Details for: IQSEC1

Gene ID: 9922

Symbol: IQSEC1

Ensembl ID: ENSG00000144711

Description: IQ motif and Sec7 domain ArfGEF 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.54
    Marker Score: 4,282
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.75
    Marker Score: 54,729
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.69
    Marker Score: 1,572
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.65
    Marker Score: 3,051
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.5
    Marker Score: 1,495
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.39
    Marker Score: 5,248
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.36
    Marker Score: 9,770
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.35
    Marker Score: 3,159
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.35
    Marker Score: 17,983
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.29
    Marker Score: 34,300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.26
    Marker Score: 83,486
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.19
    Marker Score: 917
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.17
    Marker Score: 20,386
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.12
    Marker Score: 8,179
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.1
    Marker Score: 8,787
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.09
    Marker Score: 79,338
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.06
    Marker Score: 126,729
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.96
    Marker Score: 41,863
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.95
    Marker Score: 9,041
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.9
    Marker Score: 18,065
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.86
    Marker Score: 19,197
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.85
    Marker Score: 3,771
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.84
    Marker Score: 15,806
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.84
    Marker Score: 7,476
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.83
    Marker Score: 957
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.73
    Marker Score: 548
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.71
    Marker Score: 899
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.69
    Marker Score: 528
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.67
    Marker Score: 538
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.64
    Marker Score: 447
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.61
    Marker Score: 28,643
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.61
    Marker Score: 2,479
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.48
    Marker Score: 440
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.47
    Marker Score: 465
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.42
    Marker Score: 854
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.39
    Marker Score: 492
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.37
    Marker Score: 1,028
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.35
    Marker Score: 21,076
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.32
    Marker Score: 797
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.31
    Marker Score: 2,202
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.31
    Marker Score: 502
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.29
    Marker Score: 3,668
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.27
    Marker Score: 402
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.25
    Marker Score: 1,229
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.24
    Marker Score: 421
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.23
    Marker Score: 683
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.21
    Marker Score: 2,851
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.16
    Marker Score: 65,018
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.12
    Marker Score: 415
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.12
    Marker Score: 2,679
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.1
    Marker Score: 1,047
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.09
    Marker Score: 1,354
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.06
    Marker Score: 517
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.06
    Marker Score: 6,386
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.06
    Marker Score: 2,550
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.05
    Marker Score: 307
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.04
    Marker Score: 1,129
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.04
    Marker Score: 604
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.02
    Marker Score: 3,507
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.02
    Marker Score: 26,106
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.02
    Marker Score: 268
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.01
    Marker Score: 1,960
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1
    Marker Score: 995
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,671
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,898
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.98
    Marker Score: 468
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,386
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.98
    Marker Score: 1,983
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.95
    Marker Score: 8,262
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.95
    Marker Score: 1,044
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,394
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.94
    Marker Score: 813
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.93
    Marker Score: 1,616
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 475
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.91
    Marker Score: 434
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 431
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.91
    Marker Score: 1,912
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.91
    Marker Score: 393
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,700
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.89
    Marker Score: 892
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,293
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.87
    Marker Score: 486
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.86
    Marker Score: 2,817
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.86
    Marker Score: 222
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.85
    Marker Score: 9,935
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.85
    Marker Score: 4,541
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4,822
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.84
    Marker Score: 1,624
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.83
    Marker Score: 336
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.82
    Marker Score: 456
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.81
    Marker Score: 544
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.81
    Marker Score: 471
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.81
    Marker Score: 178
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 614
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.8
    Marker Score: 737
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 321
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.79
    Marker Score: 1,499
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.79
    Marker Score: 521
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.79
    Marker Score: 536

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IQSEC1 exhibits a unique combination of IQ and Sec7 domains, which are essential for its ArfGEF activity. The IQ domain mediates interactions with Arf1, while the Sec7 domain facilitates the exchange of GDP for GTP. IQSEC1's ability to bind to membranes, lipids, and other proteins further highlights its versatility and potential for regulating diverse cellular processes. The protein's expression is significantly restricted to specific cell types, suggesting that IQSEC1 plays distinct roles in these cells. **Pathways and Functions:** IQSEC1 is involved in several key pathways, including: 1. **Actin Cytoskeleton Organization:** IQSEC1 modulates the activity of Arf1, which in turn regulates the actin cytoskeleton's dynamic reorganization. This process is essential for cell migration, division, and morphogenesis. 2. **Dendritic Spine Development:** IQSEC1's expression in GABAergic cortical interneurons suggests a role in regulating dendritic spine formation, a critical process for synaptic plasticity and learning. 3. **Synaptic Vesicle Regulation:** IQSEC1's interaction with the synaptic vesicle protein, SNAP25, implies a role in regulating vesicle trafficking and neurotransmitter release. 4. **Cell Migration and Adhesion:** IQSEC1's involvement in regulating focal adhesion disassembly and keratinocyte migration highlights its importance in cell movement and tissue homeostasis. **Clinical Significance:** Dysregulation of IQSEC1 has been implicated in various neurological and ocular disorders, including: 1. **Neurodevelopmental Disorders:** Mutations in IQSEC1 have been associated with autism spectrum disorder and intellectual disability, highlighting its importance in brain development and function. 2. **Ocular Diseases:** IQSEC1's expression in lens epithelial cells and its role in regulating actin cytoskeleton organization suggest a potential link to lens development and cataract formation. 3. **Cancer:** IQSEC1's involvement in regulating cell migration and adhesion implies a potential role in cancer progression and metastasis. In conclusion, IQSEC1 is a critical regulator of actin cytoskeleton organization, dendritic spine development, and synaptic function. Its expression is highly restricted to specific cell types, underscoring its importance in distinct cellular contexts. Further research is needed to elucidate the molecular mechanisms underlying IQSEC1's functions and to explore its potential therapeutic applications in neurological and ocular disorders.

Genular Protein ID: 422490166

Symbol: IQEC1_HUMAN

Name: ADP-ribosylation factors guanine nucleotide-exchange protein 100

UniProtKB Accession Codes:

Q6DN90 A0A087WWK8 O94863 Q96D85

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 12 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 6 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 4 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16461286

Title: The Arf6 GEF GEP100/BRAG2 regulates cell adhesion by controlling endocytosis of beta1 integrins.

PubMed ID: 16461286

DOI: 10.1016/j.cub.2005.12.032

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 9872452

Title: Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9872452

DOI: 10.1093/dnares/5.5.277

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11226253

Title: ARF-GEP(100), a guanine nucleotide-exchange protein for ADP-ribosylation factor 6.

PubMed ID: 11226253

DOI: 10.1073/pnas.051634798

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24058294

Title: Integrated conformational and lipid-sensing regulation of endosomal ArfGEF BRAG2.

PubMed ID: 24058294

DOI: 10.1371/journal.pbio.1001652

PubMed ID: 31607425

Title: Bi-allelic Variants in IQSEC1 Cause Intellectual Disability, Developmental Delay, and Short Stature.

PubMed ID: 31607425

DOI: 10.1016/j.ajhg.2019.09.013

Sequence Information:

  • Length: 963
  • Mass: 108314
  • Checksum: 5B31F9918F9CFF11
  • Sequence:
    • MWCLHCNSER TQSLLELELD SGVEGEAPSS ETGTSLDSPS AYPQGPLVPG SSLSPDHYEH 
TSVGAYGLYS GPPGQQQRTR RPKLQHSTSI LRKQAEEEAI KRSRSLSESY ELSSDLQDKQ 
VEMLERKYGG RLVTRHAART IQTAFRQYQM NKNFERLRSS MSENRMSRRI VLSNMRMQFS 
FEGPEKVHSS YFEGKQVSVT NDGSQLGALV SPECGDLSEP TTLKSPAPSS DFADAITELE 
DAFSRQVKSL AESIDDALNC RSLHTEEAPA LDAARARDTE PQTALHGMDH RKLDEMTASY 
SDVTLYIDEE ELSPPLPLSQ AGDRPSSTES DLRLRAGGAA PDYWALAHKE DKADTDTSCR 
STPSLERQEQ RLRVEHLPLL TIEPPSDSSV DLSDRSERGS LKRQSAYERS LGGQQGSPKH 
GPHSGAPKSL PREEPELRPR PPRPLDSHLA INGSANRQSK SESDYSDGDN DSINSTSNSN 
DTINCSSESS SRDSLREQTL SKQTYHKEAR NSWDSPAFSN DVIRKRHYRI GLNLFNKKPE 
KGVQYLIERG FVPDTPVGVA HFLLQRKGLS RQMIGEFLGN RQKQFNRDVL DCVVDEMDFS 
TMELDEALRK FQAHIRVQGE AQKVERLIEA FSQRYCICNP GVVRQFRNPD TIFILAFAII 
LLNTDMYSPN VKPERKMKLE DFIKNLRGVD DGEDIPREML MGIYERIRKR ELKTNEDHVS 
QVQKVEKLIV GKKPIGSLHP GLGCVLSLPH RRLVCYCRLF EVPDPNKPQK LGLHQREIFL 
FNDLLVVTKI FQKKKNSVTY SFRQSFSLYG MQVLLFENQY YPNGIRLTSS VPGADIKVLI 
NFNAPNPQDR KKFTDDLRES IAEVQEMEKH RIESELEKQK GVVRPSMSQC SSLKKESGNG 
TLSRACLDDS YASGEGLKRS ALSSSLRDLS EAGKRGRRSS AGSLESNVEF QPFEPLQPSV 
LCS

Genular Protein ID: 1153117692

Symbol: A0A0C4DGT3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0C4DGT3

Database IDs:

ARBA 2 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 7 EPD 1 Ensembl 2 GO 2 Gene3D 3 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 7 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 Pfam 2 Proteomes 2 RefSeq 2 SAM 1 SMART 2 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 814
  • Mass: 91999
  • Checksum: 243A613C168729D2
  • Sequence:
    • MLERKYGGRL VTRHAARTIQ TAFRQYQMNK NFERLRSSMS ENRMSRRIVL SNMRMQFSFE 
GPEKVHSSYF EGKQVSVTND GSQLGALVSP ECGDLSEPTT LKSPAPSSDF ADAITELEDA 
FSRQVKSLAE SIDDALNCRS LHTEEAPALD AARARDTEPQ TALHGMDHRK LDEMTASYSD 
VTLYIDEEEL SPPLPLSQAG DRPSSTESDL RLRAGGAAPD YWALAHKEDK ADTDTSCRST 
PSLERQEQRL RVEHLPLLTI EPPSDSSVDL SDRSERGSLK RQSAYERSLG GQQGSPKHGP 
HSGAPKSLPR EEPELRPRPP RPLDSHLAIN GSANRQSKSE SDYSDGDNDS INSTSNSNDT 
INCSSESSSR DSLREQTLSK QTYHKEARNS WDSPAFSNDV IRKRHYRIGL NLFNKKPEKG 
VQYLIERGFV PDTPVGVAHF LLQRKGLSRQ MIGEFLGNRQ KQFNRDVLDC VVDEMDFSTM 
ELDEALRKFQ AHIRVQGEAQ KVERLIEAFS QRYCICNPGV VRQFRNPDTI FILAFAIILL 
NTDMYSPNVK PERKMKLEDF IKNLRGVDDG EDIPREMLMG IYERIRKREL KTNEDHVSQV 
QKVEKLIVGK KPIGSLHPGL GCVLSLPHRR LVCYCRLFEV PDPNKPQKLG LHQREIFLFN 
DLLVVTKIFQ KKKNSVTYSF RQSFSLYGMQ VLLFENQYYP NGIRLTSSVP GADIKVLINF 
NAPNPQDRKK FTDDLRESIA EVQEMEKHRI ESELEKQKGV VRPSMSQCSS LKKESGNGTL 
SRACLDDSYA SGEGLKRSAL SSSLRDLSEA GVHH

Genular Protein ID: 667188263

Symbol: B4DGC5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DGC5

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 3 Genevisible 1 GenomeRNAi 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 1 SMART 2 SUPFAM 2 iPTMnet 1

Sequence Information:

  • Length: 1114
  • Mass: 124415
  • Checksum: D974D78E2C622F41
  • Sequence:
    • MACRRRYFVE GEAPSSETGT SLDSPSAYPQ GPLVPGSSLS PDHYEHTSVG AYGLYSGPPG 
QQQRTRRPKL QHSTSILRKQ AEEEAIKRSR SLSESYELSS DLQDKQVEML ERKYGGRLVT 
RHAARTIQTA FRQYQMNKNF ERLRSSMSEN RMSRRIVLSN MRMQFSFEGP EKVHSSYFEG 
KQVSVTNDGS QLGALVSPEC GDLSEPTTLK SPAPSSDFAD AITELEDAFS RQVKSLAESI 
DDALNCRSLH TEEAPALDAA RARDTEPQTA LHGMDHRKLD EMTASYSDVT LYIDEEELSP 
PLPLSQAGDR PSSTESDLRL RAGGAAPDYW ALAHKEDKAD TDTSCRSTPS LERQEQRLRV 
EHLPLLTIEP PSDSSVDLSD RSERGSLKRQ SAYERSLGGQ QGSPKHGPHS GAPKSLPREE 
PELRPQPPRP LDSHLAINGS ANRQSKSESD YSDGDNDSIN STSNSNDTIN CSSESSSRDS 
LREQTLSKQT YHKEARNSWD SPAFSNDVIR KRHYRIGLNL FNKKPEKGVQ YLIERGFVPD 
TPVGVAHFLL QRKGLSRQMI GEFLGNRQKQ FNRDVLDCVV DEMDFSTMEL DEALRKFQAH 
IRVQGEAQKV ERLIEAFSQR YCICNPGVVR QLRNPDTIFI LAFAIILLNT DMYSPNVKPE 
RKMKLEDFIK NLRGVDDGED IPREMLMGIY ERIRKRELKT NEDHVSQVQK VEKLIVGKKP 
IGSLHPGLGC VLSLPHRRLV CYCRLFEVPD PNKPQKLGLH QREIFLFNDL LVVTKIFQKK 
KNSVTYSFRQ SFSLYGMQVL LFENQYYPNG IRLTSSVPGA DIKVLINFNA PNPQDRKKFT 
DDLRESIAEV QEMEKHRIES ELEKQKGVVR PSMSQCSSLK KESGNGTLSR ACLDDSYASG 
EGLKRSALSS SLRDLSEAGK RGRRSSAGSL ESNVEGSIIS SPHMRRRATS TRECPSRPHQ 
TMPNSSSLLG SLFGSKRGKP PPQAHLPSAP ALPPPHPPVV LPHLQHSVAG HHLGPPEGLP 
QAAMHGHHTQ YCHMQNPPPY HHHHHHHPPQ HIQHAHQYHH GPHGGHPAYG AHAHGHPPLP 
SAHVGHTVHH HGQPPAPPPP TSSKAKPSGI STIV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.