FATASAAVPV STSKPSSDLL DLQPDFSSGG 
AAAAAAPAPP PPAGGATAWG DLLGEDSLAA LSSVPSEAQI SDPFAPEPTP PTTTAEIATA 
SASASTTTTV TAVTAEVDLF GDAFAASPGE APAASEGAAA PATPTPVAAA LDACSGNDPF 
APSEGSAEAA PELDLFAMKP PETSVPVVTP TASTAPPVPA TAPSPAPAVA AAAAATTAAT 
AAATTTTTTS AATATTAPPA LDIFGDLFES TPEVAAAPKP DAAPSIDLFS TDAFSSPPQG 
ASPVPESSLT ADLLSVDAFA APSPATTASP AKVDSSGVID LFGDAFGSSA SEPQPASQAA 
SSSSASADLL AGFGGSFMAP SPSPVTPAQN NLLQPNFEAA FGTTPSTSSS SSFDPSVFDG 
LGDLLMPTMA PAGQPAPVSM VPPSPAMAAS KALGSDLDSS LASLVGNLGI SGTTTKKGDL 
QWNAGEKKLT GGANWQPKVA PATWSAGVPP SAPLQGAVPP TSSVPPVAGA PSVGQPGAGF 
GMPPAGTGMP MMPQQPVMFA QPMMRPPFGA AAVPGTQLSP SPTPASQSPK KPPAKDPLAD 
LNIKDFL

Genular Protein ID: 2567667981

Symbol: B7Z2N2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z2N2

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 5 Gene3D 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 783
  • Mass: 78788
  • Checksum: AA4995693B810934
  • Sequence:
    • MSTFIRRYSR YLNEKAFSYR QMAFDFARVK KGADGVMRTM APEKLLKSMP ILQGQIDALL 
EFDVHPNELT NGVINAAFML LFKDLIKLFA CYNDGVINLL EKFFEMKKGQ CKDALEIYKR 
FLTRMTRVSE FLKVAEQVGI DKGDIPDLTQ APSSLMETLE QHLNTLEGKK PGNNEGSGAP 
SPLSKSSPAT TVTSPNSTPA KTIDTSPPVD LFATASAAVP VSTSKPSSDL LDLQPDFSSG 
GAAAAAAPAP PPPAGGATAW GDLLGEDSLA ALSSVPSEAQ ISDPFAPEPT PPTTTAEIAT 
ASASASTTTT VTAVTAEVDL FGDAFAASPG EAPAASEGAA APATPTPVAA ALDACSGNDP 
FAPSEGSAEA APELDLFAMK PPETSVPVVT PTASTAPPVP ATAPSPAPAV AAAAAATTAA 
TAAATTTTTT SAATATTAPP ALDIFGDLFE STPEVAAAPK PDAAPSIDLF STDAFSSPPQ 
GASPVPESSL TADLLSVDAF AAPSPATTAS PAKVDSSGVI DLFGDAFGSS ASEPQPASQA 
ASSSSASADL LAGFGGSFMA PSPSPVTPAQ NNLLQPNFEA AFGTTPSTSS SSSFDPSGDL 
LMPTMAPAGQ PAPVSMVPPS PAMAASKALG SDLDSSLASL VGNLGISGTT TKKGDLQWNA 
GEKKLTGGAN WQPKVAPATW SAGVPPSAPL QGAVPPTSSV PPVAGAPSVG QPGAGFGMPP 
AGTGMPMMPQ QPVMFAQPMM RPPFGAAAVP GTQLSPSPTP ASQSPKKPPA KDPLADLNIK 
DFL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.