Details for: IQSEC1

Gene ID: 9922

Symbol: IQSEC1

Ensembl ID: ENSG00000144711

Description: IQ motif and Sec7 domain ArfGEF 1

Associated with

Other Information

Genular Protein ID: 422490166

Symbol: IQEC1_HUMAN

Name: ADP-ribosylation factors guanine nucleotide-exchange protein 100

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16461286

Title: The Arf6 GEF GEP100/BRAG2 regulates cell adhesion by controlling endocytosis of beta1 integrins.

PubMed ID: 16461286

DOI: 10.1016/j.cub.2005.12.032

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 9872452

Title: Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9872452

DOI: 10.1093/dnares/5.5.277

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11226253

Title: ARF-GEP(100), a guanine nucleotide-exchange protein for ADP-ribosylation factor 6.

PubMed ID: 11226253

DOI: 10.1073/pnas.051634798

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24058294

Title: Integrated conformational and lipid-sensing regulation of endosomal ArfGEF BRAG2.

PubMed ID: 24058294

DOI: 10.1371/journal.pbio.1001652

PubMed ID: 31607425

Title: Bi-allelic Variants in IQSEC1 Cause Intellectual Disability, Developmental Delay, and Short Stature.

PubMed ID: 31607425

DOI: 10.1016/j.ajhg.2019.09.013

Sequence Information:

  • Length: 963
  • Mass: 108314
  • Checksum: 5B31F9918F9CFF11
  • Sequence:
  • MWCLHCNSER TQSLLELELD SGVEGEAPSS ETGTSLDSPS AYPQGPLVPG SSLSPDHYEH 
    TSVGAYGLYS GPPGQQQRTR RPKLQHSTSI LRKQAEEEAI KRSRSLSESY ELSSDLQDKQ 
    VEMLERKYGG RLVTRHAART IQTAFRQYQM NKNFERLRSS MSENRMSRRI VLSNMRMQFS 
    FEGPEKVHSS YFEGKQVSVT NDGSQLGALV SPECGDLSEP TTLKSPAPSS DFADAITELE 
    DAFSRQVKSL AESIDDALNC RSLHTEEAPA LDAARARDTE PQTALHGMDH RKLDEMTASY 
    SDVTLYIDEE ELSPPLPLSQ AGDRPSSTES DLRLRAGGAA PDYWALAHKE DKADTDTSCR 
    STPSLERQEQ RLRVEHLPLL TIEPPSDSSV DLSDRSERGS LKRQSAYERS LGGQQGSPKH 
    GPHSGAPKSL PREEPELRPR PPRPLDSHLA INGSANRQSK SESDYSDGDN DSINSTSNSN 
    DTINCSSESS SRDSLREQTL SKQTYHKEAR NSWDSPAFSN DVIRKRHYRI GLNLFNKKPE 
    KGVQYLIERG FVPDTPVGVA HFLLQRKGLS RQMIGEFLGN RQKQFNRDVL DCVVDEMDFS 
    TMELDEALRK FQAHIRVQGE AQKVERLIEA FSQRYCICNP GVVRQFRNPD TIFILAFAII 
    LLNTDMYSPN VKPERKMKLE DFIKNLRGVD DGEDIPREML MGIYERIRKR ELKTNEDHVS 
    QVQKVEKLIV GKKPIGSLHP GLGCVLSLPH RRLVCYCRLF EVPDPNKPQK LGLHQREIFL 
    FNDLLVVTKI FQKKKNSVTY SFRQSFSLYG MQVLLFENQY YPNGIRLTSS VPGADIKVLI 
    NFNAPNPQDR KKFTDDLRES IAEVQEMEKH RIESELEKQK GVVRPSMSQC SSLKKESGNG 
    TLSRACLDDS YASGEGLKRS ALSSSLRDLS EAGKRGRRSS AGSLESNVEF QPFEPLQPSV 
    LCS

Genular Protein ID: 1153117692

Symbol: A0A0C4DGT3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 814
  • Mass: 91999
  • Checksum: 243A613C168729D2
  • Sequence:
  • MLERKYGGRL VTRHAARTIQ TAFRQYQMNK NFERLRSSMS ENRMSRRIVL SNMRMQFSFE 
    GPEKVHSSYF EGKQVSVTND GSQLGALVSP ECGDLSEPTT LKSPAPSSDF ADAITELEDA 
    FSRQVKSLAE SIDDALNCRS LHTEEAPALD AARARDTEPQ TALHGMDHRK LDEMTASYSD 
    VTLYIDEEEL SPPLPLSQAG DRPSSTESDL RLRAGGAAPD YWALAHKEDK ADTDTSCRST 
    PSLERQEQRL RVEHLPLLTI EPPSDSSVDL SDRSERGSLK RQSAYERSLG GQQGSPKHGP 
    HSGAPKSLPR EEPELRPRPP RPLDSHLAIN GSANRQSKSE SDYSDGDNDS INSTSNSNDT 
    INCSSESSSR DSLREQTLSK QTYHKEARNS WDSPAFSNDV IRKRHYRIGL NLFNKKPEKG 
    VQYLIERGFV PDTPVGVAHF LLQRKGLSRQ MIGEFLGNRQ KQFNRDVLDC VVDEMDFSTM 
    ELDEALRKFQ AHIRVQGEAQ KVERLIEAFS QRYCICNPGV VRQFRNPDTI FILAFAIILL 
    NTDMYSPNVK PERKMKLEDF IKNLRGVDDG EDIPREMLMG IYERIRKREL KTNEDHVSQV 
    QKVEKLIVGK KPIGSLHPGL GCVLSLPHRR LVCYCRLFEV PDPNKPQKLG LHQREIFLFN 
    DLLVVTKIFQ KKKNSVTYSF RQSFSLYGMQ VLLFENQYYP NGIRLTSSVP GADIKVLINF 
    NAPNPQDRKK FTDDLRESIA EVQEMEKHRI ESELEKQKGV VRPSMSQCSS LKKESGNGTL 
    SRACLDDSYA SGEGLKRSAL SSSLRDLSEA GVHH

Genular Protein ID: 667188263

Symbol: B4DGC5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 1114
  • Mass: 124415
  • Checksum: D974D78E2C622F41
  • Sequence:
  • MACRRRYFVE GEAPSSETGT SLDSPSAYPQ GPLVPGSSLS PDHYEHTSVG AYGLYSGPPG 
    QQQRTRRPKL QHSTSILRKQ AEEEAIKRSR SLSESYELSS DLQDKQVEML ERKYGGRLVT 
    RHAARTIQTA FRQYQMNKNF ERLRSSMSEN RMSRRIVLSN MRMQFSFEGP EKVHSSYFEG 
    KQVSVTNDGS QLGALVSPEC GDLSEPTTLK SPAPSSDFAD AITELEDAFS RQVKSLAESI 
    DDALNCRSLH TEEAPALDAA RARDTEPQTA LHGMDHRKLD EMTASYSDVT LYIDEEELSP 
    PLPLSQAGDR PSSTESDLRL RAGGAAPDYW ALAHKEDKAD TDTSCRSTPS LERQEQRLRV 
    EHLPLLTIEP PSDSSVDLSD RSERGSLKRQ SAYERSLGGQ QGSPKHGPHS GAPKSLPREE 
    PELRPQPPRP LDSHLAINGS ANRQSKSESD YSDGDNDSIN STSNSNDTIN CSSESSSRDS 
    LREQTLSKQT YHKEARNSWD SPAFSNDVIR KRHYRIGLNL FNKKPEKGVQ YLIERGFVPD 
    TPVGVAHFLL QRKGLSRQMI GEFLGNRQKQ FNRDVLDCVV DEMDFSTMEL DEALRKFQAH 
    IRVQGEAQKV ERLIEAFSQR YCICNPGVVR QLRNPDTIFI LAFAIILLNT DMYSPNVKPE 
    RKMKLEDFIK NLRGVDDGED IPREMLMGIY ERIRKRELKT NEDHVSQVQK VEKLIVGKKP 
    IGSLHPGLGC VLSLPHRRLV CYCRLFEVPD PNKPQKLGLH QREIFLFNDL LVVTKIFQKK 
    KNSVTYSFRQ SFSLYGMQVL LFENQYYPNG IRLTSSVPGA DIKVLINFNA PNPQDRKKFT 
    DDLRESIAEV QEMEKHRIES ELEKQKGVVR PSMSQCSSLK KESGNGTLSR ACLDDSYASG 
    EGLKRSALSS SLRDLSEAGK RGRRSSAGSL ESNVEGSIIS SPHMRRRATS TRECPSRPHQ 
    TMPNSSSLLG SLFGSKRGKP PPQAHLPSAP ALPPPHPPVV LPHLQHSVAG HHLGPPEGLP 
    QAAMHGHHTQ YCHMQNPPPY HHHHHHHPPQ HIQHAHQYHH GPHGGHPAYG AHAHGHPPLP 
    SAHVGHTVHH HGQPPAPPPP TSSKAKPSGI STIV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.