SRGAP3 | ENSG00000196220 | NCBI 9901

Details for: SRGAP3

Gene ID: 9901

Symbol: SRGAP3

Ensembl ID: ENSG00000196220

Description: SLIT-ROBO Rho GTPase activating protein 3

Associated with

Axon guidance
(R-HSA-422475)
Cdc42 gtpase cycle
(R-HSA-9013148)
Developmental biology
(R-HSA-1266738)
Inactivation of cdc42 and rac1
(R-HSA-428543)
Nervous system development
(R-HSA-9675108)
Rac1 gtpase cycle
(R-HSA-9013149)
Rho gtpase cycle
(R-HSA-9012999)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by robo receptors
(R-HSA-376176)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Gtpase activator activity
(GO:0005096)
Negative regulation of cell migration
(GO:0030336)
Protein binding
(GO:0005515)
Regulation of small gtpase mediated signal transduction
(GO:0051056)
Signal transduction
(GO:0007165)

Other Information

Proteins

SLIT-ROBO Rho GTPase-activating protein 3

Genular Protein ID: 3839912273

Symbol: SRGP3_HUMAN

Name: SLIT-ROBO Rho GTPase-activating protein 3

UniProtKB Accession Codes:

O43295 Q8IX13 Q8IZV8

Database IDs:

Citations:

PubMed ID: 12447388

Title: The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling.

PubMed ID: 12447388

DOI: 10.1038/ncb886

PubMed ID: 12195014

Title: The novel Rho-GTPase activating gene MEGAP/ srGAP3 has a putative role in severe mental retardation.

PubMed ID: 12195014

DOI: 10.1073/pnas.162241099

PubMed ID: 9455477

Title: Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9455477

DOI: 10.1093/dnares/4.5.307

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 11672528

Title: Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway.

PubMed ID: 11672528

DOI: 10.1016/s0092-8674(01)00530-x

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19807924

Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

PubMed ID: 19807924

DOI: 10.1186/1471-2172-10-53

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 1099
Mass: 124504
Checksum: 2D1BA2D338E1BF13
Sequence:

MSSQTKFKKD KEIIAEYEAQ IKEIRTQLVE QFKCLEQQSE SRLQLLQDLQ EFFRRKAEIE 
LEYSRSLEKL AERFSSKIRS SREHQFKKDQ YLLSPVNCWY LVLHQTRRES RDHATLNDIF 
MNNVIVRLSQ ISEDVIRLFK KSKEIGLQMH EELLKVTNEL YTVMKTYHMY HAESISAESK 
LKEAEKQEEK QFNKSGDLSM NLLRHEDRPQ RRSSVKKIEK MKEKRQAKYS ENKLKCTKAR 
NDYLLNLAAT NAAISKYYIH DVSDLIDCCD LGFHASLART FRTYLSAEYN LETSRHEGLD 
VIENAVDNLD SRSDKHTVMD MCNQVFCPPL KFEFQPHMGD EVCQVSAQQP VQTELLMRYH 
QLQSRLATLK IENEEVRKTL DATMQTLQDM LTVEDFDVSD AFQHSRSTES VKSAASETYM 
SKINIAKRRA NQQETEMFYF TKFKEYVNGS NLITKLQAKH DLLKQTLGEG ERAECGTTRP 
PCLPPKPQKM RRPRPLSVYS HKLFNGSMEA FIKDSGQAIP LVVESCIRYI NLYGLQQQGI 
FRVPGSQVEV NDIKNSFERG EDPLVDDQNE RDINSVAGVL KLYFRGLENP LFPKERFQDL 
ISTIKLENPA ERVHQIQQIL VTLPRVVIVV MRYLFAFLNH LSQYSDENMM DPYNLAICFG 
PTLMHIPDGQ DPVSCQAHIN EVIKTIIIHH EAIFPSPREL EGPVYEKCMA GGEEYCDSPH 
SEPGAIDEVD HDNGTEPHTS DEEVEQIEAI AKFDYMGRSP RELSFKKGAS LLLYHRASED 
WWEGRHNGVD GLIPHQYIVV QDMDDAFSDS LSQKADSEAS SGPLLDDKAS SKNDLQSPTE 
HISDYGFGGV MGRVRLRSDG AAIPRRRSGG DTHSPPRGLG PSIDTPPRAA ACPSSPHKIP 
LTRGRIESPE KRRMATFGSA GSINYPDKKA LSEGHSMRST CGSTRHSSLG DHKSLEAEAL 
AEDIEKTMST ALHELRELER QNTVKQAPDV VLDTLEPLKN PPGPVSSEPA SPLHTIVIRD 
PDAAMRRSSS SSTEMMTTFK PALSARLAGA QLRPPPMRPV RPVVQHRSSS SSSSGVGSPA 
VTPTEKMFPN SSADKSGTM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SRGAP3

Associated with

Other Information

The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling. PubMed ID: 12447388

The novel Rho-GTPase activating gene MEGAP/ srGAP3 has a putative role in severe mental retardation. PubMed ID: 12195014

Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 9455477

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. PubMed ID: 12168954

Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. PubMed ID: 11672528

Phosphoproteome of resting human platelets. PubMed ID: 18088087

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. PubMed ID: 19807924

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974