Details for: JOSD1

Gene ID: 9929

Symbol: JOSD1

Ensembl ID: ENSG00000100221

Description: Josephin domain containing 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.05
    Marker Score: 5,042
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.88
    Marker Score: 2,767
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.6
    Marker Score: 799
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.57
    Marker Score: 390
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.55
    Marker Score: 1,548
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.54
    Marker Score: 1,645
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.38
    Marker Score: 428
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.37
    Marker Score: 4,308
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.36
    Marker Score: 1,433
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.26
    Marker Score: 855
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.24
    Marker Score: 536
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.21
    Marker Score: 957
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.21
    Marker Score: 349
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.19
    Marker Score: 73,222
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.15
    Marker Score: 10,964
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.15
    Marker Score: 1,768
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.14
    Marker Score: 1,381
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.13
    Marker Score: 4,201
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.13
    Marker Score: 9,712
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.1
    Marker Score: 11,406
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.1
    Marker Score: 10,379
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1
    Marker Score: 2,512
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.1
    Marker Score: 1,026
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.09
    Marker Score: 17,111
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.08
    Marker Score: 36,907
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.08
    Marker Score: 3,032
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.07
    Marker Score: 5,156
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.05
    Marker Score: 2,569
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.05
    Marker Score: 894
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.01
    Marker Score: 1,795
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1
    Marker Score: 6,395
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1
    Marker Score: 839
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,623
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,846
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.98
    Marker Score: 236
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,379
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.96
    Marker Score: 1,039
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.96
    Marker Score: 276
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.95
    Marker Score: 989
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,384
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.93
    Marker Score: 207
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.92
    Marker Score: 555
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 473
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.92
    Marker Score: 382
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 431
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.91
    Marker Score: 3,526
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.91
    Marker Score: 523
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.91
    Marker Score: 1,039
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.91
    Marker Score: 1,002
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.9
    Marker Score: 310
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9
    Marker Score: 9,093
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5,120
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9
    Marker Score: 214
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.89
    Marker Score: 2,679
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.89
    Marker Score: 510
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.89
    Marker Score: 227
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.89
    Marker Score: 851
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.89
    Marker Score: 361
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.88
    Marker Score: 507
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.88
    Marker Score: 32,552
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.88
    Marker Score: 233
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.88
    Marker Score: 1,427
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.87
    Marker Score: 2,414
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.87
    Marker Score: 190
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,287
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.87
    Marker Score: 200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.86
    Marker Score: 1,752
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.86
    Marker Score: 1,105
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.85
    Marker Score: 929
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.85
    Marker Score: 4,165
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.85
    Marker Score: 395
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.85
    Marker Score: 16,818
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.84
    Marker Score: 266
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.84
    Marker Score: 570
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.83
    Marker Score: 411
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.83
    Marker Score: 820
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.83
    Marker Score: 485
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.83
    Marker Score: 31,480
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.83
    Marker Score: 702
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.83
    Marker Score: 28,592
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.82
    Marker Score: 520
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.82
    Marker Score: 303
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.82
    Marker Score: 338
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.81
    Marker Score: 288
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.81
    Marker Score: 213
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.81
    Marker Score: 613
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.81
    Marker Score: 221
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.81
    Marker Score: 281
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.8
    Marker Score: 198
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.8
    Marker Score: 162
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.8
    Marker Score: 198
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.8
    Marker Score: 211
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.79
    Marker Score: 462
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.79
    Marker Score: 470
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.79
    Marker Score: 188
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.78
    Marker Score: 195
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.78
    Marker Score: 360
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.78
    Marker Score: 401
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 596

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** JOSD1 is a member of the cysteine-type deubiquitinase family, enzymes that remove ubiquitin proteins from target substrates, thereby modulating protein stability, localization, and activity. The Josephin domain, a characteristic structural motif in JOSD1, is essential for its deubiquitinating activity and protein-protein interactions. This domain is also present in other deubiquitinating enzymes, such as USP14 and USP18, suggesting a conserved functional mechanism. **Pathways and Functions:** JOSD1 is widely expressed in various cell types, including epithelial, immune, and muscle cells. Its deubiquitinating activity is implicated in several signaling pathways, including: 1. **Cytosol and Plasma Membrane Signaling:** JOSD1 regulates the stability and localization of proteins at the cytosol and plasma membrane, influencing cell signaling, migration, and proliferation. 2. **Metabolism of Proteins:** JOSD1 modulates protein degradation and synthesis, affecting cellular homeostasis and response to stress. 3. **Protein Binding and Deubiquitination:** The Josephin domain of JOSD1 interacts with various proteins, including ubiquitin ligases, to regulate deubiquitination and protein degradation. **Clinical Significance:** Dysregulation of JOSD1 has been implicated in various human diseases, including: 1. **Cancer:** Overexpression of JOSD1 has been observed in several types of cancer, including breast, lung, and colon cancer, suggesting its potential role in tumorigenesis and cancer progression. 2. **Neurodegenerative Diseases:** JOSD1 has been implicated in the regulation of protein degradation and clearance in the brain, potentially contributing to neurodegenerative diseases such as Alzheimer's and Parkinson's. 3. **Immune System Dysregulation:** JOSD1 regulates immune cell function, and its dysregulation may contribute to immune system disorders, such as autoimmune diseases and immunodeficiency. In conclusion, JOSD1 is a multifunctional protein that plays a crucial role in regulating protein stability, localization, and activity. Its dysregulation has been implicated in various human diseases, highlighting the need for further research into the mechanisms and clinical significance of JOSD1.

Genular Protein ID: 663405739

Symbol: JOS1_HUMAN

Name: Josephin-1

UniProtKB Accession Codes:

Q15040 A8K712

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7584044

Title: Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7584044

DOI: 10.1093/dnares/1.5.223

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17696782

Title: Josephin domain-containing proteins from a variety of species are active de-ubiquitination enzymes.

PubMed ID: 17696782

DOI: 10.1515/bc.2007.107

PubMed ID: 21118805

Title: Crystal structure of a Josephin-ubiquitin complex: evolutionary restraints on ataxin-3 deubiquitinating activity.

PubMed ID: 21118805

DOI: 10.1074/jbc.m110.177360

PubMed ID: 23625928

Title: JosD1, a membrane-targeted deubiquitinating enzyme, is activated by ubiquitination and regulates membrane dynamics, cell motility, and endocytosis.

PubMed ID: 23625928

DOI: 10.1074/jbc.m113.463406

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12486728

Title: Structural modeling of ataxin-3 reveals distant homology to adaptins.

PubMed ID: 12486728

DOI: 10.1002/prot.10280

Sequence Information:

  • Length: 202
  • Mass: 23198
  • Checksum: 837268C393C0A5A9
  • Sequence:
    • MSCVPWKGDK AKSESLELPQ AAPPQIYHEK QRRELCALHA LNNVFQDSNA FTRDTLQEIF 
QRLSPNTMVT PHKKSMLGNG NYDVNVIMAA LQTKGYEAVW WDKRRDVGVI ALTNVMGFIM 
NLPSSLCWGP LKLPLKRQHW ICVREVGGAY YNLDSKLKMP EWIGGESELR KFLKHHLRGK 
NCELLLVVPE EVEAHQSWRT DV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.