CDC6 | ENSG00000094804 | NCBI 990

Details for: CDC6

Gene ID: 990

Symbol: CDC6

Ensembl ID: ENSG00000094804

Description: cell division cycle 6

Associated with

Activation of atr in response to replication stress
(R-HSA-176187)
Activation of the pre-replicative complex
(R-HSA-68962)
Assembly of the pre-replicative complex
(R-HSA-68867)
Cdc6 association with the orc:origin complex
(R-HSA-68689)
Cdk-mediated phosphorylation and removal of cdc6
(R-HSA-69017)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
G0 and early g1
(R-HSA-1538133)
G1/s-specific transcription
(R-HSA-69205)
G1/s transition
(R-HSA-69206)
G2/m checkpoints
(R-HSA-69481)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Orc1 removal from chromatin
(R-HSA-68949)
S phase
(R-HSA-69242)
Switching of origins to a post-replicative state
(R-HSA-69052)
Synthesis of dna
(R-HSA-69239)
Transcription of e2f targets under negative control by dream complex
(R-HSA-1362277)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Cell division
(GO:0051301)
Cellular response to angiotensin
(GO:1904385)
Cellular response to vasopressin
(GO:1904117)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna replication checkpoint signaling
(GO:0000076)
Dna replication initiation
(GO:0006270)
Dna replication origin binding
(GO:0003688)
Intercellular bridge
(GO:0045171)
Kinase binding
(GO:0019900)
Mitotic dna replication checkpoint signaling
(GO:0033314)
Mitotic spindle
(GO:0072686)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna replication
(GO:0008156)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Positive regulation of chromosome segregation
(GO:0051984)
Positive regulation of cytokinesis
(GO:0032467)
Positive regulation of fibroblast proliferation
(GO:0048146)
Protein binding
(GO:0005515)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)
Regulation of mitotic metaphase/anaphase transition
(GO:0030071)
Spindle midzone
(GO:0051233)
Spindle pole
(GO:0000922)
Traversing start control point of mitotic cell cycle
(GO:0007089)

Other Information

Proteins

Cell division control protein 6 homolog

Genular Protein ID: 3970664929

Symbol: CDC6_HUMAN

Name: Cell division control protein 6 homolog

UniProtKB Accession Codes:

Q99741 Q8TB30

Database IDs:

Citations:

PubMed ID: 8990175

Title: A human protein related to yeast Cdc6p.

PubMed ID: 8990175

DOI: 10.1073/pnas.94.1.142

PubMed ID: 9566895

Title: Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase.

PubMed ID: 9566895

DOI: 10.1128/mcb.18.5.2758

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14672932

Title: The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells.

PubMed ID: 14672932

DOI: 10.1074/jbc.m311933200

PubMed ID: 17567951

Title: Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage.

PubMed ID: 17567951

DOI: 10.1091/mbc.e07-02-0173

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18320024

Title: The human TPR protein TTC4 is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells.

PubMed ID: 18320024

DOI: 10.1371/journal.pone.0001737

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23711367

Title: A role for the Ankyrin repeat containing protein Ankrd17 in Nod1- and Nod2-mediated inflammatory responses.

PubMed ID: 23711367

DOI: 10.1016/j.febslet.2013.05.037

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25990725

Title: Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture.

PubMed ID: 25990725

DOI: 10.1093/nar/gkv509

PubMed ID: 26818844

Title: SCF(Cyclin F)-dependent degradation of CDC6 suppresses DNA re-replication.

PubMed ID: 26818844

DOI: 10.1038/ncomms10530

PubMed ID: 21358632

Title: Mutations in the pre-replication complex cause Meier-Gorlin syndrome.

PubMed ID: 21358632

DOI: 10.1038/ng.775

Sequence Information:

Length: 560
Mass: 62720
Checksum: 3ED7DE4AF80CB017
Sequence:

MPQTRSQAQA TISFPKRKLS RALNKAKNSS DAKLEPTNVQ TVTCSPRVKA LPLSPRKRLG 
DDNLCNTPHL PPCSPPKQGK KENGPPHSHT LKGRRLVFDN QLTIKSPSKR ELAKVHQNKI 
LSSVRKSQEI TTNSEQRCPL KKESACVRLF KQEGTCYQQA KLVLNTAVPD RLPAREREMD 
VIRNFLREHI CGKKAGSLYL SGAPGTGKTA CLSRILQDLK KELKGFKTIM LNCMSLRTAQ 
AVFPAIAQEI CQEEVSRPAG KDMMRKLEKH MTAEKGPMIV LVLDEMDQLD SKGQDVLYTL 
FEWPWLSNSH LVLIGIANTL DLTDRILPRL QAREKCKPQL LNFPPYTRNQ IVTILQDRLN 
QVSRDQVLDN AAVQFCARKV SAVSGDVRKA LDVCRRAIEI VESDVKSQTI LKPLSECKSP 
SEPLIPKRVG LIHISQVISE VDGNRMTLSQ EGAQDSFPLQ QKILVCSLML LIRQLKIKEV 
TLGKLYEAYS KVCRKQQVAA VDQSECLSLS GLLEARGILG LKRNKETRLT KVFFKIEEKE 
IEHALKDKAL IGNILATGLP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CDC6

Associated with

Other Information

A human protein related to yeast Cdc6p. PubMed ID: 8990175

Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase. PubMed ID: 9566895

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells. PubMed ID: 14672932

Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage. PubMed ID: 17567951

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

The human TPR protein TTC4 is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells. PubMed ID: 18320024

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

A role for the Ankyrin repeat containing protein Ankrd17 in Nod1- and Nod2-mediated inflammatory responses. PubMed ID: 23711367

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture. PubMed ID: 25990725

SCF(Cyclin F)-dependent degradation of CDC6 suppresses DNA re-replication. PubMed ID: 26818844

Mutations in the pre-replication complex cause Meier-Gorlin syndrome. PubMed ID: 21358632