Details for: WASHC5

Gene ID: 9897

Symbol: WASHC5

Ensembl ID: ENSG00000164961

Description: WASH complex subunit 5

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.71
    Marker Score: 4,089
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.34
    Marker Score: 17,790
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.31
    Marker Score: 2,284
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.27
    Marker Score: 13,124
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.25
    Marker Score: 76,799
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.25
    Marker Score: 1,926
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.23
    Marker Score: 10,599
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.23
    Marker Score: 11,675
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.17
    Marker Score: 10,960
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.07
    Marker Score: 4,147
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.03
    Marker Score: 499
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.02
    Marker Score: 1,124
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.02
    Marker Score: 37,514
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.01
    Marker Score: 926
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.01
    Marker Score: 38,241
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,724
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,948
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,397
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,402
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.94
    Marker Score: 18,796
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.94
    Marker Score: 14,122
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 483
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 439
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.92
    Marker Score: 3,733
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.91
    Marker Score: 19,378
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,716
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.88
    Marker Score: 6,747
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,294
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.87
    Marker Score: 775
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4,920
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.84
    Marker Score: 3,501
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.84
    Marker Score: 672
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.82
    Marker Score: 1,331
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.81
    Marker Score: 1,483
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.8
    Marker Score: 488
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.8
    Marker Score: 789
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.78
    Marker Score: 326
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.77
    Marker Score: 12,025
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.77
    Marker Score: 956
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 307
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 579
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.73
    Marker Score: 250
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 376
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3,030
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.72
    Marker Score: 509
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.72
    Marker Score: 2,975
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.71
    Marker Score: 1,438
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.71
    Marker Score: 193
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 641
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.69
    Marker Score: 345
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.68
    Marker Score: 784
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.67
    Marker Score: 2,610
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.67
    Marker Score: 892
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.66
    Marker Score: 1,451
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.66
    Marker Score: 710
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.64
    Marker Score: 640
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.64
    Marker Score: 1,450
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.63
    Marker Score: 458
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.62
    Marker Score: 3,764
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.61
    Marker Score: 880
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.61
    Marker Score: 1,171
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.61
    Marker Score: 893
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.6
    Marker Score: 1,421
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.6
    Marker Score: 746
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.6
    Marker Score: 243
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.6
    Marker Score: 175
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.59
    Marker Score: 1,246
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.59
    Marker Score: 399
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.58
    Marker Score: 146
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.58
    Marker Score: 384
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.58
    Marker Score: 2,428
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.58
    Marker Score: 1,425
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.57
    Marker Score: 920
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.57
    Marker Score: 1,633
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.57
    Marker Score: 427
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.57
    Marker Score: 299
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.57
    Marker Score: 197
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.57
    Marker Score: 596
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.56
    Marker Score: 139
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.56
    Marker Score: 139
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.56
    Marker Score: 793
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.56
    Marker Score: 207
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.55
    Marker Score: 377
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.55
    Marker Score: 304
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.54
    Marker Score: 343
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.54
    Marker Score: 564
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.54
    Marker Score: 675
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.54
    Marker Score: 469
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.54
    Marker Score: 30,216
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.54
    Marker Score: 13,757
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 428
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.54
    Marker Score: 322
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.53
    Marker Score: 510
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.53
    Marker Score: 6,179
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.53
    Marker Score: 539
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.53
    Marker Score: 552
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.53
    Marker Score: 2,429
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.52
    Marker Score: 293

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The WASHC5 gene is a member of the Wash complex, a hetero-oligomeric protein complex composed of five subunits (WASHC1, WASHC2, WASHC3, WASHC4, and WASHC5). The WASHC5 subunit is specifically involved in the regulation of actin nucleation and the formation of actin filaments. The Wash complex plays a vital role in maintaining cellular structure, regulating cell migration, and controlling the transport of vesicles and proteins within the cell. **Pathways and Functions:** The WASHC5 gene is involved in several key pathways, including: 1. **Actin filament polymerization**: The WASHC5 subunit regulates the formation of actin filaments, which are essential for maintaining cellular structure, motility, and intracellular transport. 2. **Endosomal transport**: The Wash complex is involved in the sorting and transport of endosomes and lysosomes within the cell, regulating the degradation of proteins and lipids. 3. **Neuronal development**: The WASHC5 gene is specifically expressed in neuronal cells, where it plays a crucial role in the development and maturation of neurons. 4. **Meiotic spindle assembly**: The Wash complex is involved in the assembly of the meiotic spindle during meiosis, ensuring proper chromosome segregation. **Clinical Significance:** Dysregulation of the WASHC5 gene has been implicated in various neurological disorders, including: 1. **Neurodevelopmental disorders**: Mutations in the WASHC5 gene have been associated with neurodevelopmental disorders, such as autism spectrum disorder and intellectual disability. 2. **Neurodegenerative diseases**: The Wash complex has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 3. **Cancer**: The WASHC5 gene has been identified as a potential oncogene, with its overexpression contributing to cancer progression and metastasis. In conclusion, the WASHC5 gene plays a critical role in maintaining cellular structure, regulating endosomal transport, and controlling neuronal development. Dysregulation of this gene has been implicated in various neurological disorders, highlighting its importance in understanding the underlying mechanisms of these diseases. Further research is necessary to fully elucidate the functions of the WASHC5 gene and its implications in human disease.

Genular Protein ID: 3509084000

Symbol: WASC5_HUMAN

Name: Strumpellin

UniProtKB Accession Codes:

Q12768 A8K4R7 Q3KQX5 Q8TBQ2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 10 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 22 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8724849

Title: Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 8724849

DOI: 10.1093/dnares/3.1.17

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19922875

Title: The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex.

PubMed ID: 19922875

DOI: 10.1016/j.devcel.2009.09.010

PubMed ID: 20833645

Title: Strumpellin is a novel valosin-containing protein binding partner linking hereditary spastic paraplegia to protein aggregation diseases.

PubMed ID: 20833645

DOI: 10.1093/brain/awq222

PubMed ID: 20498093

Title: WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes.

PubMed ID: 20498093

DOI: 10.1073/pnas.0913293107

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23085491

Title: The hereditary spastic paraplegia protein strumpellin: characterisation in neurons and of the effect of disease mutations on WASH complex assembly and function.

PubMed ID: 23085491

DOI: 10.1016/j.bbadis.2012.10.011

PubMed ID: 24065355

Title: A novel mutation in KIAA0196: identification of a gene involved in Ritscher-Schinzel/3C syndrome in a First Nations cohort.

PubMed ID: 24065355

DOI: 10.1136/jmedgenet-2013-101715

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23676666

Title: The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIalpha.

PubMed ID: 23676666

DOI: 10.1091/mbc.e13-02-0088

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 17160902

Title: Mutations in the KIAA0196 gene at the SPG8 locus cause hereditary spastic paraplegia.

PubMed ID: 17160902

DOI: 10.1086/510782

PubMed ID: 23881105

Title: Exome sequencing expands the mutational spectrum of SPG8 in a family with spasticity responsive to L-DOPA treatment.

PubMed ID: 23881105

DOI: 10.1007/s00415-013-7044-6

PubMed ID: 23455931

Title: Pure adult-onset Spastic Paraplegia caused by a novel mutation in the KIAA0196 (SPG8) gene.

PubMed ID: 23455931

DOI: 10.1007/s00415-013-6870-x

PubMed ID: 25454649

Title: A novel strumpellin mutation and potential pitfalls in the molecular diagnosis of hereditary spastic paraplegia type SPG8.

PubMed ID: 25454649

DOI: 10.1016/j.jns.2014.10.018

Sequence Information:

  • Length: 1159
  • Mass: 134286
  • Checksum: D6156D359981FC5F
  • Sequence:
    • MLDFLAENNL CGQAILRIVS CGNAIIAELL RLSEFIPAVF RLKDRADQQK YGDIIFDFSY 
FKGPELWESK LDAKPELQDL DEEFRENNIE IVTRFYLAFQ SVHKYIVDLN RYLDDLNEGV 
YIQQTLETVL LNEDGKQLLC EALYLYGVML LVIDQKIEGE VRERMLVSYY RYSAARSSAD 
SNMDDICKLL RSTGYSSQPG AKRPSNYPES YFQRVPINES FISMVIGRLR SDDIYNQVSA 
YPLPEHRSTA LANQAAMLYV ILYFEPSILH THQAKMREIV DKYFPDNWVI SIYMGITVNL 
VDAWEPYKAA KTALNNTLDL SNVREQASRY ATVSERVHAQ VQQFLKEGYL REEMVLDNIP 
KLLNCLRDCN VAIRWLMLHT ADSACDPNNK RLRQIKDQIL TDSRYNPRIL FQLLLDTAQF 
EFILKEMFKQ MLSEKQTKWE HYKKEGSERM TELADVFSGV KPLTRVEKNE NLQAWFREIS 
KQILSLNYDD STAAGRKTVQ LIQALEEVQE FHQLESNLQV CQFLADTRKF LHQMIRTINI 
KEEVLITMQI VGDLSFAWQL IDSFTSIMQE SIRVNPSMVT KLRATFLKLA SALDLPLLRI 
NQANSPDLLS VSQYYSGELV SYVRKVLQII PESMFTSLLK IIKLQTHDII EVPTRLDKDK 
LRDYAQLGPR YEVAKLTHAI SIFTEGILMM KTTLVGIIKV DPKQLLEDGI RKELVKRVAF 
ALHRGLIFNP RAKPSELMPK LKELGATMDG FHRSFEYIQD YVNIYGLKIW QEEVSRIINY 
NVEQECNNFL RTKIQDWQSM YQSTHIPIPK FTPVDESVTF IGRLCREILR ITDPKMTCHI 
DQLNTWYDMK THQEVTSSRL FSEIQTTLGT FGLNGLDRLL CFMIVKELQN FLSMFQKIIL 
RDRTVQDTLK TLMNAVSPLK SIVANSNKIY FSAIAKTQKI WTAYLEAIMK VGQMQILRQQ 
IANELNYSCR FDSKHLAAAL ENLNKALLAD IEAHYQDPSL PYPKEDNTLL YEITAYLEAA 
GIHNPLNKIY ITTKRLPYFP IVNFLFLIAQ LPKLQYNKNL GMVCRKPTDP VDWPPLVLGL 
LTLLKQFHSR YTEQFLALIG QFICSTVEQC TSQKIPEIPA DVVGALLFLE DYVRYTKLPR 
RVAEAHVPNF IFDEFRTVL

Genular Protein ID: 3941736881

Symbol: E7EQI7_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7EQI7

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 2 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 1 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 1011
  • Mass: 117066
  • Checksum: 5810C6A99389134C
  • Sequence:
    • MLLVIDQKIE GEVRERMLVS YYRYSAARSS ADSNMDDICK LLRSTGYSSQ PGAKRPSNYP 
ESYFQRVPIN ESFISMVIGR LRSDDIYNQV SAYPLPEHRS TALANQAAML YVILYFEPSI 
LHTHQAKMRE IVDKYFPDNW VISIYMGITV NLVDAWEPYK AAKTALNNTL DLSNVREQAS 
RYATVSERVH AQVQQFLKEG YLREEMVLDN IPKLLNCLRD CNVAIRWLML HTADSACDPN 
NKRLRQIKDQ ILTDSRYNPR ILFQLLLDTA QFEFILKEMF KQMLSEKQTK WEHYKKEGSE 
RMTELADVFS GVKPLTRVEK NENLQAWFRE ISKQILSLNY DDSTAAGRKT VQLIQALEEV 
QEFHQLESNL QVCQFLADTR KFLHQMIRTI NIKEEVLITM QIVGDLSFAW QLIDSFTSIM 
QESIRVNPSM VTKLRATFLK LASALDLPLL RINQANSPDL LSVSQYYSGE LVSYVRKVLQ 
IIPESMFTSL LKIIKLQTHD IIEVPTRLDK DKLRDYAQLG PRYEVAKLTH AISIFTEGIL 
MMKTTLVGII KVDPKQLLED GIRKELVKRV AFALHRGLIF NPRAKPSELM PKLKELGATM 
DGFHRSFEYI QDYVNIYGLK IWQEEVSRII NYNVEQECNN FLRTKIQDWQ SMYQSTHIPI 
PKFTPVDESV TFIGRLCREI LRITDPKMTC HIDQLNTWYD MKTHQEVTSS RLFSEIQTTL 
GTFGLNGLDR LLCFMIVKEL QNFLSMFQKI ILRDRTVQDT LKTLMNAVSP LKSIVANSNK 
IYFSAIAKTQ KIWTAYLEAI MKVGQMQILR QQIANELNYS CRFDSKHLAA ALENLNKALL 
ADIEAHYQDP SLPYPKEDNT LLYEITAYLE AAGIHNPLNK IYITTKRLPY FPIVNFLFLI 
AQLPKLQYNK NLGMVCRKPT DPVDWPPLVL GLLTLLKQFH SRYTEQFLAL IGQFICSTVE 
QCTSQKIPEI PADVVGALLF LEDYVRYTKL PRRVAEAHVP NFIFDEFRTV L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.