Details for: WASHC5

Gene ID: 9897

Symbol: WASHC5

Ensembl ID: ENSG00000164961

Description: WASH complex subunit 5

Associated with

Other Information

Genular Protein ID: 3509084000

Symbol: WASC5_HUMAN

Name: Strumpellin

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8724849

Title: Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 8724849

DOI: 10.1093/dnares/3.1.17

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19922875

Title: The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex.

PubMed ID: 19922875

DOI: 10.1016/j.devcel.2009.09.010

PubMed ID: 20833645

Title: Strumpellin is a novel valosin-containing protein binding partner linking hereditary spastic paraplegia to protein aggregation diseases.

PubMed ID: 20833645

DOI: 10.1093/brain/awq222

PubMed ID: 20498093

Title: WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes.

PubMed ID: 20498093

DOI: 10.1073/pnas.0913293107

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23085491

Title: The hereditary spastic paraplegia protein strumpellin: characterisation in neurons and of the effect of disease mutations on WASH complex assembly and function.

PubMed ID: 23085491

DOI: 10.1016/j.bbadis.2012.10.011

PubMed ID: 24065355

Title: A novel mutation in KIAA0196: identification of a gene involved in Ritscher-Schinzel/3C syndrome in a First Nations cohort.

PubMed ID: 24065355

DOI: 10.1136/jmedgenet-2013-101715

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23676666

Title: The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIalpha.

PubMed ID: 23676666

DOI: 10.1091/mbc.e13-02-0088

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 17160902

Title: Mutations in the KIAA0196 gene at the SPG8 locus cause hereditary spastic paraplegia.

PubMed ID: 17160902

DOI: 10.1086/510782

PubMed ID: 23881105

Title: Exome sequencing expands the mutational spectrum of SPG8 in a family with spasticity responsive to L-DOPA treatment.

PubMed ID: 23881105

DOI: 10.1007/s00415-013-7044-6

PubMed ID: 23455931

Title: Pure adult-onset Spastic Paraplegia caused by a novel mutation in the KIAA0196 (SPG8) gene.

PubMed ID: 23455931

DOI: 10.1007/s00415-013-6870-x

PubMed ID: 25454649

Title: A novel strumpellin mutation and potential pitfalls in the molecular diagnosis of hereditary spastic paraplegia type SPG8.

PubMed ID: 25454649

DOI: 10.1016/j.jns.2014.10.018

Sequence Information:

  • Length: 1159
  • Mass: 134286
  • Checksum: D6156D359981FC5F
  • Sequence:
  • MLDFLAENNL CGQAILRIVS CGNAIIAELL RLSEFIPAVF RLKDRADQQK YGDIIFDFSY 
    FKGPELWESK LDAKPELQDL DEEFRENNIE IVTRFYLAFQ SVHKYIVDLN RYLDDLNEGV 
    YIQQTLETVL LNEDGKQLLC EALYLYGVML LVIDQKIEGE VRERMLVSYY RYSAARSSAD 
    SNMDDICKLL RSTGYSSQPG AKRPSNYPES YFQRVPINES FISMVIGRLR SDDIYNQVSA 
    YPLPEHRSTA LANQAAMLYV ILYFEPSILH THQAKMREIV DKYFPDNWVI SIYMGITVNL 
    VDAWEPYKAA KTALNNTLDL SNVREQASRY ATVSERVHAQ VQQFLKEGYL REEMVLDNIP 
    KLLNCLRDCN VAIRWLMLHT ADSACDPNNK RLRQIKDQIL TDSRYNPRIL FQLLLDTAQF 
    EFILKEMFKQ MLSEKQTKWE HYKKEGSERM TELADVFSGV KPLTRVEKNE NLQAWFREIS 
    KQILSLNYDD STAAGRKTVQ LIQALEEVQE FHQLESNLQV CQFLADTRKF LHQMIRTINI 
    KEEVLITMQI VGDLSFAWQL IDSFTSIMQE SIRVNPSMVT KLRATFLKLA SALDLPLLRI 
    NQANSPDLLS VSQYYSGELV SYVRKVLQII PESMFTSLLK IIKLQTHDII EVPTRLDKDK 
    LRDYAQLGPR YEVAKLTHAI SIFTEGILMM KTTLVGIIKV DPKQLLEDGI RKELVKRVAF 
    ALHRGLIFNP RAKPSELMPK LKELGATMDG FHRSFEYIQD YVNIYGLKIW QEEVSRIINY 
    NVEQECNNFL RTKIQDWQSM YQSTHIPIPK FTPVDESVTF IGRLCREILR ITDPKMTCHI 
    DQLNTWYDMK THQEVTSSRL FSEIQTTLGT FGLNGLDRLL CFMIVKELQN FLSMFQKIIL 
    RDRTVQDTLK TLMNAVSPLK SIVANSNKIY FSAIAKTQKI WTAYLEAIMK VGQMQILRQQ 
    IANELNYSCR FDSKHLAAAL ENLNKALLAD IEAHYQDPSL PYPKEDNTLL YEITAYLEAA 
    GIHNPLNKIY ITTKRLPYFP IVNFLFLIAQ LPKLQYNKNL GMVCRKPTDP VDWPPLVLGL 
    LTLLKQFHSR YTEQFLALIG QFICSTVEQC TSQKIPEIPA DVVGALLFLE DYVRYTKLPR 
    RVAEAHVPNF IFDEFRTVL

Genular Protein ID: 3941736881

Symbol: E7EQI7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 1011
  • Mass: 117066
  • Checksum: 5810C6A99389134C
  • Sequence:
  • MLLVIDQKIE GEVRERMLVS YYRYSAARSS ADSNMDDICK LLRSTGYSSQ PGAKRPSNYP 
    ESYFQRVPIN ESFISMVIGR LRSDDIYNQV SAYPLPEHRS TALANQAAML YVILYFEPSI 
    LHTHQAKMRE IVDKYFPDNW VISIYMGITV NLVDAWEPYK AAKTALNNTL DLSNVREQAS 
    RYATVSERVH AQVQQFLKEG YLREEMVLDN IPKLLNCLRD CNVAIRWLML HTADSACDPN 
    NKRLRQIKDQ ILTDSRYNPR ILFQLLLDTA QFEFILKEMF KQMLSEKQTK WEHYKKEGSE 
    RMTELADVFS GVKPLTRVEK NENLQAWFRE ISKQILSLNY DDSTAAGRKT VQLIQALEEV 
    QEFHQLESNL QVCQFLADTR KFLHQMIRTI NIKEEVLITM QIVGDLSFAW QLIDSFTSIM 
    QESIRVNPSM VTKLRATFLK LASALDLPLL RINQANSPDL LSVSQYYSGE LVSYVRKVLQ 
    IIPESMFTSL LKIIKLQTHD IIEVPTRLDK DKLRDYAQLG PRYEVAKLTH AISIFTEGIL 
    MMKTTLVGII KVDPKQLLED GIRKELVKRV AFALHRGLIF NPRAKPSELM PKLKELGATM 
    DGFHRSFEYI QDYVNIYGLK IWQEEVSRII NYNVEQECNN FLRTKIQDWQ SMYQSTHIPI 
    PKFTPVDESV TFIGRLCREI LRITDPKMTC HIDQLNTWYD MKTHQEVTSS RLFSEIQTTL 
    GTFGLNGLDR LLCFMIVKEL QNFLSMFQKI ILRDRTVQDT LKTLMNAVSP LKSIVANSNK 
    IYFSAIAKTQ KIWTAYLEAI MKVGQMQILR QQIANELNYS CRFDSKHLAA ALENLNKALL 
    ADIEAHYQDP SLPYPKEDNT LLYEITAYLE AAGIHNPLNK IYITTKRLPY FPIVNFLFLI 
    AQLPKLQYNK NLGMVCRKPT DPVDWPPLVL GLLTLLKQFH SRYTEQFLAL IGQFICSTVE 
    QCTSQKIPEI PADVVGALLF LEDYVRYTKL PRRVAEAHVP NFIFDEFRTV L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.