SV2A | ENSG00000159164 | NCBI 9900

Details for: SV2A

Gene ID: 9900

Symbol: SV2A

Ensembl ID: ENSG00000159164

Description: synaptic vesicle glycoprotein 2A

Associated with

Bacterial infection pathways
(R-HSA-9824439)
Disease
(R-HSA-1643685)
Infectious disease
(R-HSA-5663205)
Neurotoxicity of clostridium toxins
(R-HSA-168799)
Toxicity of botulinum toxin type a (bota)
(R-HSA-5250968)
Toxicity of botulinum toxin type d (botd)
(R-HSA-5250955)
Toxicity of botulinum toxin type e (bote)
(R-HSA-5250992)
Toxicity of botulinum toxin type f (botf)
(R-HSA-5250981)
Uptake and actions of bacterial toxins
(R-HSA-5339562)
Cell-cell junction
(GO:0005911)
Dendrite
(GO:0030425)
Endoplasmic reticulum
(GO:0005783)
Gaba-ergic synapse
(GO:0098982)
Glutamatergic synapse
(GO:0098978)
Intracellular calcium ion homeostasis
(GO:0006874)
Neuromuscular junction
(GO:0031594)
Neuronal cell body
(GO:0043025)
Neuron projection
(GO:0043005)
Plasma membrane
(GO:0005886)
Presynaptic active zone
(GO:0048786)
Protein kinase binding
(GO:0019901)
Regulation of gamma-aminobutyric acid secretion
(GO:0014052)
Synaptic vesicle
(GO:0008021)
Synaptic vesicle membrane
(GO:0030672)
Synaptic vesicle priming
(GO:0016082)
Transmembrane transport
(GO:0055085)
Transmembrane transporter activity
(GO:0022857)

Other Information

Proteins

Synaptic vesicle glycoprotein 2A
B4E000_HUMAN

Genular Protein ID: 922518718

Symbol: SV2A_HUMAN

Name: Synaptic vesicle glycoprotein 2A

UniProtKB Accession Codes:

Q7L0J3 D3DUZ7 O94841 Q5QNX8 Q7Z3L6 Q8NBJ6 Q9BVZ9

Database IDs:

Citations:

PubMed ID: 9872452

Title: Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9872452

DOI: 10.1093/dnares/5.5.277

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15210974

Title: The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam.

PubMed ID: 15210974

DOI: 10.1073/pnas.0308208101

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 29649119

Title: Crystal structure of botulinum neurotoxin A2 in complex with the human protein receptor SV2C reveals plasticity in receptor binding.

PubMed ID: 29649119

DOI: 10.3390/toxins10040153

Sequence Information:

Length: 742
Mass: 82695
Checksum: 913E216D5CFC2FB2
Sequence:

MEEGFRDRAA FIRGAKDIAK EVKKHAAKKV VKGLDRVQDE YSRRSYSRFE EEDDDDDFPA 
PSDGYYRGEG TQDEEEGGAS SDATEGHDED DEIYEGEYQG IPRAESGGKG ERMADGAPLA 
GVRGGLSDGE GPPGGRGEAQ RRKEREELAQ QYEAILRECG HGRFQWTLYF VLGLALMADG 
VEVFVVGFVL PSAEKDMCLS DSNKGMLGLI VYLGMMVGAF LWGGLADRLG RRQCLLISLS 
VNSVFAFFSS FVQGYGTFLF CRLLSGVGIG GSIPIVFSYF SEFLAQEKRG EHLSWLCMFW 
MIGGVYAAAM AWAIIPHYGW SFQMGSAYQF HSWRVFVLVC AFPSVFAIGA LTTQPESPRF 
FLENGKHDEA WMVLKQVHDT NMRAKGHPER VFSVTHIKTI HQEDELIEIQ SDTGTWYQRW 
GVRALSLGGQ VWGNFLSCFG PEYRRITLMM MGVWFTMSFS YYGLTVWFPD MIRHLQAVDY 
ASRTKVFPGE RVEHVTFNFT LENQIHRGGQ YFNDKFIGLR LKSVSFEDSL FEECYFEDVT 
SSNTFFRNCT FINTVFYNTD LFEYKFVNSR LINSTFLHNK EGCPLDVTGT GEGAYMVYFV 
SFLGTLAVLP GNIVSALLMD KIGRLRMLAG SSVMSCVSCF FLSFGNSESA MIALLCLFGG 
VSIASWNALD VLTVELYPSD KRTTAFGFLN ALCKLAAVLG ISIFTSFVGI TKAAPILFAS 
AALALGSSLA LKLPETRGQV LQ

Genular Protein ID: 4075015459

Symbol: B4E000_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E000

Database IDs:

Sequence Information:

Length: 194
Mass: 20613
Checksum: F66BEB2E703E9AA3
Sequence:

MTACLSWPLP TDLFEYKFVN SRLINSTFLH NKEGCPLDVT GTGEGAYMVY FVSFLGTLAV 
LPGNIVSALL MDKIGRLRML AGSSVMSCVS CFFLSFGNSE SAMIALLCLF GGVSIASWNA 
LDVLTVELYP SDKRTTAFGF LNALCKLAAV LGISIFTSFV GITKAAPILF ASAALALGSS 
LALKLPETRG QVLQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SV2A

Associated with

Other Information

Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 9872452

Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. PubMed ID: 16303743

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. PubMed ID: 15210974

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Crystal structure of botulinum neurotoxin A2 in complex with the human protein receptor SV2C reveals plasticity in receptor binding. PubMed ID: 29649119