Details for: CDC6

Gene ID: 990

Symbol: CDC6

Ensembl ID: ENSG00000094804

Description: cell division cycle 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 22.7090
    Cell Significance Index: -5.7600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 14.5967
    Cell Significance Index: -5.9300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.5663
    Cell Significance Index: -5.6300
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 3.5353
    Cell Significance Index: 1.6100
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 1.7033
    Cell Significance Index: 1.3000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.6168
    Cell Significance Index: -6.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.5517
    Cell Significance Index: 295.2900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8438
    Cell Significance Index: 50.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7401
    Cell Significance Index: 73.2200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6375
    Cell Significance Index: 6.9300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5688
    Cell Significance Index: 61.8700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.5585
    Cell Significance Index: 14.9400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.5406
    Cell Significance Index: 13.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5210
    Cell Significance Index: 15.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5167
    Cell Significance Index: 23.4200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5004
    Cell Significance Index: 81.3800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4687
    Cell Significance Index: 55.2700
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.4596
    Cell Significance Index: 3.4700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4279
    Cell Significance Index: 14.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4157
    Cell Significance Index: 11.1000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3528
    Cell Significance Index: 41.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3319
    Cell Significance Index: 10.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2938
    Cell Significance Index: 58.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2455
    Cell Significance Index: 221.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2262
    Cell Significance Index: 11.7500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1944
    Cell Significance Index: 4.1400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1918
    Cell Significance Index: 3.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1707
    Cell Significance Index: 9.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1517
    Cell Significance Index: 82.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1478
    Cell Significance Index: 4.1300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1366
    Cell Significance Index: 2.8600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0775
    Cell Significance Index: 1.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0769
    Cell Significance Index: 15.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0591
    Cell Significance Index: 26.1200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0549
    Cell Significance Index: 1.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0538
    Cell Significance Index: 1.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0534
    Cell Significance Index: 6.5700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0241
    Cell Significance Index: 16.6700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0213
    Cell Significance Index: 3.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0117
    Cell Significance Index: 1.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0079
    Cell Significance Index: 2.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0075
    Cell Significance Index: 0.4800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0045
    Cell Significance Index: 0.3100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0019
    Cell Significance Index: 0.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0012
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0023
    Cell Significance Index: -4.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0028
    Cell Significance Index: -2.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0042
    Cell Significance Index: -7.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0060
    Cell Significance Index: -9.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0065
    Cell Significance Index: -8.8100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0090
    Cell Significance Index: -6.6400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0091
    Cell Significance Index: -5.7600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0101
    Cell Significance Index: -7.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0102
    Cell Significance Index: -1.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0136
    Cell Significance Index: -7.6900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0154
    Cell Significance Index: -6.9700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0176
    Cell Significance Index: -5.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0262
    Cell Significance Index: -4.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0293
    Cell Significance Index: -3.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0326
    Cell Significance Index: -1.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0358
    Cell Significance Index: -4.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0380
    Cell Significance Index: -8.0000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0390
    Cell Significance Index: -1.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0411
    Cell Significance Index: -4.2000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0426
    Cell Significance Index: -0.6100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0445
    Cell Significance Index: -3.1500
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.0499
    Cell Significance Index: -0.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0577
    Cell Significance Index: -6.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0609
    Cell Significance Index: -6.3400
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0739
    Cell Significance Index: -0.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0754
    Cell Significance Index: -5.0700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0794
    Cell Significance Index: -5.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0836
    Cell Significance Index: -6.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0842
    Cell Significance Index: -6.4600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0891
    Cell Significance Index: -4.5000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0900
    Cell Significance Index: -5.6700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0906
    Cell Significance Index: -2.6600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0922
    Cell Significance Index: -4.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0934
    Cell Significance Index: -4.3900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0964
    Cell Significance Index: -2.0000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0968
    Cell Significance Index: -0.6600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0981
    Cell Significance Index: -1.6500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1066
    Cell Significance Index: -6.5500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1089
    Cell Significance Index: -5.7200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1092
    Cell Significance Index: -1.3800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1121
    Cell Significance Index: -4.9600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1152
    Cell Significance Index: -7.0600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1203
    Cell Significance Index: -4.9300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1230
    Cell Significance Index: -4.3100
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.1280
    Cell Significance Index: -1.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1302
    Cell Significance Index: -4.9300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1384
    Cell Significance Index: -1.9200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1398
    Cell Significance Index: -3.6800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1473
    Cell Significance Index: -2.0100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.1513
    Cell Significance Index: -0.9400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1532
    Cell Significance Index: -5.0200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1620
    Cell Significance Index: -5.1600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1626
    Cell Significance Index: -2.4500
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1670
    Cell Significance Index: -1.8900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1704
    Cell Significance Index: -4.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell cycle regulation:** CDC6 is essential for the progression from the G1 phase to the S phase, where DNA replication occurs. It is also involved in the regulation of mitotic entry and the metaphase/anaphase transition. 2. **DNA replication initiation:** CDC6 forms a complex with ORC to recognize and bind to DNA origins, allowing for the initiation of DNA replication. 3. **Cell cycle checkpoint signaling:** CDC6 is involved in the regulation of cell cycle checkpoints, ensuring that cells with damaged DNA do not proceed to mitosis. 4. **Phosphorylation and degradation:** CDC6 is subject to phosphorylation by CDKs, which leads to its degradation, regulating its levels and activity throughout the cell cycle. 5. **Expression in different cell types:** CDC6 is expressed in various cell types, including germ cells, kidney proximal convoluted tubule epithelial cells, and cerebral cortex GABAergic interneurons. **Pathways and Functions:** 1. **Activation of the pre-replicative complex:** CDC6 forms a complex with ORC to recognize and bind to DNA origins, initiating DNA replication. 2. **Assembly of the pre-replicative complex:** CDC6 is involved in the assembly of the pre-replicative complex, which is necessary for the initiation of DNA replication. 3. **Regulation of cyclin-dependent kinase activity:** CDC6 regulates the activity of cyclin-dependent kinases (CDKs), which are essential for the progression of the cell cycle. 4. **Regulation of mitotic spindle assembly:** CDC6 is involved in the regulation of mitotic spindle assembly, ensuring proper chromosome segregation during mitosis. 5. **Regulation of cytokinesis:** CDC6 is involved in the regulation of cytokinesis, ensuring proper cell division. **Clinical Significance:** 1. **Cancer:** Dysregulation of CDC6 has been implicated in various cancers, including breast, lung, and colon cancer, where it can contribute to genomic instability and tumor progression. 2. **Genomic instability:** CDC6 mutations or dysregulation can lead to genomic instability, increasing the risk of cancer and other diseases. 3. **Reproductive diseases:** CDC6 is involved in the regulation of meiosis and spermatogenesis, making it a potential target for the treatment of reproductive diseases, such as infertility and testicular cancer. 4. **Neurological diseases:** CDC6 is expressed in the brain and is involved in the regulation of neuronal development and function, making it a potential target for the treatment of neurological diseases, such as Alzheimer's and Parkinson's disease. In conclusion, CDC6 is a critical gene that plays a central role in the regulation of cell division and DNA replication. Its dysregulation has been implicated in various diseases, including cancer and reproductive diseases. Further research is needed to fully understand the mechanisms by which CDC6 regulates the cell cycle and to identify potential therapeutic targets for the treatment of these diseases.

Genular Protein ID: 3970664929

Symbol: CDC6_HUMAN

Name: Cell division control protein 6 homolog

UniProtKB Accession Codes:

Q99741 Q8TB30

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 4 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 8 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8990175

Title: A human protein related to yeast Cdc6p.

PubMed ID: 8990175

DOI: 10.1073/pnas.94.1.142

PubMed ID: 9566895

Title: Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase.

PubMed ID: 9566895

DOI: 10.1128/mcb.18.5.2758

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14672932

Title: The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells.

PubMed ID: 14672932

DOI: 10.1074/jbc.m311933200

PubMed ID: 17567951

Title: Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage.

PubMed ID: 17567951

DOI: 10.1091/mbc.e07-02-0173

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18320024

Title: The human TPR protein TTC4 is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells.

PubMed ID: 18320024

DOI: 10.1371/journal.pone.0001737

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23711367

Title: A role for the Ankyrin repeat containing protein Ankrd17 in Nod1- and Nod2-mediated inflammatory responses.

PubMed ID: 23711367

DOI: 10.1016/j.febslet.2013.05.037

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25990725

Title: Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture.

PubMed ID: 25990725

DOI: 10.1093/nar/gkv509

PubMed ID: 26818844

Title: SCF(Cyclin F)-dependent degradation of CDC6 suppresses DNA re-replication.

PubMed ID: 26818844

DOI: 10.1038/ncomms10530

PubMed ID: 21358632

Title: Mutations in the pre-replication complex cause Meier-Gorlin syndrome.

PubMed ID: 21358632

DOI: 10.1038/ng.775

Sequence Information:

  • Length: 560
  • Mass: 62720
  • Checksum: 3ED7DE4AF80CB017
  • Sequence:
    • MPQTRSQAQA TISFPKRKLS RALNKAKNSS DAKLEPTNVQ TVTCSPRVKA LPLSPRKRLG 
DDNLCNTPHL PPCSPPKQGK KENGPPHSHT LKGRRLVFDN QLTIKSPSKR ELAKVHQNKI 
LSSVRKSQEI TTNSEQRCPL KKESACVRLF KQEGTCYQQA KLVLNTAVPD RLPAREREMD 
VIRNFLREHI CGKKAGSLYL SGAPGTGKTA CLSRILQDLK KELKGFKTIM LNCMSLRTAQ 
AVFPAIAQEI CQEEVSRPAG KDMMRKLEKH MTAEKGPMIV LVLDEMDQLD SKGQDVLYTL 
FEWPWLSNSH LVLIGIANTL DLTDRILPRL QAREKCKPQL LNFPPYTRNQ IVTILQDRLN 
QVSRDQVLDN AAVQFCARKV SAVSGDVRKA LDVCRRAIEI VESDVKSQTI LKPLSECKSP 
SEPLIPKRVG LIHISQVISE VDGNRMTLSQ EGAQDSFPLQ QKILVCSLML LIRQLKIKEV 
TLGKLYEAYS KVCRKQQVAA VDQSECLSLS GLLEARGILG LKRNKETRLT KVFFKIEEKE 
IEHALKDKAL IGNILATGLP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.