Details for: CDC20
Associated with
Other Information
Genular Protein ID: 842320359
Symbol: CDC20_HUMAN
Name: Cell division cycle protein 20 homolog
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7513050
Title: A novel mammalian protein, p55CDC, present in dividing cells is associated with protein kinase activity and has homology to the Saccharomyces cerevisiae cell division cycle proteins Cdc20 and Cdc4.
PubMed ID: 7513050
PubMed ID: 9811605
Title: Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family.
PubMed ID: 9811605
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9734353
Title: Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1.
PubMed ID: 9734353
PubMed ID: 9637688
Title: The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation.
PubMed ID: 9637688
PubMed ID: 10459014
Title: Regulation of APC activity by phosphorylation and regulatory factors.
PubMed ID: 10459014
PubMed ID: 15824138
PubMed ID: 11459826
Title: MAD2B is an inhibitor of the anaphase-promoting complex.
PubMed ID: 11459826
DOI: 10.1101/gad.898701
PubMed ID: 14657031
Title: Mitotic regulation of the human anaphase-promoting complex by phosphorylation.
PubMed ID: 14657031
DOI: 10.1093/emboj/cdg627
PubMed ID: 15525512
Title: Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint.
PubMed ID: 15525512
PubMed ID: 17403670
Title: Cell cycle-dependent expression of centrosomal ninein-like protein in human cells is regulated by the anaphase-promoting complex.
PubMed ID: 17403670
PubMed ID: 17443180
Title: Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities.
PubMed ID: 17443180
DOI: 10.1038/nature05694
PubMed ID: 18794143
Title: HSF1 as a mitotic regulator: phosphorylation of HSF1 by Plk1 is essential for mitotic progression.
PubMed ID: 18794143
PubMed ID: 18997788
Title: The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction.
PubMed ID: 18997788
DOI: 10.1038/ncb1799
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19098431
Title: APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation.
PubMed ID: 19098431
DOI: 10.4161/cc.8.1.7606
PubMed ID: 19282672
Title: CDK5RAP2 is required for spindle checkpoint function.
PubMed ID: 19282672
DOI: 10.4161/cc.8.8.8205
PubMed ID: 20034488
Title: Nek2 targets the mitotic checkpoint proteins Mad2 and Cdc20: a mechanism for aneuploidy in cancer.
PubMed ID: 20034488
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21926987
Title: APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment.
PubMed ID: 21926987
DOI: 10.1038/ncb2347
PubMed ID: 22014574
Title: SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity.
PubMed ID: 22014574
PubMed ID: 22692537
Title: Fcp1-dependent dephosphorylation is required for M-phase-promoting factor inactivation at mitosis exit.
PubMed ID: 22692537
DOI: 10.1038/ncomms1886
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 27653696
Title: APC/C and SCF(cyclin F) Constitute a Reciprocal Feedback Circuit Controlling S-Phase Entry.
PubMed ID: 27653696
PubMed ID: 29162720
Title: Direct interactions of mitotic arrest deficient 1 (MAD1) domains with each other and MAD2 conformers are required for mitotic checkpoint signaling.
PubMed ID: 29162720
PubMed ID: 32666501
Title: Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development.
PubMed ID: 32666501
PubMed ID: 33094908
Title: Premature aging syndrome showing random chromosome number instabilities with CDC20 mutation.
PubMed ID: 33094908
DOI: 10.1111/acel.13251
PubMed ID: 33898437
Title: Identification of novel mutations in CDC20: Expanding the mutational spectrum for female infertility.
PubMed ID: 33898437
PubMed ID: 34218387
Title: The homozygous p.Tyr228Cys variant in CDC20 causes oocyte maturation arrest: an additional evidence supporting the causality between CDC20 mutation and female infertility.
PubMed ID: 34218387
PubMed ID: 33683667
Title: Novel Mutations in CDC20 Are Associated with Female Infertility Due to Oocyte Maturation Abnormality and Early Embryonic Arrest.
PubMed ID: 33683667
Sequence Information:
- Length: 499
- Mass: 54723
- Checksum: FD5C967AF84089E8
- Sequence:
MAQFAFESDL HSLLQLDAPI PNAPPARWQR KAKEAAGPAP SPMRAANRSH SAGRTPGRTP GKSSSKVQTT PSKPGGDRYI PHRSAAQMEV ASFLLSKENQ PENSQTPTKK EHQKAWALNL NGFDVEEAKI LRLSGKPQNA PEGYQNRLKV LYSQKATPGS SRKTCRYIPS LPDRILDAPE IRNDYYLNLV DWSSGNVLAV ALDNSVYLWS ASSGDILQLL QMEQPGEYIS SVAWIKEGNY LAVGTSSAEV QLWDVQQQKR LRNMTSHSAR VGSLSWNSYI LSSGSRSGHI HHHDVRVAEH HVATLSGHSQ EVCGLRWAPD GRHLASGGND NLVNVWPSAP GEGGWVPLQT FTQHQGAVKA VAWCPWQSNV LATGGGTSDR HIRIWNVCSG ACLSAVDAHS QVCSILWSPH YKELISGHGF AQNQLVIWKY PTMAKVAELK GHTSRVLSLT MSPDGATVAS AAADETLRLW RCFELDPARR REREKASAAK SSLIHQGIR
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.